I-NMN powder (1094-61-7)

October 30, 2018

Ifektri yethu inamandla okukhiqiza ngaphezulu kwe-1370kg Nicotinamide Mononucleotide (nmn) powder ngenyanga ngaphansi kwezimo ze-GMP.


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum
Umthamo: 1370kg / inyanga

Ividiyo

 

Imininingwane

Igama Product Iphunga elimnyama likaNicotinamide Mononucleotide (NMN)
Igama lomqondofana I-NAMN, β-NMN, β-Nicotinamide Mononucleotide noma i-Beta Nicotinamide Mononucleotide;

i-beta-NMN

I-Drug Class Ukwengeza kokudla
CAS Inombolo 1094-61-7
InChIKey DAYLJWODMCOQEW-TURQNECASA-N
Ifomula Yamamolekhula C11H15N2O8P
Isisindo Semolekyuli I-334.22 g / mol
IMisa ye-Monoisotopic I-334.056602 g / mol
Indawo Yokuncibilika  166 ° C (isinqumo.)
Indawo Ebandayo N / A
I-Half Half-Life N / A
Color Mhlophe uphawuda omhlophe
solubility  I-Beta-NMN inikezwa njenge-crystalline solid. I-Beta-NMN incibilika kancane kuma-solvents we-organic njenge-ethanol, i-DMSO, ne-dimethyl formamide. Ekuhlolweni kwezinto eziphilayo, siphakamisa ukuthi izixazululo ezinamanzi ezingena-solvent ezingenamanzi ze-Beta-NMN zilungiswe ngokuqedwa ngqo okuqinile kwe-crystalline kuma-buffers aqueous. Ukuncibilika kwe-Beta-NMN ku-PBS, pH 7.2, icishe ibe yi-10 mg / ml. Asikukhuthazi ukugcina isixazululo samanzi isikhathi esingaphezu kosuku olulodwa.
Isitoreji sokushisa  Igumbi le-temperatur;

Gcina ku -20 ° C kuze kube yiminyaka engu-2.

Isicelo Izithako zokudla zokulwa nokuguga

 

Umlando we-NMN

I-Nicotinamide mononucleotide (ifomula yamangqamuzana: C11H15N2O8P, inombolo ye-CAS: 1094-61-7, eyaziwa nangokuthi i-NMN, i-beta-Nicotinamide mononucleotide noma i-β-NMN) iyi-vitamin B3 metabolite [1], etholakala ngokwemvelo emzimbeni womuntu, futhi ngokufanayo ukudla okufana ne-broccoli neklabishi ngamanani amancane [2].

I-NMN iqale ukuthola inzalo njengokungezelela okungenzeka kube nokudla okunempilo ngo-2013, ngemuva kocwaningo lwentuthuko olwenziwe ososayensi baseHarvard kumagundane [3,4].

I-NMN yaqala ukukhiqizwa njengesengezo sabantu ngo-2015 [5], kodwa yayibiza kakhulu ukukhiqiza, kuze kutholakale izindlela zokunciphisa izindleko zokukhiqiza nokwandisa ubumsulwa ngo-2018 [6], lapho-ke ama-laboratories azilungiselela ukukhiqizwa kwabantu abaningi aqala khona woza ku-inthanethi.

 

Yini i-NMN powder?

I-Nicotinamide mononucleotide (ifomula yamangqamuzana: C11H15N2O8P, inombolo ye-CAS: 1094-61-7, eyaziwa nangokuthi i-NMN, i-beta-Nicotinamide mononucleotide noma i-β-NMN) iyi-vitamin B3 metabolite [1], etholakala ngokwemvelo emzimbeni womuntu, futhi ngokufanayo ukudla okufana ne-broccoli neklabishi ngamanani amancane [2].

INicotinamide Mononucleotide (NMN) iyinhlanganisela eyenzeka ngokwemvelo engamanani amancane emzimbeni womuntu kanye nokudla okuthile. I-NMN ayitholakali ngomlomo, futhi uma ithathwa ngomlomo ingasekela amazinga e-NAD + ngaphakathi kwezicubu zesibindi nezicubu.

Ucwaningo lwamuva luye lwaphakamisa ukuthi i-NMN ingaxhasa impilo yenhliziyo, ukukhiqizwa kwamandla, impilo yokuqonda, kanye nempilo yethambo neyethambo. Ukutholwa okuthakazelisa ngokukhethekile kocwaningo lwe-NMN ukuthi kungakhuthaza ukulungiswa kwe-DNA futhi kusekele ukwenziwa kohlobo lwe-SIRTUIN okucatshangwa ukuthi ludlala indima ekugugeni okunempilo.

 

Isebenza kanjani?

I-NMN iyisandulela semolekyuli ye-NAD +; umzimba womuntu udinga i-NMN ukuze yakhe iNAD +.

I-NAD + iyindlela ene-oxidised ye-NAD (Nicotinamide adenine dinucleotide), i-molecule eyaqala ukutholwa ngo-1906, futhi yatholakala kuwo wonke amaseli aphilayo [7].

Ukwengeza nge-NAD + uqobo akuyona inketho yokukhulisa amazinga we-NAD +, ngoba kukhulu kakhulu ukuwela kalula ulwelwesi lwamaseli ukungena kumaseli, ngakho-ke ngeke ikwazi ukuthinta kahle imetabolism [8].

 

Izinzuzo ze-NMN.

Enye indlela esingaxhasa ngayo amazinga aphilile we-NAD + ngokwengeza imizimba yethu ngesandulela sayo, i-nicotinamide mononucleotide (i-NMN).

Ucwaningo lwamanje lukhombisa ukuthi lolu shintsho phakathi kwe-NR ne-NMN kumele lwenzeke ukungena ezinhlotsheni ezimbalwa zamaseli. Lokhu kuholela abacwaningi ukuthi bakholelwe ukuthi i-NMN, empeleni, ingenye yezindlela ezisheshayo zokukhuthaza ukukhiqizwa kwe-NAD. Kodwa-ke, iNicotinamide mononucleotide powder nayo ikhombisa ukuthi inezinzuzo zayo zokulwa nokuguga ezingaphezu kwalezo zokukhiqizwa kwe-NAD kuphela.

Ngaphezu kwendlela ye-metabolic ye-NAD, i-NMN powder ingangezwa ngqo kumaseli ngaphandle kokuguqulela ku-NAD. Lesi simo senziwa ukuthi senziwe ngamaprotheni asanda kutholakala ezokuthutha akhula ngenombolo ngemuva kokuwa kwamazinga e-NAD. Kuleli fomu, i-NMN ifaka isandla emandleni eseli futhi ivumela indawo ngayinye eshiwo ngaphambili yokulwa nokuguga ekhuthazwa ngamaseli anekhono elanele lokukhula nokuvuselela kabusha.

Ukukhetha ukwengeza nge-NMN powder kanye ne-NAD kunikeza indlela eqonde kakhulu yokuqhakambisa i-cell metabolism ngakho-ke kuyindlela esheshayo yokwenza okufanayo. Ngaphezu kwalokho, iNicotinamide mononucleotide powder itholakale ithuthukisa umsebenzi we-insulin nokukhiqiza, okuholela ezinzuzweni ezengeziwe ze-metabolic kanye nokubekezelelana kwe-glucose. Ikakhulu, izengezo ze-NMN zingasiza ukusebenza ukunciphisa izimo zemetabolic ezifana nesifo sikashukela, isifo sesibindi esinamafutha, nokukhuluphala. [11]

 

Ezinye Izinzuzo Ezingaba khona ze-NMN

  • Ikhuthaza impilo ye-Vascular kanye nokugeleza kwegazi. [11]
  • Kuthuthukisa ukukhuthazela kwemisipha namandla
  • Kuvikela Izifo Zenhliziyo
  • Yehlisa Ubungozi Bokukhuluphala. [10]
  • Kuthuthukisa Ukulungiswa Kwe-DNA
  • Kukhulisa Umsebenzi We-Mitochondrial. [9]

 

Ungathola kanjani i-NMN ezinzile, emsulwa, nephephile?

Ukuze kunqunywe ukuthi umkhiqizo ozinzile, oyiqiniso, omsulwa nophephile ungatholakala kanjani, kwenziwa uchungechunge lwezivivinyo nokuhlaziywa. Imibiko ye-COA, HPLC ne-HNMR ingahlinzekwa.

 

Ukuqina okuthuthukile

Ngokuhlaziya isakhiwo seNicotinamide mononucleotide nokusebenzisa indlela yokudlulisa imali kanye ne-in-situ FTIR yokuqapha, kutholakale ukuthi i-NMN inesakhiwo sangaphakathi sikasawoti kanye nephuzu le-isoelectric likasawoti wangaphakathi kuyisici esibalulekile sokungazinzi kwe-NMN. Amanzi, njenge-molecule eyodwa ye-polar, azobanga ukudluliswa kukagesi ngaphakathi kwe-NMN okungabhubhisa amathambo kasawoti angaphakathi aqinile e-NMN. Uma kunjalo, i-NMN izokhombisa isakhiwo esiguqukayo esiguquka kalula, okungukuthi okuqukethwe amanzi kulo mkhiqizo kanye nama-molecule wamanzi asemoyeni azobhubhisa ngqo iphuzu likasawoti wangaphakathi futhi kwehlise ubumsulwa be-NMN. Lokhu kungukuthuthuka okukhulu ocwaningweni lokuqina lokuqina kwe-NMN, okuzoba ukuqala okukodwa kokuthuthuka.

Ukwenza ngcono ukusimama kwempuphu yeNMN ngaphakathi, abacwaningi baklama ngobuciko impuphu entsha yeNMN ngokuhleleka nokuhlangana okuncane kakhulu.

 

Ukuqina okuqinile, impilo yeshalofu ende.

I-Phcoker NMN powder ihleleke kakhulu futhi ihlangene, ivimba ngempumelelo ukuxhumana namanzi amahhala emoyeni, kukhulisa kakhulu ukuzinza kwe-NMN nokwelula impilo yeshalofu yomkhiqizo. Ngokuphikisana nohlelo lwenoveli lwe-NMN oluncane, isakhiwo se-sawtooth sesizukulwane sokuqala sikhombisa ukungahleleki okungaphezulu futhi okungahambelani, ngakho-ke yonke i-molecule izothola ukuvezwa okuningi emoyeni futhi imunce amanzi amaningi.

 

Ubuningi obuphakeme, umthamo ozinzile ngokwengeziwe kanye nokwakhiwa okuguqukayo.

I-NMN powder enelungiselelo elincane elihlelekile nelicwecwe linobuningi obuphezulu kakhulu nobuningi, okugwema isilinganiso esingazinzile ngenxa yokuphakamisa uthuli ngenkathi kulungiswa. Ngaphezu, kuzothinta isilinganiso esifanayo samaphilisi. Okwamanje, njengoba ine-fluidity engcono, i-NMN powder yethu ingasiza ukunciphisa isikhathi sokukhiqiza kanye nezindleko zokukhiqiza ngesikhathi sokukhiqiza.

 

Ikhwalithi ephezulu eqinisekisiwe futhi emsulwa

Imibiko yokuhlola ilebhu yomuntu wesithathu kufanele idingekile ukuqinisekisa ubunikazi nobumsulwa be-NNM. Iqoqo ngalinye lezinto zokusetshenziswa kumele lidlule ukuzihlola okuqinile nokuhlolwa komuntu wesithathu. Imibiko yokuhlolwa kwe-HNMR ne-HPLC ingaqhubeka nokuqinisekisa ubuqiniso, ikhwalithi ephezulu kanye nobumsulwa be-NMN.

 

I-Phcoker ingumkhiqizi we-powder weNicotinamide mononucleotide (NMN)

Ngefektri ezenzela yona, umkhiqizo wethu we-NMN powder njalo ngenyanga ufinyelela ngaphezu kwamathani ama-2.

 

Isicelo

Impahla eluhlaza yezimonyo:

I-NMN iyinto esemzimbeni wamaseli, futhi i-NMN iyimolekyuli ye-monomer, umphumela wokulwa nokuguga usobala, ngakho-ke ungasetshenziswa ezintweni eziluhlaza zokwenziwa.

 

Imikhiqizo yokunakekelwa kwezempilo:

I-NMN powder ingalungiswa ngemvubelo yokuvutshelwa, ukuhlanganiswa kwamakhemikhali noma i-in vitro enzymatic catalysis.

I-NMN powder esetshenziswa kabanzi embonini yokunakekelwa kwezempilo.

 

Izikhombo:

[1] I-Nicotinamide mononucleotide. Kusuka kuWikipedia, i-encyclopedia yamahhala.

[2] Ukuphathwa Kwesikhathi Eside kweNicotinamide Mononucleotide Kunciphisa Ukwehla Kwemvelo Okuhambisana Nobudala Emagundeni. Ama-Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Iseli Metab. 2016 Dec 13.

[3] Ukwenqaba i-NAD + Kubanga Isimo se-Pseudohypoxic Siphazamisa Ukuxhumana Kwe-Nuclear-Mitochondrial ngesikhathi Sokuguga. IGomes AP, Intengo NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair I-DA. Iseli. 2013 Disemba 19; 155 (7): 1624-38. i-doi: 10.1016 / j.cell.2013.11.037.

[4] Intsha — Ebuyiselwayo — Imbangela Yokuguga. UDavid Cameron. IHarvard Medical School, Izindaba & Ucwaningo, ngoDisemba 19, 2013

[5] Iphakethe elibophekayo le-NAD + elilawula ukusebenzisana kwamaprotheni-protein ngesikhathi sokuguga. Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. Isayensi. 2017 Mar 24; 355 (6331): 1312-1317. i-doi: 10.1126 / science.aad8242.

[6] Indlela Yokuhlukaniswa Kosayizi We-Chromatography Yokuhlanzwa kweNicotinamide Mononucleotide (NMN) evela kumaSeli wamaGciwane. UGeorge Cătălin Marinescu, uRoua-Gabriela Popescu no-Anca Dinischiotu. Imibiko YesayensiIvolume 8, Inombolo ye-athikili: 4433 (2018).

[7] I-Nicotinamide adenine dinucleotide. Kusuka kuWikipedia, i-encyclopedia yamahhala. 2019.

[8] Ukukhonjwa kwe-mitochondrial NAD + transporter e-Saccharomyces cerevisiae., Todisco S, Agrimi G, Castegna A, Palmieri F. J Biol Chem. 2006 uJan 20; 281 (3): 1524-31. I-Epub 2005 Novemba 16.

[9] Katalin Sas, Elza Szabó, László Vécsei. IMitochondria, i-Oxidative Stress kanye neKynurenine System, egxile ekugugeni naseNeuroprotection. Amamolekyu, 2018; I-DOI: 10.3390 / molecule23010191.

[10] Ukwengeza kweNicotinamide mononucleotide (NMN) kuthuthukisa umthelela wokukhuluphala komama kumagundane: ukuqhathanisa nokuzivocavoca. U-Oddin GM, u-Youngson NA, uDoyle BM, uSinclair DA, uMorris MJ.

[11] UJun Yoshino, uKathryn F. Mills, uMyeong Jin Yoon, uShin-ichiro Imai. INicotinamide Mononucleotide, eyi-Key NAD + Intermediate, Iphatha iPathophysiology yeDiet- kanye ne-Age-Induced Diabetes Kumagundane. Iseli Metab, 2011; INGXENYE: 10.1016 / j.cmet.2011.08.014.

[12] Izidakamizwa Zakamuva Zokulwa Nokuguga: I-Nicotinamide Mononucleotide (NMN)