I-Cannabidiol (i-CBD)

June 21, 2021

I-Cannabidiol (i-Cannabidiol, i-CBD) ingesinye sezithako ezingaphezu kwekhulu ezisebenzayo ze-cannabis ezinenani lezokwelapha kakhulu. Ipholisa umzimba nengqondo, ivikele izinzwa, ithuthukise ukuvuvukala kwesikhumba, ama-antioxidants, iqeda ukubomvu kwesikhumba, futhi yakhe umgoqo wokuvikela isikhumba. Thuthukisa ikhono lokuzilungisa lesikhumba; ukubuyisa impilo yesikhumba nokuqeda izinkinga zesikhumba, kungelapha i-eczema nezinye izifo.

I-Cannabidiol (i-CBD) yingxenye eyinhloko engeyona yengqondo ye-cannabis futhi inemiphumela ehlukahlukene yezemithi, kubandakanya anti-ukukhathazeka, anti-psychotic, antiemetic kanye ne-anti-inflammatory properties.

Imininingwane yamakhemikhali yeCannabidiol (CBD)

Igama Product I-Cannabidiol powder
omqondofana (-) - ICannabidiol

(-) - iTrans-Cannabidiol

I-Epidiolex

I-CBD

Ukuhlanzeka 99% Hlukanisa / Extrapure Hlukanisa (CBD≥99.5%)
CAS Inombolo 13956-29-1
I-Drug Class I-Cannabinoid
InChI Key I-QHMBSVQNZZTUGM-ZWKOTPCHSA-N
SMILE CCCCCC1 = CC (= C (C (= C1) O) C2C = C (CCC2C (= C) C) C) O
Formula Yamamolekhula C21H30O2
isisindo Yamamolekhula 314.5 g / mol
IMisa ye-Monoisotopic 314.224580195
I-Melting Point 66 ° C
ukubila Point 160 ° C - 180 ° C
Eimpilo enqunyelwe isigamu sempilo Amahora we-18-32
Color I-powder emhlophe ekhanyayo ephuzi
solubility Incibilika emafutheni, encibilika ngokweqile ku-ethanol ne-methanol, ayincibiliki emanzini
Sithempeli le-torage Izinga lokushisa ekamelweni, hlala womile futhi ungakhanyisi
Isicelo Ngezinhloso zocwaningo lwesayensi kuphela, noma njengezinto zokusetshenziswa zokuthuthukiswa komkhiqizo osezansi, noma ezithengiswayo emazweni asemthethweni nasezifundeni zaphesheya. Uyacelwa ukuthi uqaphele ukuthi le mikhiqizo akufanele idliwe ngqo noma isetshenziselwe ukwelashwa emtholampilo ezweni lase China
Izinzuzo Zethu Eziyinhloko l 100% ukukhishwa kwemvelo, ukukhiqizwa kwezimboni, ukunikezwa okuzinzile

l Ukuqinisekiswa kwekhwalithi (GMPC, ISO22716, KOSHER, HALAL)

l I-laboratory yomuntu wesithathu ihlolwe, izinzile futhi iphezulu ye-CBD, iTHC mahhala

l Indlela HPLC. Izinsimbi ezisindayo, izinsalela kanye ne-microbial zihlangabezana namazinga we-CHP, JP ne-USP

 

Yini iCannabidiol (CBD)? Incazelo yeCannabidiol

ICannabidiol ikhemikhali esitshalweni seCannabis sativa, esaziwa nangokuthi insangu noma i-hemp. Ngaphezulu kwamakhemikhali angama-80, aziwa ngama-cannabinoids, akhonjwe esitshalweni seCannabis sativa. Ngenkathi i-delta-9-tetrahydrocannabinol (iTHC) iyisithako esiyinhloko sentsangu, i-cannabidiol nayo itholakala ku-hemp, equkethe amanani amancane kakhulu we-THC. Kokubili i-hemp nensangu kunguhlobo lweCannabis sativa, kepha ngokuhlukahluka okuhlukahlukene.

  • Insangu ikhula ngamaphesenti aphezulu weTHC (psychoactive; kubangela umuzwa "ophakeme"), kanye namaphesenti aphansi e-CBD (angadakisi).
  • I-Hemp ikhula ngamaphesenti aphezulu we-Cannabidiol (CBD), namaphesenti aphansi we-THC.

Yize i-THC ilula kakhulu i-cannabinoid ngenxa yemiphumela yayo yokusebenza kwengqondo, i-Cannabidiol (i-CBD) ithole ukubambeka ngenxa yokungadakwa kwayo [2], izinzuzo zokwelapha. Ngokusho kweWorld Health Association, i-CBD ayisiyomlutha, ayinazimpawu zokuhoxa, futhi inephrofayili enhle yokuphepha, ngakho-ke akumangazi ukuthi abaningi baphendukela ku-Cannabidiol (CBD) powder ngezinzuzo zayo eziningi zokwelapha. Okuphawuleka kakhulu, i-CBD powder ingasiza ekunciphiseni ukukhathazeka kokukhathazeka [1], izimo zokuvuvukala, nobuhlungu obungapheli.

I-Phcoker cannabidiol powder, i-100% ngokwemvelo ikhishwa kwi-hemp yezimboni, i-THC mahhala.

I-Cannabidiol ijwayele ukusetshenziselwa ukugula (isithuthwane). Ibuye isetshenziselwe ukukhathazeka [1], ubuhlungu, ukuphazamiseka kwemisipha okubizwa nge-dystonia, isifo se-Parkinson, isifo se-Crohn, nezinye izimo eziningi, kepha abukho ubufakazi obuhle besayensi bokusekela lokhu kusetshenziswa.

 

I-Cannabidiol (i-CBD) ne Ubuhlobo beTHC

I-CBD inobudlelwano obuyinkimbinkimbi ne-cannabinoid delta-9-tetrahydrocannabinol (THC) yayo, okuyisithako esikhulu esisebenzayo ku-cannabis, futhi enesibopho semiphumela yayo ejabulisayo yensangu noma i-hashish.

Ngokungafani ne-THC, i-CBD ayisebenzisi ingqondo ngokuqondile ngomqondo wokuthi ayinikezi injabulo noma 'ephezulu'. Lokhu akufani nokuthi i-CBD ayisebenzisi nhlobo ingqondo. Okokuqala, kunobufakazi obuningi bokuthi i-CBD ilungisa imiphumela ye-THC. [8] [10]

Okwesibili, idlanzana labantu (cishe amaphesenti ama-5) libika imiphumela emibi ye-CBD, ngendlela efanayo nezinye iziguli ezingathola imiphumela ye-psychoactive evela eTylenol noma e-Advil. Kodwa-ke, kukholakala ukuthi iningi lale mibiko lisuselwa ekudleni i-CBD equkethe iminonjana ye-THC. Ngakho-ke ukubaluleka kokuthola i-Cannabidiol kusuka emithonjeni esezingeni eliphakeme.

 

Isebenza kanjani iCannabidiol? Indlela yokusebenza ye-CBD

I-CBD ne-THC zihlangana nemizimba yethu ngezindlela ezahlukahlukene. Enye yezindlela eziyinhloko ukulingisa nokwengeza imiphumela yamakhemikhali emizimbeni yethu abizwa ngokuthi "ama-cannabinoid endogenous" - aqanjwe kanjalo ngenxa yokufana kwawo namakhemikhali atholakala esitshalweni se-cannabis.

I-Cannabidiol powder inemiphumela ebuchosheni. Imbangela ngqo yale miphumela ayicaci. Kodwa-ke, i-cannabidiol ibonakala ivimbela ukuwohloka kwekhemikhali ebuchosheni ethinta izinhlungu, imizwa nokusebenza kwengqondo. Ukuvimbela ukuwohloka kwaleli khemikhali nokwandisa amazinga alo egazini kubonakala kunciphisa izimpawu zengqondo ezihambisana nezimo ezifana ne-schizophrenia. I-Cannabidiol (i-CBD) ingahle futhi ivimbele eminye yemiphumela yokusebenza kwengqondo ye-delta-9-tetrahydrocannabinol (THC). Futhi, i-cannabidiol ibonakala inciphisa ubuhlungu nokukhathazeka [1].

 

I-CBD kanye ne-Endocannabinoid System (ECS)

I-ECS yatholwa ngawo-1990 futhi kucatshangwa ukuthi ingenye yezinhlelo ezibaluleke kakhulu futhi ezinkulu zokwamukela impilo enhle futhi yamukelwa njengohlelo olubalulekile lokumodela ekusebenzeni kobuchopho, i-endocrine kanye nezicubu zomzimba.

Isayensi yakamuva ithole ukuthi i-ECS ayiphenduli kuphela kuma-cannabinoid angaphandle akhiqizwa emzimbeni kodwa futhi iphendula nakwi-Phytocannabinoids yangaphandle noma i-CBD njengendlela yokuthuthukisa imizimba ukusebenza kwe-ECS. [7]

Ngaphakathi kwe-ECS kunama-receptors CB1 ne-CB2, atholakala kuwo wonke umzimba. La ma-neuron awuhlobo lokukhiya, ngama-cannabinoids asebenza njengokhiye. Ama-receptors e-CB1 akhona ngamanani aphezulu ebuchosheni, ikakhulukazi kwiHypothalamus, Hippocampus nase-Amygdala. Ama-receptors e-CB2 avela kakhulu ebuchosheni, emathanjeni, e-thymus kanye nasemaseleni omzimba. Uhlelo lwe-endocannabinoid ludlala indima yokungenisa ku-homeostasis.

I-CBD ayihlangani ngqo nama-cannabinoid receptors (i-CB1 ne-CB2) [9], kodwa kunalokho, ivuselela uhlelo lwe-endocannabinoid ukukhiqiza ama-cannabinoids alo. Ngaphezu kwalokho, kubambezela ukuwohloka kwabo ngokuvimbela i-enzyme ye-FAAH, ngakho-ke ama-endocannabinoids angahlala emzimbeni wakho isikhathi eside. I-CBD iyi-cannabinoid eyinkimbinkimbi ngokumangazayo futhi ukuxhumana kwayo nohlelo lwe-endocannabinoid kudinga ukucwaningwa ngokujulile ukuveza amandla ayo aphelele.

 

Ingabe i-CBD isemthethweni? Ubuthi be-Cannabidiol

I-CBD iyingxenye engadakisi yesitshalo se-cannabis enamandla amakhulu okuphulukisa [2]. I-Cannabidiol (i-CBD) ithole ukubambeka ngenxa yezinzuzo zayo ezingadakisi, nezokwelapha. Ngokusho kweWorld Health Association, i-CBD ayisiyomlutha, ayinazo izimpawu zokuhoxa, futhi inephrofayili enkulu yezokuphepha. Ngenkathi i-Food and Drug Administration (i-FDA) ingalawuli ubumsulwa noma ukuphepha kwento, i-CBD ibhekwa njengephephile.

Ukudluliswa koMthethosivivinywa Wepulazi we-2018 wakwenza kwaba semthethweni ukuthengisa imikhiqizo ye-hemp ne-hemp e-US Kepha lokho akusho ukuthi yonke imikhiqizo etholakala nge-hemp ye-cannabidiol isemthethweni. Njengoba i-cannabidiol ifundwe njengesidakamizwa esisha, ayinakufakwa ngokusemthethweni ekudleni noma kwizithasiselo zokudla. Futhi, i-cannabidiol ayikwazi ukufakwa emikhiqizweni emakethwa ngezimangalo zokwelapha. ICannabidiol ingafakwa kuphela kwimikhiqizo “yezimonyo” futhi kuphela uma iqukethe ngaphansi kuka-0.3% THC. Kepha kusekhona imikhiqizo enelebula njengezithako zokudla emakethe equkethe i-cannabidiol. Inani le-cannabidiol eliqukethwe kule mikhiqizo alihlali libikwa ngokunembile kwilebula yomkhiqizo.

 

Izinzuzo zezempilo ze-CBD

Kuvunyelwe Ukwelapha Isifo Sokuwa

Izici ezingezona ezengqondo ze-CBD zenza kube kuhle ekusetshenzisweni kokwelashwa. Ku-2018, umuthi wokuqala owagunyazwa yi-FDA, i-cannabidiol (i-Epidiolex), equkethe i-CBD ikhishwe emakethe ukwelapha izinhlobo ezimbili ezihlukene zesifo sokuwa [3] [4] - iDravet syndrome neLennox-Gastaut syndrome.

I-FDA ivume ukwelashwa kweziguli ezineminyaka emibili ubudala. Ucwaningo lukhombise ukuthi lusebenza kahle uma kuqhathaniswa ne-placebo ekwehliseni imvamisa yokuquleka.

 

Ukwelapha ukukhathazeka[1]

Yize sidinga ucwaningo olwengeziwe, i-athikili yokubuyekezwa kwephephabhuku lezokwelapha lika-2015 ibheke i-CBD nomphumela wayo ezinkingeni eziningi zokukhathazeka, kufaka phakathi ukukhathazeka okujwayelekile, ukuphazamiseka kwesizini, ukuphazamiseka kwesifo, kanye nengcindezi yangemva kokuhlukumezeka.

Imiphumela ikhombise ukuthi kukhona "ubufakazi obuqinile benkambiso" yokuxhasa ukwelashwa kwezifo zokukhathazeka ne-CBD, yize ucwaningo olwengeziwe ludingeka ekwenziweni kwesilinganiso sesikhathi eside.

 

Kungabuqeda Ubuhlungu

Ucwaningo luye lwabonisa ukuthi i-CBD ingasiza ekunciphiseni ubuhlungu obungapheli ngokuthinta umsebenzi we-endocannabinoid receptor, ukunciphisa ukuvuvukala [6] nokusebenzisana nama-neurotransmitters. Lapho i-CBD ithonya i-TRPV1, ivimba ngempumelelo amasiginali obuhlungu ekufinyeleleni kuwo wonke umzimba. Isiphetho sinikeza induduzo ebangelwa izinhlungu, ukuvuvukala nokungaphatheki kahle.

 

Kwangathi Yehlisa Umqubuko

Izinduna yisimo esivamile sesikhumba esithinta abantu abangaphezu kuka-9%.

Kucatshangwa ukuthi kudalwa yizinto eziningi, kufaka phakathi ufuzo, amabhaktheriya, ukuvuvukala okuyisisekelo nokukhiqizwa ngokweqile kwe-sebum, uketshezi olunamafutha olwenziwe yizindlala zesikhumba esikhunjeni.

Ngokuya ngocwaningo lwakamuva lwesayensi, uwoyela we-CBD ungasiza ekwelapheni induna ngenxa yezakhiwo zayo ezilwa nokuvuvukala [6] kanye nekhono lokunciphisa ukukhiqizwa kwe-sebum.

Olunye ucwaningo lwe-test-tube luthole ukuthi uwoyela we-CBD uvimbele amaseli endlala ye-sebaceous ekuthumeleni i-sebum ngokweqile, enza izenzo zokulwa nokuvuvukala futhi avimbele ukwenziwa kwama-ejenti "we-pro-acne" njengama-cytokines wokuvuvukala.

Olunye ucwaningo lube nokutholakele okufanayo, kuphetha ngokuthi i-CBD ingaba yindlela ephumelelayo nephephile yokwelapha izinduna, ngenxa yezimpawu zayo ezimangazayo zokulwa nokuvuvukala.

 

Ukusetshenziswa kwe-Cannabidiol (CBD) nokusetshenziswa kwepowder

Ucwaningo selusheshisile njengoba uhlaka lwezenhlalo, ezomthetho kanye nolwezomthetho mayelana nokusetshenziswa kwensangu lungaphansi kokulungiswa ezingxenyeni eziningi zomhlaba, kuveza imininingwane emisha.

Ucwaningo lomtholampilo lwe-CBD powder lufake izifundo zokukhathazeka, ukuqonda, ukuphazamiseka kokuhamba nobuhlungu.

I-CBD powder ingafakwa emzimbeni ngezindlela eziningi, kufaka phakathi ukuhogela intuthu noma umusi, njenge-spray ye-aerosol esihlathini, nangomlomo. Ingakhishwa njengoyela we-CBD noma njengesixazululo soketshezi kadokotela.

Kuwo wonke ama-US, abantu bahlikihla ibhalsamu le-CBD emajoyintini abuhlungu, befaka imishanguzo ye-CBD ngaphansi kwezilimi ezikhathele, bevela ngama-gummies e-CBD, futhi bekhukhumeza ama-vaporizers agcwele uwoyela we-CBD ngethemba lokuthi bazophela amandla.

 

References:

[1] I-Cannabidiol njengokwelashwa okungenzeka kube nezinkinga zokukhathazeka. I-Blessing EM, iSteenkamp MM, iManzanares J, iMarmar CR. Izidakamizwa ze-Neurotherapeutics. 2015 Okthoba; 12 (4): 825-36. i-doi: 10.1007 / s13311-015-0387-1.

[2] Imiphumela emibi ye-Cannabidiol nobuthi. UHuestis MA, uSolimini R, uPichini S, uPacifici R, uCarlier J, uBusardò FP. I-Curr Neuropharmacol. 2019; 17 (10): 974-989. i-doi: 10.2174 / 1570159X17666190603171901.

[3] Isifo sokuwa ne-cannabidiol: umhlahlandlela wokwelashwa. I-Arzimanoglou A, uBrandl U, uCross JH, uGil-Nagel A, uLagae L, uLandmark CJ, uSpecchio N, uNabbout R, u-Thiele EA, uGubbay O, Iphaneli Yezazi ZaseCannabinoids; Abahleli. Ukuphazamiseka Kwesithuthwane. 2020 Feb 1; 22 (1): 1-14. i-doi: 10.1684 / epd.2020.1141.

[4] I-Cannabidiol: Ukubuyekezwa kokusebenza kahle kwemitholampilo nokuphepha ku-Epilepsy. USamanta D. Pediatr Neurol. 2019 Julayi; 96: 24-29. i-doi: 10.1016 / j.pediatrneurol.2019.03.014. I-Epub 2019 Mar 22.

[5] I-Cannabidiol: Isimo sobuciko nezinselelo ezintsha zezicelo zokwelapha. UPisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M, Faggiana G, Proto MC, Fiore D, Laezza C, Bifulco M. Pharmacol Ther. 2017 Julayi; 175: 133-150. i-doi: 10.1016 / j.pharmthera.2017.02.041. I-Epub 2017 Feb 22.

[6] I-Cannabidiol (i-CBD) kanye nama-analogs ayo: ukubuyekezwa kwemiphumela yokuvuvukala. UBurstein S. Bioorg Med Chem. 2015 Ephreli 1; 23 (7): 1377-85. i-doi: 10.1016 / j.bmc.2015.01.059. I-Epub 2015 Feb 7.

[7] Uhlelo lwe-Endocannabinoid kanye nokushintshashintsha kwalo nguCannabidiol (CBD). UCorroon J, uFelice JF. I-Altern Ther Health Med. 2019 Juni; 25 (S2): 6-14.

[8] Ukubuyekezwa Okubalulekile Kwendima ye-Cannabinoid Compounds delta (9) -Tetrahydrocannabinol (delta (9) -THC) kanye neCannabidiol (CBD) kanye nenhlanganisela yabo ku-Multiple Sclerosis Treatment. UJones É, Vlachou S. Amolekyuli. 2020 Okthoba 25; 25 (21): 4930. i-doi: 10.3390 / ama-molecule25214930.

[9] I-CB1 ne-CB2 receptor pharmacology yezitshalo ezintathu ze-cannabinoids: i-delta9-tetrahydrocannabinol, i-cannabidiol ne-delta9-tetrahydrocannabivarin. I-Pertwee RG. UBr J Pharmacol. 2008 uJan; 153 (2): 199-215. i-doi: 10.1038 / sj.bjp.0707442. I-Epub 2007 Septhemba 10.

[10] Ubufakazi Bemitholampilo Nokuqanjwa Kwemithi Ngokusebenzisana Okusebenzayo kweCannabidiol ne-delta (9) -Tetrahydrocannabinol. IBoggs DL, Nguyen JD, Morgenson D, Taffe MA, Ranganathan M. Neuropsychopharmacology. 2018 Jan; 43 (1): 142-154. i-doi: 10.1038 / npp.2017.209. I-Epub 2017 Septhemba 6.