I-Urolithin A） 1143-70-0） ividiyo
I-Urolithin A （1143-70-0）Imininingwane
| Igama Product | I-Urolithin A powder |
| Igama leKhemikhali | 3,8-dihydroxy-6H-benzo [c] chromen-6-one;
3,8-Dihydroxy-6H-dibenzo (b, d) pyran-6-one; 3,8-Dihydroxyurolithin; 3,8-dihydroxybenzo [c] chromen-6-one; I-6H-Dibenzo [b, d] i-pyran-6-eyodwa, i-3,8-dihydroxy-; 3,8-Hydroxydibenzo-alpha-pyrone; |
| CAS Inombolo | 1143-70-0 |
| InChIKey | I-RIUPLDUFZCXCHM-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O |
| I-molecular Fi-ormula | C13H8O4 |
| I-molecular Weziyisishiyagalombili | I-228.2 g / mol |
| IMisa ye-Monoisotopic | I-228.042259 g / mol |
| Iphuzu lokuxuba | I-340-345 ° C |
| Iphuzu lokubilisa | 527.9 ± 43.0 ° C (Kubikezelwe) |
| I-Flash Point | I-214.2ºC |
| I-Half Half-Life | I-Urolithin A ikhona emchameni kuze kufike emahoreni angama-48 ngemuva kokusetshenziswa kwejomegranate juice. |
| Color | Mhlophe kuya ku-beige |
| Sukufaneleka | I-DMSO: 20 mg / mL, icacile |
| Sukuhlushwa Tukushisa | I-2-8 ° C |
| Aukuphikisana | Isetshenziswa njengesengezo sokudla nomkhiqizo olwa nokuguga, ingasetshenziswa ukunciphisa ukuvuvukala nokulwa nomdlavuza; |
Izikhombo:
[1] UGarcia-Munoz, uCristina; UVaillant, uFabrice (2014-12-02). "I-Metabolic Fate ye-Ellagitannins: Imiphumela Yezempilo, Nemibono Yocwaningo Yezinto Ezintsha Zokudla Okusebenzayo". Ukubuyekezwa Okubalulekile kuSayensi Yezokudla Nondlekile. 54 (12): 1584-1598. i-doi: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. I-PMID 24580560. S2CID 5387712.
[2] URyu, D. et al. I-Urolithin A induces mitophagy futhi yelula isikhathi sempilo ku-C. elegans futhi inyuse ukusebenza kwemisipha kumagundane. Nat. IMed. 22, 879-888 (2016).
[3] “Isaziso se-FDA GRAS GRN No. 791: urolithin A”. Ukuphathwa Kwezokudla Nezidakamizwa zase-US. 20 Disemba 2018. Ibuyiswe ngomhlaka 25 Agasti 2020.
[4] USingh, A .; Andreux, P.; UBlanco-Bose, W .; URyu, D.; I-Aebischer, P .; I-Auwerx, J .; URinsch, C. (2017-07-01). "I-urolithin A elawulwa ngomlomo iphephile futhi ihlehlisa ama-biomarker emisipha kanye ne-mitochondrial kubantu asebekhulile". Ukuqamba ekugugeni. 1 (suppl_1): 1223–
[5] UHeilman, uJacqueline; U-Andreux, uPénélope; ITran, Nga; URinsch, uChris; UBlanco-Bose, uWilliam (2017). "Ukuhlolwa kokuphepha kwe-urolithin A, i-metabolite ekhiqizwa yi-gut gut microbiota ekudleni kokudla kwezitshalo ezitholwe ngama-ellagitannins ne-ellagic acid". Ukudla kanye neKhemikhali Toxicology. 108 (Pt A): 289– doi: 10.1016 / j.fct.2017.07.050. I-PMID 28757461.
