I-Nicotinamide adenine dinucleotide (53-84-9) ividiyo
I-Nicotinamide adenine dinucleotide (53-84-9) Siziqu
| Igama Product | I-Nicotinamide adenine dinucleotide (NAD +) |
| Igama leKhemikhali | Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride; |
| CAS Inombolo | 53-84-9 |
| InChIKey | BAWFJGJZGIEFAR-NNYOXOHSSA-N |
| SMILE | C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N |
| Formula Yamamolekhula | C21H27N7O14P2 |
| isisindo Yamamolekhula | I-663.4 g / mol |
| IMisa ye-Monoisotopic | I-663.109123 g / mol |
| I-Melting Point | 160 ° C (320 ° F; 433 K) |
| Color | White |
| Sithempeli le-torage | I-2-8 ° C |
| solubility | I-H2O: 50 mg / mL |
| Isicelo | Ukudla kwezempilo, izimonyo, okungezwayo kokuphakelayo |
Kuyini I-Nicotinamide adenine dinucleotide(NAD +)?
I-Nicotinamide adenine dinucleotide (NAD) iyi-cofactor esiza i-metabolism etholakala kuwo wonke amaseli aphilayo. Itholakala ngezindlela ezimbili, i-oxidised (NAD +) futhi incishisiwe (NADH).
ICoenzyme NAD +, uhlobo lwe-NAD oxidised, yaqala ukutholwa ngonyaka we-1906 ngabaphengululi bamakhemikhali baseBrithani u-Arthur Harden noWohn John Young. I-NAD + yenziwa izindlela ezimbili ze-metabolic, ezingakhiqizwa kusuka ku-de novo amino acidway pathway, noma ezingakhiqizwa kabusha ngezinto ezakhiwe ngaphambili (ezinjenge-nicotinamide) ebuyela kumzila wokutakula weNAD +. Kuyinto ebalulekile ye-pyridine nucleotide futhi isebenza njenge-cofactor ebalulekile futhi isakhi esingaphansi kwezinqubo eziningi ezibalulekile zamaselula ezibandakanya i-phosphorylation ye-oxidative nokukhiqizwa kwe-ATP, ukulungiswa kwe-DNA, i-epigenetic regree of gene expression, intracellular calcium signaling kanye nomsebenzi we-Immunological.
I-NAD + yi-molekyuli eyamukelayo ye-elektroni ekuxhunyweni kwe-oxotic. Yamukela ama-elektroni kwamanye ama-molecule bese incishiswa. Isebenza futhi njenge-coenzyme ye-hydride transferase kanye ne-substrate esebenzisa iNAD (+) polymerase, futhi yakha i-coenzyme redox pair ene-β-nicotinamide adenine dinucleotide (NADH). I-NAD (R) iyi-ribosylation ye-ADP-ribose donor unit ku-ADP-A. Kubuye kube yisanduleli ku-cyclic ADP-ribose (i-ADP-ribosyl cyclase).
Njenge-oxidant ekuguqulweni kwamaseli, i-NAD (R) nayo ibamba iqhaza ku-adenosine diphosphate (ADP) -ihambisa ukusabela kokudlulisa okubandakanya i-diadenylate (ADP-ribose) polymerase nezinye izinqubo ze-enzymatic. Kunganikeza i-NAD ukuvimbela noma ukunciphisa isifo sikashukela, umdlavuza nezinye izifo ezihlobene nobudala. Futhi, izikhuthazi ze-NAD + zingasebenza ngokusebenzisana nezithasiselo ezifana ne-resveratrol ukusiza ukuvuselela i-mitochondria nokulwa nezifo eziguga.
I-Nicotinamide adenine dinucleotide(NAD +) izinzuzo
Njengesikhutha esisebenzayo, iNicotinamide adenine dinucleotide ikhombisa ukuthi ezinye izinzuzo ezinhle emisebenzini yabantu.
Im Lungiselela umsebenzi wakho weselula,
♦ Khulisa amandla akho ngokwemvelo;
Rove Thuthukisa ukusebenza kobuchopho, ukugxila nenkumbulo;
Ost Thuthukisa umzimba wakho;
Rove Thuthukisa ukulala;
Thuthukisa umsebenzi we-sirtuin global;
♦ Thuthukisa ukusebenza kwe-antioxidant;
♦ Nciphisa ukuvuvukala;
Balance Ukuthuthuka okulinganiselayo, imizwa, umbono nokuzwa;
I-Nicotinamide adenine dinucleotid nayo ibhekiswe ngqo kwisidakamizwa i-isoniazid, esisetshenziswa ekwelashweni kwesifo sofuba, isifo esithathwa yi-Mycobacterium tuberculosis. Kokunye ukuhlolwa, amagundane anikezwe i-NAD isonto elilodwa ayenze ngcono ukuxhumana kwe-nuclear-mitochrondrial.
Ngaphezu kwalokho, i-Nicotinamide adenine dinucleotide (NAD +) nayo inezinto zokuvimbela kanye nokwelashwa kwe-inhliziyo block, ukusebenza kwe-sinus node kanye ne-anti-okusheshayo yokulinga i-arrhythmias, i-nicotinamide ingathuthukisa kakhulu isilinganiso senhliziyo ne-atriove ntricular block ebangelwa i-verapamil.
I-Nicotinamide adenine dinucleotide(NAD +) Isicelo:
- Ukuxilonga ama-reagents izinto zokusetshenziswa, ucwaningo lwesayensi.
- Ukudla kwezempilo, izimonyo, okungezwayo kokuphakelayo
- Ukukhiqizwa kwe-API
Okuningi I-Nicotinamide adenine dinucleotide(NAD +) ucwaningo
Ama-enzyme enza futhi asebenzise i-NAD + ne-NADH abalulekile kukho kokubili ukwelashwa kwemithi kanye nocwaningo ekwelashweni kwezifo okuzayo. I-coenzyme NAD + ayisetshenziswanga njengokwelashwa kwanoma yisiphi isifo. Kodwa-ke, isafundelwa ukusetshenziswa kwayo ekwelashweni kwezifo ezingenayo i-neurodegenerative njenge-Alzheimer's andParkinson isifo.
Izikhombo:
- UBelenky P, uBogan KL, uBrenner C (2007). "I-NAD + metabolism kwezempilo kanye nezifo" (PDF). Amathrendi Biochem. Isayensi. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Kufakwe kungobo yomlando kusuka koqobo (PDF) ngomhla ka-4 Julayi 2009. Kubuyiswe ngomhla ka-23 Disemba 2007.
- UTodisco S, Agrimi G, uCastegna A, uPalmieri F (2006). "Ukukhonjwa kwe-mitochondrial NAD + Transporter ku-Saccharomyces cerevisiae". J. Biol. I-Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. I-PMID 16291748.
- ULin SJ, uGuarente L (Ephreli 2003). "I-Nicotinamide adenine dinucleotide, isilawuli se-metabolic sokubhalwa, impilo ende nesifo". I-Curr. Opin. Iseli Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. I-PMID 12648681.
- UWillionon DH, uLund P, uKrebs HA (1967). "Isimo se-redox se-nicotinamide-adenine dinucleotide yamahhala ku-cytoplasm kanye ne-mitochondria yesibindi segundane". I-Biochem. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
- UFoster JW, Moat AG (1 Mashi 1980). "I-Nicotinamide adenine dinucleotide biosynthesis kanye ne-pyridine nucleotide cycle metabolism in microbial systems". I-Microbiol. IsAm. 44 (1): 83– PMC 373235. PMID 6997723.
- I-French SW. Ukuphuza utshwala okungapheli kulimaza isibindi nezinye izitho ngokunciphisa amazinga we-NAD⁺ adingekayo emsebenzini we-sirtuin's deacetylase. I-Exp Mol Pathol. 2016 Apr; 100 (2): 303-6. i-doi: 10.1016 / j.yexmp.2016.02.004. I-Epub 2016 Feb 16. PMID: 26896648.
- Kane AE, Sinclair DA. I-Sirtuins ne-NAD + ekuThuthukisweni naseKwelashweni kwezifo ze-Metabolic and Cardiovascular Disease. Isiyingi Res. I-2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.
