USulforaphane (4478-93-7)

I-Sulforaphane (4478-93-7) ividiyo

I-Sulforaphane Siziqu

Kuyini iSulfapha?

I-Sulforaphane, eyaziwa nangokuthi "i-dl-sulforaphane", iyinhlanganisela yezitshalo zemvelo etholakala kwimifino eminingi ye-cruciferous efana ne-broccoli, iklabishi, ukholifulawa ne-kale.

I-antioxidant ejwayelekile futhi into enhle kakhulu yesitshalo esebenzayo etholakala emifino. ISulforaphane ayigcini ngokuba nomsebenzi oqinile wokulwa nomdlavuza, kodwa futhi inamandla aqinile okulwa ne-oxidation. Yaziwa njengomunye wemikhiqizo yemvelo enomphumela wokulwa nomdlavuza kanye nobuhle.

I-Sulforaphane ikhiqizwa lapho i-enzyme myrosinase iguqula i- glucoraphanin, i-glucosinolate, ibe yi-sulforaphane lapho kulimala isitshalo (njengokuhlafuna), okuvumela lezi zakhi ezimbili ukuxubana futhi zisabele. Amahlumela amasha e-broccoli ne-cauliflower acebile ikakhulukazi nge-glucoraphanin ne-sulforaphane.

I-Sulforaphane (SFN) iyi-isothiocyanate, i-sulphur equkethe i-organic compound.Sulforaphane khipha i-antioxidant, i-antimicrobial, anticancer, anti-inflammatory, anti-ukuguga, i-neuroprotective, kanye ne-anti-diabetesic.

I-Sulforaphane izinzuzo

Izinzuzo Zempilo zeSulforaphane

Izithasiselo zeSulforaphane azange zivunyelwe yi-FDA ukusetshenziswa kwezokwelapha futhi ngokujwayelekile zingenalo ucwaningo oluqinile lomtholampilo. Imithetho ibabekela izindinganiso zokukhiqiza kodwa abaqinisekisi ukuthi baphephile noma bayasebenza.

• ukugqugquzela ukukhipha izidakamizwa
• ukukhulisa ubuchopho
• ukusiza umzimba ukudala amakhambi alwa nomdlavuza
• ukusekela ukusebenza kwenhliziyo okunempilo
• ukwanda kwe-glutathione njenge-activator ye-Nrf2
• ukukhuthaza ukunciphisa umzimba
• ukubambezela ukuguga ngokusebenzisa ama-protein-shock protein
• ukukhulisa umsebenzi wesibindi
• ukunciphisa ukuvuvukala nobuhlungu
• ukumisa nokubuyisela emuva ukulahleka kwezinwele.
• ISulforaphane inganciphisa i-cholesterol ye-LDL
• Diabetes

Amahlumela weBroccoli athuthukisa imikhakha eminingi yesifo sikashukela. Ku-2 diabetesics, ukudla i-broccoli amahlumela kukhuphule umthamo we-antioxidant ne-HDL cholesterol, futhi kwehlise ukucindezela kwe-oxidative, triglycerides, insulin, ukumelana ne-insulin, ne-CRP.

• Ukulimala kwesikhumba

ISulforaphane ingahlinzeka ngokuvikela ekulimazeni i-UVA ne-UVB, ukushiswa yilanga, kanye nokulimala kwesikhumba.

• I-Sulforaphane Yehlisa Izimpawu ze-Autism

I-Sulforaphane ingahle ivuse izakhi ezithile ezivikela amaseli ekucindezelekeni kwe-oxidative, ukuvuvukala, kanye nokulimala kwe-DNA, konke okuhambisana ne-autism spectrum disorder.

• Umsebenzi we-antiviral

I-Sulforaphane ikhombise umsebenzi ongasebenzi lapho amaseli athelelekile evezwa ngqo

Imiphumela emibi ye-Sulforaphane nokuphepha.

I-Sulforaphane iphephile uma isetshenziswa kumanani atholakala ekudleni. Kepha alukho ulwazi olwanele olutholwayo ukwazi ukuthi kuphephile yini ukuthatha ngomlomo njengomuthi.

ISulforaphane isebenzisa nokusebenzisa

-Sulforaphane ingasetshenziselwa ukusula amagciwane ayingozi wamaphaphu.

-Sulforaphane inomsebenzi wokulwisa ukuvuvukala kanye nokudambisa izinhlungu ebuhlungu besifo samathambo.

-Sulforaphane ingaqala ngokushesha uhlelo lokuphulukisa lomzimba, uhlelo lokukhipha ubuthi emzimbeni, ukulungisa izitho ezinhlanu zangaphakathi, ibhalansi, ukulungisa izitho ezilimele, i-sulforaphane inomphumela wokuvimbela nokwelashwa kwe-gout.

-Sulforaphane ingasetshenziselwa ukulwa nomdlavuza. I-Sulforaphane ingavimbela ngempumelelo isilonda esiswini, i-atrophic gastritis eguqula umdlavuza wesisu

-Sulforaphane isetshenziswa emkhakheni wokudla, i-sulforaphane uhlobo lokudla oluhlaza oluhle ukunciphisa isisindo;

-Sulforaphane isetshenziswa emkhakheni womkhiqizo wezempilo, isilimo esidliwayo esinamagatsha anamanzi angakwazi ukugxilisa imizwa futhi aqede angadabuki;

-Sulforaphane isetshenziswa emkhakheni wezemithi, ukwelapha i-rheumatism kanye ne-gout kunomphumela omuhle.

Okuningi Ucwaningo

I-Sulforaphane i-powder ku I-prostate Cancer ucwaningo

USulforaphane (osesimweni sokukhishwa kwe-broccoli ihlumela) unobufakazi obuthile obuqine kakhulu bezomtholampilo ngeqhaza lendima ekuvinjelweni komdlavuza wendlala yesinye kanye namasu wokuphatha wokuvimbela ukuphindaphinda komdlavuza wendlala yesinye.

Ekuhlolweni kwemitholampilo eminingi, amadoda anomdlavuza wendlala yesibeletho othatha ama-60 mg we-sulforaphane ngosuku ayene-antigen ethize (i-PSA, umaka osetshenziselwa ukukala ukuqhubeka komdlavuza we-prostate) kunalabo abangazange bathathe i-sulforaphane.

Lokhu kushiwo, i-FDA ayigunyazanga i-sulforaphane yokuvimbela ukwanda komdlavuza wendlala yesinye.

Izikhombo:

• I-Dietary Sulforaphane ku-Cancer Chemoprevention: Indima ye-Epigenetic Regulation kanye ne-HDAC Inhibition Stephanie M. Tortorella, Simon G. Royce, Paul V. Licciardi, Tom C. Karagiannis Antioxid Redox Signal. 2015 Jun 1; 22 (16): 1382-1424. doi: 10.1089 / ars.2014.6097 Sulforaphane ilawula i-apoptosis- ne-proliferation-related signwaysways and synergize with cisplatin to compress cancer of ovarian cancer Shi-Feng Kan, Jian Wang, Guan-Xing Sun Int J Mol Med. 2018 Nov; 42 (5): 2447–2458. Ishicilelwe online 2018 Sep 6. doi: 10.3892 / ijmm.2018.3860
• Bioavailability of Glucoraphanin and Sulforaphane from High ‐ Glucoraphanin Broccoli Tharsini Sivapalan, Antonietta Melchini, Shikha Saha, Paul W. Needs, Maria H. Traka, Henri Tapp, Jack R. Dainty, Richard F. Mithen Mol Nutr Food Res. I-2018 Sep; 62 (18): 1700911. Ishicilelwe online 2018 Mar 8. doi: 10.1002 / mnfr.201700911
• Ukuvimbela Umdlavuza Womdlavuza We-Carcinogen-Indosed Oral nguSulforaphane Julie E. Bauman, Yan Zang, Malabika Sen, Changyou Li, Lin Wang, Patricia A. Egner, Jed W. Fahey, UDaniel P. Normolle, uJennifer R. Grandis, uThomas W. Kensler , Umbhalo wesandla kaDaniel E. Johnson Cancer Prev Res (Phila); etholakala ku-PMC 2017 Jul 1. Ishicilelwe ngohlobo lokugcina lokuhlelwa njenge: Cancer Prev Res (Phila). 2016 Jul; 9 (7): 547-557. Kushicilelwe online 2016 Jun 23. doi: 10.1158 / 1940-6207.CAPR-15-0290
• Ucwaningo lwesigaba II lwe-broccoli ecebile nge-sulforaphane luhlunga emadodeni anomdlavuza wendlala yesibeletho uJoshi J. Alumkal, uRachel Slottke, uJacob Schwartzman, uGanesh Cherala, uMyrna Munar, uJulie N. Graff, uTomasz M. Beer, uChristopher W. Ryan, uDennis UR. Koop, u-Angela Gibbs, uLina Gao, uJason F. Flamiatos, u-Erin Tucker, uRichard Kleinschmidt, uMotomi Mori Invest Izidakamizwa Ezintsha. Umbhalo wesandla; etholakala ku-PMC 2016 Apr 1. Ishicilelwe ngefomu lokugcina elihlelwe ngokuthi: Tshala Izidakamizwa Ezintsha. 2015 Apr; 33 (2): 480-489. Kushicilelwe online 2014 Nov 29. doi: 10.1007 / s10637-014-0189-z