I-86 (1812) i-4514114 info@phcoker.com

Ubuchopho bezinsobe ze-sodium (i-GM1) i-Monosialotetrahexosylganglioside (37758-47-7)

I-GM1 powder isetshenziselwa kabanzi ukulimala kwe-neonatal-ischemic brain injection, isifo sika-Parkinson ...


Isimo: Ekukhiqizeni kweMisa
Izakhiwe futhi zenziwe ngokwezifiso zitholakalayo
Umthamo: 1277kg / inyanga

Incazelo

I-sodium ye-Monosialotetrahexosylganglioside (GM1) yengqondo yengulube (i-37758-47-7) ividiyo

I-sodium ye-Monosialotetrahexosylganglioside (GM1) yengqondo yengulube (37758-47-7) Incazelo

Ubuchopho bezingulube ze-sodium (GM1) ye-Monosialotetrahexosylganglioside (37758-47-7), igama elifushane lingaba yi-GM1, elikhishwe ebuchosheni bengulube futhi ilungu le-ganglio chungechunge lama-gangliosides one-resial acid ase-sialic.

I-GMl ingakhuthaza ukubuyiswa kwemisebenzi yezinzwa ngemuva kokulimala kwesistimu yezinzwa eziyinhloko yezimbangela ezihlukahlukene, ukugqugquzela ukungasebenzi kwe-neuroplasticity. Ukuhlolwa kuveza ukulimala kwe-GMl isisombululo se-brain, ubuchopho obubuhlungu bokubuyisela amangqamuzana omgogodla ukulimala komgogodla kunomthelela wokuvikela futhi kukhuthaze indima yeseli.

Isigaba esiphezulu sesivivinyo sesibili se-clinic sibonise, singanciphisa i-neurotoxicity (OIN) ye-oxaliplatin. Kodwa akaqinisekiswanga yicala lesigaba III. Ukuhlolwa kwesigaba III kuyadingeka ukuphenya umphumela nokuphepha kwe-Sodium Injection ye-monosialotetrahexosylganglioside yokuvikela i-OIN emdlalweni wesisu.

Ubuchopho bezinsobe ze-sodium (i-XXUMUM-1-37758) i-Monosialotetrahexosylganglioside (GM47)pecifications

Igama Product I-Sodium Monosialotetrahexosylganglioside (GM1) yengqondo yengulube
Igama leKhemikhali I-sodium ye-Monosialotetrahexosylganglioside (i-Porcine ubuchopho)

Noma i-GM1

ukulandelana /
Brand NAme Shenjie
I-Drug Class Sphingolipids
CAS Inombolo 37758-47-7
InChIKey I-GTTLZSUWCRJZRC-CRQBLQEMSA-N
I-molecular Fi-ormula C73H134N4O31
I-molecular Weziyisishiyagalombili 1563.85
IMisa ye-Monoisotopic 1563.85
Ukuxuba Pi-oint N / A
I-Half Half-Life /
Color I-powder engasebenzi emhlophe
solubility i-chloroform / i-methanol (i-9: i-1): i-10 mg / mL, icacile, ayibalabala
Storage Tukushisa -20 ° C
Aukuphikisana Ama-receptors aqondile e-toxin ekholera eqoqa ebuchosheni ekupheleni kwe-infantile lipidosis.
Izinto zokuhlola Ezindlini zezinga eliphezulu
Chai-racter Powder omhlophe noma omhlophe; ephunga kancane, enganambitheki; imanzi. Lo mkhiqizo uncibilikisiwe emanzini, uhlakazeka kancane emethanol, cishe engenayo i-ethanol anhydrous.
Ubunikazi
Umbala wokunikeza imibala 1 Thatha isisombululo sokuhlola i-0.2ml ngaphansi kokuzimisela kokuqukethwe, engeza amanzi 2ml, bese ufaka isixazululo se-Hydroquinone hydrochloric acid (i-hydroquinone 0.2g, engeza amanzi 10ml, engeza i-hydrochloric acid 90ml, engeza isixazululo se-0.1mol / L Copper sulfate 0.25ml, i-Friji Preservation) 2ml, ukugeza amanzi ngamaminithi we-15, isixazululo esibhakabhaka nokubomvu, nge-Ne utshwala 5ml isisindo sokubhukuda, akukho-ungqimba ophuzo oluhlaza okwesibhakabhaka.
Umbala wokunikeza imibala 2 Thatha lo mkhiqizo mayelana ne-20mg, engeza i-glacial acetic acid 1ml, ukugeza okushisayo kwamanzi okushisa okuqedwa ngokugcwele, engeza ezintathu ze-chloride test fluid 1 amaconsi, emanzini okushisa ashisayo eduze nodonga lwepayipi kancane kancane wengeze i-sulfuric acid 1ml, ukuze isixazululo sibe izingqimba ezimbili , isikhombimsebenzisi se-two-liquid kufanele sibe nsundu
Usawoti sodium Ukusabela okubonakalayo kosawoti sodium kulo mkhiqizo (i-Chinese Pharmacopoeia edition 2015 ezine 0301).
I-chromatography yamanzi (LC) Esigabeni se-chromatographic eqoshiwe ngaphansi kokuzimisela kokuqukethwe, isikhathi sokugcina esiphezulu esiyinhloko sesisombululo sokuhlola kufanele sihambisane nesikhathi sokugcina esiqongweni esiyinhloko sesisombululo sokulawula.
I-spectroscopy engathintekile Ibalazwe lokungenisa ukukhanya kwe-infrared lomkhiqizo kufanele lihambisane nemephu yomkhiqizo wokulawula (i-Chinese Pharmacopoeia edition 2015 ezine 0402).
Hlola
PH 5.0 ~ 6.5
Ukucaca nombala wesisombululo Kufanele kucaciswe umbala; uma kunamafu, angeke abe mkhulu kune-liquid standard of turbidity No. 1th; Uma ukukhishwa kombala akufanele kube okujulile kunesixazululo se-Yellow No 1th colorimetric.
Ukuzimisela okuphezulu kokucindezela Isixazululo esiphelile kufanele sibe sobala futhi sibe sobala ngemuva kokushisa okuphezulu, akukho ubisi obukhanyayo, akukho mvula
Isici sokuhlonza (amaprotheni amaningi) ≤50000
Inani le-sialic acid Ngokomphumela owomile womkhiqizo, amathe ane-asidi kufanele abe yi-19.0 ~ 21.0%
izinto ezihlobene I-sialic acid ≤0.3%; GD3, GD1a, ukungcola okungaziwa yi-≤ 0.5%; ukungcola kanye ≤2.0%
amaprotheni ≤1.0%
Ukuphakama kwamandla emangqamuzana aphezulu ≤0.5%
I-solvents ehlala njalo I-Methanol ≤ 0.1%; i-acetone ≤ 0.3%; I-Trichloromethane ≤0.003%
Water ≤4.0%
Amafutha okushisa ≤5.0%
Insimbi enamandla ≤20ppm
Ubuthi obungavamile Ukuhambisana nemigomo
Izinto ezinamanzi ezinamandla Kufanele kube ngokuhambisana nemithethonqubo (izibalo eziningi zokuphatha)
I-pyrogen Kufanele kube ngokuhambisana nemithethonqubo (izibalo eziningi zokuphatha)
Imingcele ye-Microbial Inani lamabhaktheriya aerobic kufanele libe yi- <100cfu / g, futhi inani eliphelele lemikhunta namagile kufanele kube <50cfu / g
Specific ≥98.0%

Raw I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7) Incazelo

I-Sodium ye-Monosialotetrahexosylganglioside (37758-47-7), igama elifushane lingaba yi-GM1, elikhishwe ebuchosheni bengulube futhi ilungu le-ganglio chungechunge lama-gangliosides aqukethe ama-resial ase-asialic acid.

I-GM1 ingakhuthaza ukubuyiswa komsebenzi wezinzwa ngemuva kokulimala kwesistimu yomphakathi oyinhloko yezimbangela ezihlukahlukene, ukukhuthaza ukuqina kwe-neuroplasticity. Ukuhlolwa kubonisa ukulimala kwengqondo ye-GM1, ubuchopho obubuhlungu bokubuyisela amangqamuzana omgogodla ukulimala komgogodla kunomthelela wokuvikela futhi kukhuthaze indima yeseli.

Isigaba esiphezulu sesivivinyo sesibili se-clinic sibonise, singanciphisa i-neurotoxicity (OIN) ye-oxaliplatin. Kodwa akaqinisekiswanga yicala lesigaba III. Ukuhlolwa kwesigaba III kuyadingeka ukuphenya umphumela nokuphepha kwe-Sodium Injection ye-monosialotetrahexosylganglioside yokuvikela i-OIN emdlalweni wesisu.

I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7) Inqubo yezenzo?

I-GM1 (i-monosialotetrahexosylganglioside) i-ganglioside, ilungu le-ganglio uchungechunge lwe-gangliosides eliqukethe i-resial eyodwa ye-asialic acid. I-GM1 inezici ezibalulekile zomzimba nemithelela ye-plastic neuronal nokulungisa izinto, nokukhululwa kwama-neurothrophin ebuchosheni. Ngaphandle komsebenzi walo kumzimba we-brain, i-GM1 yenza njengendawo yokubopha kokubili i-cholera toxin no-E. coli ukushisa-labile enterotoxin (isifo sohudo).

Izinzuzo of I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7)

I-Ganglioside GM1 iyilungu lomndeni we-ganglioside osetshenziswe emazweni amaningi futhi kucatshangwa ngokuthi ukwelashwa okunye okuthembisayo okuvimbela izifo eziningana zezinzwa, kuhlanganise nokulimala kwe-cerebral ischemic. Imiphumela yokwelapha ye-GM1 iye yafakazelwa kokubili kuma-neonates nakwabantu abadala ngemuva kokulimala kwengqondo ye-ischemic.

Kunconywe I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7) Isilinganiso

Isidakamizwa senziwa ngomthamo we-20-40 mg nsuku zonke ngejoza elincane noma elincane lentamo ngokwemigomo yodokotela. Esikhathini esiyinkimbinkimbi sezinguquko ze-pathological: Imithi yasetshenziselwa umthamo we-100 mg nsuku zonke nge-injection yangaphakathi; Ngemuva kwamaviki e-2-3, ngokuvamile igcina inani le-20-40 mg nsuku zonke amasonto ayisithupha, umthamo wokuqala we-500-1000 mg ulawulwa yi-drill ye-Parkinson's; kusukela ngosuku lwesibili, izidakamizwa zasetshenziselwa umthamo we-200 mg nsuku zonke nge-subcutaneous, injection ye-intramuscular noma i-drill emangcwabeni yamaviki e-18 ngokuvamile. lapho lesi sidakamizwa senziwa yi-injection engaphansi kwe-subcutaneous noma emangcwabeni, kufanele ichithezwe futhi ihlanjululwe emanzini ukwenzela umjovo kuze kube yi-10 mg / ml; lapho i-Intravenous drip, izidakamizwa zazingathandwa futhi zihlanjululwe ku-0.9% umjovo we-chloride we-sodium noma i-5% umjovo we-glucose.

Okuqhamuka uma udla imishanguzo of I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7)

Umthelela ohlangothini we-GM1 powder ngokuyinhloko ukuphendula ngokuqhuma ngemuva kokusetshenziswa.


=

Okubhekiselweyo nokuhlungwa komkhiqizo

I-Shangke Chemical yinkampani ephezulu echwepheni ezisebenzayo ezizimele eziphambili zokwelapha (APIs). Ukuze ulawule ikhwalithi ngesikhathi sokukhiqiza, inqwaba yabachwepheshe abanolwazi, imishini yokukhiqiza yokuqala kanye nama-laboratories yiwona amaphuzu ayisihluthulelo.

Xhumana nathi