L - (+) - I-Ergothioneine (EGT) (497-30-3)

Mashi 15, 2020
SKU: 1010396-29-8
5.00 koku 5 ngokusekelwe ku 1 isilinganiso ikhasimende

I-Ergothioneine i-amino acid engokwemvelo futhi isuselwa ku-histidine ye-thiourea, equkethe i-athomu lesibabule ku …… ..


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum

L - (+) - ividiyo ye-Ergothioneine (EGT) (497-30-3)


L - (+) - I-Ergothioneine (EGT) powder Siziqu

Igama Product L - (+) - I-Ergothioneine (EGT)
Igama leKhemikhali I-ERGOTHIONEINE;

L-Ergothioneine;

I-Sympectothion;

l ergothioneine

Brand NAme N / A
I-Drug Class N / A
CAS Inombolo 497-30-3
InChIKey SSISHJJTAXXQAX-ZETCQYMHSA-N
I-molecular Fi-ormula C9H15N3O2S
I-molecular Weziyisishiyagalombili I-229.3 g / mol
IMisa ye-Monoisotopic I-229.088498 g / mol
Iphuzu lokubilisa N / A
Fukuvuselela kabusha Pi-oint N / A
I-Half Half-Life N / A
Color I-White noma i-off-white
Sukufaneleka I-soluble in Amanzi (kufika ku-10 mg / ml)
Sukuhlushwa Tukushisa -20 ° C
Aukuphikisana I-l ergothioneine powder isebenzise ku-supplements enempilo

L - (+) - I-Ergothioneine (EGT) (497-30-3) Sibutsetelo

I-Ergothioneine i-amino acid engokwemvelo futhi isuselwa ku-histidine ye-thiourea, equkethe i-athomu le-sulphur endongeni ye-imidazole. Leli khompiyutha lenziwa ezintweni ezimbalwa, ikakhulukazi i-Actinobacteria, i-Cyanobacteria, kanye nesikhunta esithile. I-Ergothioneine idinga umgibeli othize, i-EGT, eyaziwa nangokuthi i-OCTN1 (uphawu lwezinhlobo ze-SLC22A4), ukufaka amaseli. Inkulumo ye-EGT iqinisekisiwe emigqeni yeseli yomuntu nowezilwane namandla ayo asebenzayo ukuthutha i-ergothioneine kuqinisekisiwe ku-vivo.

I-L-ergothioneine i-amino acid ngokwemvelo futhi itholakala ku-thiol / thione ye-histidine. I-L-ergothioneine itholakala ekugxileni okuphezulu kakhulu kumakhowe nama-bacteria futhi ngamanani aphansi kokunye ukudla kufaka i-king crab, inyama yenkomo, ingulube, iwundlu, nenkukhu.

Naphezu kokuba khona kwe-L-ergothioneine ekudleni okudla abantu, i-biosynthesis yayo ibonwe kuphela kumagciwane athile nesikhunta.

Kuyini L - (+) - I-Ergothioneine (EGT) ?

I-L-Ergothioneine iyi-amino acid etholakala ikakhulu kumakhowe, kepha futhi kumakhaza enkomo, inyama evela ezilwaneni ezidle otshanini obune-ergothioneine, nokunye ukudla. Ama-amino acid amakhemikhali ayizakhi zokwakha amaprotheni. I-Ergothioneine isetshenziswa njengomuthi.

Abantu bathatha i-ergothioneine ngomonakalo wesibindi, ikati, isifo se-Alzheimer's, isifo sikashukela nesifo senhliziyo.

I-L - (+) - i-ERGOTHIO iyi-bialynthesized yemvelo ye-chiral amino-acid antioxidant ebacteria ethile kanye nesikhunta. Yikheyithali ebalulekile ye-bioactive esetshenziswe njenge-scavenger enobuhlungu, isihlungi se-ultraviolet ray, umlawuli wokuphendula okunciphisa ukuncipha kwama-oxidation kanye ne-bioenergetics yeselula, kanye ne-cytoprotector yomzimba, njll.

I-L-Ergothioneine kwesinye isikhathi isetshenziswa ngqo esikhunjeni ukuvimba imibimbi, ukunciphisa izimpawu zesikhumba sokuguga, kanye nokunciphisa ukulimala kwelanga.

L - (+) - Izinzuzo ze-Ergothioneine (EGT)

I-L-ergothioneine ihlukile ngoba ingafinyelela ekujuleni kwamaseli athile njenge-erythrocyte, ngokungafani namanye ama-antioxidants asendulo afana namavithamini C no-E. Eqinisweni ine-gene ekhodi yamaprotheni athwala, ivumela ukuthi ithathwe iye ngqo inhliziyo yamaseli. Ngakho-ke i-antioxidant enamandla amakhulu we-intracellular, ebaluleke njenge-L-glutathione. Ngaphezu kwalokho, kuphinde kwaboniswa ukuba yi-chelator enamandla, kuyenza ikwazi ukubopha izinsimbi ezinobuthi, ngenkathi kuvikela amaseli egazi kuzo zonke izinhlobo zomonakalo.

Bakhuthazwe yizakhiwo zayo ze-antioxidant, abacwaningi baphinde baphenya ngemiphumela yokulwa nokuvuvukala, ngoba i-ergothioneine isebenza, phakathi kokunye, i-pro-inflammatory cytokine, interleukin. I-L - (+) - I-Ergothioneine (EGT) ngakho-ke inezakhiwo eziningi ezisebenza ngaphakathi komzimba womuntu:

  • ihlukanisa i-oxygen molecule esebenzayo (ama-radicals wamahhala), ngaleyondlela ilwe nengcindezelo ye-oxidative futhi inciphise ukulimala kwe-mitochondrial DNA, oxidation wamaprotheni ne-lipid peroxidation;
  • AmaChelates - noma izicupho - izinkomba ezihlukene zensimbi;
  • Ungasebenza ama-enzyme e-antioxidant anjenge-glutathione peroxidase noma i-SOD, ngenkathi evimbela ama-enzyme akhiqiza i-superoxide radical;
  • Yehlisa i-oxidation yama-haemoprotein ahlukahlukene njenge-hemoglobin ne-myoglobin;
  • Vikela i-mitochondria;
  • I-L-ergothioneinereduces imiphumela emibi yemisebe ye-UV, njenge-ejenti evikela Ukunakekelwa Kwesikhumba.
  • Igcina futhi igcine amazinga amanye ama-antioxidants anjengevithamini C no-E, glutathione ne-SOD;
  • Kuvikela ubuchopho kuma-neurotoxins futhi ngaleyondlela idlala indima yokuzivikela ekwehleni kwengqondo;
  • Ikhuthaza ukuphefumula kwamaselula kanye ne-lipolysis yamafutha, ngaleyo ndlela ikhulisa amandla namandla okuzivocavoca umzimba;
  • Lapho kuhlangene ne-hyaluronic acid, i-glucosamine, i-collagen, kwaboniswa ukunciphisa kakhulu izinhlungu ezihlangene futhi kwandise ukuhamba okuhlanganayo, okuhambisana ikakhulukazi nemikhuba emibi yokusebenza ngemuva, ngemuva kokusetshenziswa kwamaviki ayisithupha nje.

L - (+) - I-Ergothioneine (EGT) ukuphepha

Yize i-l-ergothioneine ihlanganyela igama futhi ingaqhamuka ku-ergot fungus, ayinobuthi nganoma iyiphi indlela.

I-European Union inezindinganiso ezilukhuni zokuqina kuneMelika futhi inqume ukuthi izithasiselo ze-l-ergothioneine ziphephile futhi azivezi imiphumela emibi kubantu abadala nasezinganeni ngaphezulu.

I-Panel on Dietetic Products ye-European Food Safety Authority ithola ukuthi imikhawulo evikelekile yansuku zonke ye-2.82 mg / kg yesisindo somzimba sezinsana, i-3.39 mg / kg yezingane ezincane, kanye ne-1.31 mg / kg kubantu abadala, kufaka phakathi abesifazane abakhulelwe nabancelisayo.

L - (+) - i-Ergothioneine (EGT) powder kusebenzisa kanye nesicelo

Ukungezelelwa okufanele kanye / noma ukudla okuthuthukisiwe kufaka phakathi amavithamini wokuphila isikhathi eside njenge-L-ergothioneine isengezo kunganciphisa ingozi enkulu elandelayo yesifo esingamahlalakhona nokuguga ngaphambi kwesikhathi.

I-L-ergothioneine powder iyisithako esifanele i-formula yokuguga enempilo.

Ucwaningo lukhombisa ukuthi imisebenzi engaba khona ye-antigidant ye-EGT njenge-anti-inflammatory ukuvikela amanye amaseli ezifweni zezifo zomzimba neze-neurodegenerative.

  1. Ukuvuvukala

Ucwaningo lukhombisa ukuthi njenge-antioxidant, i-EGT ingahle ivikele ekulimaleni.

I-rheumatoid arthritis ingukuphazamiseka kwe-autoimmune okuphawulwa ukuvuvukala okukhulu (futhi okuvame ukungachazwa).

Kungenzeka ukuthi i-EGT inganciphisa ukuvuvukala ezigulini ezine-rheumatoid arthritis.

  1. Izifo ze-Neurodegenerative

Njenge-cytoprotectant, i-EGT iyisengezo esidumile phakathi kweziguli ze-Alzheimer's and Parkinson.

I-EGT isekela uhlelo lwakho lwemvelo lokuvikela umzimba lwe-antioxidant futhi ingahle ivikele amaseli obuchopho ekulimaleni kwe-oxidative nasekucindezelekeni kwama-radicals wamahhala.

Ngokuvikela amangqamuzana obuchopho, kungenzeka ukuthi kuvikele ukufa kweseli yobuchopho kwasekuqaleni futhi kuvikeleke ezifweni ze-neurodegenerative.

  1. Izifo zesibindi

Ngenxa ye-cytoprotectant yayo kanye ne-antioxidant engaba khona, i-EGT iyintandokazi ye-amino acid ezigulini ezinesifo sesibindi.

  1. Anti-Ukuguga Okungenzeka

Uvame ukuthola i-EGT emikhiqizweni eminingi ye-skincare ngenxa yezakhi zayo ze-cytoprotectant kanye ne-antioxidant- ezingavikela amaseli wesikhumba emonakalweni we-oxidative.

Ukulimala kwamahhala okucindezelayo nokucindezelwa kwama-oxidative kuyasiza kakhulu ekugugeni ngaphambi kwesikhathi, esikhunjeni esikhulayo, nasemikhawulweni.

  1. Izifo Zamaphaphu

UMnyango Wezokuvikela eMelika unikeze isibonelelo semali engu- $ 1.34 yezigidi kubacwaningi base-University of Colorado ukuthi batadishe isenzo se-antioxidant se-EGT sokulwa nezifo zamaphaphu ekulweni namavolontiya.

Izikhombo:

  • U-Olera M, et al. Ukuvuselelwa kwe-ergothioneine ngemuva kokusabela nge-singlet oxygen. I-Radic Biol Med yamahhala. 2019 Apr; 134: 498-504.
  • UCheah, uLK, uHalliwell, uB. Ergothioneine; amandla we-antioxidant, umsebenzi wokuphila kanye neqhaza lesifo, i-Biochim. Ama-biophys. I-Acta 2012; (5): 784-793.
  • UGenghof, DS Biosynthesis we-Ergothioneine noHercynine ngu. I-fungus ne-Actinomycetales, uJ. Bacteriol., 1970; 103 (2): 475-478.
  • Ukuphinda, i-JE, i-Elkins, i-ND Umphumela we-ergothioneine ekulimaleni kwamaphaphu okukhinyayo kanye nokuvuvukala kumagundane we-cytokine angafakwanga, i-Prev. UMedi. 2012; (54): S79-S82.
  • Iphaneli ye-EFSA Kwimikhiqizo Yezidakamizwa, Ukudla Okunomsoco kanye Nezinkinga Zomzimba (2017). "Isitatimende ngokuphepha kwezokwenziwa l-ergothioneine njengokudla kokudliwayo - ukuvezwa kokudla kanye nokuhlolwa kokuphepha kwezinsana nezingane ezincane, abesifazane abakhulelwe nabancelisa ibele". I-EFSA Journal. 15 (11): 5060. doi: 10.2903 / j.efsa.2017.5060.

UKUHLELWA KANYE Nesitatimende:

Le Material ithengiswa Ukusetshenziswa Kocwaningo Kuphela. Imibandela Yokuthengisa Faka isicelo. Hhayi Ukusetshenziswa Komuntu, noma Ezokwelapha, Izilwane, noma Ukusetshenziswa Kwasekhaya.