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I-Raw Flibanserin HCL powder (147359-76-0)

I-Raw Flibanserin hydrochloride powder, edayiswa ngaphansi kwegama lokuhweba elithi Addyi, imithi evunyelwe ukwelashwa ...


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum
Umthamo: 1250kg / inyanga

Incazelo

I-Raw Flibanserin HCL powder (147359-76-0) ividiyo

I-Raw Flibanserin HCL powder (147359-76-0) Siziqu

Igama Product I-Flibanserin hydrochloride powder
Igama leKhemikhali UNII-96XTC36K1B, 96XTC36K1B
Brand NAme Engeza
I-Drug Class I-multifunctional serotonin agonist antagonist (MSAA)
CAS Inombolo 147359-76-0
InChIKey I-XGAGFLQFMFCIHZ-UHFFFAOYSA-N
I-molecular Fi-ormula C20H22ClF3N4O
I-molecular Weziyisishiyagalombili 426.8630896
IMisa ye-Monoisotopic I-426.143 g / mol
Ukuxuba Pi-oint > 225 ° C (umq.)
Fukuvuselela kabusha Pi-oint Ayikho idethi etholakalayo
I-Half Half-Life 11 amahora
Color Ukuqina okumhlophe
Sukufaneleka I-DMSO (Okuncane), i-Methanol (Kancane kancane)
Sukuhlushwa Tukushisa Ukushisa kwamakamelo
Aukuphikisana Kuthuthukiswe ekwelapheni ukukhathazeka kwesifiso socansi ocansini kwabesifazane.

I-Raw Flibanserin HCL powder (147359-76-0) Incazelo

I-Flibanserin hydrochloride iyisidakamizwa sokuqala sokugunyazwa kwesifo socansi esingazenzisi (HSDD) kubesifazane besandulela-mbuso yi-FDA ngo-Agasti 2015. Ekuqaleni kwakhiwa imithi eyi-anti-depressant yi-Boehringer Ingelheim, kodwa yabonisa ukuntuleka kokuphumelela ekuvivinyweni futhi yaqhutshwa phambili njengesidakamizwa se-hypoactive sex disorder yi-Sprout Pharmaceuticals. Indlela yokusebenza kaFlibanserin ibangelwa ukuhlangana kwayo okuphezulu kwe-5-HTA1 kanye ne-5-HTA2 receptors, ebonisa umsebenzi we-agonist ku-5-HTA1 nomphikisi ku-5-HTA2, okuholela ekunciphiseni i-serotonin ebuchosheni kanye nomphumela wokwandisa i-norepinephrine kanye ne-dopamine neurotransmitters.

I-Flibanserin hydrochloride powder (147359-76-0) Indlela Yokusebenza

I-Flibanserin hydrochloride isebenza ngamakhemikhali amathathu obuchopho obubalulekile: i-dopamine, i-norepinephrine, ne-serotonin. Lezi zimakhemikhali ziyi-neurotransmitters. Bayibophezele ukuthumela izimpawu phakathi kobuchopho nezinye izingxenye zomzimba ngesistimu yezinzwa.

I-dopamine ne-norepinephrine zihilelekile ekuzijabuliseni ngokobulili. Noma kunjalo, i-serotonin inegalelo ekuvimbelaneni ngokocansi futhi inganciphisa ukushayela ucansi. Kucatshangwa ukuthi uma la amakhemikhali ahlulekile - uma ama-dopamine namazinga we-norepinephrine ephansi kakhulu futhi / noma amazinga e-serotonin aphakeme kakhulu - owesifazane angase azizwe enesifiso sobulili esincane.

I-Flibanserin hydrochloride isebenza ngokukhulisa amazinga we-dopamine ne-norepinephrine ngenkathi ehlisa amazinga we-serotonin. Ngale ndlela, amakhemikhali akusiza ukukhuthaza isifiso socansi ayenyuka kanti enye engakwazi ukuvimbela isifiso isinciphile.

Isicelo se-Raw Flibanserin HCL powder (147359-76-0)

I-Flibanserin hydrochloride i-5-HT1A i-agonist kanye ne-5-HT2A ephikisanayo eyenzelwe ukwelashwa kwesifo sengqondo esingazenzisi ngocansi kwabesifazane (1,2).

I-Raw Flibanserin HCL ipayipi (147359-76-0) enconyiwe

100 mg ngomlomo kanye ngosuku ngosuku lokulala

Isikhathi sokwelashwa: Lesi sidakamizwa kufanele sikhiphe ngemuva kwamasonto e-8 uma isiguli singabibizi ukuthuthukisa izimpawu.

Amazwana: Lesi sidakamizwa asikhonjisiwe ukuze kuthuthukiswe ukusebenza kocansi, futhi akukhonjisiwe ekwelapheni kwabesifazane be-postmenopausal noma kumadoda.

Imiphumela emibi ye-Flibanserin hydrochloride powder (147359-76-0)

Izenzakalo ezimbi zivame kakhulu phakathi kwabesifazane abathatha i-flibanserin. Iningi lezehlakalo ezimbi zazinomusa ukulinganisa. Izenzakalo ezibi kakhulu ezibikiwe zibandakanya ukuzondeka, ukuhlukumeza, ukuzwa ukhathele, ukulala nokuhlupheka ukulala.

Ukuphuza utshwala ngenkathi i-flibanserin kungabangela ukucindezeleka kwegazi okuphansi (ukucindezeleka kwegazi okuphansi okwakhiqiza izimpawu ngemuva kwezingilazi zewayini ze-2 kwenzeka ku-17%).


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I-Shangke Chemical yinkampani ephezulu echwepheni ezisebenzayo ezizimele eziphambili zokwelapha (APIs). Ukuze ulawule ikhwalithi ngesikhathi sokukhiqiza, inqwaba yabachwepheshe abanolwazi, imishini yokukhiqiza yokuqala kanye nama-laboratories yiwona amaphuzu ayisihluthulelo.

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