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I-Raw Tianeptine usawoti usawoti we-sodium (30123-17-2)

I-tianeptine i-sodium usawoti wesikhumba iyinhlanganisela ye-tricyclic, umgqugquzeli okhethayo we-5-HT (i-serotonin; sc-201146) etholakala ku-vitro ....


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum
Umthamo: 1290kg / inyanga

Incazelo

I-Raw Tianeptine i-sodium usawoti powder (ividiyo ye-30123-17-2)

I-Raw Tianeptine usawoti usawoti we-sodium (30123-17-2) Imininingwane

Igama Product I-Raw Tianeptine usawoti usawoti
Igama leKhemikhali I-Tianeptine sodium; I-Tianeptine usawoti sodium; 30123-17-2; IStablon; Coaxil;
Brand NAme N / A
I-Drug Class N / A
CAS Inombolo 30123-17-2
InChIKey I-HNTRDGDHBBFLPG-UHFFFAOYSA-M
I-molecular Fi-ormula C21H24ClN2NaO4S
I-molecular Weziyisishiyagalombili 458.93
IMisa ye-Monoisotopic I-458.104 g / mol
Ukuxuba Pi-oint 1800C
BilisaIng Pi-oint 609.2 ° C ku-760 mmHg
I-Half Half-Life N / A
Color I-white to off-white powder
Sukufaneleka I-DMSO: ≥20mg / mL
Sukuhlushwa Tukushisa Desiccate ku-RT
Aukuphikisana I-tianeptine usawoti usawoti wesodium yile usawoti we-Tianeptine.

I-tianeptine i-anti-depressant.

I-Raw Tianeptine usawoti usawoti we-sodium (30123-17-2) Incazelo

I-Tianeptine usawoti ka-sodium yile usawoti we-Tianeptine. I-Tianeptine, isakhi se-tricyclic, ngumgqugquzeli okhethayo we-5-HT (i-serotonin; i-sc-201146) etholakala ku-vitro futhi ku-vivo. Ukwengeza, i-Tianeptine ibikwa ukuthi isebenza njenge-inhibitor ekhethiwe yokuthola i-dopamine futhi ifana ne-amineptine. I-Tianeptine ayinayo impumelelo ephawulekayo ekufakeni i-monoamine. Esicwaningweni esisebenzisa i-synaptosomes ehlanjululwe ebuchosheni be-rat, i-Tianeptine ibikwa ukuthi ikhulise ukutholakala kwe-serotonin ezindaweni ezikhethiwe zobuchopho. Ama-syaptosomes ahlanzekile atholakala kumagundane futhi ahlanganiswe ne-tritium-eqoshiwe i-5-HT ne-Tianeptine in vitro. I-synaptosomes yahlaziywa ngokususwa nokukhululwa kwe-5-HT nge-counter scintillation counter.

I-Raw Tianeptine usawoti wesikhumba sodium i-antiypical antiypical ngezinyathelo ezihlukahlukene, ikakhulukazi ohlelweni lwe-glutamatergic.Ivimbela ukukhululwa kwe-glutamate futhi ihambise umsebenzi we-AMPA receptor.I-tianeptine iphinde ibe njenge-agonist ye-μ-opioid receptor (EC50s = 194 futhi I-641 nM yama-receptors womuntu kanye negundane, ngokulandelana). Kusebenza ngendlela efana ne-fluoxetine ekuphathweni kwe-post-traumatic stress disorder.

Umuthi usawoti we-Tianeptine unama-nootropic amakhono ngokuqondene nomuntu onokuhlukumezeka kwakhe okungathinteki kabi yizinkinga zemizwelo futhi unekhono lokuthuthukisa ukugxilisa nokugxila kubantu abanobuchwepheshe obukhulu.

I-Tianeptine usawoti usawoti (i-30123-17-2) Inqubo yesenzo

Ucwaningo lwamuva lubonisa ukuthi i-tianeptine isebenza njenge-agonist egcwele ku-receptionor ye-opioid (MU). I-tianeptine inselele inkolelo ye-monoaminergic yokucindezeleka, kanye nezinqubo ezixhaswa kakhulu ze-monoaminergic lapho kushiwo khona isenzo sezinkinga zokulwa nokucindezeleka. Ngokuqondile, lesi sidakamizwa sicatshangelwa ukuthi siphikelele ngokuqhubekayo i-glutamate receptor ukuqhuma kwe-syppse yokuxhumana ye-CA3 yokusebenzisana nomsebenzi we-hippocampal. Ucwaningo lwamanje luveza ukuthi i-tianeptine ikhiqiza imiphumela yayo yokulwa nokucindezeleka ngokushintsha kwe-glutamate receptor umsebenzi (isibonelo, ama-receptors we-AMPA nama-receptors we-NMDA) futhi kuthinte ukukhululwa kwe-neurotrophic factor (BDNF) etholakala ebuchosheni, echaphazela i-plastiki ye-neural. Ucwaningo lwamuva nje ngokusekela indima ye-tianeptine ekuguquleni kwemisebenzi ye-glutaminergic ku-amygdala, isifunda somqondo sobuchopho obuhambisana nezinkumbulo.

I-Tianeptine inciphisa impendulo ye-hypothalamic-pituitary-adrenal ekucindezelekeni, ngakho-ke ivimbela izinkinga zokuziphatha ezihlobene nokucindezeleka. Ezingxenyeni, ukucindezeleka kokucindezeleka okunamandla kwandisa ama-extracellular ama-glutamate ku-amygdala ye-basolateral umphumela owawuvinjwe yi-tianeptine. Kuyathakazelisa ukuthi i-SSRI fluoxetine yandisa ama-glutamate e-extracellular e-amygdala engaphansi kokungakhathaliseki ukuthi izimo zokucindezeleka ziphi. Le datha ibonisa ukuthi indlela yokusebenza ye-tianeptine ihlukile kuma-SSRIs futhi isekela umbono wokuthi indlela yokusebenza ye-tianeptine ihlobene nokuguqulwa komsebenzi we-glutaminergic ku-amygdala kanye ne-hippocampus.

Ngaphezu kwalezi zindlela ezingenhla, i-tianeptine iyi-anti-depressant kanye ne-anxiolytic imithi ekhethekile eyenza ukutholakala kwe-serotonin (i-5-hydroxytryptamine; i-5-HT), ne-5-hydroxyindoleacetic acid (i-5-HIAA) emathisini ebuchopho.

Nakuba i-serotonin ye-monoaminergic neurotransmitters (i-5-HT), i-noradrenaline (NA) ne-dopamine (DA) ikhonjiswe ukuthi ihlobene nokuvela kwezinkinga zokucindezeleka, manje sekuqaphele ukuthi ukulahlekelwa kwe-monoamine akwanele ukuchaza indlela yokwenza i-anti-depressant imithi.

Izinzuzo of I-Tianeptine usawoti usawoti we-sodium (30123-17-2)

  • I-tianeptine usawoti ka-sodium ingaphatha isifo esikhulu sokucindezeleka.
  • I-Tianeptine usawoti ka-sodium inezimpawu zokulwa nokukhathazeka nokucindezeleka nokuziqhenya.
  • I-Tianeptine usawoti ka-sodium yenza ngcono isimo sengqondo futhi sithuthukise isimo sengqondo.
  • I-Tianeptine usawoti ka-sodium ingavimbela ukuhlaselwa kwe-panic okwenzekayo.
  • I-tianeptine usawoti ka-sodium ithinta ubuhlungu obuhlobene ne-fibromyalgia.
  • I-Tianeptine usawoti we-sodium osetshenziswa ekwelapheni ukudangala kubantu besilisa abangasebenzi.
  • I-tianeptine usawoti ka-sodium ine-efficacy ephansi ye-ADHD.
  • I-Tianeptine usawoti ka-sodium iphinde ikhuthaze ukungasebenzi kwegazi.

Kunconywe I-tianeptine i-sodium usawoti wesikhumba (30123-17-2) Isilinganiso

I-Tianeptine Sodium ine-half-life short kuphela ngamahora angu-2.514, futhi idinga ukubuyiswa kokubili ngosuku lonke. Isilinganiso se-tianeptine sodium i-12.5 mg ithathwe kathathu nsuku zonke, ngokuphelele kwe-37.5mg ngosuku.

Ungadluli i-50mg ye-Tianeptine Sodium ngosuku olulodwa. Ukwenza kanjalo kungavula umnyango wokuxhashazwa nokulutha umlutha.

Okuqhamuka uma udla imishanguzo of Tianeptine usawoti usawoti (30123-17-2)

I-Tianeptine usawoti u-sodium usawoti uxhumana nezingxenye eziningi zobuchopho kuhlanganise ne-opiod receptors, engabangela umphumela ohlangothini wokuzijabulisa. Ezinye imiphumela emibi ngezimvamisa ezihlukahlukene zifaka okulandelayo:

Amakhanda (kuze kube yi-18%)

Isizungu (kuze kufike ku-10%)

Ukungalali / ubusuku obusabisayo (kuze kufike ku-20%)

Ukulala (kuze kufike ku-10%)

Umlomo omile (kufika ku-20%)

Ezinye imiphumela emibi zihlanganisa izinto ezifana nokuqothulwa, ukuhlukumeza, ukukhathazeka noma isifo sobungozi. Ukukhathazeka okubaluleke kakhulu kufaka ukuhoxiswa ngemuva kokuhlukumeza futhi kulinganiselwa ukuthi i-0.1 - 0.3% yabasebenzisi bayoba nale nkinga. Kusoze kube nini, njengoba ubona, imiphumela emibi ye-Tianeptine usawoti sodium izoxhomeka kumuntu ngamunye kanye ne-biochemistry yomuntu ngamunye.

Kuyafaneleka ukuthi:

Iziguli ezindala kufanele zithathe umthamo omncane we-Tianeptine usawoti sodium, njengoba kufanele iziguli ezinokuhluleka kwenqunu. Isilinganiso asidingi ukulungiswa ezigulini ezinokudakwa ngokweqile noma ukukhubazeka ngokweqile, noma iziguli ezisebenza nge-dialysis .Nakuba izifo ezicindezelayo, njenge-tianeptine, zandisa ingozi yobuthi besibindi.


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