I-Chenodeoxycholic Acid Specifications
| Igama Product | I-Chenodeoxycholic acid |
| Igama leKhemikhali | (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid |
| I-synonym | I-Chenodeoxycholic Acid;
i-anthropodeoxycholic acid; i-anthropodesoxycholic acid; I-CCRIS 2195; I-Chendol; i-chenic acid; I-Chenix; I-Chenodeoxycholic acid; I-Chenodesoxycholic acid; I-Chenodiol; i-gallodesoxycholic acid; I-NSC 657949; I-Xenbilox |
| CAS Inombolo | 474-25-9 |
| InChIKey | RUDATBOHQWOJDD-BSWAIDMHSA-N |
| I-molecular Fi-ormula | C24H40O4 |
| I-molecular Weziyisishiyagalombili | 392.57 |
| IMisa ye-Monoisotopic | 392.29265975 |
| I-Melting Point | 165-167 °C (okhanyisiwe) |
| Ukubilisa Pi-oint | I-437.26 ° C (ukulinganisa okulinganiselwe) |
| Ubuningi | 0.9985 (isilinganiso esinzima) |
| Color | Mhlophe ukuya ekukhanyeni |
| solubility | NGOKWENZA AKUNQULISEKILE |
| Storage Tukushisa | igumbi temp |
| Isicelo | I-Chenodeoxycholic acid isetshenziswe ocwaningweni ukuhlola imiphumela yayo njengokwelashwa okuthatha indawo yesikhathi eside kwe-cerebrotendinous xanthomatosis (CTX). Iphinde yasetshenziswa ocwaningweni ukuze kuphenywe imiphumela yayo ekumuncwani kwe-bile acid emathunjini amancane ezigulini ezine-ileostomies. |
| Umbiko Wokuhlola | Iyatholakala |
I-Chenodeoxycholic I-Acid
I-Chenodeoxycholic acid, eyaziwa kakhulu ngokuthi i-chenodiol, iwuhlobo lwe-bile acid etholakala ngokwemvelo emzimbeni womuntu futhi iphinde isetshenziswe ngaphandle kwezinzuzo ze-chenodeoxycholic acid. Ukusetshenziswa kwale acid ye-bile kunconywa ekwelapheni izimo zezokwelapha ezahlukahlukene futhi lezi zincomo zisekelwa ubufakazi besayensi. Indlela yokusebenza ye-chenodeoxycholic acid ifundwe ngokuningiliziwe, ezifundweni eziningi ezahlukene, ngenhloso yokuthola ukusetshenziswa, izinzuzo, kanye nemiphumela emibi ye-chenodiol.
Yini Ama-Bile Acids?
Ama-bile acids, njengoba igama lichaza kahle, ama-steroidal acid atholakala enyongweni yomuntu kanye nenyongo yezinye izilwane ezincelisayo. I-bile iwuketshezi lokugaya ukudla oluhlanganiswa yisibindi futhi lugcinwe ku-gallbladder. Iningi lama-bile acids ahlanganiswa esibindini futhi angahlangana nama-amino acid; i-taurine ne-glycine, ukukhiqiza usawoti we-bile.
Ama-bile acids ahlanganiswa yisibindi abizwa ngokuthi ama-primary bile acids futhi afaka i-colic acid ne-chenodeoxycholic acid. Ngaphambi kokukhipha lawa ma-acid ayisisekelo e-bile, aguqulwa abe usawoti we-bile. Yilawa ma-bile salts abese ededelwa, afinyelele emathunjini amancane. Uma esengxenyeni ye-duodenal yamathumbu amancane, ama-amino acid ahlanganiswe ne-bile acids akhishwa yi-gut flora. Babhekana nezinye izinguquko eziholela ekutheni i-colic acid iguqulwe ibe yi-deoxycholic acid kanye ne-chenodeoxycholic acid ibe ama-lithocholic acid. I-Deoxycholic ne-lithocholic acids yi-bile acid yesibili.
Njengoba ama-bile acids enziwa esibindini asuka ku-cholesterol, anesakhiwo esiyindandatho esiyi-steroid njengesisekelo sawo. Lesi ngesinye sezizathu zokuthi kungani ama-bile acid enza njengamahomoni e-steroid emzimbeni futhi enze indima ebalulekile ekudluliselweni kwesignali. Kodwa-ke, umsebenzi oyinhloko we-bile acids ukuthuthukisa ukugaya kwamafutha namafutha asetshenzisiwe, futhi akwenza ngokuzungezile amafutha okudla, ukudala i-micelle.
I-Micelle yakheka lapho ama-lipids ekudleni embozwa futhi ethwalwa endaweni eyenziwe ngosawoti we-bile. Kuhle ukusho ukuthi ama-micelles aqukethe i-bile acids kodwa akhiwa usawoti we-bile olele ngqo emanzini kanye ne-lipid interface. Indawo yabo kanye nemvelo yabo ye-hydroponic kanye ne-hydrophilic ivumela usawoti we-bile ukuthi akhe lawa ma-micelles endaweni efanele. Kubalulekile ukuqaphela ukuthi ukwakheka kwe-micelle kuyisihluthulelo sokuqhekeka kwamafutha ngama-enzyme adingekayo.
Ama-bile acid aneminye imisebenzi ebalulekile, omunye wayo ukunciphisa izimbali zamathumbu, okubalulekile futhi ekwakhekeni kwe-bile acid yesibili. Ukususwa kwe-cholesterol nokwenza lula ukumuncwa kwamaVithamini ancibilika kumafutha kungenye yeminye imisebenzi yama-bile acid. Badlala indima ebalulekile emzimbeni womuntu futhi into encane njengoshintsho lokugxilisa ingqondo ingashintsha umzimba womzimba kakhulu.
Iyini i-Chenodeoxycholic Acid(CDCA) Powder?
I-Chenodeoxycholic Acid Powder(474-25-9) noma i-Chenodiol Powder iyi-exogenous bile acid engakwazi
kudliwe ukuze kuzuzwe izinzuzo ezifanayo nalezo ezizuzwe ku-chenodiol engapheli. Impushana isetshenziselwa ukwelapha, ikakhulukazi ekwelapheni amatshe enyongo, okungamadiphozithi nje e-bile eqinile ku-gallbladder. I-Chenodiol ingasetshenziswa futhi ekwelapheni okunye ukuphazamiseka okufana nezindaba ze-bile synthesis kanye ne-metabolism. Kuwumuthi ogunyazwe yi-FDA ojwayele ukunqunyelwa ukuphazamiseka kwesibindi, okusuka kuwo ezinkingeni ze-bile.
Ivelaphi I-Chenodeoxycholic Acid Powder?
I-chenodeoxycholic acid ikhiqizwa ngamaseli e-hepatic avela ku-cholesterol. I-chenodiol powder yangaphandle nokho ihlukanisiwe nenyongo yedada, i-Cygnus melanocoryphus.
Isebenza Kanjani I-Chenodeoxycholic Acid Powder?
I-Chenodioxycholic acid powder isetshenziselwa ngokuyinhloko ukwelapha ama-gallstones, ahlukaniswe abe yizigaba ezimbili ngokusekelwe kokuqukethwe kwawo kanye nokubukeka kwawo ku-radiography. I-Chenodiol ikwazi kuphela ukwelapha ngempumelelo amatshe enyongo akhiwe nge-cholesterol futhi abonakale e-radiolucent. Amatshe enyongo angama-radiopaque noma uma anemisebe kodwa akhiwe nge-bile pigment, awaphathwa nge-CDCA powder.
I-Chenodiol iphatha amatshe enyongo ngokuhlakaza i-cholesterol kuwo okuwumphumela we-biliary cholesterol desaturation yi-CDCA powder. I-chenodeoxycholic acid powder mechanism of action ilula, njengoba ivimbela ukuhlanganiswa kwe-cholesterol ne-colic acid esibindi. Ngokuhamba kwesikhathi, ithatha indawo ye-cholic acid kanye nokuphuma kwayo emzimbeni. Ngakho-ke, ukugcwala kwe-cholesterol kuncipha, okuphoqa amatshe e-cholesterol ukuthi ancibilike ukuze kulinganiswe ukugcwala kwe-cholesterol.
Uma ithathwa ngomlomo, i-chenodiol yenza indlela yayo iye emathunjini, lapho imuncwa futhi ithunyelwe esibindini ukuze ihlanganiswe nezinsalela ze-taurine ne-glycine. Uma usuhlanganisiwe, okusho ukuthi usawoti we-bile uhlanganisiwe, usawoti we-bile we-CDCA ukhishwa ku-bile. Usawoti we-bile we-CDCA uhlala ekujikelezeni kwe-enterohepatic okusho ukuthi amazinga e-serum noma amazinga omchamo we-CDCA azohlala engashintshile kakhulu.
Iyini I-Chenodeoxycholic Acid Isetshenziselwa?
I-Chenodeoxycolic acid powder isetshenziselwa:
- Ukwelashwa kwe-cholesterol ene-radiolucent gallstones, akukwazi ukuhlinzwa ngenxa yokuba khona kwezinye izimo ezenza ukuhlinzwa kube yisinqumo esinzima.
- Ukwelashwa kwe-cerebrotendineous xanthomatosis
- Ukusebenza kwamathumbu okuthuthukisiwe nokulawulwa kokuqunjelwa
- Ukwelashwa kwamaphutha okuzalwa noma isihlahla se-biliary
- Ukwelashwa kwe-hyperlipidemia
Yini Ukubaluleka Kwe-Chenodeoxycholic Acid Ekugayeni Ukudla?
I-Chenodeoxycholic acid inenzuzo ikakhulukazi ekwenzeni lula ukugaya kwe-lipid ngokwenza ama-micelles azungeze ama-fatty acids amuncwa emathunjini. Inhloso yokwenza i-micelle ezungeze i-lipids ukuwenza ancibilike emanzini ukuze alethwe endaweni yamathumbu ukuze amunce kahle. Ama-Micelles akhiwa usawoti we-bile futhi aqukethe i-bile acids njenge-chenodeoxycholic acid, yingakho, okwenza lokhu kube isithako esibalulekile sokwenza lula ukugaya kwe-lipid emzimbeni womuntu.
Yini izi Izinzuzo kanye Nemiphumela Ye-Chenodeoxycholic Acid Powder?
I-Chenodeoxycholic acid powder ivunywe yi-FDA ukuze isetshenziswe ekulawuleni amatshe enyongo nezinye izifo ezithile. Kunezinzuzo ezimbalwa ze-chenodiol ezibikwe abasebenzisi futhi zafakazelwa idatha yesayensi ebambekayo. Lezi zinzuzo kufanele zicatshangelwe lapho ubeka i-CDCA powder ukuze kuqinisekiswe ukuthi izinzuzo zidlula izingozi.
Ukuphathwa kwe-Gallstones kuyindima eyinhloko ye-Chenodiol, nokho, ilawula futhi iphathe uhlobo oluthile lwe-gallstone. Uma i-gallstone ingenawo umsakazo futhi iqukethe i-cholesterol, ukusetshenziswa kwe-CDCA powder ngeke kwanele ekuhlakazweni kwayo. Ucwaningo olwenziwa ngenhloso yokuqhathanisa izindlela zokwelapha ezihlukene ze-cholesterol gallstones lwathola ukusetshenziswa kwe-chenodiol kanye ne-lithotripsy njengendlela yokwelapha ekhethwayo. I-Chenodiol inconywa ikakhulukazi uma ukuhlinzwa kwenyongo kungeyona inketho esebenzayo.
Izinzuzo ze-Chenodeoxycholic acid powder zihlanganisa nokwelashwa kwezinkinga ze-metabolic ezifana ne-cerebrotendinous xanthomas. Lesi sifo sihlanganisa ukuguqulwa kwezakhi zofuzo ezihlanganisa i-enzyme edingekayo ukuze kuguqulwe i-cholesterol ibe ama-bile acid esibindi. Ukungabikho kwale enzyme kuholela ekwehleni okuphelele kokuhlanganiswa kwe-bile acid kanye nokwanda okukhulu kwe-cholesterol enqwabelana ezifundeni ezahlukahlukene zomzimba, yingakho-ke kwakheka i-xanthomas. Ukwelapha nge-bile acid exogenous efana ne-chenodiol kusiza ukunciphisa ukugcwala kwe-cholesterol emzimbeni futhi kuthuthukisa izimpawu zalesi sifo sofuzo.
I-Chenodeoxycholic acid, kanye ne-epimer yayo, i-ursodeoxycholic acid, ikholelwa ukuthi ine-antioxidant ne-anti-inflammatory properties, nakuba lezi zinzuzo zibonakala kakhulu nge-ursodiol. I-Chenodiol nayo iwusizo ekwelapheni amaphutha azalwa nawo e-metabolism nezinye izifo zesibindi ezinzima.
Uyithatha Kanjani I-Chenodeoxycholic Acid Powder?
(1) Ngaphambi kokuthatha i-chenodiol powder
Ngaphambi kokuqala ukuthatha i-chenodeoxycholic powder, kunconywa kakhulu ukwazisa udokotela ochazayo ngayo yonke imithi yamanje neyedlule kanye nezimo zezempilo ukuze kuqinisekiswe ukuthi akukho ukusebenzisana okungenzeka okungabangela imiphumela ebulalayo. Isibonelo, i-CDCA powder inemiphumela emibi eminingana ehlobene ngqo nokusebenza kwesibindi yingakho ukuyisebenzisa ekuguleni kwesibindi kuphikisana. Kubalulekile futhi ukwazisa udokotela nganoma yikuphi ukungezwani komzimba nokuqukethwe kwethebhulethi ye-chenodiol noma i-powder, ukuqinisekisa ukuncipha kwengozi yemiphumela emibi.
(2)I-Chenodeoxycholic aumthamo we-cid powder
I-Chenodiol powder kufanele ithathwe ngomlomo, ngokudla noma ngaphandle. Isilinganiso esiqondile se-chenodeoxycholic acid powder sincike esisindweni somuntu, isimo sezokwelapha esisetshenziselwa sona, kanye nempendulo yokwelapha. Okushiwo ingxenye yokugcina ukuthi umthamo wokuqala kanye nomthamo wokugcina we-chenodeoxycholic acid powder ungase uhluke ngokuphawulekayo ngokusekelwe ekutheni umzimba usabela kahle noma kabi kangakanani kuwo. Ngokuvamile, kumuntu omdala, umthamo uphakathi kuka-13 mg no-16 mg ngekhilogremu yesisindo.
I-Chenodiol powder isetshenziswa ngokuyinhloko ekwelapheni amatshe enyongo, futhi njengoba ingathatha isikhathi eside ukuwohloka okuphelele nokuphuma, impushana ingasetshenziswa iminyaka emibili. Kodwa-ke, ngemuva kweminyaka emi-2, ukusetshenziswa kwe-chenodeoxycholic acid kufanele kuyekwe njengoba i-bile acid inemiphumela emibi ye-hepatotoxic enamandla. Ngaphezu kwalokho, izimpawu ze-gallstones noma ezinye izifo ze-biliary zingase zithathe unyaka ukuze zinyamalale ngokusetshenziswa kwe-CDCA powder.
(3)Kwenzekani uma ngiphuthelwa umthamo or ukweqisa izidakamizwa?
Uma kwenzeka umthamo we-chenodiol powder uphuthelwe, kungcono ukushiya lokho futhi uthathe umthamo olandelayo ngesikhathi esivamile. Ukulinganisa kabili kungaholela ekusetshenzisweni ngokweqile futhi akunconywa. Nakuba zingekho eziningi ezibikiwe ngokweqile nge-chenodiol powder, kukhona ezimbalwa ezigunyaza isixwayiso. Uma kulindelekile ukweqisa izidakamizwa futhi umuntu othintekile enenkinga yokuphefumula, kufanele afune usizo lwezokwelapha ngokushesha.
(4)Yini okufanele ngiyigweme ngenkathi ngithatha i-chenodiol?
Ukusetshenziswa kwe-chenodeoxycholic acid powder kuphikisana nezimo ezithile, njenge:
- ukusha kwesibindi kohlobo
- I-cirrhosis
- Isifo sesibindi
- Isifo se-pancreatic
- Ukuvaleka emathunjini
- I-anemia ye-hemolytic noma ezinye iziyaluyalu noma i-hemolysis
- Ukusebenzisa Utshwala njalo
- Ukusebenzisa kabi Utshwala
- ukukhulelwa
Ukusetshenziswa kwe-chenodiol ngesikhathi sokukhulelwa kungaba yi-teratogenic enzima ku-fetus futhi iphikisana ngokuphelele. Ngesikhathi sokuncelisa ibele, nokho, akwaziwa ukuthi i-bile acid CDCA ingena yini obisini lwebele ngakho-ke, iphikisana kakhulu. Ukubonisana nodokotela ngaphambi kokuqala ukuthatha i-chenodeoxycholic acid powder ngenkathi ukuncelisa kunconywa kakhulu.
Yiziphi Ezinye Izidakamizwa Ezizosebenzisana Ne-Chenodeoxycholic Acid?
Imiphumela emibi ebikiwe ye-chenodeoxycholic acid ngokuyinhloko ibangelwa umphumela we-bile acids ngokuqondile, futhi akuvamile ngenxa yokusebenzisana kwe-powder neminye imithi. Nokho, lokho akusho ukuthi i-chenodeoxycholic acid powder ngeke ihlanganyele neminye imithi. Uma i-chenodiol ithathwa ngemikhiqizo ethile ye-herbal noma imithi, umphumela we-powder uzoshintsha kakhulu. Ingozi yokuthola imiphumela emibi nayo izokhula ngalokhu kusebenzisana.
Izidakamizwa ezithile ezingenawo amandla okuxhumana ne-chenodeoxycholic acid powder yilezi:
- I-Cholestyramine
- I-Colestipol
- Amaphilisi okulawula ukuzalwa noma ukwelashwa okushintshwa kwamahomoni
- Ama-antacid aqukethe i-aluminium njengezithako zawo eziyinhloko njenge-Almacone, i-Gelusil, i-Maalox, i-Mag-al Plus, i-Mylanta, i-Rulox, nezinye.
- Izinto ezinciphisa igazi ezifana ne-warfarin, i-Coumadin, i-Jantoven.
I-Cholestyramine ne-colestipol womabili ama-bile acid sequestrants asebenza esiswini ngokubamba ama-bile acid, ngakho-ke, avimbele ukusebenza kwawo. Ukuthatha ama-sequestrants e-bile acid ane-bile acid kuzokwenza lokhu kungabi namandla futhi azikho izinzuzo ezizobonakala. Esikhundleni salokho, isimo sezokwelapha esinqunyelwe i-chenodeoxycholic acid sizoba sibi kakhulu.
Kubalulekile ukuthi ungathathi i-chenodiol nezinye izinhlobo ze-bile acids njengoba lokho kungase kwandise ingozi yemiphumela emibi. Kutuswa kakhulu ukuthi uhlole nodokotela futhi ubazise nganoma yimaphi amanye amavithamini noma izidakamizwa umuntu angase azithathe, ngaphambi kokuqala i-chenodiol njengoba imithi ethile ingase idinge ukumiswa ngaphambi kokuqala i-chenodeoxycholic acid. Akugcini lapho, ukusho imithi esanda kusetshenziswa yabe isiyekwa nakho kungase kube yinzuzo njengoba eminye imithi ingahlala ohlelweni isikhathi eside.
Uyini Umehluko Phakathi Kwe-Ursodeoxycholic Acid Powder Ne-Chenodeoxycholic Acid Powder?
I-Chenodeoxycholic acid powder kanye ne-Ursodeoxycholic acid powder zingama-bile acid amabili amakhulu angaphandle anqunyelwe futhi asetshenziselwa ukuphatha amatshe enyongo.
I-Ursodeoxycholic acid powder
I-Ursodeoxycholic acid powder noma i-ursodiol iyi-bile acid yesibili emzimbeni womuntu, ehlanganiswa kusukela ekuguqulweni kwe-bile salts yi-gut flora. Ngokungafani ne-chenodeoxycholic acid okuyi-bile acid eyinhloko futhi ehlanganiswe esibindini, i-ursodiol ihlanganiswa emathunjini amancane. I-exogenous ursodeoxycholic acid powder ikhiqizwa ku-cholic acid ekhishwa ku-bovine bile.
Ukuqhathaniswa kwezinzuzo nomsebenzi
I-Ursodiol ne-Chenodiol zisetshenziselwa ukuchithwa kwe-gallstone, noma kunjalo, okunye ukusetshenziswa kwakho kokubili akufani. I-Ursodiol isetshenziselwa ukuphatha i-primary biliary cholangitis kanye ne-primary sclerosing cholangitis. Ngenxa yephrofayili yayo ephezulu yokuphepha, i-ursodiol iyi-bile acid ekhethwayo ekwelapheni i-intrahepatic cholestasis yokukhulelwa.
Umehluko Omkhulu
Umehluko omkhulu phakathi kwe-chenodeoxycholic acid powder kanye ne-ursodeoxycholic acid powder yukuthi lesi sakamuva asiyona i-hepatotoxic futhi ingasetshenziswa ngokukhululekile kanti eyokuqala iyi-hepatotoxic futhi ingabangela isifo sesibindi esingase sibe yingozi. I-Chenodiol iyi-acid eyinhloko ye-bile futhi i-Ursodiol iyi-bile acid yesibili kanye nokuba yi-epimer ye-chenodiol.
Ucwaningo lwakamuva olwenziwa ngenjongo yokuqhathanisa i-ursodiol ne-chenodiol luthole ukuthi i-UDCA yayiphumelela kakhulu ekunciphiseni usayizi wamatshe enyongo kumaki wezinyanga ezingu-3 kanye nezinyanga ezingu-6. Kodwa-ke, ngemva kwezinyanga ezingu-12 ukusebenza kahle kokubili kwe-chenodiol ne-ursodiol kwakulinganiselwe futhi kwakungekho umehluko obalulekile phakathi kokubili. Ngaphezu kwalokho, kwatholakala ukuthi i-Ursodiol ingakhomba ngempumelelo futhi yelaphe amatshe enyongo amakhulu namancane kukho kokubili, imithamo ephezulu kanye nemithamo ephansi. I-Chenodiol, ngakolunye uhlangothi, yayisebenza kuphela ekwehliseni usayizi wamatshe amancane enyongo ngemithamo ephezulu.
Ngokusho kocwaningo oluhlukile, i-chenodiol ngemithamo ephansi yayihlotshaniswa nokwanda kwesigameko se-cholecystectomy.
Yimiphi imiphumela emibi engaba khona ye-Chenodeoxycholic Acid?
Uma i-chenodeoxycholic acid inqunywa, kutuswa ukuthi ulandele isiguli njalo. Ukuvakasha ngakunye kokulandelela kufanele kuhlanganise ukuhlolwa kwegazi okugxilwe kakhulu kuma-enzyme esibindi. Lokhu kungenxa yemvelo ye-hepatotoxic ye-chenodeoxycholic acid. Imiphumela engase ibe khona ye-chenodeoxycholic acid ingahlukaniswa ngezigaba ezinhlanu, ngokusekelwe ohlelweni lwesitho esithinteka kakhulu yimiphumela emibi:
Imiphumela emibi ye-Hematologic
Izimo ezimbalwa zemiphumela emibi ye-hematological zibikiwe, nabo bonke abantu abathintekile babika ukwehla okuphawulekayo kokuhlushwa kwamangqamuzana amhlophe egazi. Ukuhlushwa akuzange kwehle ngaphansi kuka-3000 futhi naphezu kwalokhu kuncipha, imithi yabekezelelwa kahle. Isinqumo sokuyeka i-CDCA powder asizange senziwe kunoma yisiphi salezi ziguli njengoba lo mphumela ohlangothini awuzange uphakamise ukukhathazeka okukhulu kwezempilo.
Imiphumela emibi ye-Hepatic
I-Chenodeoxycholic acid powder i-hepatotoxic yingakho ukusetshenziswa kwayo kuphikisana nezifo zesibindi. Ngaphezu kwalokho, i-hepatotoxicity ye-CDCA powder ingaba nzima ngokwanele kangangokuthi ukuqapha okuvamile kwama-enzyme esibindi kubalulekile lapho imithi iqalwa. Le miphumela engemihle ayibonakali ngokujwayelekile uma kuthathwa izinyathelo ezifanele njengokuqapha ukusebenza kwesibindi. Ukusetshenziswa kwe-chenodiol powder ngaphandle kokugxila ekuhlolweni kokusebenza kwesibindi kungabangela ukuhluleka kwesibindi esisongela ukuphila kanye nesifo.
Izimpawu zesifo sesibindi ezingase ziziveze nge-hepatotoxicity ye-chenodiol yilezi:
- Ukuphuzi kwamehlo
- Isikhumba esiphuzi
- Umchamo onombala omnyama
- Ukukhathala okungajwayelekile kanye nokukhathala
- Ubuhlungu obukhulu besisu
- Isicanucanu nokuhlanza okungaxazululi
Imiphumela emibi yesisu
Le miphumela engemihle ingase ibonakale nganoma isiphi isikhathi phakathi nohlelo lokwelapha nokho, ivame ukubonwa lapho ukwelashwa kuqala. Lokhu kuwumphumela ongemuhle ovamile njengoba imithi eminingi lapho isetshenziswa ekuqaleni, ingabangela ukucasuka kwamathumbu amancane. Cishe amaphesenti angu-30 kuya kumaphesenti angu-40 abantu abathatha i-chenodiol babika isifo sohudo esibekezelelwa kahle futhi esingenamandla. Amaphesenti angaba ngu-15 kuphela alabo abaphethwe isifo sohudo esincike kumthamo ababedinga ukuncishiswa komthamo. Abanye babike ukuthuthuka kwezimpawu ngemuva kokusetshenziswa okuhambisanayo kwama-anti-diarrheal agents.
Kuyaqabukela, ukunqanyulwa kwe-chenodiol kuyadingeka lapho isifo sohudo sinzima futhi sihambisana namajaqamba esiswini esiwohlokayo. Ngaphambi kokuyeka imithi, kubalulekile ukuhlukanisa phakathi kwezinhlungu zohudo ezivela ku-colicky, ubuhlungu besisu obungase bube khona nge-gallstones. Ukuphambanisa lokhu kokugcina nge-CDCA powder yangaphambili kanye nokuyeka kungase kube yingozi empilweni yonke.
Eminye yemiphumela emibi ye-gastrointestinal engavamile ihlanganisa,
- I-nausea nokuhlanza
- Ama-Cramps
- isilungulela
- ukuqunjelwa
- dyspepsia
- Ubuhlungu besisu obujwayelekile
- Flatulence
- I-anorexia
I-Cholesterol Concentration
Ukwanda okungamaphesenti angu-10 ekugxilweni kwe-cholesterol namafutha amabi, i-LDL, kungase kubonakale ngokusetshenziswa kwe-chenodeoxycholic acid powder. Abesifazane abambalwa abathatha i-bile acid baphinde babika ukunyuka okuncane kumazinga abo e-triglycerides, kanye nenani le-cholesterol namazinga e-LDL. Alukho ushintsho ku-HDL noma amafutha amahle okubikiwe.
Ukususwa kwe-Gallbladder noma amazinga we-cholecystectomy
Abantu abane-gallstones kanye nomlando wobuhlungu be-biliary ngokuvamile badinga inqubo ye-cholecystectomy njengokwelashwa kwamatshe abo enyongo. Ngaphezu kwalokho, lezi ziguli nazo azikwazanga ukubekezelela umthamo ophezulu we-chenodeoxycholic acid powder futhi zanikezwa amanani aphansi esikhundleni salokho. Ukungakwazi ukubekezelela umthamo ophezulu we-CDCA powder kuye, ngakho-ke, kuhlotshaniswa nokwanda kwamazinga e-cholecystectomy.
Yiziphi Izinyathelo Ezithathwayo Ukuqinisekisa Ukusetshenziswa Okuphephile Nokuphumelelayo Kwe-Chenodeoxycholic Acid?
Abasebenzi bezempilo kanye nabasebenzi abajwayelekile benza ukuvakashelwa okulandelwayo ukuze babheke ngenkuthalo noma yimiphi imiphumela emibi engase ibe khona ye-chenodeoxycholic acid powder ukuze kuqinisekiswe ukuphepha kwayo kanye nokusebenza kahle kwe-powder.
Ngingalutholaphi Ulwazi Olwengeziwe Nge-Chenodeoxycholic Acid Powder Ethengiswayo?
Ukuze uthole ulwazi olwengeziwe mayelana nokuthengiswa kwe-chenodeoxycholic acid powder ngobuningi, ungasebenzisa izinsiza ze-intanethi ezifana namawebhusayithi abakhiqizi abahlukene be-chenodeoxycholic acid powder noma imboni.
Ucwaningo Olwengeziwe Nge-Chenodeoxycholic Acid
I-Chenodeoxycholic acid okwamanje isafundelwa okunye ukusetshenziswa okungase kube khona kwenhlanganisela, ngaphandle kokusetshenziswa kwayo okuqondene nebiliary. Inkampani yase-Australia ye-biotechnology okwamanje ifunda i-chenodiol ihlanganiswe nomuthi owehlisa i-lipid, i-bezafibrate yokwelapha i-Hepatitis C.
imibuzo ejwayelekile ukubuzwa
(1)Kungani ci-henodeoxycholic acid (chenodiol) kuphela kubantu abakhethiwe?
I-Chenodiol iyi-bile acid enamandla engasiza ekwelapheni amatshe enyongo. Kodwa-ke, futhi i-hepatotoxic futhi ingabangela isifo sesibindi esibi. Yingakho kunganconywa kulabo abanesifo sesibindi njengoba izimpawu zalesi sifo zingase zenziwe ihaba nge-bile acid.
(2)Ngingakwazi yini ukuthatha i-Chenodal (chenodiol) uma ngikhulelwe?
Ukusetshenziswa kwe-chenodiol akunconywa ngesikhathi sokukhulelwa ngenxa yamandla we-teratogenic womuthi.
(3)Kufanele ngithathe isikhathi esingakanani i-Chenodal (chenodeoxycholic acid)
I-Chenodal ingathathwa kuze kube yiminyaka emibili ngesikhathi, futhi ingathatha i-chenodeoxycholic acid CDCA powder kuze kube unyaka ukuze unciphise izimpawu futhi uphathe isimo. Ngemuva kokusebenzisa i-CDCA powder iminyaka emibili, kubalulekile ukuthatha ikhefu.
(4)Kungani ngicelwa ukuthi ngibone umhlinzeki wami ngezikhathi ezithile ukuze ngihlolwe?
Umhlinzeki wakho uhlola ama-enzyme esibindi sakho namazinga e-cholesterol ukuze aqinisekise ukuthi yonke into ingaphakathi kwebanga elijwayelekile, futhi i-chenodiol ayizange ibe nomthelela omubi empilweni yakho iyonke. Ngenxa yemvelo ye-hepatotoxic eyedlulele ye-CDCA powder kanye nekhono layo lokubangela isifo sesibindi kunalokho ngokushesha, umphakeli wakho we-chenodeoxycholic acid uzokubuza ngezikhathi ezithile ukuhlolwa. Amazinga e-cholesterol nawo atholakale ekhula ngokusetshenziswa kwe-chenodiol, okungesinye ukuhlola umhlinzeki wakho azosicela kuwe.
(5)Yimiphi imithi okufanele ngiyigweme ngenkathi ngithatha i-Chenodal (chenodiol)?
Uma uthatha i-Chenodiol, kufanele ugweme ama-sequestrants e-bile acid afana ne-cholestyramine ne-colestipol njengoba ayezosebenzisana ne-CDCA powder futhi enze ukusetshenziswa kwayo kungafuneki. Akunconywa ukuphuza ama-anticoagulants afana ne-warfarin ne-coumadin, amaphilisi okulawula ukuzalwa ane-estrogen kuwo, noma ama-antacids neminye imithi equkethe i-aluminium. Uma uthatha noma iyiphi i-vitamin supplement, izithako ze-herbal, kanye ne-herbal teas, noma usanda kuyeka ukuthatha imithi, kufanele wazise udokotela wakho ukuqinisekisa ukuthi ayikho imithi yakho yamanje noma yakamuva esebenzisana ne-chenodiol.
Izikhombo
- URussell DW (2003). "Ama-enzyme, ukulawulwa, kanye nofuzo lwe-bile acid synthesis". Annu. Umfundisi Biochem. 72: 137– doi: 10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
- Bhagavan, NV; Ha, Chung-Eun (2015). "Ukugaya Kwamathunjini Nokumuncwa". Okubalulekile kwe-Medical Biochemistry. kk. 137– doi:10.1016/B978-0-12-416687-5.00011-7. I-ISBN 9780124166875.
- Dawson, PA; Karpen, SJ (Juni 2015). "Ukuthuthwa kwamathumbu kanye ne-metabolism ye-bile acids". Ijenali yocwaningo lwe-Lipid. 56 (6): 1085– doi:10.1194/jlr.R054114. I-PMC 4442867. PMID 25210150.
- Carey MC (December 1975). "Umhleli: I-Cheno kanye ne-urso: lokho okufana kwehansi nebhere". N. IsiNgisi. J. Med. 293 (24): 1255– doi:10.1056/NEJM197512112932412. PMID 1186807.
- Berginer VM, Salen G, Shefer S (December 1984). "Ukwelashwa kwesikhathi eside kwe-cerebrotendinous xanthomatosis nge-chenodeoxycholic acid". N. IsiNgisi. J. Med. 311 (26): 1649– doi:10.1056/NEJM198412273112601. PMID 6504105.
- Rao, AS; Wong, BS; Camilleri, M; Odunsi-Shiyanbade, ST; McKinzie, S; Ryks, M; Burton, D; UCarlson, P; Lamsam, J; Singh, R; Zinsmeister, AR (Novemba 2010). "Chenodeoxycholate kwabesifazane abane-irritable bowel syndrome-constipation: ukuhlaziywa kwe-pharmacodynamic kanye ne-pharmacogenetic". I-Gastroenterology. 139 (5): 1549–58, 1558.e1. doi:10.1053/j.gastro.2010.07.052. I-PMC 3189402. PMID 20691689.
- Thistle JL, Hofmann AF (September 1973). "Ukusebenza kanye nokucaciswa kwe-chenodeoxycholic acid therapy yokuqeda amatshe enyongo". N. IsiNgisi. J. Med. 289 (13): 655– doi:10.1056/NEJM197309272891303. PMID 4580472.
- Hofmann, AF (September 1989). "Ukuqedwa kokwelashwa kwamatshe enyongo nge-oral bile acid therapy". I-American Journal of Surgery. 158 (3): 198– doi:10.1016/0002-9610(89)90252-3. PMID 2672842.
