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I-Raw Flibanserin powder (167933-07-5)

I-Raw Flibanserin powder iyisidakamizwa semithi esetshenziselwa ukwelashwa kwabesifazane be-premenopausal abane-generalized hypoactive ngokocansi ....


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum
Umthamo: 1489kg / inyanga

Incazelo

I-Raw Flibanserin powder (167933-07-5) ividiyo

I-Raw Flibanserin powder (167933-07-5)

I-Raw Flibanserin powder, edayiswa ngaphansi kwegama lokuhweba i-Addyi, iyinhlangano ye-serotonin ye-multi-functional agonist kanye nephikisanayo esetshenziselwa ukwelashwa abesifazane besifazane abangaphambi komama abanesifo sengqondo esingazenzisi socansi (HSDD). Imithi ikwandisa inani lokwanelisa izenzakalo zobulili ngenyanga nge-placebo engaba yingxenye eyodwa kusukela ekuqaleni kokuqala kokubili kuya kwesithathu. Ngesikhathi esifanayo, Inendima njenge-agonist ye-serotonergic, umphikisi we-serotonergic kanye no-anti-depressant ..

I-Raw Flibanserin powder (167933-07-5) Siziqu

Igama Product I-Raw Flibanserin powder
Igama leKhemikhali 1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one
Brand NAme Engeza
I-Drug Class I-serotonin agonist ne-antagonist amaningi
CAS Inombolo 167933-07-5
InChIKey I-PPRRDFIXUUSXRA-UHFFFAOYSA-N
I-molecular Fi-ormula C20H21F3N4O
I-molecular Weziyisishiyagalombili I-390.41 g / mol
IMisa ye-Monoisotopic I-390.167 g / mol
Ukuxuba Pi-oint 225 ° C
ukubila Point N / A
I-Half Half-Life ~ Amahora angu-11
Color I-White ukuze ibambe
Sukufaneleka I-DMSO: i-soluble10mg / mL, icacile
Sukuhlushwa Tukushisa I-2-8 ° C
I-Raw Flibanserin powder Aukuphikisana Kuthuthukiswe ekwelapheni ukukhathazeka kwesifiso socansi ocansini kwabesifazane

I-Raw Flibanserin powder (167933-07-5) Incazelo

I-Flibanserin powder iyisidakamizwa sokuqala esizovunyelwa isifo socansi esingazenzisi (HSDD) kumama-premenopausal yi-FDA ngo-Agasti 2015. Ekuqaleni kwakhiwa imithi eyi-anti-depressant yi-Boehringer Ingelheim, kodwa yabonisa ukuntuleka kokuphumelela ekuvivinyweni futhi yaqhutshwa phambili njengesidakamizwa se-hypoactive sex disorder yi-Sprout Pharmaceuticals. Indlela yokusebenza kaFlibanserin ibangelwa ukuhlangana kwayo okuphezulu kwe-5-HTA1 kanye ne-5-HTA2 receptors, ibonisa umsebenzi we-agonist ku-5-HTA1 nomphikisi ku-5-HTA2, okuholela ekunciphiseni i-serotonin ebuchosheni kanye nomphumela wokwandisa i-norepinephrine kanye ne-dopamine neurotransmitters.

I-Flibanserin powder (167933-07-5) Indlela Yokusebenza

Indlela yokusebenza kaFlibanserin ibangelwa ukuhlangana kwayo okuphezulu kwe-5-HTA1 kanye ne-5-HTA2 receptors, ibonisa umsebenzi we-agonist ku-5-HTA1 nomphikisi ku-5-HTA2, okuholela ekunciphiseni i-serotonin ebuchosheni kanye nomphumela wokwandisa i-norepinephrine kanye ne-dopamine neurotransmitters. I-Flibansetrin inokubambisana okuphezulu kwe-serotonin receptors ebuchosheni: isebenza njenge-agonist ku-5-HT1A nomphikisi ku-5-HT2A. Ku-vivo, i-flibanserin ibopha ngokulinganayo kuma-receptors we-5-HT1A kanye ne-5-HT2A. Kodwa-ke, ngaphansi kwamazinga aphezulu obuchopho 5-HT (okungukuthi, ngaphansi kokucindezeleka), i-flibanserin ingathatha ama-receptors we-5-HT2A engaphezulu kunama-receipt 5-HT (1A). Kungase futhi ngokulinganayo imelane ne-D4 (dopamine) receptors ne-5-HT2B ne-5-HTB2C. Isenzo salo kuma-receptors we-neurotransmitter singasiza ekwenzeni ukunciphisa amazinga we-serotonin futhi ukwandisa kwi-dopamine namazinga we-norepinephrine, konke okungahle kudlale ekusebenzeni komvuzo. U-Flibanserin uthengiswa ngaphansi kwegama lokuhweba elithi Addyi futhi kuboniswe ukwelashwa kwabesifazane be-premenopausal abane-generalized hypoactive sex disorder disorder (HSDD) etholakale ngesifiso sobulili obuphansi esibangele ukucindezeleka noma ubunzima bokuzibandakanya.

Isicelo seFlibanserin powder (167933-07-5)

I-Flibanserin powder i-5-HT1A i-agonist ne-5-HT2A ephikisanayo eyenzelwe ukwelashwa kwesifo sengqondo socansi ocansini kwabesifazane (1,2).

Kunconywe i-Flibanserin powder (167933-07-5) Isilinganiso

100 mg ngomlomo kanye ngosuku ngosuku lokulala

Isikhathi sokwelashwa: Lesi sidakamizwa kufanele sikhiphe ngemuva kwamasonto e-8 uma isiguli singabibizi ukuthuthukisa izimpawu.

Amazwana: Lesi sidakamizwa asikhonjisiwe ukuze kuthuthukiswe ukusebenza kocansi, futhi akukhonjisiwe ekwelapheni kwabesifazane be-postmenopausal noma kumadoda.

Imiphumela emibi ye-Flibanserin powder (167933-07-5)

Izenzakalo ezimbi zivame kakhulu phakathi kwabesifazane abathatha i-flibanserin powder. Iningi lezehlakalo ezimbi zazinomusa ukulinganisa. Izenzakalo ezibi kakhulu ezibikiwe zibandakanya ukuzondeka, ukuhlukumeza, ukuzwa ukhathele, ukulala nokuhlupheka ukulala.

Ukuphuza utshwala ngenkathi i-flibanserin powder kungabangela ukucindezeleka okukhulu kwegazi (ukucindezeleka kwegazi okuphansi okwakhiqiza izimpawu emva kwezingilazi zewayini ze-2 ku-17%).


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I-Shangke Chemical yinkampani ephezulu echwepheni ezisebenzayo ezizimele eziphambili zokwelapha (APIs). Ukuze ulawule ikhwalithi ngesikhathi sokukhiqiza, inqwaba yabachwepheshe abanolwazi, imishini yokukhiqiza yokuqala kanye nama-laboratories yiwona amaphuzu ayisihluthulelo.

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