I-Ganglioside GT1b (59247-13-1)

Mashi 15, 2020
SKU: 167933-07-5
5.00 koku 5 ngokusekelwe ku 1 isilinganiso ikhasimende

Igama elithi Ganglioside laqala ukusetshenziswa ngusosayensi waseJalimane u-Ernst Klenk ngonyaka we-1942 ukuthola ama-lipid asanda kwehlukanisa amaseli ebuchosheni bengqondo… ..


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum

IGanglioside GT1b (59247-13-1) ividiyo

IGanglioside GT1b Siziqu

Igama Product I-Ganglioside GT1b
Igama leKhemikhali I-GANGLIOSIDE GT1B TRISODIUM SALT; GT1B 3NA; I-GT1B-GANGLIOSIDE; I-GT1B (NH4 + SALT); ganglioside, gt1; (ganglioside gt1B) kusuka ebuchosheni bovine; trisialoganglioside-gt1b kusuka ebuchosheni bovine; I-GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; I-Trisialoganglioside GT1b (NH4 + usawoti)
CAS Inombolo 59247-13-1
InChIKey SDFCIPGOAFIMPG-VLTFPFDUSA-N
Formula Yamamolekhula C95H162N5Na3O47
isisindo Yamamolekhula I-2158.4 g / mol
IMisa ye-Monoisotopic I-2157.119189 g / mol
I-Melting Point N / A
Sithempeli le-torage -20 ° C
solubility I-DMSO: inyibilika
Isicelo Umuthi; chromatography;

Kuyini I-Ganglioside GT1b?

Igama iGanglioside laqala ukusetshenziswa ngusosayensi waseJalimane u-Ernst Klenk ngo-1942 ukuthola ama-lipid asanda kwehlukanisa amaseli ebuchosheni. Kuyi-molecule eyenziwe ngama-glycosphingolipids (i-ceramides ne-oligosaccharides) kanye ne-asidi eyodwa noma ngaphezulu ye-sialic exhunywe kwiketanga likashukela. Kuyingxenye ye-membtane ye-cytoplasmic elawula imicimbi yokudluliselwa kwesiginali amaselula. Izinhlobo ezingaphezu kwama-60 zama-gangliosides ziyaziwa, futhi umehluko omkhulu phakathi kwazo yisikhundla nenombolo yezinsalela zeNANA.

IGanglioside GT1b ingelinye lama-ganglioside amaningi futhi iyi-gangisioside ye-trisialic enezinsalela ezimbili ze-sialic acid ezixhunywe kuyunithi yangaphakathi ye-galactose. Inomphumela wokuvimbela ukusabela kokuzivikela komzimba okuphathekayo. Ku-0.1-10 μM, kungavimbela ukukhiqizwa okuzenzakalelayo kwe-IgG, i-IgM ne-IgA ngamangqamuzana egazi omuntu wegazi. IGanglioside GT1b nayo ihlongoziwe njenge-receptor cell host yegciwane leMerkel cell polyoma futhi njengendlela ekwazi ukubangela izifo ezithinta iMerkel cell carcinoma.

IGanglioside GT1b nayo ibilokhu ifakwe emikhakheni eminingi yomdlavuza we-neuronal futhi kubhekwa njengeqembu lezigelekeqe elihlotshaniswa nama-metastases obuchopho. Ucwaningo luthole ukuthi i-GM1, GD1a, ne-GT1b inemiphumela emvimbelayo yokuqhamuka kwe-epermermal factor factor receptor signation and adhesion kanye nokufuduka kwe-keratinocyte, futhi ukuba khona kwayo kungenzeka kube i-biomarker ewusizo yokuhlola amandla we-brain metastatic.

IGanglioside GT1b nayo ithinta amasosha omzimba. IGanglioside GT1b inemiphumela emvimbelayo ekuphenduleni kokuzivikela komzimba womuntu futhi ivimbele ama-immunoglobulins akhiqizwa amaseli wegazi omzimba we-mononuclear cell. Kunobufakazi bokuthi i-GD1b, GT1b, ne-GQ1b ingakhuphula ukukhiqizwa kwama-cytokines e-Th1 ngokuvimbela umsebenzi we-adenylate cyclase, ngenkathi kuvimbela ukwenziwa kwe-Th2.

Njenge-receptor ebona ubuthi obunhlobonhlobo besakhiwo sayo i-oligosaccharide, i-ganglioside GT1b iyi-receptor lapho uClostridium botulinum bacterium botulinum neurotoxin engena kumaseli wezinzwa. Ucwaningo luye lwabonisa ukuthi i-tetanus toxin ingena kumaseli wezinzwa ngokuxutshwa ne-GT1b namanye ama-gangliosides, ivimbela ukukhishwa kwama-neurotransmitters ohlelweni lwezinzwa oluphakathi, futhi ibangele ukukhubazeka kwe-spastic. Uhlobo lwe-botulinum C i-neurotoxin engena ku-nerve luphenye umphumela ongaba khona we-apoptotic wamaseli akhiqizwa yi-ganglioside GT1b ebopha i-neuroblastoma.

Ngaphezu kwalokho, i-ganglioside GT1b ilawula ukungahambi kahle kwamaseli, ukufakwa emzimbeni, nokubambelela ku-fibronectin (FN) ngokusebenzisana ngqo kwamangqamuzana ne-α5 subunit ye-α5β1 inclin, ukutholwa okungasetshenziswa ukuthuthukisa ukwelashwa komdlavuza. Ukuhlanganiswa kwe-GT1b ne-MAG ngaphezulu kwama-neurons kungalawula ukusebenzisana kwe-GT1b engxenyeni ye-plasma yama-neurons, okuholele ekuvimbeleni ukukhula kwe-neurite.

Izinzuzo ze-Ganglioside GT1b

IGanglioside GT1b iyi-acid glycosphingolipid eyakha ama-lipid rafts kumaseli we-neuronal wesistimu yezinzwa ephakathi futhi ibandakanyeka ekwandisweni kweseli, umehluko, ukunamathela, ukuguqulwa kwesiginali, ukuhlangana kwamaseli, iseli ne-metastasis.

Izimpendulo ze-Autoimmune kuma-gangliosides zingaholela ku-Guillain-Barre syndrome. IGanglioside GT1b inducula i-dopaminergic neuron degeneration, engahle ibe nomthelela ekuqalwa noma ekuthuthukisweni kwesifo sikaParkinson.

IGanglioside GT1b iyi-scavenger ye • radical yamahhala ye-OH, evikela ubuchopho ekulimaleni kwe-mtDNA, ekuthatheni kanye ne-lipid peroxidation ebangelwa ngabakhiqizi be-oksijini abasebenzayo.

Ama-Ehrlich tumors aveza i-ganglioside GT1b, futhi i-anti-GT1b inamandla amakhulu okwelapha kulo mdlavuza. Le ganglioside nayo ihlotshaniswa ne-Miller Fisher syndrome.

Imiphumela emibi ye I-Ganglioside GT1b

Ama-gangliosides angabopha kuma-lectins, asebenze njengama-immune and cell adhesion receptors, abambe iqhaza ekusayinisweni kwamaseli, i-carcinogeneis kanye nokwehluka kweseli, athinte ukwakheka kwe-placenta nokukhula kwezinzwa, abambe iqhaza ekuqineni kwe-myelin nasekuvuseleleni izinzwa, futhi enze njengamagciwane kanye nokungena kokufaka ubuthi kumaseli .

Ukuqongelelwa kwe-ganglioside GT1b kuxhunyaniswe nezifo eziningana kufaka phakathi isifo saseThailand-Sachs nesifo seSandhof

IGanglioside GT1b ivimbela impendulo ye-antigen noma ye-mitogen-ikiwa i-T cell proliferation futhi ikhonjwe njenge-receptor ye-botulinum receptor, ubuthi obunqabile obunemiphumela emibi ngokomzimba.

IGanglioside GT1b ikhona cishe kuphela kumaseli wezinzwa futhi ivezwa kuma-adventitia. I-GT1b ikhuthaza ukwahluka kwe-neuronal nokwakheka kwe-dendritic, okuveza ukungaziphathi kahle futhi kuthuthukise i-hyperalgesia ne-allodynia.

IGanglioside GT1b ingathinta amasosha omzimba. Inomphumela ovimbela amandla omzimba womuntu ekuphenduleni futhi ivimbela i-immunoglobulin ekhiqizwa amaseli wegazi omzimba we-peripheral.

Ngokungezwa, iGanglioside GT1b ihlobene nezifo ezilandelayo: umkhuhlane, isifo se-guillain-garré syndrome, ikholera, i-tetanus, i-botulism, uchoko kanye nokukhuluphala.

Izikhombo:

  • U-Erickson, KD, uGarcea, RL, no-Tsai, uB. Ganglioside GT1b yisithasiselo esingesihle sokwamukela iseli seMerkel cell polyomavirus. Ijenali ye-Virology 83 (19), 10275-10279 (2009).
  • I-Kanda, N., neTamaki, K. Ganglioside GT1b icindezela ukukhiqizwa kwe-immunoglobulin ngamangqamuzana egazi omuntu wegazi eliphakeme. I-Immunology 96 (4), 628-633 (1999).
  • I-Schengrund, C.-L., DasGupta, BR, neRandler, NJ Ukubopha kwe-botulinum ne-tetanus neurotoxins kumagenge e-ganglioside GT1b nokuphuma kuyo. J. Neurochem. 57 (3), 1024-1032 (1991).
  • I-Gangliosides, isakhiwo, izehlakalo, i-biology kanye nokuhlaziywa ”. Umtapo weLipid. Inhlangano Yamafutha Yamafutha aseMelika. Kulondolozwe kusukela kwangempela ngomhla ka-2009-12-17.
  • UNicole Gaude, Ijenali yeBiological Chemistry, Vol. 279: 33 maq. 34624-34630, 2004.
  • U-Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, njll Biosynthesis ye-gangliosides enkulu ye-GD1a ne-GT1b. I-Glycobiology, uMqulu 22, Isikhombi 10, Okthoba 2012, amakhasi 1289–

UKUHLELWA KANYE Nesitatimende:

Le Material ithengiswa Ukusetshenziswa Kocwaningo Kuphela. Imibandela Yokuthengisa Faka isicelo. Hhayi Ukusetshenziswa Komuntu, noma Ezokwelapha, Izilwane, noma Ukusetshenziswa Kwasekhaya.