I-rough Lorcaserin HCL powder (846589-98-8)

October 30, 2018

I-Raw Lorcaserin hydrochloride powder iyi-serotonin 2C (5-HT2C) receptor agonist kanye nemithi elawulwa ngomlomo ekhuthaza….


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum
Umthamo: 1380kg / inyanga

I-Raw Lorcaserin HCL powder (846589-98-8) ividiyo

 

I-Lorcaserin HCL powder (846589-98-8) Imininingwane

Igama Product I-Lorcaserin Hydrochloride powder
Igama leKhemikhali I-Lorcaserin HCL powder, Lorcaserin
Brand NAme I-BELVIQ
I-Drug Class I-5-HT2C i-receptor inhibitor
CAS Inombolo 846589-98-8
InChIKey I-ITIHHRMYZPNGRC-QRPNPIFTSA-N
I-molecular Fi-ormula C11H15Cl2N
I-molecular Weziyisishiyagalombili 232.15
IMisa ye-Monoisotopic 231.058154899
Ukuxuba Pi-oint  Ayikho idatha etholakalayo
Fukuvuselela kabusha Pi-oint Ayikho idatha etholakalayo
I-Half Half-Life I-half-life ye-lorcaserin cishe amahora angu-11.I-powcaserin powder iqedwa ngokuyinhloko emcinini (92%) nasendlini (2.2%)
Color powder emhlophe
solubility  Umswakama wamanzi: 0.0709 mg / mL
Storage Tukushisa  -20 ° C.
Aukuphikisana I-Serotonin 2C (HT2C) ye-receptor agonist yokunciphisa isisindo.Iyakudliwa ukusetshenziswa kokudla futhi ikhuthaza ukuzithokozisa phakathi

 

I-Lorcaserin Hcl powder (846589-98-8) Incazelo

I-Raw Lorcaserin hydrochloride powder iyi-hydrochloride etholakala ngokuphendula kwe-lorcaserin powder ngokulingana ne-hydrochloric acid. Isetshenziswa njengesidakamizwa sokulwa nokukhuluphala. ILorcaserin hydrochloride iyi-5HT2c receptor agonist ekhonjiswe ukuthi isetshenziswe kubantu abadala abane-BMI ≥30, noma labo abane-BMI ≥27 futhi okungenani isimo esisodwa esihlobene nesisindo esifana nomfutho wegazi ophezulu, uhlobo lwesifo sikashukela se-2 noma i-dyslipidemia. kubanga umuzwa wokusutha, futhi kucatshangwa ukuthi kugwema imvula yesifo senhliziyo ye-valvular ehambisana nokusebenza kwama-5-HT2B receptors, indawo yobuchopho eyaziwa ngokudlala indima enkulu ekulawuleni indlala nokudla ukudla. Ngokwenza la ma-receptors asebenze, i-Lorcaserin hydrochloride powder inganciphisa ukusetshenziswa kokudla ngokwehlisa isifiso sokwenza umuntu azizwe egcwele ngisho noma esedle ukudla okuncane kunokujwayelekile. ivunyelwe namuhla yi-FDA esinqumweni esiyingqopha-mlando ngemuva kweminyaka emibili yokuhlolisiswa.

I-Lorcaserin hydrochloride powder iboniswe ngokucacile njengendlela yokudla okunciphisa ukudla kwekhalori kanye nokwenyuka komzimba okwenziwe ukuphathwa kwesisindo esingapheliyo kubantu abadala abadala (BMI ye-30 kg / m2 noma ngaphezulu) nabantu abadala (overnight weight) (BMI ye-27 kg / m2 noma ngaphezulu) okungenani nesimo esisodwa se-comorbid esihlobene nesisindo.

I-Lorcaserin hydrochloride powder isetshenziselwa kanye nokudla nokuzivocavoca ukwelapha ukukhuluphala. Ngezinye izikhathi kusetshenziselwa ukuphatha ukukhuluphala okungase kuhlobene nesifo sikashukela, i-cholesterol ephezulu, noma ukucindezelwa kwegazi eliphezulu.

I-Lorcaserin hydrochloride ngeke iphathe noma yiziphi izimo zempilo ezingaphansi (ezifana nesifo senhliziyo, isifo sikashukela, umfutho wegazi ophezulu). Qhubeka uthatha noma yiziphi ezinye izidakamizwa udokotela wakho anikezele ukuphatha lezi zimo.

I-Lorcaserin Hcl powder (846589-98-8) Indlela Yokusebenza

Yize noma indlela ecacile engaziwa, kucatshangwa ukuthi ihilela ukusebenza okukhethiwe kwe-5-HT2C receptors kuma-neuron anorexigenic pro-opiomelanocortin e-nucleus e-arcuate ye-hypothalamus. Lokhu kubangela ukwehla kokudla nokudla okunciphisa ngokukhuthaza ukukhululwa kwe-alpha-melanocortin evuselela i-hormone, eyenzeka kuma-receptors ama-melanocortin.

I-Lorcaserin hydrochloride powder isebenza ngokulawula isifiso sokudla - ikakhulukazi ngokuvula ama-receptors ebuchosheni be-serotonin, i-neurotransmitter edala imizwa yokwaneliseka nokwaneliseka. Ukungena kokudla kulawulwa yisikhungo satiety, esise-nucleus ye-ventromedial ye-hypothalamus kanye nendawo yokulamba ekhona ku-lateral hypothalamus. Okokufaka okuhlukahlukene okuvela ezikhungweni eziphakeme nasemapheshaneni emathunjini kuyahlangana ku-arcuate nucleus, lapho kunezinhlobo ezimbili ze-neurons ezilawula ukudla. Okokuqala, iqembu lokuvuselela ukudla elikhiqiza amaprotheni ahlobene ne-agouti ne-neuropeptide Y; okwesibili, iqembu lokuvimbela ukudla eline-cocaine ne-amphetamine elawulwa ngombhalo (CART) kanye ne-pro-opiomelanocortin (POMC) neurons. I-POMC iqukethe ama-5-HT 2C receptors, okuthi uma kusebenze kukhishwe i-alpha-melanocyte-stimulating hormone (alfa-MSH). Zombili lezi zinzwa ezivimbelayo nezishukumisayo ziqhubekisela phambili amaphrojekthi we-nucleus ebonakalayo ku-hypothalamus. I-Paraventricular nucleus iqukethe i-melanocyte 4 receptors (MC4R) evimbela isifiso sokudla ekwelashweni i-lorcaserin hydrochloride powder isebenza njenge-agonist ekhethiwe ye-5-HT 2C kuma-POMC neurons, nawo abangela ukukhishwa kwe-alfa MSH. Ukuqhubeka kwe-alfa MSH kusebenza kwi-MC4R ku-nucleus ebonakalayo lapho ku-hypothalamus, okuholela ekwehliseni ukudla. Emithamo ye-supratherapeutic, i-lorcaserin hydrochlorider nayo isebenza kuma-5-HT 2B naku-5-HT 2A receptors.

Izinzuzo we-Lorcaserin Hcl powder (846589-98-8)

  • I-Lorcaserin HCL powder iyisifo se-5-HT2C se-receptor agonist esicatshangelwa ukunciphisa ukudla okudliwayo ngokusebenzisa uhlelo lwePOMC oluphakathi. Izinzuzo ze-Lorcaserin HCL:
  • I-Lorcaserin HCL powder isetshenziselwa kanye nokudla nokuzivocavoca ukwelapha ukukhuluphala.
  • I-Lorcaserin HCL powder ngezinye izikhathi isetshenziselwa ukuphatha ukukhuluphala okungase kuhlobene nesifo sikashukela, i-cholesterol ephakeme noma ukucindezelwa kwegazi eliphezulu.
  • I-Lorcaserin HCL powder ngeke iphathe noma yiziphi izimo zempilo ezingaphansi (njengezifo zenhliziyo, isifo sikashukela, umfutho wegazi ophezulu).

Kunconywe i-Lorcaserin Hcl powder (846589-98-8) Isilinganiso

I-Lorcaserin HCL powder iza ngendlela yethebhulethi futhi ithathwa ngokujwayelekile izikhathi ezingu-1-2 ngosuku, noma ngaphandle kokudla. I-Lorcaserin kufanele isetshenziswe kanye nokunciphisa ukudla kwekhalori kanye nohlelo lokuzivocavoca.

Umthamo onconywayo we-lorcaserin hcl powder yi-10 mg elawulwa ngomlomo kabili ngosuku. I-Lorcaserin ingathathwa ngaphandle kokubheka ukudla. ILorcaserin hcl kufanele iyekwe ezigulini ezihluleka ukufeza okungenani ukwehla kwesisindo esingu-5% ngeviki le-12 ngoba lezi ziguli akunakwenzeka ukuthi zenze ukulahleka kwesisindo okunengqondo ngokwelashwa okuqhubekayo.

Okuqhamuka uma udla imishanguzo we-Lorcaserin Hcl powder (846589-98-8)

I-Lorcaserin Hcl powder isetshenziselwa ukwelashwa kokuphathwa kwesisindo okungapheli kubantu abadala abanenkomba yomzimba (BMI) engama-30 noma ngaphezulu (abakhuluphele) njengokungezelelwa kokudla okuncishisiwe kwekhalori nokuzivocavoca umzimba. Iphinde yamukelwa ukuthi isetshenziswe ngabantu abadala abane-BMI engama-27 noma ngaphezulu (ukukhuluphala ngokweqile) futhi okungenani abanesimo esisodwa esihlobene nesisindo esifana nomfutho wegazi ophakeme (umfutho wegazi ophakeme), noma i-cholesterol ephezulu (i-dyslipidemia). Kodwa-ke, futhi ingahle ibe neminye imiphumela emibi. Njengoba ngezansi:

 TImiphumela emibi kakhulu:

  • -Isifundo,
  • -Izinkinga,
  • -Ukukhathazeka,
  • -Isizathu,
  • -Umlomo omile,
  • -Isivumelwano, futhi
  • -Hyglycemia (ushukela wegazi ophansi).

 Ezinye imiphumela ezingavamile kodwa ezibi kakhulu ezihambisana ne-lorcaserin zihlanganisa:

  • -Thola izinkinga ze-valve,
  • -Changelela ukunakekelwa noma inkumbulo,
  • -Izinkinga zempilo,
  • -Ukucindezeleka noma imicabango yokuzibulala,
  • -Erections ezibuhlungu,
  • -Ukushaya kwenhliziyo,
  • -Ukwehla kwesibalo segazi, futhi
  • - Ukwanda kwe-hormone, i-prolactin.