I-cycloastragenol powder

April 17, 2020

ICycloastragenol iyisithako sokudla esidala sokulwa nokuguga emakethe.

I-cycloastragenol powder (78574-94-4) ividiyo

I-cycloastragenol powder Siziqu

Igama Product I-cycloastragenol powder
Igama leKhemikhali N / A
omqondofana sibongile

cyclogalegigenin

GRN510

CAG

I-Drug Class N / A
CAS Inombolo 78574-94-4
InChIKey I-WENNXORDXYGDTP-UOUCMYEWSA-N
I-molecular Fi-ormula C30H50O5
I-molecular Weziyisishiyagalombili I-490.7 g / mol
IMisa ye-Monoisotopic I-490.365825 g / mol
Iphuzu lokubilisa  N / A
Fukuvuselela kabusha Pi-oint N / A
I-Half Half-Life N / A
Color ezimhlophe ukuze zibheke
Sukufaneleka  I-DMSO: 10 mg / mL, icacile
Sukuhlushwa Tukushisa  I-2-8 ° C
Aukuphikisana ICycloastragenol iyisishoshovu esinamandla se-telomerase. Futhi, kuhlobene ne-anti-ukuguga emithini yendabuko yama-Chinese.

Uhlolojikelele

ICycloastragenol iyisithako sokudla esidala sokulwa nokuguga emakethe. Ibuye isetshenziswe ngamafomula ama-skincare nama-cosmetics. ICycloastragenol yaqala ukuthengiswa ku-supplements yokudla e-USA ngonyaka we-2007 ngaphansi kwegama le-TA-65, yingakho i-TA 65 noma i-TA65 iseyigama elijwayelekile kakhulu le-cycloastragenol.

Kuyini uCycloastragenol?

ICycloastragenol imolekyulu etholakala ku-Astragalus membranaceus herb. Umuthi i-Astragalus ubusetshenziswa emithini yaseChina amakhulu eminyaka. AmaShayina athi i-Astragalus ingakhulisa impilo futhi isetshenziselwe ukwelapha ukukhathala, komzimba, umkhuhlane, isifo senhliziyo nesifo sikashukela.

ICycloastragenol ngesinye sezithako ezisebenzayo ku-Astragalus. ICycloastragenol inesakhiwo esifanayo samakhemikhali esifana ne-Astragaloside IV molecule IV, kodwa sincane futhi siphawuleka kakhulu i-bioavava, okwenza ukuba kuthathwe imithamo ephansi. Ivele isetshenziswa njenge-immunostimulant ngenxa yekhono layo lokukhulisa ukukhula kwe-T lymphocyte. Kodwa-ke, iyindawo yayo ekhethekile yokulwa nokuguga enesithakazelo esikhulayo emphakathini wesayensi.

I-cycloastragenol ivuselela ukulungiswa komonakalo we-DNA ngokwenza i-telomerase, i-enzyme ye-nucleoprotein eyenza ukwanda kwe-DNA nokukhula kwe-telomeric DNA. Ama-Telomeres enziwe ngemicu emincane futhi atholakala kuzeluleko zama-chromosomes. Ukugcina ukuzinza kwabo kunika amandla amaseli ukuthi agweme ukuphindaphindeka kwe-senescence nokwanda okungapheli ngaphesheya komkhawulo 'we-Hayflick'. Ama-Telomeres anciphisa ngomjikelezo ngamunye wokwahlukaniswa kwamaseli, noma lapho ecindezelwa nge-oxidative. Kuze kube manje, lokhu bekuyindlela engenakugwenywa yokuguga.

Izindlela zesenzo Cycloastragenol

Inombolo enkulu yezifundo ikhombisile ukuthi ukunqunyelwa kancane kancane kwama-telomeres kuhlotshaniswa kakhulu nezifo eziningi ezihlobene nobudala (isifo senhliziyo, izifo, njll) futhi kubikezela nokufa ngaphambi kwesikhathi ezifundweni ezindala. I-Telomeres ifinyeza ngomjikelezo ngamunye wesigaba sokuhlukaniswa kwamaseli, noma lapho icindezelwa kakhulu yi-oxidative. Kuze kube manje, le kube yindlela yokugwema ukuguga.

I-Telomerase iyi-enzyme ye-nucleoprotein eveza ukwakheka nokukhula kwe-telomeric DNA futhi ivuselele ukulungiswa komonakalo we-DNA.

ICycloastragenol isebenze futhi ivuselele le enzyme, ngaleyo ndlela inciphise ukufinyezwa kwama-telomeres futhi ikhulise namanani ayo. Ngale ndlela, ivumela ukwandiswa kwama-telomeres futhi ngenxa yalokho, ikhulisa isikhathi sokuphila seseli.

Ngenxa yesisindo sayo esiphansi samangqamuzana, iCycloastragenol idlula kalula odongeni lwamathumbu. Ukufakazelwa okufanele kuvumela ukusebenza okuphezulu, noma ngethamo eliphansi. Ukungezelelwa kwansuku zonke kungaba kukodwa, noma kuhlangene noma kuhlangana ne-astragaloside IV, kuzosiza ukubamba ukuguga futhi kwandise ngokwemvelo isikhathi sokuphila.

I-cycloastragenol izinzuzo

I-Astragalus membranaceus iphakathi kwamakhambi ayisisekelo emlandweni we-Traditional Chinese Medicine njengezindlela zemvelo zokwelapha ukukhathala, ukugula, izilonda, umdlavuza, i-hay fever, i-post stroke, impilo ende njll. Kodwa-ke, izinzuzo ezibalulekile ze-cycloastragenol powder zinjengemiphumela yokulwa nokuguga nokuvikela amasosha omzimba.

I-cycloastragenol nokusekelwa komzimba

I-cycloastragenol ingasetshenziswa ukuvikela amasosha omzimba, ama-antibacterial, ne-antiinfrance, ekugwemeni umkhuhlane ovamile kanye nezifo eziphezulu zesifo sokuphefumula. Ibuye isetshenziswe njengezithuthukisi zomzimba ngoba ikwazi ukukhulisa ukwanda kwe-T lymphocyte. Kodwa-ke, lokho umphakathi wesayensi osekuthakazelela ngokwengeziwe ukumelana nakho okuhle kakhulu kokuguga. I-cycloastragenol ikhuthaza iDNA ukulungisa umonakalo ngokuqala i-telomerase futhi ivumele i-proteinase yenuzi ukuthi ibangele ukwanda nokukhula kwe-telomere DNA.

I-cycloastragenol kanye nokulwa nokuguga

Ukulwa nokuguga yinzuzo ebonakalayo kakhulu ye-cycloastragenol. I-cycloastragenol ayigcini nje ukubambezela ukuguga kwabantu, kodwa ngaphezu kwalokho ithuthukise ukungatheleleki, ubuthi obusongela umkhondo, ukuvikela amaseli enhliziyo, ikakhulukazi okususelwa ku-hydragaloside (Astragaloside Ⅳ) hydrolysis.

Ezinye izinzuzo zeCycloastragenol

  1. i-cycloastragenol powder inomphumela wokususa izingcindezi nokuvikela umzimba ekucindezelweni okuhlukahlukene, kufaka phakathi ukucindezela ngokomzimba, ngokwengqondo noma ngokomzwelo;
  2. i-cycloastragenol powder iqukethe ama-antioxidants, avikela amaseli emonakalweni obangelwa ama-radicals wamahhala;
  3. i-cycloastragenol powder inomphumela ekwehliseni umfutho wegazi, ekwelapheni isifo sikashukela nasekuvikeleni isibindi.

I-cycloastragenol imiphumela emibi yempuphu

Kuze kube manje, awukho umbiko noma ukubuyekezwa komphumela omubi noma ukuphikiswa kokuthatha isengezo se-cycloastragenol.

I-cycloastragenol engeza umthamo

I-cycloastragenol imisha ngokuqhathaniswa futhi ayiwona ama-brand amaningi wokulekelela emakethe, futhi akukho dosi elituswayo elikhona. Ngokwokuhlangenwe nakho kwethu, umthamo uyahluka ngezinhloso ezihlukile, iminyaka. Impela i-cycloastragenol inamandla kakhulu kune-Astragaloside IV omthamo wayo onconywayo ngu-50mg ngosuku. Ngenkathi i-cycloastragenol, ukudonsa kusuka ku-10mg kuya ku-50mg konke kulungile. Isidingo esidala sokuthatha ngaphezu kwabantu abadala abaneminyaka ephakathi. Abanye basikisela ukuqala nge-5mg ngosuku, bese banezela kancane kancane. Njengoba i-cycloastragenol ingukukhishwa kwemvelo, kungathatha isikhathi ukubona imiphumela, cishe izinyanga eziyisithupha.

I-cycloastragenol ukuphepha

I-cycloastragenol iye yaziswa abanye njenge-ejenti eyisimangaliso yokulwa nokuguga. Ucwaningo lwakudala lubonakala luthembisa, lukhombisa ukuthi lunamandla okukhulisa ubude be-telomere, noma kunjalo kunokuntengantenga kocwaningo olubukezwe ontanga. Ngaphezu kwalokho, kunokukhathazeka okuthile ukuthi ukuthatha i-Cycloastragenol kungakhuphula ubungozi bemdlavuza ethile. Kodwa-ke, izifundo zocwaningo azikwazanga ukuthola noma iyiphi ingozi yomdlavuza ehambisana nokusetshenziswa kweCycloastragenol.

I-cycloastragenol ibukeka njengenhlanganisela ethembisayo yokulwa nokuguga. Yize kungakhonjiswanga ukuthi kukhulisa isikhathi sokuphila kodwa kukhonjisiwe ukuthi kunciphisa ama-biomarker ahlobene nobudala ahlukahlukene. Ngaphezu kwalokho kukhonjisiwe ukunciphisa izimpawu zokuguga ezinjengolayini abahle nemibimbi. Kunganciphisa nengozi yezifo eziwohlozayo ezifana ne-Alzheimer's, i-Parkinson's, i-retinopathies, ne-cataract.

I-cycloastragenol Ukusetshenziswa kwempuphu nokusetshenziswa

I-cycloastragenol isetshenziselwa ukwelashwa, ukulawula, ukuvimbela kanye nokwenza ngcono izifo, izimo kanye nezimpawu ezilandelayo:

  • Ukuvuvukala
  • I-Apoptosis
  • Ukuphazamiseka kwe-Homeostasis
  • I-cycloastragenol nayo ingasetshenziselwa izinhloso ezingekho lapha.

Ubuningi be-cycloastragenol powder isetshenzisiwe kule nkambu engezansi:

  1. Kusetshenziswa emkhakheni wokudla, kuvame ukusetshenziswa njengezengezo zokudla;
  2. Kusetshenziswe emkhakheni womkhiqizo wezempilo, lokhu kukhishwa kuyasiza emzimbeni womuntu;
  3. Kusetshenziswe emkhakheni wezimonyo, njengohlobo lwezinto ezingavuthiwe, kungaxuba izimonyo zemvelo.

Izikhombo:

  • Izakhi zokulwa nokuguga ze-cycloastragenol ezikhiqizwa yi-biotransformation.Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G. Nat Prod Res. 2019 Sep 9: 1-6. i-doi: 1080 / 14786419.2019.1662011.
  • I-Cycloastragenol: Oqokelwa inoveli othokozisayo wezifo ezihambisana nobudala. Yu Y et al. I-Exp Ther Med. (2018) Okutholakala ngokulwa nokuguga kwe-cycloastragenol okukhiqizwa yi-biotransformation. UChen C, Ni Y, Jiang B, Yan S, Xu B, uFan B, uHuang H, uKen G. Nat Prod Res. 2019 Sep 9: 1-6. i-doi: 10.1080 / 14786419.2019.1662011
  • I-Cycloastragenol inganciphisa ukwenziwa kwe-STAT3 futhi ikhuthaze i-paclitaxel-indased apoptosis kumaseli womdlavuza wesisu somuntu.Hwang ST, Kim C, Lee JH, Chinnathambi A, Alharbi SA, Shair OHM, Sethi G, Ahn KS. 2019 Jun
  • I-Astragaloside VI ne-cycloastragenol-6-O-beta-D-glucoside ikhuthaza ukuphulukiswa kwenxeba ku-vitro naku-vivo.Lee SY et al. I-Phytomedicine. (2018)