I-Anandamide (AEA) (94421-68-8)

Mashi 15, 2020
SKU: 77472-70-9

I-Anandamide, eyaziwa nangokuthi i-N-arachidonoylethanolamine (AEA), iyi-fatty acid neurotransmitter etholakala ku …… ..

 


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum

 

I-Anandamide (AEA) (94421-68-8) ividiyo

I-Anandamide (AEA) (94421-68-8) Siziqu

Igama Product I-Anandamide (AEA)
Igama leKhemikhali I-Arachidonylethanolamide; N-Arachidonoylethanolamine; Anandamide (20.4, n-6);

I-N-Arachidonoyl-2-hydroxyethylamide; i-Arachidonoyl ethanolamide; AEA;

CAS Inombolo 94421-68-8
InChIKey I-LGEQQWMQCRIYKG-DOFZRALJSA-N
SMILE CCCCCC = CCC = CCC = CCC = CCCCC (= O) NCCO
Formula Yamamolekhula C22H37NO2
isisindo Yamamolekhula 347.53
IMisa ye-Monoisotopic I-347.282429 g / mol
I-Melting Point N / A
ukubila Point 522.3 ± 50.0 ° C (Kubikezelwe)
Ubuningi I-0.92 g / mL ku-25 ° C (ilitha)
Color ukukhanya okuphuzi
Sithempeli le-torage -20 ° C
solubility ethanol: inyibilika
Isicelo Isetshenziselwa inkumbulo, ukugqugquzela, izinqubo zokuqonda, ukulawulwa kokuhamba, ukulawula izinhlungu, ukuvusa inkanuko nokuzala.

 

Yini i-Anandamide (AEA)?

I-Anandamide, eyaziwa nangokuthi i-N-arachidonoylethanolamine (AEA), i-fatty acid neurotransmitter etholakala kwimetabolism engeyona ye-oxidative ye-eicosatetraenoic acid (i-arachidonic acid. Inesakhiwo esifana ncamashi neso se-tetrahydrocannabinol, indawo esebenzayo ye-cannabis. yonakaliswe ngokuyinhloko yi-enzyme enamafutha e-fatty acid amide hydrolase (FAAH), eguqula i-anandamide ibe yi-ethanolamine ne-arachidonic acid, Ekugcineni, i-Anandamide ihlanganiswa ne-neuron ngokuphendula kwe-condensation kwenzeka phakathi kwe-arachidonic acid ne-ethanolamine ngaphansi kokulawulwa kwe-calcium ion ne-cyclic monophosphate adenosidase. Isandulela seqembu lezinto zomzimba ezisebenzayo (i-Prostamides) ezidlala indima emisebenzini eminingi yomzimba, kubandakanya isifiso sokudla, inkumbulo, ubuhlungu, ukudangala, nokuzala.Ngaphezu kwalokho, i-Anandamide futhi ivimbela abantu Ukwanda kwamangqamuzana omdlavuza webele.

I-Anandamide ikhona ezintweni eziningi eziphilayo, ezinjenge-sea urchin roe, izingulube zezingulube kanye nezibindi zamagundane, njll, kepha inombolo yayo incane. Futhi, abacwaningi bathole i-Anandamide nezinto ezimbili (i-N-oleoylethanolamine ne-N-Linoleylethanolamine) ngoshokoledi omnyama. I-Anandamide ikhona nakwezinye izinhlamvu ezicutshunguliwe, (isinkwa esimhlophe), i-Alcohol (ikakhulukazi, ukusetshenziswa okungapheli noma ukuphuza ngokweqile), ushukela oCwengiweyo, amafutha kaTrans, Ukudla okuthosiwe emafutheni omifino kanye nokudla okungewona okwemvelo okuqukethe izibulala-zinambuzane njll.

Njengengxenye yohlelo lwe-endocannabinoid (ECS), i-Anandamide ihlukaniswa njengomlawuli we-homeostasis kanye nelinye isigaba se-cannabis-efana ne-2-AG yamakhemikhali e-cannabinoid emzimbeni wonke. Lolu hlelo lukhona Kuwo wonke ama-vertebrates. I-Anandamide idlala indima yokulawula ukusebenza kokuphaka kanye nogqozi lwe-neurogenic kanye nenjabulo, ukugcina umzimba nengqondo yethu kusesilinganisweni. Ucwaningo luthole ukuthi imizwa yethu, injabulo, ukwesaba, ukukhathazeka, kanye nokukwazi ukubekezelela ukucindezelwa konke kulawulwa ngohlelo lwe-endocannabinoid, kanye nezifo ezahlukahlukene kusuka ku-schizophrenia kuya ekucindezelekeni kuhambisana namazinga angajwayelekile we-anandamide.

I-Anandamide, efana ne-THC, i-agonist eyingxenye ye-CB1R. Kungadala izithuthukisi ezingaba khona ngokwenza kusebenze "okugcwele" kohlelo lobuchopho. Kumele uqaphele ukuthi yonke le miphumela ye-Anandamide ibonakala ithuthukiswa yi-pharmacologically evimbela ukonakaliswa kwayo komzimba. Ukutholwa kuka-Anandamide kungaholela ekwakhiweni komndeni omusha ngokuphelele wemithi yokwelapha.

 

Izinzuzo ze-Anandamide (AEA)

I-Anandamide, eyaziwa nangokuthi "i-molecule yenjabulo", iyisithuthukisi semizwa, i-neurotransmitter ne-endocannabinoid, enezinzuzo eziningi zezempilo nezengqondo:

I-Anandamide inciphisa ukwakheka okusheshayo kwamaseli womdlavuza. Ngo-1998, iqembu lososayensi base-Italiya bathola ukuthi i-anandamide ingakhuthaza i-neurogeneis futhi yakhe amaseli amasha ezinzwa, anciphise ukwakheka / ukwandisa inani lamaseli womdlavuza webele.

Amandla ka-Anandamide wokukhuthaza i-neurogeneis (ukwakheka kwama-neuron amasha) adlala indima ekulawuleni indlela yokuziphatha yokondla futhi akhiqize ugqozi nobumnandi kumagundane. Lokhu kusiza ekunciphiseni izimpawu zokudangala nokukhathazeka. Ucwaningo olwenziwe ngo-2015 lwabantu namagundane lwathola ukuthi amazinga aphezulu e-anandamide angakhuthaza ukuthuthukiswa kwemizwelo nokunciphisa ukwesaba.

Ngaphezu kwalokho, amandla ka-anandamide okubopha kuma-CB1 kanye nama-CB2 receptors nawo azothinta kakhulu izindlela eziningi zomzimba, ekhombisa izinzuzo ezinhle ngokwenkumbulo, ukugqugquzela, izinqubo zokuqonda, ukulawula ukunyakaza, ukulawula izinhlungu, ukukhuthaza inkanuko nokuzala.

 

Ungayandisa kanjani i-anandamide(AEA) amazinga emzimbeni womuntu?

Ngoba i-anandamide ineqhaza njenge-neurotransmitter, i-vasodilator agent ne-serum metabolite yegazi lomuntu, kanye nezinzuzo zezempilo nezengqondo ezibonisiwe, ungafuna ukukhuphula izinga le-anandamide emzimbeni wakho. Nazi izindlela zokunyusa okwesikhashana amazinga we-anandamide emzimbeni womuntu:

- UkuzivocavocaIng

Ucwaningo luthole ukuthi ngemuva kokusebenza imizuzu engama-30 kuphela, okuqukethwe kwe-anandamide (AEA) kokubili kwabantu nezinja kwanda. Ngakho-ke uma ufuna ukuthola inzuzo enkulu, zivocavoca ngokuvivinya umzimba njalo.

- Ukudla ushokoledi omnyama

I-chocolate emnyama inesilinganiso esiphakeme se-theobromine ku-chocolate enempilo, futhi i-theobromine isiza ukukhulisa ukukhiqizwa kwe-anandamide ebuchosheni futhi ibambe okwesikhashana ukuwohloka kwayo.

- Ukudla i-truffle emnyama

I-black truffle (isikhunta esimnyama) ngokwemvelo iqukethe i-anandamide. Yize isikhunta singakwazi ukusebenzisa i-anandamide nganoma iyiphi indlela, abacwaningi bakholelwa ukuthi isetshenziselwa ukuheha izilwane ukuze ziyidle futhi ikhiqize futhi izinsalela zayo.

- Ukuthola ukugxila

Ucwaningo lukhombisa ukuthi lapho umuntu esesimweni (esibizwa ngokuthi "ukugeleza" noma "esifundeni,") sokuhlushwa okuphezulu, ukusebenza, kanye nokuhlushwa, ngeke nje kuphela ukhiqize ngokwengeziwe noma wakhe imisebenzi engcono ebuchosheni bakho. inani elikhulu lamakhemikhali, njenge-serotonin, i-dopamine, i-endorphin ne-anandamide.

Ngaphezu kwalokho, itiye, i-coriander kanye ne-celery nakho kungasiza ukukhulisa ukukhiqizwa kwe-anandamide.

 

Izikhombo:

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  • U-El-Talatini MR, Taylor AH, Konje JC (Ephreli 2010). "Ubudlelwano obuphakathi kwamazinga e-plasma we-endocannabinoid, i-anandamide, i-sex steroids, ne-gonadotrophins phakathi nomjikelezo wokuya esikhathini". Umanyolo. Oyinyumba. 93 (6): 1989– doi: 10.1016 / j.fertnstert.2008.12.033. I-PMID 19200965.
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  • UMahler SV, uSmith KS, uBerridge KC (Novemba 2007). "I-Endocannabinoid hedonic hotspot yokuzijabulisa kwezinzwa: i-anandamide ku-nucleus accumbens shell yandisa 'ukuthanda' komvuzo omuhle". I-Neuropsychopharmacology. 32 (11): 2267– doi: 10.1038 / sj.npp.1301376. I-PMID 17406653.
  • UMechoulam R, uFride E (1995). "Umgwaqo ongakhonkiwe oya ezingqondweni ze-cannabinoid ligands, i-anandamides". Ku-Pertwee RG (ed.). Ama-cannabinoid receptors. IBoston: I-Academic Press. amakhasi 233– ISBN 978-0-12-551460-6.
  • IMallet PE, iBeninger RJ (1996). "I-endo native cannabinoid receptor agonist anandamide iphazamisa imemori kumagundane". Ukuziphatha Kwemithi. 7 (3): 276– doi: 10.1097 / 00008877-199605000-00008.