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I-Lorcaserin hydrochloride hemihydrate powder (i-856681-05-5)

I-Lorcaserin hydrochloride hemihydrate powder i .......


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum
Umthamo: 1280kg / inyanga

Incazelo

I-Lorcaserin hydrochloride hemihydrate powder (i-856681-05-5) ividiyo

I-Lorcaserin hydrochloride hemihydrate powder (856681-05-5) Imininingwane

Igama Product I-Lorcaserin hydrochloride hemihydrate powder
Igama leKhemikhali I-Lorcaserin hydrochloride, (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride hemihydrate; (R) -8-chloro-2,3,4,5-tetrahydro-1-methyl-1h-3-benzazepine i-hydrochloride hemihydrate
Brand NAme Belviq
I-Drug Class I-5-HT2C i-receptor inhibitor
CAS Inombolo 856681-05-5
InChIKey I-WRZCAWKMTLRWPR-VSODYHHCSA-N
I-molecular Fi-ormula C22H32Cl4N2O
I-molecular Weziyisishiyagalombili 482.31
IMisa ye-Monoisotopic 480.1268745
Ukuxuba Pi-oint Ayikho idatha etholakalayo
Fukuvuselela kabusha Pi-oint Ayikho idatha etholakalayo
I-Half Half-Life I-Lorcaserin inempilo yengxenye ye-plasma ye ~ amahora angu-11
Color powder emhlophe
solubility Umswakama wamanzi 0.0709 mg / mL
Storage Tukushisa Ayikho idatha etholakalayo
Aukuphikisana I-Lorcaserin hydrochloride i-hemihydrate powder esetshenziswa njengesidakamizwa sokulwa nokukhuluphala ngokweqile. Inendima njengengcindezi yondla futhi i-agonist ye-serotonergic.

I-Lorcaserin hydrochloride hemihydrate powder (856681-05-5) Incazelo

I-Lorcaserin hydrochloride i-hemihydrate powder iyi-hydrate eyinhlobo ye-hemihydrate ye-lorcaserin hydrochloride. Isetshenziswa njengesidakamizwa sokulwa nokukhuluphala ngokweqile. Inendima njengengcindezi yondla futhi i-agonist ye-serotonergic. Iqukethe i-lorcaserin hydrochloride.

I-Lorcaserin hydrochloride hemihydrate powder isetshenziswa ukuphatha ukukhuluphala okuhambisana ne-cholesterol ephezulu, ukucindezelwa kwegazi, noma ukuthayipha i-2 sikashukela.

I-FDA igunyaze i-Raw Lorcaserin hydrochloride hemihydrate powder kubantu abakhuluphele (abanezibalo zomzimba, noma i-BMI, ye-30 noma ngaphezulu) noma abakhuluphele (abane-BMI ye-27 noma ngaphezulu) futhi banenani okungenani isisindo esisodwa- isimo sezempilo esihlobene nohlobo lwe-2 yesifo sikashukela, umfutho wegazi ophakeme noma i-cholesterol ephakeme.

I-Lorcaserin hydrochloride i-hemihydrate powder isebenza ngokulawula ukudla - ikakhulukazi ngokusungula izinkinga zokuphefumula ze-serotonin, i-neurotransmitter edala imizwa yokukhathazeka nokwaneliseka. I-Serotonin nayo ihilelekile ekudumeni; izidakamizwa eziningi ezicindezelayo zisebenza ngokuvimbela i-reuptake ye-serotonin nokugcina ubuchopho bamukelekile emakhemikhali. Abacwaningi e-Arena bathi izidakamizwa zabo zenzelwe ukufuna kuphela izamukeli ze-serotonin ezithinta ukudla.

I-Lorcaserin hydrochloride i-hemihydrate powder (i-856681-05-5) Inqubo yesenzo

I-Lorcaserin ikholelwa ukuthi iyanciphisa ukusetshenziswa kokudla futhi ikhuthaze ukungahambi kahle ngokukhetha ngokuphumelelayo ama-receptor we-5-HT2C kuma-neuron an-opiomelanocortin anorexigen ase-hypothalamus. Indlela eqondile yokusebenza ayaziwa.

I-Lorcaserin kumthamo wansuku zonke onconywayo usebenzelana ngokukhetha nama-receptor we-5-HT2C uma kuqhathaniswa namamukeli we-5-HT2A kanye ne-5-HT2B (bona ithebula le-5), amanye ama-subtypes we-5-HT receptor, kanye ne-5-HT. .

Isicelo we-Lorcaserin hydrochloride hemihydrate powder (856681-05-5)

  • Ukucindezela ukudla: I-Agent esetshenziselwa ukunciphisa ukudla.
  • i-serotonergic agonist: I-agent ene-affinity ye-serotonin receptors futhi iyakwazi ukulinganisa imiphumela ye-serotonin ngokugqugquzela umsebenzi we-physiologic ema-receipt cell. Ama-agonists aseSerotonin asetshenziswa njengama-anti-depressants, i-anxiolytics, kanye nokwelashwa kwezidakamizwa ze-migraine.

Kunconywe i-Lorcaserin hydrochloride hemihydrate powder (i-856681-05-5)

Njengoba ulwazi olufanele mayelana nokusetshenziswa kukaLorcaserin hydrochloride hemihydrate alutholakalanga, ulwazi olulandelayo lubhekisela kuphela:

I-Lorcaserin HCL powder i-846589-98-8 ifika efomini yethebhulethi futhi ithathwa izikhathi ezingu-1-2 ngezikhathi, noma ngaphandle kokudla. I-Lorcaserin kumele isetshenziswe kanye nokudla okunciphile khalori kanye nohlelo lokuzivocavoca.

Umthamo ophakanyisiwe we-lorcaserin ngu-10 mg olawulwa ngomlomo kabili ngosuku. I-Lorcaserin ingathathwa ngaphandle kokudla. I-Lorcaserin kufanele ishiywe ezigulini ezingaphumeleli ukufezekisa okungenani ukulahlekelwa kwe-5% ngesonto 12 kusukela lezi ziguli zingenakuthola ukulahlekelwa kwesisindo esinomsoco ngokuphathwa okuqhubekayo.

Izinzuzo I-Lorcaserin hydrochloride i-hemihydrate powder (i-856681-05-5)

I-Lorcaserin hydrochloride i-hemihydrate powder iyinhlangano ye-5-HT2C ye-receptor agonist ecatshangelwa ukunciphisa ukudla okudliwayo ngokusebenzisa uhlelo lwePOMC oluphakathi. Izinzuzo ze-Lorcaserin HCL:

  • I-Lorcaserin hydrochloride i-hemihydrate powder isetshenziselwa kanye nokudla nokuzivocavoca ukwelapha ukukhuluphala.
  • I-Lorcaserin hydrochloride i-hemihydrate powder ngezinye izikhathi isetshenziselwa ukuphatha ukukhuluphala okungase kuhlobene nesifo sikashukela, i-cholesterol ephakeme noma ukucindezelwa kwegazi eliphezulu.
  • I-Lorcaserin hydrochloride i-hemihydrate powder ngeke iphathe noma yiziphi izimo zempilo ezingaphansi (ezifana nesifo senhliziyo, isifo sikashukela, umfutho wegazi ophezulu).

Okuqhamuka uma udla imishanguzo we-Lorcaserin hydrochloride hemihydrate powder (856681-05-5)

I-Lorcaserin hydrochloride i-hemihydrate powder isetshenziselwa ukwelashwa kokuphathwa kwesisindo esingapheli kubantu abadala abane-index mass body (BMI) ye-30 noma enkulu (obese kakhulu) njengokungeza ekudleni okuncishisiwe-khalori nokuzivocavoca. Iphinde ivunyelwe ukusetshenziswa ngabantu abadala abane-BMI ye-27 noma enkulu (ngokweqile kakhulu) futhi okungenani abanesimo esisodwa esisondelene nesisindo esinjengesiphakamiso esiphakeme segazi (i-hypertension), noma i-cholesterol ephakeme (i-dyslipidemia). Nokho, kungase kube neminye imiphumela emibi. Njengezansi:

TImiphumela emibi kakhulu:

  • -Isifundo,
  • -Izinkinga,
  • -Ukukhathazeka,
  • -Isizathu,
  • -Umlomo omile,
  • -Isivumelwano, futhi
  • -Hyglycemia (ushukela wegazi ophansi).

Ezinye imiphumela ezingavamile kodwa ezibi kakhulu ezihambisana ne-lorcaserin zihlanganisa:

  • -Thola izinkinga ze-valve,
  • -Changelela ukunakekelwa noma inkumbulo,
  • -Izinkinga zempilo,
  • -Ukucindezeleka noma imicabango yokuzibulala,
  • -Erections ezibuhlungu,
  • -Ukushaya kwenhliziyo,
  • -Ukwehla kwesibalo segazi, futhi
  • - Ukwanda kwe-hormone, i-prolactin.


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I-Shangke Chemical yinkampani ephezulu echwepheni ezisebenzayo ezizimele eziphambili zokwelapha (APIs). Ukuze ulawule ikhwalithi ngesikhathi sokukhiqiza, inqwaba yabachwepheshe abanolwazi, imishini yokukhiqiza yokuqala kanye nama-laboratories yiwona amaphuzu ayisihluthulelo.

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