I-Urolithin A

April 8, 2021

I-Urolithin A ikhonjisiwe ukukhuthaza i-mitophagy nokwenza ngcono impilo yemisipha ezilwaneni ezindala nakumamodeli wangaphambi kokuguga. Okwamanje, futhi kukhonjisiwe ukuthi kweqa isithiyo sobuchopho begazi, futhi kungahle kube nemiphumela yokuvikela isifo ekulweni nesifo i-Alzheimer's.

I-Urolithin A) 1143-70-0) ividiyo

I-Urolithin A (1143-70-0)Imininingwane

Igama Product I-Urolithin A powder
Igama leKhemikhali 3,8-dihydroxy-6H-benzo [c] chromen-6-one;

3,8-Dihydroxy-6H-dibenzo (b, d) pyran-6-one;

3,8-Dihydroxyurolithin;

3,8-dihydroxybenzo [c] chromen-6-one;

I-6H-Dibenzo [b, d] i-pyran-6-eyodwa, i-3,8-dihydroxy-;

3,8-Hydroxydibenzo-alpha-pyrone;

CAS Inombolo 1143-70-0
InChIKey I-RIUPLDUFZCXCHM-UHFFFAOYSA-N
SMILES C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
I-molecular Fi-ormula C13H8O4
I-molecular Weziyisishiyagalombili I-228.2 g / mol
IMisa ye-Monoisotopic I-228.042259 g / mol
Iphuzu lokuxuba I-340-345 ° C
Iphuzu lokubilisa  527.9 ± 43.0 ° C (Kubikezelwe)
I-Flash Point I-214.2ºC
I-Half Half-Life I-Urolithin A ikhona emchameni kuze kufike emahoreni angama-48 ngemuva kokusetshenziswa kwejomegranate juice.
Color Mhlophe kuya ku-beige
Sukufaneleka  I-DMSO: 20 mg / mL, icacile
Sukuhlushwa Tukushisa  I-2-8 ° C
Aukuphikisana Isetshenziswa njengesengezo sokudla nomkhiqizo olwa nokuguga, ingasetshenziswa ukunciphisa ukuvuvukala nokulwa nomdlavuza;

 

Izikhombo:

[1] UGarcia-Munoz, uCristina; UVaillant, uFabrice (2014-12-02). "I-Metabolic Fate ye-Ellagitannins: Imiphumela Yezempilo, Nemibono Yocwaningo Yezinto Ezintsha Zokudla Okusebenzayo". Ukubuyekezwa Okubalulekile kuSayensi Yezokudla Nondlekile. 54 (12): 1584-1598. i-doi: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. I-PMID 24580560. S2CID 5387712.

[2] URyu, D. et al. I-Urolithin A induces mitophagy futhi yelula isikhathi sempilo ku-C. elegans futhi inyuse ukusebenza kwemisipha kumagundane. Nat. IMed. 22, 879-888 (2016).

[3] “Isaziso se-FDA GRAS GRN No. 791: urolithin A”. Ukuphathwa Kwezokudla Nezidakamizwa zase-US. 20 Disemba 2018. Ibuyiswe ngomhlaka 25 Agasti 2020.

[4] USingh, A .; Andreux, P.; UBlanco-Bose, W .; URyu, D.; I-Aebischer, P .; I-Auwerx, J .; URinsch, C. (2017-07-01). "I-urolithin A elawulwa ngomlomo iphephile futhi ihlehlisa ama-biomarker emisipha kanye ne-mitochondrial kubantu asebekhulile". Ukuqamba ekugugeni. 1 (suppl_1): 1223–

[5] UHeilman, uJacqueline; U-Andreux, uPénélope; ITran, Nga; URinsch, uChris; UBlanco-Bose, uWilliam (2017). "Ukuhlolwa kokuphepha kwe-urolithin A, i-metabolite ekhiqizwa yi-gut gut microbiota ekudleni kokudla kwezitshalo ezitholwe ngama-ellagitannins ne-ellagic acid". Ukudla kanye neKhemikhali Toxicology. 108 (Pt A): 289– doi: 10.1016 / j.fct.2017.07.050. I-PMID 28757461.