Anandamide (AEA) (94421-68-8)

Mashi 15, 2020
SKU: 77472-70-9
5.00 koku 5 ngokusekelwe ku 1 isilinganiso ikhasimende

I-Anandamide, eyaziwa nangokuthi yi-N-arachidonoylethanolamine (AEA), iyi-fatty acid neurotransmitter ethathwe ku …… ..


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum

I-Anandamide (AEA) (94421-68-8) ividiyo

Anandamide (AEA) (94421-68-8) Siziqu

Igama Product I-Anandamide (AEA)
Igama leKhemikhali I-Arachidonylethanolamide; N-Arachidonoylethanolamine; Anandamide (20.4, n-6);

I-N-Arachidonoyl-2-hydroxyethylamide; i-Arachidonoyl ethanolamide; AEA;

CAS Inombolo 94421-68-8
InChIKey LGEQQWMQCRIYKG-DOFZRALJSA-N
SMILE CCCCCC = CCC = CCC = CCC = CCCCC (= O) NCCO
Formula Yamamolekhula C22H37NO2
isisindo Yamamolekhula 347.53
IMisa ye-Monoisotopic I-347.282429 g / mol
I-Melting Point N / A
ukubila Point 522.3 ± 50.0 ° C (Kubikezelwe)
Ubuningi I-0.92 g / mL ku-25 ° C (ilitha)
Color ukukhanya okuphuzi
Sithempeli le-torage -20 ° C
solubility ethanol: inyibilika
Isicelo Isetshenziselwa inkumbulo, ukugqugquzela, izinqubo zokuqonda, ukulawulwa kokuhamba, ukulawula izinhlungu, ukuvusa inkanuko nokuzala.

Yini i-Anandamide (AEA)?

I-Anandamide, eyaziwa nangokuthi yi-N-arachidonoylethanolamine (AEA), yi-fatty acid neurotransmitter ethathwe emgomeni ongeyona i-oxidative we-eicosatetraenoic acid (i-arachidonic acid. Inesakhiwo esifana kakhulu ne-tetrahydrocannabinol, isici esisebenzayo se-cannabis. onakaliswe ngokuyinhloko ngama-enzyme e-fatty acid amide hydrolase (i-FAAH), eguqula i-ancamide ibe yi-ethanolamine ne-arachidonic acid, Ekugcineni, i-Anandamide ihlanganiswe ne-neuron ngokusabela kwe-conduction kwenzeka phakathi kwe-arachidonic acid ne-ethanolamine ngaphansi komthetho we-calcium ion ne-cyclic monophosphate adenosidase. Kuyisandulelo seqembu lezinto ezisebenza ngokuzivocavoca (Prostamides) ezibamba iqhaza emisebenzini eminingi yomzimba, kufaka phakathi isifiso sokudla, inkumbulo, izinhlungu, ukucindezeleka, kanye nokuzala. Ngaphezu kwalokho, i-Anandamide futhi ivimbela abantu Ukudlondlobala kwamaseli womdlavuza webele.

I-Anandamide ikhona ezintweni eziningi ezinjenge-urchin roe yasolwandle, ubuchopho bezingulube kanye nama-ligie livers, njll., Kepha isibalo sayo sincane. Futhi, abacwaningi baphinde bathola i-Anandamide nezinto ezimbili (i-N-oleoylethanolamine ne-N-Linoleylethanolamine) kukashokolethi omnyama. I-Anandamide ikhona nakwezinye okusanhlamvu Ezicutshunguliwe, (isinkwa esimhlophe), I-Alcohol (ngokuqondile, ukusetshenziswa okungamahlalakhona noma ukuphuza ngokweqile), Ushukela ocolisisiwe, Amafutha eTrans, Ukudla okuthosiwe emafutheni wemifino nokudla okungekhona okuphathelene nokudla okuqukethe izinambuzane njll.

Njengengxenye yohlelo lwe-endocannabinoid (ECS), i-Anandamide ihlukaniswa njengomlawuli we-homeostasis kanye nelinye isigaba se-cannabis-efana ne-2-AG yamakhemikhali e-cannabinoid emzimbeni wonke. Lolu hlelo lukhona Kuwo wonke ama-vertebrates. I-Anandamide idlala indima yokulawula ukusebenza kokuphaka kanye nogqozi lwe-neurogenic kanye nenjabulo, ukugcina umzimba nengqondo yethu kusesilinganisweni. Ucwaningo luthole ukuthi imizwa yethu, injabulo, ukwesaba, ukukhathazeka, kanye nokukwazi ukubekezelela ukucindezelwa konke kulawulwa ngohlelo lwe-endocannabinoid, kanye nezifo ezahlukahlukene kusuka ku-schizophrenia kuya ekucindezelekeni kuhambisana namazinga angajwayelekile we-anandamide.

I-Anandamide, efana ne-THC, iyi-agonist eyingxenye ye-CB1R. Kungadala izithuthukisi ezingaba khona ngokuthi kusebenze "ngokugcwele" kohlelo lobuchopho. Kuyaqapheleka ukuthi yonke le miphumela ye-Anandamide ibonakala sengathi yathuthukiswa yi-pharmacologic ekuvimbeleni ukonakaliswa kwayo kwe-metabolic. Ukutholwa kuka-Anandamide kungaholela ekwakhiweni komndeni omusha ngokuphelele wezidakamizwa zokwelapha.

Izinzuzo ze-Anandamide (AEA)

I-Anandamide, eyaziwa nangokuthi "i-molecule eyi-bliss", isithuthukisi semizwa, i-neurotransmitter ne-endocannabinoid, enezinzuzo eziningi zezempilo nezengqondo:

I-Anandamide inciphisa ukwakheka okusheshayo kwamaseli womdlavuza. Ngo-1998, iqembu lososayensi base-Italiya bathola ukuthi i-anandamide ingakhuthaza i-neurogeneis futhi yakhe amaseli amasha ezinzwa, anciphise ukwakheka / ukwandisa inani lamaseli womdlavuza webele.

Amandla ka-Anandamide wokuqhakambisa i-neurogeneis (ukwakheka kwama-neurons amasha) ubamba iqhaza ekulawulweni kokuziphatha kokudla futhi akhiphe isisusa nentokozo kumagundane. Lokhu kusiza ukunciphisa izimpawu zokudangala nokukhathazeka. Ucwaningo olwenziwe ngo-2015 lwabantu nezamagundane lwathola ukuthi amazinga aphezulu e-anandamide angakhuthaza ukuphuculwa kwesimo somoya kanye nokwehlisa ukwesaba.

Ngaphezu kwalokho, amandla we-anandamide okubopha ama-CB1 kanye nama-receptors e-CB2 nawo azothinta kakhulu izindlela eziningi zomzimba, okukhombisa izinzuzo ezinhle ngokuya ngememori, ukugqugquzelwa, izinqubo zokuqonda, ukulawula kokuhamba, ukulawula izinhlungu, ukuvusa inkanuko nokuzala.

Ungayandisa kanjani i-anandamide(AEA) amazinga emzimbeni womuntu?

Ngoba i-anandamide ineqhaza njenge-neurotransmitter, i-vasodilator agent ne-serum metabolite yegazi lomuntu, kanye nezinzuzo zezempilo nezengqondo ezibonisiwe, ungafuna ukukhuphula izinga le-anandamide emzimbeni wakho. Nazi izindlela zokunyusa okwesikhashana amazinga we-anandamide emzimbeni womuntu:

- UkuzivocavocaIng

Ucwaningo luthole ukuthi ngemuva kwemizuzu engama-30 kuphela yokugijima, okuqukethwe kwe-anandamide (AEA) kwabantu nezinja kukhuphukile. Ngakho-ke uma ufuna ukuzuza kakhulu, yenza izivivinyo eziningi ze-aerobic njalo.

- Ukudla ushokoledi omnyama

I-chocolate emnyama inesilinganiso esiphakeme se-theobromine ku-chocolate enempilo, futhi i-theobromine isiza ukukhulisa ukukhiqizwa kwe-anandamide ebuchosheni futhi ibambe okwesikhashana ukuwohloka kwayo.

- Ukudla i-truffle emnyama

I-black truffle (isikhunta esimnyama) ngokwemvelo iqukethe i-anandamide. Yize isikhunta singakwazi ukusebenzisa i-anandamide nganoma iyiphi indlela, abacwaningi bakholelwa ukuthi isetshenziselwa ukuheha izilwane ukuze ziyidle futhi ikhiqize futhi izinsalela zayo.

- Ukuthola ukugxila

Ucwaningo lukhombisa ukuthi lapho umuntu esesimweni (esibizwa ngokuthi "ukugeleza" noma "esifundeni,") sokugxila okukhulu, ukusebenza, kanye nokuxineka, hhayi kuphela ukuthi uzokhiqiza kakhulu noma udale imisebenzi engcono ebuchosheni bakho futhi ukhipha i inani elikhulu lamakhemikhali, njenge-serotonin, i-dopamine, i-endorphin ne-anandamide.

Ngaphezu kwalokho, itiye, i-coriander kanye ne-celery nakho kungasiza ukukhulisa ukukhiqizwa kwe-anandamide.

Izikhombo:

  • Berger, Alvin; UCrozier, uGayle; I-Bisogno, Tiziana; UCavaliere, uPaolo; U-Innis, uSheila; UDi Marzo, uVincenzo (15 Meyi 2001). "I-Anandamide nokudla: Ukufakwa kwe-arachidonate yokudla kanye ne-docosahexaenoate kuholela ekukhuleni kwamazinga obuchopho be-N-acylethanolamines ehambelana nezingulube". Ukuqhubeka kweNational Academy of Science. 98 (11): 6402– Bibcode: 2001PNAS… 98.6402B. doi: 10.1073 / pnas.101119098. PMC 33480. PMID 11353819.
  • U-El-Talatini MR, Taylor AH, Konje JC (Ephreli 2010). "Ubudlelwano obuphakathi kwamazinga e-plasma we-endocannabinoid, wandamide, sexidsids, kanye ne-gonadotrophins ngesikhathi sokujikeleza kokuya esikhathini". Umanyolo. I-Steril. 93 (6): 1989– doi: 10.1016 / j.fertnstert.2008.12.033. PMID 19200965.
  • Habib, Abdella M .; I-Okorokov, u-Andrei L .; I-Hill, uMathewu N .; UBras, uJose T .; U-Lee, uMan-Cheung; ULi, uShengnan; Gossage, uSamuel J .; van Drimmelen, Marie; Morena, Maria (Mashi 2019). "I-Microdeletion ku-pseudogene ekhonjwe esigulini ngokugxila okuphezulu kwe-anandamide nokuzwa kobuhlungu". Ijenali yaseBrithani ye-Anesthesia. 123: e249- doi: 10.1016 / j.bja.2019.02.019. PMID 30929760.
  • Mahler SV, Smith KS, Berridge KC (Novemba 2007). "I-Endocannabinoid hedonic hotspot yenjabulo yezinzwa: i-wandamide ku-nucleus accumbens igobolondo ithuthukisa 'ukuthanda' komvuzo omnandi". I-Neuropsychopharmacology. 32 (11): 2267– doi: 10.1038 / sj.npp.1301376. PMID 17406653.
  • Mechoulam R, Fride E (1995). "Umgwaqo ongakhanjwanga oya ezingqondweni zama-cannabinoid ligands, ama-ancamides". KuPertwee RG (ed.). Ama-cannabinoid receptors. IBoston: I-Academic Press. iphe. 233- ISBN 978-0-12-551460-6.
  • IMallet PE, uBeninger RJ (1996). "I-endo native cannabinoid receptor agonist anandamide iphazamisa inkumbulo kumagundane". I-Behahlangual Pharmacology. 7 (3): 276- doi: 10.1097 / 00008877-199605000-00008.

UKUHLELWA KANYE Nesitatimende:

Le Material ithengiswa Ukusetshenziswa Kocwaningo Kuphela. Imibandela Yokuthengisa Faka isicelo. Hhayi Ukusetshenziswa Komuntu, noma Ezokwelapha, Izilwane, noma Ukusetshenziswa Kwasekhaya.