Yini i-pyrroloquinoline quinone (pqq)?

I-Pyrroloquinoline quinone (PQQ) eyaziwa nangokuthi i-methoxatin yisithako se-cofactor esifana nevithamini ekudleni kwezitshalo eziningi. I-PQQ nayo yenzeka ngokwemvelo obisini lwebele lomuntu nasezithanjeni zezilwane ezincelisayo.

Kodwa-ke, kutholakala kuphela ngamanani weminithi kulokhu kudla ubuningi be-pqq powder ukukhiqizwa kuyadingeka ukuthola amanani anele emzimbeni.

I-PQQ yaqala ukutholwa njenge-coenzyme emabhakithini omsebenzi wayo ufana nowe-B-Vitamin ebantwini, futhi idlala indima ekuqhubekiseni ukukhula kwalezi zidalwa.

Ebantwini, kusebenza njengento engeyona eye-Vitamin yokukhula enezinzuzo eziningi zezempilo.

Indlela Yokusebenza

I-Pyrroloquinoline quinone (pqq) ikhombisa izinzuzo eziningi zezempilo ngokusebenzisa izindlela ezahlukahlukene njengokulawulwa kwemigwaqo yokusayina amaselula, ukuqeda ama-radicals wamahhala nomsebenzi we-redox.

Izinqubo ze-pqq zesenzo zifaka:

• Thinta indlela izakhi zofuzo ezisebenza ngayo

I-Pyrroloquinoline quinone ingathinta indlela izakhi zofuzo ezahlukahlukene ezivezwa ngayo ikakhulukazi izakhi zofuzo ezihilelekile emsebenzini we-mitochondria. Umsebenzi wayo we-antioxidant kuthiwa uphindwe ka-100 ukwedlula uvithamini C.

I-supplement ye-PQQ ibonisiwe ukwenza kusebenze izindlela zeCREB ne-PGC-1a ezibandakanya ngqo i-mitochondria biogeneis.

Isebenza njenge-antioxidant

Umsebenzi we-Pyrroloquinoline quinone (pqq) wokulwa ne-oxidative ubangelwa amandla ayo ancishiswe ku-PQQH2 ngokusebenzisa ukusabela kwama-ejenti wokunciphisa anjenge-cysteine, glutathione noma i-nicotinamide adenine dinucleotide phosphate (NADPH).

• Ivimbela ama-enzyme

I-Pyrroloquinoline quinone nayo iyayiphazamisa i-enzyme Ukunciphisa i-thioredoxin 1 (TrxR1), nayo ebangela izinto ezi-2 ze-Nuclear factor erythroid 2-Nrf2) ezikhuthaza ukukhiqizwa kwe-antioxidant.

I-PQQ yaziwa nangokuthi ivimbela ukuthuthukiswa kwama-quinoprotein (amaprotheni alimazayo) aholela ekuphazamisekeni kukaParkinson.

Umhlomulo obalulekile (PQQ) we-pyrroloquinoline quinone

Kunezinzuzo eziningi ze-pyrroloquinoline quinone kufaka phakathi:

i. I-PQQ inyusa umsebenzi we-mitochondrial

AmaMitochondria angama-organelles akhiqiza amandla emangqamuzaneni ngesimo se-ATP ngokusebenzisa ukuphefumula kwamangqamuzana. Imvamisa idluliselwa kumagumbi okuphehla amandla efemu noma izimboni zamandla.

Ukukhiqizwa kwamandla kuyisihluthulelo sokuba yinyama enempilo.

Ukungasebenzi kahle kwe-Mitochondrial kuhlobene nokuphazamiseka okuningi njengokukhula okuncishisiwe, ubuthakathaka bemisipha, ukuphazamiseka kwe-neurodegenerative njengesifo senhliziyo, ukudangala nesifo sikashukela phakathi kwezinye izimo zezempilo.

I-Pyrroloquinoline quinone ithuthukisa umsebenzi we-mitochondrial ngokukhuthaza ukukhiqizwa kwamaseli amasha we-mitochondria (mitochondrial biogenesis). Lokhu kwenzeka ngokwenza kusebenze i-CAMP ephendula i-protein 1 (CREB) ne-Peroxisome proliferator-activated receptor-gamma coactivator (PGC) -1alpha, izindlela ezikhulisa i-mitochondrial biogeneis.

I-Pyrroloquinoline quinone futhi yandisa izinto zokuloba ezisebenza njengama-antioxidants ngaphakathi kwe-mitochondria yingakho esivikela ekucindezelekeni kwe-oxidative.

I-Pqq iqhubekisela phambili ama-enzyme ku-mitochondria ekhulisa ukukhiqizwa kwamandla.

Kumodeli we-rat, ukuntuleka kwe-PQQ ekudleni kubikwa kuphazamisa umsebenzi we-mitochondrial.

izinzuzo ze-pyrroloquinoline quinone

ii. Ikhumbula ukuvuvukala

Ukuvuvukala okungapheli kuyimbangela yokuphazamiseka okuningi okufana nesifo senhliziyo nesifo sikashukela. I-Pyrroloquinoline quinone inezinto ezingama-antioxidant ezizisiza zisuse ama-free radicals ngaleyo ndlela zivimbele ukuvuvukala kanye nokulimala kweseli.

Olunye ucwaningo lukhombisa lokho Ukungezelelwa kwe-PQQ kuholela ekwehleni okumangazayo kwamamaki amaningi okuvuvukala njenge-nitric oxide ngezinsuku ezintathu nje.

Ocwaningweni lwamagundane ahlushwa isifo samathambo, i-PQQ eyalawulwa kwathiwa izovikela ekuwohlokeni kokulimala ngemuva kwezinsuku ezingama-45.

Iii. Kuthuthukisa impilo yobuchopho nokusebenza

I-Pyrroloquinoline quinone inamandla okukhulisa ubuchopho futhi (neurogeneis) ngokukhiqiza izinto eziningi zokukhula kwezinzwa.

Olunye ucwaningo lwaphetha ukuthi i-pqq supplement ivusa ukuhlangana kwe-nerve ukukhula factor (NGF) namaseli we-neuron.

I-Pyrroloquinoline quinone ihlotshaniswe nokukhumbula okuthuthukile nokufunda ngenxa yekhono layo lokuvuselela amangqamuzana obuchopho.

Esifundweni esenziwe ngabantu abangama-41 abaphilile kodwa asebekhulile, i-PQQ elawulwa nge-20 mg / ngosuku amasonto ayi-12 yatholakala ukuthikameza ukuncipha komsebenzi wobuchopho, ikakhulu ekulaleleni nasekukhumbuleni okubandakanyekile.

I-Pyrroloquinoline quinone nayo ingasiza ekuvimbeleni ukulimala kobuchopho.

Ngo-2012, ucwaningo lwamagundane anikezwa i-pqq izinsuku ezingama-3 ngaphambi kokulimala kobuchopho obuhlungu bathola ukuthi lo mbala ukwazile ukuvikela amangqamuzana obuchopho kulokhu kulimala.

iv. I-PQQ ithuthukisa ukulala

I-Pyrroloquinoline quinone (PQQ) isiza ekwandiseni ikhwalithi yakho yokulala ngokunciphisa isikhathi esithathwe ukuze ulale, ikhulisa isikhathi sokulala futhi ithuthukise ikhwalithi yokulala ephelele.

I-Pyrroloquinoline quinone nayo ingahle yehlise inani le-hormone yokucindezela (i-cortisol) ngaphakathi kwabantu ngakhoke ithuthukisa ukulala kwabo.

Ocwaningweni lwabantu abadala abangu-17, i-PQQ enikezwe ngo-20 mg / ngosuku amasonto ayi-8 yatholakala ukuthuthukisa ikhwalithi yokulala ngokuya ngesikhathi sokulala nesikhathi esengeziwe sokulala.

I-PQQ ithuthukisa ukulala

v. Kuthuthukisa impilo yenhliziyo

Amandla we-pyrroloquinoline quinone ukulawula amazinga e-cholesterol ayenza inciphise ingozi yesifo senhliziyo njengokushaywa unhlangothi.

Ocwaningweni lwabantu abadala abangama-29, ukungezelelwa kwe-pqq kunciphise kakhulu amazinga amabi we-cholesterol ye-LDL.

I-Pyrroloquinoline quinone ibuye inciphise amazinga e-triglycerides aholela ekusebenzeni okuthuthukisiwe kwe-mitochondrial. Ocwaningweni namagundane, i-ppq enikeziwe yatholakala ukwehlisa amazinga abo e-triglyceride.

I-Pqq supplement ingasiza ukuvikela noma ukuguqula i-atherossteosis (unhlangothi). Olunye ucwaningo luye lwabonisa ukuthi i-ppq ingangehlisa ama-protein e-C-reactive ne-trimethylamine-N-oxide okuyizinto eziwuphawu oluphambili lwalesi sifo.

vi. Umenzeli ongahlala isikhathi eside

I-Pyrroloquinoline quinone ibhekwa njengento engakhuli ngevithamini yingakho ingasiza ukukhuthaza ukukhula kwakho futhi nentuthuko.

Umsebenzi we-prinone we-Pyrroloquinoline ekulweni nokuvuvukala, ukuvimbela ukucindezela kwe-oxidative nokusekela umsebenzi we-mitochondrial kufakazela amandla ayo ekwandiseni impilo yomuntu.

I-PQQ nayo ifakazelwe ukuthi isebenze izindlela zokubonisa amaseli eziguqula ukubuyela kweselula emuva.

Umphumela we-synergetic osuselwe kulezi zinqubo unika amandla i-PQQ ukukuvikela ekuguga kwamaselula futhi futhi ithuthukise impilo ende.

Kumodeli yezilwane, i-supplementation ne-pqq itholwe ukunciphisa ukucishwa kwe-oxidative kanye nokwelula isikhathi sobomi be-roundworms.

vii. Ukuvikelwa ekucindezelekeni kwe-oxidative

I-PQQ ibopha amaprotheni yingakho evimbela i-oxidation kumaseli. Iyakwazi nokukhipha ama-free radicals emzimbeni.

Esifundweni sezilwane, i-pqq supplementation yatholakala ukuvikela ukufa kwe-neuron cell ehambelana ne-oxidative.

Kwenziwe olunye ucwaningo kwesibeletho ibike ukuthi i-PQQ ivikele amaseli wesitopikisi esisele sangasese emonakalweni ngemuva kokuxineka okune-oxidative futhi kuqedwe nemisebe ye-superoxide.

Ukuqhubeka kokufunda ngegundane lesifo sikashukela se-streptozotocin-indedu (STZ), i-PQQ enikezwe ku-20 mg / kg isisindo sezinsuku eziyi-15 kuye kwanciphisa amazinga we-serum we-glucose kanye nemikhiqizo ye-lipid peroxidation, futhi futhi yaphakamisa imisebenzi yama-antioxidants ebuchosheni begundane lesifo sikashukela. .

Okunye ukusetshenziswa kwe-pyrroloquinoline quinone futhi izinzuzo zifaka:

Ukuvimbela ukukhuluphala

Kuthuthukisa amasosha omzimba

Kuthuthukisa ukuzala

Ikhuthaza ukusebenza kwengqondo nememori

Siza ukulwa nokukhathala

Esimweni samanje emhlabeni, izindaba ezingezinhle ngenxa ye-COVID 19 ziyeza ngaso sonke isikhathi. I-Pyrroloquinoline quinone coronavirus Fight ingasetjenziswa. Lesi sengezo esijabulisayo sizothuthukisa ukungatheleleki kwakho futhi sinikeze nosizo lokulala ukuze kudambise ingcindezi.

i-pyrroloquinoline quinone isebenzisa

Imiphi imiphumela emibi ye-pyrroloquinoline quinone (pqq)?

Lapho uthola i-PQQ emithonjeni yokudla akukho miphumela emibi elindelekile ngaphandle kokuthi umuntu angayidli ukudla okuthile.

Ezifundweni zezilwane ngamagundane, ukuphazamiseka kwe-renal kuhlobene nokuhlanganiswa kwe-PQQ. Kokunye ukuhlola okwenziwa ngamagundane, i-PQQ ilimale isisindo somzimba esingu-11-12 mg / kg kwabikwa ukuthi ibanga ukuvuvukala kwezinso.

Kokunye ukuhlola kwamagundane, i-PQQ ku-20 mg / kg bodyweight yatholakala ibangela ubuthi ku-renal kanye ne-hepatic izicubu.

Ukushona kwamagciwane kuye kwabikwa ngemithamo ephezulu ye-500 mg.

Ebantwini, akukho miphumela emibi ye-pyrroloquinoline quinone eye yabikwa ngemithamo efinyelela ku-20 mg / ngosuku.

Kodwa-ke, ezimeni ezingejwayelekile, eminye imiphumela emibi ye-pyrroloquinoline quinone ingenzeka ngenxa yokuphuza ngokweqile. Le miphumela emibi ifaka ikhanda, ukukhathala, ukozela, i-hypersensitivity kanye nokuqwasha.

Umthamo we-PQQ

Njengoba i-pyrroloquinoline quinone (pqq) ingakagunyazwa ngokuphelele yi-Federal Drug Administration ukusetshenziswa kwezokwelapha, akukho dosage ejwayelekile ye-pyrroloquinoline quinone esethiwe, yize ezinye izifundo zithole ukuthi imithamo ye-pyrroloquinoline quinone kusuka 2 mg / ngosuku iyazuzisa. Kodwa-ke, izithasiselo eziningi ze-PQQ zikwimithamo engama-20 kuye kwangama-40 mg.

Prosroloquinoline quinone dosage ingahluka ngokuya ngenhloso okuhlosiwe. Olunye ucwaningo lukhombisa ukuthi umthamo we-0.075 kuya ku-0.3 mg / kg ngosuku usebenza kahle ekuthuthukiseni umsebenzi we-mitochondria, kuyilapho umthamo ophakeme ongama-20 mg ngosuku ungadingeka ukuze ulwe nokuvuvukala.

Lapho kuthathwa ndawonye ne-COQ10, imithamo ye-20 mg PQQ ne-200 mg COQ10 iyalulekwa, yize ezinye izifundo zisebenzisa i-20 mg ye-PQQ ne-300 mg COQ10 zingazange zibike noma yimiphi imiphumela emibi.

Ama-PQQ ama-supplement kufanele athathwe ngomlomo futhi ikakhulukazi ngaphambi kokudla-esiswini esingenalutho.

Uyelulekwa-ke ukuthi uqale kusuka kumthamo ophansi futhi ukhuphuke ngokwesidingo.

Futhi okubalulekile ukuthi izifundo eziningi azikukhuthazi ukuthatha umthamo ngaphezu kwe-80 mg ngosuku.

Yini Ukudla Okuqukethe i-pyrroloquinoline quinone (pqq)?

IPyrroloquinoline quinone (pqq) itholakala ekudleni okuningi kwezitshalo, yize kuvame ngamanani aphansi kakhulu. Izitshalo zithola i-PQQ ngqo kusuka kumabhaktheriya omhlabathi nawomhlaba njenge-methylotrophic, i-rhizobium, namagciwane we-acetobacter.

I-Pqq kwezicubu zomuntu ivela ngokuhlukile ekudleni futhi ngokwengxenye ekukhiqizweni kwamagciwane e-enteric.

Izinga le-pyrroloquinoline quinine kule mithombo yokudla liyahlukahluka ngokusuka ku-0.19 kuya ku-61ng / g. Kodwa-ke, i-pqq igxilwe kakhulu kulokhu kudla okulandelayo:

I-Pqq-Ukudla

Eminye imithombo yokudla ye-PQQ ifaka amahlumela ama-broccoli, isinaphi sensimu, ubhontshisi we-fava, ama-aphula, amaqanda, isinkwa, iwayini nobisi.

Ngenxa yamazinga aphansi we-pqq ekudleni okuningi, kungaba nzima ukuthola amanani anele wokuxhuma izinzuzo ezihambisana ne-pqq ngaphandle kokuthi sithathe inani elikhulu kakhulu lokudla okuthile. Lokhu-ke kudinga umuntu ukuthi athenge i-pqq isengezo ukugcwalisa ukudla okuhle.

I-PQQ ne-COQ10

I-coenzyme Q10 (COQ10) evame ukubhekwa njenge-mitochondria enhancer iyenzeka emzimbeni womuntu nasekudleni okuningi. Kuyafana ne-PQQ; noma kunjalo, i-pyrroloquinoline quinine ne-CQ10 basebenza ngezindlela ezihlukile kakhulu noma basebenzisa izindlela ezahlukahlukene zokuthuthukisa imisebenzi ye-mitochondrial.

I-coenzyme Q10 iyi-cofactor ebalulekile esebenza ngaphakathi kwe-mitochondria futhi idlala indima ebalulekile ekuphefumuleni kweselula nasekusetshenzisweni kwe-oksijini ukukhiqizwa kwamandla. Ngakolunye uhlangothi i-PQQ inyusa inani lamaseli we-mitochondria futhi ithuthukisa ukusebenza kahle kwe-mitochondria.

Lapho kuthathwa ndawonye, ​​i-pyrroloquinoline quinine ne-CQ10, inikeza imiphumela ye-synergetic ekwenzeni umsebenzi we-mitochondrial, isivikele ekucindezelekeni kwe-oxidative nasekulawuleni izindlela zokubonisa amaselula.

Thenga i-PQQ Supplement

Ziningi izinzuzo ezingenakugwenywa ze-pqq supplement powder futhi kufanele ucabangele ukuncoma ukudla kwakho ngayo. I-PQQ powder ethengiswayo iyatholakala kalula online. Noma kunjalo, ngemiphumela engcono kakhulu yiba ophapheme ngokwengeziwe lapho uthenga i-pqq supplement ukuze uqinisekise ukuthi uthola ikhwalithi enhle kakhulu.

Uma ucabanga ukuthenga i-pqq bulk powder kuqinisekisa ukuthi uyithola kubaphakeli abanedumela elihle.

Okubhekwayo

  1. UChowanadisai W., Bauerly KA, Tchaparian E., Wong A., Cortopassi GA, Rucker RB (2010). I-Pyrroloquinoline quinone ivuselela i-mitochondrial biogenesis ngokusebenzisa i-cAMP yokuphendula element-binding protein phosphorylation futhi yandise inkulumo ye-PGC-1α. Biol. Amakhemikhali. 285: 142–152.
  2. Harris CB1, UChowanadisai W, Mishchuk YENZA, I-Satre MA, I-Slupsky CM, I-Rucker RB. (2013). Izinkomba ze-Dietary pyrroloquinoline quinone (PQQ) zishintsha izinkomba zokuvuvukala kanye ne-mitochondrial-metabolism ehlobene nezifundo zabantu. J Nutr Biochem.Dec; 24 (12): 2076-84. I-Doi: 10.1016 / j.jnutbio.2013.07.008.
  3. Kumazawa T., Sato K., Seno H., Ishii A., noSuzuki O. (1995). Amazinga e-pyrroloquinoline quinone ekudleni okuhlukahlukene. J.307: 331-333.
  4. UNunome K., Miyazaki S., Nakano M., Iguchi-Ariga S., Ariga H. (2008). I-Pyrroloquinoline quinone ivimbela ukufa kwe-neuronal okubangelwa ukucindezela kwe-oxonal mhlawumbe ngokushintsha kwesimo se-oxidative se-DJ-1. UPhilisi. Bull. 31: 1321–1326.
  5. UPaul Hwang & Darryn S. Willoughby (2018). I-Mechanisms Behind Pyrroloquinoline Quinone Supplement on Skeletal Muscle Mitochondrial Biogenesis: Imiphumela ye-Synergistic engahle ibe nokuzivocavoca, i-Journal of the American College of Nutrition, 37: 8, 738-748, DOI: 1080 / 07315724.2018.1461146.
  6. Izibalo T, iStrorms D, kanye noBauerly K, et al. (2006). Umbhalo ogcwele: I-Pyrroloquinoline quinone modulates ubungako be-mitochondrial nomsebenzi wamagundane. J Nutriti. Feb; 136 (2): 390-6.
  7. UZhang L, uLiu J, uCheng C, uYuan Y, uYu B, uShen A, uYan M. (2012). Umphumela we-neuroprotective we-pyrroloquinoline quinone ekulimaleni kobuchopho kobuhlungu. J Neurotrauma. Mar 20; 29 (5): 851-64.

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