Oleoylethanolamide (OEA) (111-58-0)

Mashi 11, 2020
SKU: 16589-24-5
5.00 koku 5 ngokusekelwe ku 1 isilinganiso ikhasimende

I-Oleoylethanolamide (OEA) iyi-endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Kuyinto …………… ..


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum

I-Oleoylethanolamide (OEA) (111-58-0) ividiyo

Imininingwane ye-Oleoylethanolamide (OEA) (111-58-0)

Igama Product I-Oleoylethanolamide (OEA) powder
Igama leKhemikhali n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Inombolo 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
SMILE CCCCCCCCC = CCCCCCCCC (= O) NCCO
Formula Yamamolekhula C20H39NO2
isisindo Yamamolekhula I-325.5 g / mol
IMisa ye-Monoisotopic I-325.537 g · mol-1
I-Melting Point I-59-60 ° C (138-140 ° F; 332-333 K)
ukubila Point 496.4 ± 38.0 ° C (Kubikezelwe)
Ubuningi 0.915 0.06 3 g / cmXNUMX (Kubikezelwe)
Color powder emhlophe
Sithempeli le-torage -20 ° C
I-solubility e-ethanol ne-DMSO I-Soluble
Isicelo Inkambu yePhamaceutical; izinto ezinkulu;

Uhlolojikelele

I-Oleoylethanolamide (OEA) noma i-N-Oleoylethanolamide (OEA) yi-molecule ekhiqizwa emzimbeni, imvamisa etholakala emathunjini. Ubufakazi obukhuphukayo bukhombisa ukuthi i-OEA ingahle isebenze njengento endo native neuroprotective factor futhi ibambe iqhaza kulawulo lokuziphatha okuhlobene nomvuzo. Futhi, kuchazwe njenge-ejenti esebenza ngokungaguquki ebambelela ekunciphiseni ukungena kokudla kanye nesisindo somzimba.

Yini i-Oleoylethanolamide (OEA)?

I-Oleoylethanolamide (OEA) iyi-endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Kuvela ngokwemvelo i-glycolamide lipid enezinto ezihlukile ezihlukile ze-homeostasis ezifana nokulawulwa kokudla, umsebenzi wokulwa nokuvuvukala, ukukhuthaza i-lipolysis ne-fatty acid oxidation. I-Oleoylethanolamide ingabhekwa njenge-hormone yomsipha wobuchopho bamathumbu. I-Oatmeal, amantongomane, ne-cocoa powder yimithombo yokudla ephambili ye-Oleoylethanolamide ekudleni. Kodwa-ke, inani le-Oleoylethanolamide elitholakala kulokhu kudla liphansi (lingaphansi kuka-2 µg / g).

Njengomuntu osebenzayo we-lipid medium, i-oleylethanolamide (OEA) ikhiqizwa emathunjini kanye nezinye izicubu, futhi ibandakanyeka emthethweni wokulinganisa amandla we-mammalia, ilawula ukungena kokudla kanye ne-lipid metabolism, njengokulawula ukudla kwe-Vertebrate kanye nesisindo somzimba. I-Oleoylethanolamide iyi-fatty acid ethanolamide (FAE), i-analog ye-monounsaturated ye-endocannabinoid arachidonic acid ethanolamide (anandamide), kanye nomphikisi osebenzayo we-ancamide. Kuyaqapheleka ukuthi i-Oleoylethanolamide yehlukile kune-anandamide, izimele nge-cannabinoid receptor, futhi ifaka umsebenzi wayo webhayoloji ngeminye imikhondo, ilawula umsebenzi wePPAR-α ukukhuthaza i-lipolysis. I-Oleoylethanolamide umuthi ongaba futhi onqabile wokulwa nokukhuluphala ongena esikhundleni se-CB1 antagonism.

Ucwaningo lwe-preclinical luye lwabonisa ukuthi i-Oleoylethanolamide nayo iyinhlangano esebenza ngempumelelo yokulwa nokuvuvukala ne-antioxidant ekhipha imiphumela ye-neuroprotective etshwaleni. Ukuphathwa kwe-Exo native kwe-Oleoylethanolamide kungavimba ngempumelelo amakhasethi e-TLR4-mediated proinfigueatory, ngaleyo ndlela kunciphisa ukukhishwa kwama-cytokines we-proinfigueatory kanye namakhemikhali, ukucindezela kwe-oxidative ne-nitrosative, futhi ekugcineni kuvimbele ukulimala kwezinzwa ku-cortex yangaphambili yamagundane.

Imithombo ye-Oleoylethanolamide (OEA)

Kunemithombo emibili yokuthola i-Oleoylethanolamide (OEA), eyodwa isuka ezitshalweni zemvelo, kanti enye yenzelwe kuphela ilabhu.

Ama-Achyranthes Aspera, odabuka eNdiya, China nakwamanye amazwe amaningi ase-Asia, kuthiwa aqukethe i-Oleoylethanolamide OEA. Inkinga ye-Oleoylethanolamide engumbala wemvelo ukuthi kukhona okukhishwa kwesilinganiso kuphela okutholakalayo, i-15: 1 ispecial ethandwayo, futhi ayinamandla njengoba amaklayenti noma abakhiqizi abengeziwe belindele. Vele, ingaba phezulu, kepha izindleko zizobe ziphakeme ngokwedlulele, ngakho-ke akusebenzi kangako ukukhiqiza i-Oleoylethanolamide OEA yemvelo ngobuningi.

Umthombo ophambili we-Oleoylethanolamide wenziwa kusuka ku-oleic acid, wasebenza njengomsunguli weN-oleoyl-phosphatidylethanolamine, ocaciswa yi-N-acyl-phosphatidylethanolamine-selection phospholipase D (PLD) ukukhipha i-Oleoylethanolamide OEA.

I-Oleoylethanolamide iyi-metabolite yemvelo ye-oleic acid. Ngakho-ke, ukudla okuphikisana ne-oleic acid kungumthombo oqondile we-OEA.

Ngabe isebenza kanjani i-Oleoylethanolamide (OEA)?

Kubantu abakhuluphele, i-OEA ingalawula i-homeostasis yamandla nokuthambekela ikakhulukazi kokusebenza kwama-receptor ahlukahlukene kufaka phakathi i-proximal proliferator-activated receptor-α (PPAR-α), i-receptor-g-protein-ehlanganisiwe eyi-119 (GPR119) ne-receptor yesikhashana ye-ceptor engaba khona (TRPV1). Ngempela, i-OEA yenza kusebenze lezi zi-receptors futhi ibambezele ukuqalwa kokudla, inciphise usayizi wokudla, inciphise izikhathi eziphakathi kokudla futhi ekugcineni ilinganise isisindo somzimba.

Ngaphezu kwalokho, ucwaningo oluthile lokuhlola lukhombisa ukuthi i-OEA iphinde icindezele ukubonakaliswa kwe-IL-6, i-interleukin-8 (IL-8), i-molecule-1 (i-ICAM-1) ne-vasell cell adhesion molecule-1 (VCAM-1) ne-vascular cell adhesion molecule-50 (VCAM-1) ku-TNF -I-inclension yokuvuvukala kwamaseli womuntu wesibeletho se-umbilical vein endothelial ngokusebenzisa ukusebenza kwama-receptors okuvuvukala. I-OEA iphinde yavimba indlela yenyukiliya kappa-B (NF-kB) emzimbeni. Ocwaningweni lukaYT et al, i-OEA (XNUMX µmol / L) ivimbele i-TNF-α eyenga inkulumo ye-VCAM-XNUMX eHUVEC.

Izinzuzo ze-Oleoylethanolamide (OEA)

I-Oleoylethanolamide (OEA) i-powder kuhle ukwehlisa isisindo njengomlawuli wokudla futhi isekela amazinga we-cholesterol anempilo kubantu abadala.

U-Oleoylethanolamide (OEA) njengomcindezeli we-Appetite

Ukucindezela isifiso sokudla futhi ngaleyo ndlela kunciphise ukudliwa kokudla kuyindlela ephumelelayo yokulawula ukulingana kwamandla nesisindo somzimba. Njengoba ukucindezela kokudla kuyindawo enkulu yokulawula amandla (ukudla), ukuphatha isifiso kubalulekile ukulawula isisindo somzimba esinempilo, ikakhulukazi uma kuhlangene nezinketho zokuphila ezempilo ezibandakanya ukunakwa kokudla okufanele, ukungezelelwa kokudla, nokuzivocavoca.

I-Oleoylethanolamide isengezo isiza ukulawula i-lipid metabolism, isiza ukulawula indlala ngokuthumela imiyalezo yokulangazelela ukudla futhi iboniswe ukusiza ukwehlisa womabili amazinga we-triglyceride kanye ne-cholesterol yegazi.

I-Oleoylethanolamide yokuphathwa kwamafutha omzimba

I-OEA iyindlela ephephile yokuphelela elawula isifiso sokudla kanye nokusebenzisa amandla.

Imiphumela ye-OEA yaqala ukufundwa ngoba ihlanganyela ngokufana kwelinye ikhemikhali, i-cannabinoid eyaziwa ngokuthi i-anandamide. Ama-cannabinoids ahlobene nesitshalo i-Cannabis, kanti ama-anandamides akhona kulesi simila (nensangu) angakhulisa isifiso somuntu sokuntula ngokuvusa impendulo yokudla. Ngokuya nge-Wikipedia, i-Oleoylethanolamide yi-analogue ye-monounsaturated ye-endocannabinoid anandamide. Yize i-OEA inesakhiwo samakhemikhali esifana ne-anandamide, imiphumela yaso ekudleni nasekuphatheni isisindo yehlukile. Ngokungafani ne-anandamide, i-OEA isebenza ngokuzimela komgwaqo we-cannabinoid, elawula umsebenzi we-PPAR-α ukukhuthaza i-lipolysis.

Oleoylethanolamide wokwakha umzimba

Wonke umuntu ufuna impilo ngokwakha umzimba ejimini. I-OEA idlalwa kakhulu ngabakhi bomzimba. Emasimini wokulekelela okwakha umzimba, i-TTA (i-tetradecylthioacetic acid) isetshenziswa ngokujwayelekile ngama-oleoylethanolamide (OEA), womabili lawo asiza ekushiseni amanoni nasekunciphiseni indlala. I-TTA ingahle futhi ithembise kakhulu phakathi kwezithasiselo zama-anti-fat, ngoba kubonakala sengathi ishisa amanoni azimele ngokuzivocavoca; Imiphumela yokuqala ibonakalisa ukuthi umzimba ubonakala nje “ususa” amanoni kuwo kunokuba ufune ukuwushisa ngomzimba.

I-Oleoylethanolamide (OEA) inciphisa i-triglycerides ne-cholesterol, futhi, ihlanganiswe ne-cannabinoid antagonist, ivimba ukuzuza kwesisindo somzimba futhi ithuthukise i-dyslipidaemia kumamodeli wezilwane okukhuluphala.

Ngaphezu kwalokho, ukuphathwa kwe-systemic kwe-oleoylethanolamide kutholakele ukulinganisa i-glucose homeostasis, kanye nokukhishwa kwe-insulin kanye nokusayina kwe-insulin kuzo zombili i-hepatocytes ne-adipocytes.

Amanye ama-rereearch akhombisa ukuthi i-oleoylethanolamide supplement inemiphumela emihle ekukhathazekeni, futhi imizila eminingi nobufakazi buyadingeka ukusekela.

Ungayisebenzisa kanjani i-Oleoylethanolamide OEA

Oimiphumela leoylethanolamide

I-Oleoylethanolamide OEA incane kakhulu emakethe yokwengeza, futhi akukho miphumela emibi ebikiwe. Abe-US Food and Drug Administration (FDA) babengenakukhathazeka maqondana nokuphepha kwe-OEA. Empilweni yansuku zonke, i-oleoylethanolamide iyindlela ephephile yokulahlekelwa isisindo, esetshenziselwa ukuhlola ubukhulu be-catabolism esegazini le-gastro-intestinal, esiza ukunciphisa amafutha ngaphandle kwemiphumela emibi engafuneki.

Oleoylethanolamide isilinganiso

Awukho umthamo ophakanyiswe esidlangalaleni we-oleoylethanolamide ngoba izengezo ze-oleoylethanolamide azisathandwa kangako futhi zisencwadini yayo yokuqala. I-RiduZone yayingowokuqala u-OEA powder owabekwa uphawu ngo-2015.

Umuthi onconyiwe we-oleoylethanolamide ungomunye we-capsule 200mg lapho uthathwa ngaphandle kwenhlanganisela

Ucwaningo lukhombisa ukuthi ungangehlisa noma ukhuphule imithamo yansuku zonke ngokuya nge-bodyweight yakho.

I-100mg yomuntu o-150lb

I-145mg yomuntu o-200lb

I-180mg yomuntu o-250lb

Ukusebenza kwe-Oleoylethanolamide (OEA)

I-Oleoylethanolamide powder isisebenzise ku-Healthcare supplement, eyenziwe kwi-Hard capsule noma kuthebhulethi yokulahleka kwesisindo.

Izikhombo:

  • UGaetani S, u-Oveisi F, uPiomelli D (2003). "Ukushintshwa kwamaphethini wokudla ku-rat yi-anorexic lipid mediator oleoylethanolamine". I-Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.

  • ULo Verme J, uGaetani S, uFu J, u-Oveisi F, uBurton K, uPiomelli D (2005). "Ukulawulwa kokudla okwenziwe yi-oleoylethanolamine". Iseli. Mol. Isayensi Yezempilo. 62 (6): 708-16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.

  • IGiuseppe Astarita; UBryan C. Rourke; Johnnie B. Andersen; UJin Fu; UJanet H. Kim; U-Albert F. Bennett; UJames W. Hick noDaniel Piomelli (2005-12-22). "Ukwanda kokunyuswa kwe-oleoylethanolamine mobilization emathunjini amancane we-Burmese python (Python molurus)". I-Am J Physiol Regulolid Comp Physiol. 290 (5): R1407-R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.

  • UGaetani S, uKaye WH, uCuomo V, uPiomelli D (Septhemba 2008). "Iqhaza le-endocannabinoids kanye nezimpawu zabo ekukhuluphele nasezinkinga zokudla". Isidlo Sokudla Isisindo. 13 (3): e42-8. PMID 19011363.

  • Serrano A, et al. I-Oleoylethanolamide: imiphumela kuma-hypothalamic transmitters nama-gut peptides alawula ukungena kokudla. I-Neuropharmacology. (2011)

UKUHLELWA KANYE Nesitatimende:

Le Material ithengiswa Ukusetshenziswa Kocwaningo Kuphela. Imibandela Yokuthengisa Faka isicelo. Hhayi Ukusetshenziswa Komuntu, noma Ezokwelapha, Izilwane, noma Ukusetshenziswa Kwasekhaya.