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Okudingayo Ukuze Ukwazi Ngokuqunjelwa Kwezidakamizwa Linaclotide
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Okudingayo Ukuze Ukwazi Ngokuqunjelwa Kwezidakamizwa Linaclotide

1 Buka
I-1. Yini iLinaclotide (iLinzess)?
I-2. Ngabe iLinaclotide isetshenziselwa ini?
I-3. Iyini indlela yokusebenza yeLinaclotide?
I-4. Kufanele kusetshenziswe kanjani iLinaclotide?
I-5. Uyini umthamo we-Linaclotide (Linzess)?
I-6. Imiphi imiphumela emibi ingabangelwa yiLinaclotide?
I-7. Yiziphi izidakamizwa noma izithasiselo ezizosebenzisana neLinaclotide?
I-8. Yini umehluko phakathi kweLinaclotide ne-lubiprostone?
I-9. Imiphi eminye imininingwane ngeLinaclotide okufanele ngiyazi?


1. Yini iLinaclotide (iLinzess)?Phcoker

I-Linaclotide (iLinzess) umuthi odluliswa ngomlomo ovunyelwe yi-FDA ovame ukusetshenziswa yiziguli ezindala ezihlangabezana nokuqunjelwa okungapheli noma ukuqunjelwa ngenxa ye-bowel syndrome. ILinaclotide 851199-59-2 iza phezulu ohlwini lwesigaba esisha sezidakamizwa okukhulunywa ngaso ngokuthi yi-guanylate cyclase-C agonists.

Igama lomkhiqizo weLinaclotide yiLinzess futhi kubalulekile ukukhumbula ukuthi okwamanje ayikho inguqulo yeLinaclotide generic. Ngakho-ke, uma ufuna iLinaclotide iyathengiswa noma ukusetshenziswa komuntu siqu, qaphela abathengisi bezidakamizwa abasebenza ngenkohliso online abangase bathengise ngokungemthetho I-Linaclotide generic isidakamizwa.

I-Linzess iyi-aganyist ye-guanylate cyclase-C kanye ne-14-amino acid peptide. igama lamakhemikhali ngu-L-cysteinyl-L-cysteinyl-L-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-acaraginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl- I-L-cysteinyl-L-tyrosine, i-cyclic (1-6), (2-10), (5-13) -tris (disulfide).

Ifomula yayo yama-molecule yi-C59H79N15O21S6 ngenkathi isisindo samangqamuzana yi-1526.

I-Linaclotide powder imhlophe qhwa-mhlophe futhi inyibilika kancane emanzini. Ingaphinde inyakaze kancane ku-aquwater sodium chloride (0.9%).

Okokugcina Linzess isesimweni samakhompiyutha ama-gelatin aqukethe ubuhlalu obuhlanganisiwe be-Linaclotide. ICalcium chloride dihydrate, i-L-leucine, i-titanium dioxide, i-microcrystalline cellulose, i-gelatin, kanye ne-hypromellose ziphakathi kwezithako ezisebenzayo eLinzess

2. Ngabe iLinaclotide isetshenziselwa ini?Phcoker

Uma kukhulunywa ngokusetshenziswa kweLinaclotide, abantu bayisebenzisa njengendlela yokwelapha izingqinamba ezithile zamathumbu ezinjenge-bowel syndrome engaqondakali ebonakaliswa ukuqunjelwa nokuqunjelwa okungapheli kwe-idiopathic.

Okudingayo Ukuze Ukwazi Ngokuqunjelwa Kwezidakamizwa Linaclotide

I-Linaclotide ye engaphathekile wamathumbu syndrome izimpawu

I-irritable bowel syndrome (i-IBS) ukugula okuhlala isikhathi eside okuvimbela amathumbu ukuba asebenze ngokujwayelekile. Lesi sikhombisi seLinaclotide sibizwa nangokuthi yi-spastic colon futhi kwesinye isikhathi isifo samathumbu esisebenzayo. Izimpawu ezinkulu zokuphazamiseka yile ukuqunjelwa, isifo sohudo nobuhlungu besisu ngokuqunjelwa noma ukushintshana nohudo.

Esifundweni somtholampilo sokuthola ukusebenza kweLinaclotide yokukhululeka kwezimpawu zesifo samathumbu esingaxineki, iziguli ezindala zasetshenziswa kwizivivinyo ezimbili ezingahleliwe, ezi-multicenter. Isivivinyo sokuqala sithinte iziguli ze-800 ezafakwa enkambisweni yokwelashwa nge-290 mcg nsuku zonke ngenkathi i-804 yabelwa eyesihlandla sesibili esasise-placebo.

Zonke iziguli ezisetshenziswe kuwo womabili amaqembu zazihlangabezane nenqubo ye-IBS Rome II futhi kulindeleke ukuthi zizuze inani elibuhlungu besisu se-3 okungenani ngezinga le-zero kuye kwayishumi futhi okungenani kube mathathu ngokuzumayo okuqhubekayo kwamathumbu isonto ngalinye phakathi nenkathi yokwelashwa inkathi.

Ekupheleni kwesikhathi sokwelashwa, iziguli ezazisenkambweni yokwelashwa okungezwani zathola izimpawu ezithuthukisiwe ze-BIS ngokuqhathaniswa nabalingani bazo be-placebo ngokuya:

  • Imvamisa yokuzenzakalelayo yamathumbu
  • Ukungaguquguquki kwesiqu
  • Inani lesikhathi nomzamo womzimba umuntu awusebenzisayo ukudlula isihlalo.
  • Ukukhululeka kobuhlungu besisu

Lokho kuqinisekisile ngempela inkomba yeLinaclotide njengokwelashwa okusebenzayo kwe-BIS.

I-Linaclotide ye Izimpawu ezingapheli ze-Idiopathic Constipation (CIC)

Esifundweni sokuhlola ukusebenza kweLinzess ye I-CIC Izimpawu zokuphatha, iziguli ezindala ezinokupheliswa okungapheli kwe-idiopathic zabekwa ekuhlolweni okungahleliwe, izilingo eziningi zemitholampilo, ngokufanayo ocwaningweni oluchazwe ngenhla lwe-BIS.

Isiguli ngasinye sasihlangane nenqubo yokuqunjelwa yokusebenza e-Roma II eguquliwe futhi sathola i-72mg, i-145 mcg Linzess, i-290 mcg Linzess noma ukwelashwa kwe-placebo nsuku zonke phakathi nesikhathi se-12-sonto.

Ekupheleni kwenkathi yokwelashwa, abacwaningi babona ukuphuculwa kwezimpawu kwe-CIC ezigulini ezaziselashwa i-Linzess kuqhathaniswa nalabo ababesezingeni le-placebo. Ikakhulu, bathola ukuthuthuka kwezinga eliphakeme ngokuya ngemvamisa ye-stool frequency, frequency stool kanye ne-mathumbu ukunyakaza kwesisindo.

Kuwo wonke ama-doses amathathu we-Linzess, ayenemiphumela emincane emincane ngaphandle kokunikeza izimpawu ezibalulekile zeCIC. Lokhu kufakazela inkomba yeLinaclotide yekhono layo lokwelapha i-CIC.

Okudingayo Ukuze Ukwazi Ngokuqunjelwa Kwezidakamizwa Linaclotide

3. Iyini indlela yokusebenza yeLinaclotide?Phcoker

Ngokungafani neminye imishanguzo esetshenziselwa ukwelapha izindaba zempilo ezichazwe ngenhla, indlela yeLinaclotide yehlukile- ayifakwa emzimbeni wakho. Umshini we-Linaclotide kwenzeka kuphela emathunjini akho ngokwanda uketshezi, ngenxa yalokho kuthuthukisa ukunyakaza kwamathumbu futhi kunciphise izinhlungu ezingabangelwa inkinga yamathumbu.

I-Linaclotide (i-Linzess) yenza amathumbu akhiqize uketshezi oluningi ngokwandisa umkhiqizo we-cyclic guanosine monophosphate.

Lapho iLinaclotide isebenzisa amandla ayo ukwandisa uketshezi emathunjini akho, ukudla kuhamba ngesisu ngokushesha futhi ukuthungwa kwesitulo kuyathuthuka. Lokhu kuthuthukisa izimpawu zezimpawu ezihlobene nokunyakaza kwamathumbu njengokuqhakaza, ukuqaqamba kwesisu / ukuqaqamba kwesisu kanye nomuzwa wokuhamba kwamathumbu ongaphelelanga.

4. Kufanele kusetshenziswe kanjani iLinaclotide?Phcoker

Lapho wenza a I-Linaclotide ithenge, nge-kadokotela kadokotela, kubalulekile ukuthi uqinisekise ukuthi ufunda umhlahlandlela wemithi oyonikezwa usokhemisi wakho ngaphambi kokuthatha umuthi. Umhlahlandlela uzokutshela umthamo ofanele we-Linaclotide wakho, izikhathi eziqondile zemithamo nesikhathi sokuncoma sokwelashwa esinconyiwe.

Uma kwenzeka udinga noma yikuphi ukucaciswa ku Umthamo we-Linaclotide, unganqikazi ukuxhumana nodokotela wakho noma osokhemisi ukugwema imiphumela emibi yeLinaclotide noma ukuxhumana kweLinaclotide.

Ukuba umuthi odluliswa ngomlomo, uLinaclotide kufanele uthathwe ngomlomo. Kufanele usithathe ngenkathi isisu singenalutho, mhlawumbe imizuzu ye-30 ngaphambi kokudla isidlo sakho sokuqala ngosuku. Umuthi wokugcina weLinaclotide usefomini le-capsule futhi kufanele ugwinywe luphelele. Akufanele uphule noma ukuhlafuna amaphilisi we-Linaclotide.

Kodwa-ke, uma uke wazama ukugwinya amaphilisi kodwa ngehluleka, ungawavula uwaxube okuqukethwe ku-spoonful ye-apula. Ngemuva kwalokho ginya inhlanganisela ngokushesha futhi njengoba injalo-ungakuhlafunisi. Hlanganisa kuphela inani okufanele ulithathe ngaleso sikhathi ngoba ukugcina ingxube kuzokwenza izidakamizwa ziphelelwe amandla.

Uma kwenzeka ungenayo i-applesauce, ungasebenzisa amanzi njengenye indlela. Linganisa i-euse elilodwa noma i-30mm yamanzi, vula amaphilisi we-linaclotide we-linaclotide enqunyiwe bese ukhipha okuqukethwe emanzini. Shayela okuqukethwe kwamanzi okuyi-Linaclotide imizuzwana engu-20 bese uyakuphuza ngokushesha. Njengoba nje nengxube ye-applesauce, ungakuhlafunisi okuqukethwe- kukugwinya ngokuphelele.

Uma kwenzeka umuthi uhlose ukuphathwa nge-nasogastric noma i-gastric tube, funa ukuholwa ekuphatheni kusuka kusokhemisi wakho noma kudokotela. Noma kunjalo, nansi inqubo ejwayelekile yokulawulwa kwe-tube.

  • Kala i-30 ml wamanzi ahlanzekile nawokushisa kwegumbi bese uwafaka esitsheni esihlanzekile.
  • Vula isembozo seLinaclotide bese ukhipha konke okuqukethwe (ubuhlalu) emanzini
  • Mid phakathi kwamanzi nobuhlalu beLinaclotide ngokuswayipha ingxube ngobumnene hhayi ngaphansi kwemizuzwana ye-20.
  • Dweba umxube wamanzi we-Linaclotide bead-syringe kwisirinji yesokudla nesihloko esifana ne-catheter nosayizi ofanele. Bese udlulisela ingxube ku-nasogastric noma ishubhu esiswini esetshenziswa yisiguli ngokusebenzisa ngokuqinile kepha ingcindezi esheshayo yemizuzwana eyi-10 mL / 10 kumasirinji.
  • Uma kwenzeka kukhona ezinye ubuhlalu be-Linaclotide obe busele esitsheni, engeza i-30ml yamanzi ahlanzekile kuwo, ushwashise ingxube, bese uyiphatha njengoba kuchaziwe ngaphambili.
  • Uma usuqedile ngokuphatha inhlanganisela yobuhlalu beLinaclotide namanzi, sebenzisa okungenani i-10 ml yamanzi ukukhanyisa ibhubhu lokuqondisa.

5. Uyini umthamo we-Linaclotide (Linzess)?Phcoker

Umthamo ofanele weLinaclotide uyahlukahluka ukusuka komunye umuntu kuye komunye, ngokuya ngesimo okuhloswe ngaso ukwelapha kanye nokusabela komuntu ekwelashweni. Futhi, kubalulekile ukuqaphela ukuthi lesi sidakamizwa akufanele sisetshenziswe ngabantu abangafinyeleli iminyaka engu-18.

Izingane ezincane zisengozini enkulu yokubhekana nezinkinga ezinkulu Imiphumela emibi ye-Linaclotide uma kufanele basebenzise umuthi.

(1) I-Adult Adose Dose ye-Irritable Bowel Syndrome

Kumuntu omdala ophethwe i-Irritable Bowel Syndrome ehambisana nokuqunjelwa, kufanele athathe umthamo we-Linaclotide we-290 mcg nsuku zonke. Njengoba kushiwo ngaphambili, umuthi kufanele uphuzwe esiswini esingenalutho. Ukuqinisekisa lokho, kuthathe ngaphambi kokudla kwakho kokuqala ngosuku.

(2) Ukusetshenziswa Kwabantu Abadala Abadala Ukuqunjelwa

Ngokusho kwe-US Food and Drug Administration, ithamo le-Linaclotide eliphakanyisiwe lomuntu omdala onesifo sokuqunjelwa esingamahlalakhona (CIC) yi-72 mcg.

Kodwa-ke, umthamo we-145 mcg nawo unganconywa esigulini esikhulile nge-CIC, ngokuya ngesimo sakhe nokubekezelelana. Ungahlola i-linzess 72 mcg ukubuyekeza ukuthola umbono wokuthi idosi lisebenza kanjani nabasebenzisi abaye bazuza kulo.

Ngokusho kokubuyekezwa okuningana kwe-72 mcg, phakathi kwezinye izindlela zokudla mayelana nomuthi, isiguli esinezinkinga zempilo ezishiwo futhi sibheke ukuzuza emandleni aso kufanele sisebenzise njalo ukufeza imiphumela efiselekayo. Ngaphandle kwalokho, kufanele kuthathwe ngasikhathi sinye nsuku zonke kuyo yonke inkathi ebekiwe yokwelashwa.

Kubalulekile ukuqaphela ukuthi iLinzess kungenzeka ukuthi ibangele ukuhlangana kweLinaclotide nezidakamizwa ezahlukahlukene. Ngakho-ke, udinga ukwazisa udokotela wakho nganoma imuphi umuthi okulo njengamanje ngaphambi kokuqala ukuwusebenzisa (i-Linaclotide).

Futhi, abesifazane abakhulelwe kufanele basebenzise ukuqaphela okukhulu lapho bebheka ukuthatha i-Linaclotide ngoba umuthi ungaba yingozi enkulu kuzingane. Kufanele bafune ukunakwa ngudokotela ukuze baqinisekise ukuphepha kwabo nokuthi izingane zabo ezingakazalwa kufanele basebenzise lo muthi. Icala elifanayo liyasebenza komama abancelayo nalabo ohlose ukukhulelwa ngenkathi usebenzisa umuthi.

Kodwa-ke, noma ngabe bane-CIC noma i-Irritable Bowel Syndrome, iziguli ezingaphansi kweminyaka engu-6 akumele zithathe I-Linzess powder (851199-59-2). Ukuhlolwa kwemitholampilo kwaphawula ukuthi lesi sidakamizwa sabangela ukufa kwezimpuku zentsha ezineminyaka engalingana nengaphansi kweminyaka ye-6 esintwini.

Kanjalo, umuthi uphulwa ku-iziguli ezingakafiki iminyaka ngoba zibabeka engcupheni enkulu yokuba nesifo sohudo kanye nemiphumela yako emibi engathi sína.

Ngaphandle kwalokho, kunedatha emtholampilo ekhombisa ukuphepha kanye nokusebenza kahle kwe-linzess phakathi kweziguli ezineminyaka engu-6 iminyaka eyi-17. Njengoba kunje, uma ingane noma osemusha engaphansi kweminyaka engu-18 edinga impumuzo ye-ICI noma i-BIS, izeluleko zikadokotela kufanele zifunwe kuqala.

Ungathatha amasonto amabili ngaphambi kokuthola impumuzo njengomphumela womuthi. Ngakho-ke, yiba nesineke kancane ngakho. Qhubeka nokuyisebenzisa njengoba uyalelwe.

Kodwa-ke, uma ngabe isibonakaliso sakho singahambi kahle noma siba sibi kakhulu ngisho nangemva kokusebenzisa i-linzess, ungathathi umthamo ongaphezu kwenani elibekiwe. Akufanele ukwenze lokho noma kunjalo. Esikhundleni salokho, yazisa udokotela wakho ukuthi athole isisusa ngemuva kwezidakamizwa ezingasebenzi kanye neseluleko enkambweni elandelayo yokusebenza.

Kuyalulekwa ukuthi ugweme ukusebenzisa i-Linaclotide uma kwenzeka ungangabelani nayo noma amathumbu akho aba nokuvinjwa.

Uma kwenzeka uphuthelwa umthamo we-Linaclotide, ungazami ukwenza umthamo owuphuthelwe. Khohlwa ngakho bese uqhubeke nokuthatha imithamo elandelayo ngesikhathi esihleliwe.

Uma kwenzeka wena noma othandekayo wakho ethatha umthamo omkhulu we-Linaclotide (i-overdose), lesi sigameko kufanele sitshelwe ngokushesha ukuthi unikezwe udokotela. Ngenye indlela, ungaxhumana nezinsizakalo Zosizo Lwama-Poison ngokudayela i-1-800-222-1222.

Okudingayo Ukuze Ukwazi Ngokuqunjelwa Kwezidakamizwa Linaclotide

6. Imiphi imiphumela emibi ingabangelwa yiLinaclotide?Phcoker

Ngokusho okuhlukahlukene Ukubuyekezwa kwe-Linaclotide nezifundo zesayensi, okulandelayo yimiphumela emibi ye-Linaclotide:

  • Isisu sohudo
  • Ubuhlungu besisu obuthambile noma ukungakhululeki
  • ukuvuvukala
  • ukushaya kwenhliziyo
  • ukuhlanza,
  • bekhanda
  • Izimpawu ezibandayo ezifana nekhala elinamanzi / elinomunyu, umphimbo obuhlungu besinono noma ukugwedla
  • izikhukhula
  • ukudonsana kwendlebe
  • imfiva
  • ukulahleka kwezwi
  • ukudlula igesi
  • ekhaleni noma elinamafutha
  • ukopha okungunxande
  • Ukudlikizela
  • amehlise amehlo
  • isifuba esiqinile

Yize kungenqabile, ungathola nenye yemiphumela emibi ye-Linaclotide:

  • Ukuhudozela okukhulu noma okuphikelelayo
  • Isifo sohudo esihambisana nesiyezi noma umuzwa okwenza uzizwe sengathi kungenzeka uphume
  • Amagundane omlenze
  • I-Mood iyashintsha
  • Umuzwa ongagxilile
  • Ukudideka okungafanele
  • Izinhliziyo ezingavamile
  • Ukoma okungapheli nokuqhubekayo
  • Isifuba siqhuma
  • Umuzwa we-Limp
  • Ubuthakathaka bemisipha
  • Ubuhlungu obukhulu besisu
  • amnyama, amachaphaza amnyama, noma amachaphaza amfushane
  • imihlathi
  • ukuphefumula okunzima
  • ebusweni, izindebe, ulimi, noma ukuvuvukala komphimbo

Udinga usizo losizo oluphuthumayo uma ungathola ukuvuvukala kulezi zingxenye ezingenhla, inkinga yokuphefumula noma okhalweni.

Uma kwenzeka uthola eminye imiphumela emibi yeLinaclotide, kufanele uyeke ukusebenzisa lo muthi bese uthintana nodokotela wakho ngokushesha ukuthola eminye imihlahlandlela.

7. Yiziphi izidakamizwa noma izithasiselo ezizosebenzisana neLinaclotide?Phcoker

Ukusebenzisana kweLinaclotide kungenzeka uma kwenzeka i-Linaclotide isetshenziswa kanye nezinye izidakamizwa kufaka phakathi izinto ezisetshenziswayo, imikhiqizo yamavithamini, imikhiqizo yamakhambi kanye nemithi enqunyelwe. Eminye yemithi eye yabikwa ukuthi kungenzeka ibangele ukusebenzisana kweLinaclotide ifaka:

  • Abilify
  • Amitiza
  • Aspir 81
  • Amandla Asiphin Amandla
  • I-Ativan
  • Umbala
  • I-Dulcolax (ukuxhumana okuncane)
  • Ukukhathazeka
  • Cymbalta
  • I-Dexilant
  • I-Flexeril
  • I-Metamucil (ukuxhumana okuncane)
  • I-Levothyroxine (ukuxhumana okuphakathi)
  • i-lubiprostone
  • I-Metoprolol Succinate ER
  • UNorco
  • I-Paracetamol
  • Ukuvuselela
  • Izimpawu
  • Vitamin B12
  • Vitamin C
  • Vitamin D3
  • Xanax
  • I-Zyrtec

8. Uyini umehlukos Phakathi I-Linaclotide ne-lubiprostone?Phcoker

Bobabili I-Linaclotide ne-lubiprostone yizidakamizwa ezigunyazwe i-DFA zokuqunjelwa okungapheli kwe-idiopathic kanye ne-bowel syndrome kubantu abadala. Uma ufuna ukunyuka kwamathumbu, ungakhetha noma yikuphi kwalokhu.

Kodwa-ke, zinokuhlukahluka okuningi ngokuya nge-:

(1)Amakilasi abo ahlukahlukene

ILubiprostone ingeyesigaba sezidakamizwa esaziwa ngokuthi izishoshovu zesiteshi se-chloride. Ngakolunye uhlangothi, uLinaclotide (Linzess) uyilungu lesigaba sezidakamizwa okubizwa ngokuthi yi-guanylate cyclase-C agonists.

(2)Umthamo wansuku zonke

Ngenkathi umthamo onconyiwe weLinaclotide kufanele uthathwe kanye ngosuku, ikakhulukazi ngaphambi kokudla kwasekuseni, iLubiprostone imvamisa iyothathwa kabili ngosuku. Ngakho-ke, uma unenkinga yokukhumbula ukuthatha imishanguzo yakho nsuku zonke, iLinaclotide kuzoba inketho enhle kuwe.

Enye into ehlukanisa la amabili ngokwemigomo yedosi inani okufanele umuntu alithathe ngasikhathi sinye. Isibonelo, kwi-CIC, umthamo owodwa onconyiwe weLinaclotide yi-72 mcg ngenkathi iLubiprostone eyi-8 mcg.

(3)Ukusebenzisana kwezidakamizwa

Omunye umehluko iLinaclotide powder (851199-59-2) kanye ne-lubiprostone ngokuya ngokusebenzisana kwezidakamizwa. Ngokuphathelene nezidakamizwa ze-58 ze-whopping ezaziwa ukusebenzisana neLinaclotide, ukuxhumana kweLinaclotide kakhulu kakhulu uma kuqhathaniswa ne-lubiprostone ehambisana nokusebenzisana kwezidakamizwa okukodwa.

(4)Usuku lokuvunywa

I-Linzess ivunyelwe ngo-30th Agasti 2012 ngenkathi ukuvunywa kwe-lubiprostone kwenzeka ngoJanuwari 31, 2006

(5)Ukuhlangana kokudla

Lapho unokudla esiswini sakho futhi uthatha i-Linaclotide, izimpawu zakho zesisu ezifana nohudo, ubuhlungu besisu negesi kungenzeka ziba zimbi kakhulu, ngenxa yokuxhumana kweLinaclotide -ukudla. Uma kwenzeka uba nesifo sohudo esinamandla kakhudlwana futhi uphuza omunye umuthi womlomo, ukumuncwa kokugcina kungaphazamiseka kabi.

Ukunciphisa ukungabekezelelani kwamathumbu ngenxa yokuhlangana kokudla, iLinaclotide kufanele ithathwe esiswini esingenalutho.

Ngakolunye uhlangothi, kunesigameko esifakazelwe ngokwesayensi sokusebenzelana kokudla kweLubiprostone. Kodwa-ke, lokhu akukhona ukunqamula ekuxhumaneni okungenzeka. Ngakho-ke, kubalulekile ukufuna ukucaciselwa okwengeziwe ngesikhathi esihle kakhulu sokusebenzisa umuthi kumhlinzeki wakho wezokunakekelwa kwempilo

(6)Ingozi yengane komama abakhulelwe

Kuze kube manje, isigaba sokucwaninga esifanele kanye nokubuyekezwa kweLinaclotide kukhombisa ukuthi iLubiprostone kungenzeka ibangele ukulimala enganeni uma umama okhulelwe ephuza umuthi. Ngakolunye uhlangothi, akukho cwaningo olulodwa olukhombisa ukuthi i-Linzess ingadala ukulimala kwe-fetus uma ithathwa ngowesifazane okhulelwe.

Ososayensi bathi lokhu kuphepha okucatshangelwe umuthi ophansi onomuthi ongahluziwe. Kodwa-ke, ubungozi abukwazi ukukhishwa ngokuphelele njengoba ucwaningo olwengeziwe njengamanje luyaqhubeka nokuphepha noma ubungozi bomuthi enganeni engakazalwa.

Ngakho-ke, noma ngabe uhlose ukuthatha iLubiprostone noma iLinaclotide, umama okhulelwe kufanele abonane nodokotela mayelana nokufaneleka kwesinqumo.

(7)Umuthi

Okudingayo Ukuze Ukwazi Ngokuqunjelwa Kwezidakamizwa Linaclotide

Ngaphandle kwe-CIC, i-lubiprostone ingakwazi b

e isetshenziswa njengokwelashwa kokuqunjelwa i-Opioid-ikiwa (i-OIC) kanye ne-Irritable bowel syndrome enokuqunjelwa kwabesifazane abaneminyaka okungenani eyi-18.

Uma kukhulunywa ngeLinaclotide, ngaphandle kweCIC, iphatha nokuxakaniseka kwamathumbu syndrome okuhambisana nokuqunjelwa (IBS-C) kwabesifazane nabesilisa. Ayisetshenziswa njengendlela yokwelapha i-OIC.

(8)Izindleko ze-Linaclotide

Uma kuziwa Izindleko ze-Linaclotide, iphakeme kancane kunele-lubiprostone. Okwamanje, izindleko zeLinaclotide cishe zingu- $ 450 wamakhompiyutha e-30 ngenkathi amaphakethe we-60 we-lubiprostone angabiza cishe nge- $ 396 Noma kunjalo, amanani entengo ayahlukahluka ukusuka kumthengisi komunye kuya kwesinye futhi ngezikhathi.

(9)Umkhiqizi

Umkhiqizi weLinaclotide yinkampani eyaziwa nge-Allergan ngenkathi i-lubiprostone ingumkhiqizo wenkampani yeSucampo.

Ngaphandle kokungafani okungehla, kubalulekile ukuthi uqaphele ukuthi i-lubiprostone neLinaclotide zithengiswa abathengi ngendlela ye-capsule yomlomo futhi abanawo ama-generics. Futhi, zombili lezi zidakamizwa zidinga ukunikezwa kadokotela ukuze umuntu azithole kunoma yimuphi umthengisi.

9. Ini eminye imininingwane mayelana I-Linaclotide kufanele ngazi?Phcoker

Njenganoma yisiphi esinye isidakamizwa, i-Linaclotide powder (851199-59-2) noma amakhompiyutha kufanele agcinwe engafinyeleleki ezinganeni ukuze azivimbe. Futhi, ngokuba umuthi obhalwe phansi, abanye abantu bangase bathambekele ekuhlanganyeleni umuthi nabanye ukugwema ukuhlupheka kokuya kudokotela ukuyonikezwa.

Kodwa-ke, ukwabelana ngeLinaclotide kuyingozi ngoba udokotela kufanele abeke izinto eziningi ngaphambi kokunquma umuthi futhi adlule leso sinyathelo kungaholela emiphumeleni emibi kakhulu.

Uma kwenzeka ufuna ukwenza iLinaclotide ithenge, kufanele wazi ukuthi emazweni amaningi, kubandakanya ne-US, udinga incwadi kadokotela ukuze uthole umuthi. Lokhu akunandaba ukuthi uhlose ukuyithenga online noma ngaphezulu kwekhawuntara.

Uma kuziwa kwisitoreji, okushisa okunconyiwe kwesitoreji seLinaclotide 851199-59-2 yi-25 ° C (77 ° F). Noma ngabe ubhekene neLinaclotide powder noma amaphilisi, umuthi kufanele ugcinwe endaweni engenawo umswakama futhi, akumele uhlukaniswe noma ubuyiselwe endaweni ethile. Esikhundleni salokho, gcina isidakamizwa sonke esitsheni saso sokuqala.

Futhi, qiniseka ukuthi isitsha sivaleke ngokuqinile nge-desiccant yaso ngaphakathi ukuvala umswakama.

Noma ngabe ufuna ukuthenga iLinaclotide 851199-59-2 yokusetshenziswa kwezimboni, iLinaclotide iyathengiswa noma okunye ukusetshenziswa kweLinaclotide, qiniseka ukuthi uyayithola emthonjeni othembekile nothembekile. Ukubuyekezwa kwe-Linaclotide okuku-inthanethi kungakuqondisa kumthengisi omuhle.

Ngaphandle kwalokho, ngaphandle kokwenza inkuthalo efanele, lowo mthengisi ungaxhunyiwe ku-inthanethi / online othi ungoqobo I-Linaclotide iyathengiswa kungahle kube ukuthi kuthengiswa imikhiqizo yesivumelwano noma kuntshontsha imali yakho etholwe kanzima.

Okubhekwayo

  1. U-Andresen, V., Camilleri, M., uBusciglio, IA, uGrudell, A., Burton, D., McKinzie, S.,… & Currie, MG (2007). Umphumela wezinsuku ze-5 ze-linaclotide zokuhamba nokusebenza kwamathumbu kubantu besifazane abane-embtipation-predominant irritable bowel syndrome. Gastroenterology, 133(3), i-761-768.
  2. UChey, WD, uLembo, AJ, uLavins, BJ, uShiff, SJ, Kurtz, CB, Currie, MG,… & Baird, MJ (2012). I-Linaclotide yesifo sokuqaqanjelwa kwamathumbu esingaqunjelwa: isonto le-26, elenziwe ngokungakhethi, elimpumputhe kabili, elilawulwa nge-placebo ukuhlola ukusebenza nokuphepha. Ijenali yaseMelika ye-gastroenterology, 107(11), i-1702.
  3. I-Cuppoletti, J., Blikslager, AT, Chakrabarti, J., Nighot, PK, & Malinowska, DH (2012). Imiphumela ehlukile ye-linaclotide ne-lubiprostone ekubuyiselweni kwezakhiwo zesithintelo se-epithelial cell barriers kanye ne-homeostasis yeselula ngemuva kokuvezwa kwengcindezi yeseli. Ikhemisi ye-BMC, 12(1), i-3.
  4. UHarris, A. (2013). I-LINACLOTIDE. umxhumanisi.
  5. UJohnston, JM, Kurtz, CB, Drossman, DA, Lembo, AJ, Jeglinski, BI, MacDougall, JE,… & Currie, MG (2009). Ucwaningo lwe-Pilot ngomphumela we-linaclotide ezigulini zokuqunjelwa okungapheli. Ijenali yaseMelika ye-gastroenterology, 104(1), i-125.
  6. Lembo, AJ, Kurtz, CB, MacDougall, JE, Lavins, BJ, Currie, MG, Fitch, DA,… noJohnston, JM (2010). Ukusebenza kwe-linaclotide ezigulini zokuqunjelwa okungapheli. Gastroenterology, 138(3), i-886-895.
  7. Lembo, AJ, Schneier, HA, Shiff, SJ, Kurtz, CB, MacDougall, JE, Jia, XD,… & Jeglinski, BI (2011). Izilingo ezimbili ezingahleliwe ze-linaclotide zokuqunjelwa okungapheli. I-New England Journal of Medicine, 365(6), i-527-536.

I-Shangke Chemical yinkampani ephezulu echwepheni ezisebenzayo ezizimele eziphambili zokwelapha (APIs). Ukuze ulawule ikhwalithi ngesikhathi sokukhiqiza, inqwaba yabachwepheshe abanolwazi, imishini yokukhiqiza yokuqala kanye nama-laboratories yiwona amaphuzu ayisihluthulelo.

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