7,8-DIHYDROXYFLAVONE (38183-03-8) Imininingwane
| Igama Product | 7,8-dihydroxyflavone |
| Igama leKhemikhali | I-Tropoflavin;
I-7,8-dihydroxy-2-phenylchromen-4-one; |
| omqondofana | I-7,8-dihydroxy-2-phenyl-4H-chromen-4-one;
7,8-dihydroxyflavone hydrate 7,8-DHF; 4H-1-Benzopyran-4-eyodwa; I-7,8-Dihydroxy-flavone; I-7,8-Dihydroxy-2-phenyl-chromen-4-one; I-7,8-Dihydroxy-2-phenyl-4-benzopyrone; |
| CAS Inombolo | 38183-03-8 |
| InChIKey | COCYGNDCWFKTMF-UHFFFAOYSA-N |
| I-molecular Fi-ormula | C15H10O4 |
| I-molecular Weziyisishiyagalombili | 254.24 |
| IMisa ye-Monoisotopic | 254.05790880 |
| Ukuxuba iphuzu | I-243-246 ° C |
| Iphuzu lokubilisa | 494.4 ± 45.0 ° C (Kubikezelwe) |
| Color | Iphuphu eliphuzi |
| Ifomu | Solid |
| Sukufaneleka | I-DMSO: i-soluble24mg/mL |
| Sukuhlushwa Tukushisa | Umkhathi ongenayo, izinga lokushisa legumbi |
| Isicelo | I-7,8-dihydroxyflavone hydrate isetshenziswe njenge-agonist ye-tropomyosin-receptor-kinase B (TrkB) kumagundane kanye nokuvimbela i-TrkB yokuqapha ama-excitatory postsynaptic currents (eEPSCs). |
| Idokhumenti yokuhlola | Iyatholakala |
I-7,8-Dihydroxyflavone powder – Yini i-7,8-DHF? Noma i-Tropoflavin?
I-Tropoflavin powder noma i-7,8-dihydroxyflavone iyi-molecule yamakhemikhali. Ilingisa imisebenzi ye-Brain-derived neurotrophic factor (BDNF). I-BDNF itholakala ngokwemvelo ebuchosheni nasentanjeni yomgogodla. I-BDNF idlala indima ebalulekile ekufundeni, ekuthuthukiseni inkumbulo, i-neuroplasticity okuyikhono lokwakha izindlela ezintsha nokuxhumana, kanye ne-neurogenesis yabantu abadala okuyikhono lokukhulisa amangqamuzana obuchopho amasha kubantu abadala abanobuchopho obuvuthwe ngokugcwele.
I-Tropoflavin powder iboniswe ukuthi iyasiza ekulungiseni ubuchopho, inkumbulo yesikhathi eside, ukucindezeleka, nezifo ze-neurodeergenerative ocwaningweni oluhlukahlukene lomtholampilo kanye nokuhlolwa okwenziwa kumagundane namagundane. Kodwa-ke, kusukela manje, azikho izivivinyo zomtholampilo noma ucwaningo olwenziwe kubantu. Ubufakazi obuningi obufakazela izinzuzo ze-tropoflavin powder buvela ezifundweni zezilwane. Ubufakazi obufana nokuthi: izinzuzo enkumbulweni, ukuvikelwa kwamangqamuzana obuchopho kanye nokulondolozwa kokusebenza kobuchopho eminye yemiphumela emihle evela ezifundweni ezihlukahlukene zezilwane.
Isebenza kanjani i-7,8-Dihydroxyflavone?
I-7,8-Dihydroxyflavone ilingisa umsebenzi wezici ze-neurotrophic ezitholakala ebuchosheni. Lokhu ikwenza ikakhulukazi ngokwenza kusebenze indlela yokwamukela abantu eyaziwa ngokuthi i-Tropomyosin-related kinase B (TrkB) receptors pathway. Lena indlela efanayo i-BDNF esebenza ngayo. Ngaphandle kwe-7,8-DHF ibonakale isebenza ngokuzimela ukuze inikeze umsebenzi we-antioxidant.
Izinzuzo ezingaba khona ze-BDNF zikhawulelwe ukuphila kwayo okufushane okungaphansi kwemizuzu eyi-10. I-BDNF futhi ayikwazi ukweqa umgoqo wegazi nobuchopho ngenxa yosayizi omkhulu we-molecule. Ngakolunye uhlangothi, i-7,8-dihydroxyflavone ingangena kumaseli ebuchosheni nasemgogodleni ngokuwela lesi sivimbelo. Kakade ucwaningo selukhombisile ukuthi i-7,8-DHF itholakala ngomlomo futhi ingangena kumgoqo wegazi lobuchopho. Ngakho-ke i-7,8-dihydroxyflavone (7,8-dhf) ingasiza ekuthuthukiseni ukusebenza kobuchopho nempilo.
Iyini i-4′-Dimethylamino-7, 8-Dihydroxyflavone (Eutropoflavin)?
I-4′-Dimethylamino-7,8-dihydroxyflavone (4'DMA-7, 8-DHF), ebizwa nangokuthi i-eutropoflavin noma i-R13 in s, inguqulo yokwenziwa ye-7,8-dihydroxyflavone. Iwuhlobo olulungiswe ngokuhlelekile futhi olusungulwe lwe-7, 8-Dihydroxyflavone. I-Eutropoflavin ine-half-life ejikelezayo ende futhi inamandla kakhulu kune-7, 8-Dihydroxyflavone.
Lezi zinhlanganisela ezimbili zinezakhiwo zamakhemikhali ezifanayo. I-4'DMA-7, 8-DHF iguqulela ku-7, 8-Dihydroxyflavone ngesikhathi sokujikeleza emzimbeni.
Kukhona ucwaningo oluncane ku-4′-Dimethylamino-7,8-dihydroxyflavone. Lonke ucwaningo olulinganiselwe olukhona lwenziwa ngezilwane. Ubufakazi obutholakalayo bubonisa ukuthi i-4′-Dimethylamino-7,8-dihydroxyflavone kanye ne-7,8-Dihydroxyflavone inezindlela ezifanayo noma ezifanayo zokusebenza.
Yenzani i-4′-DMA-7 8-dihydroxyflavone?
I-4′-Dimethylamino-7,8-dihydroxyflavone noma i-Eutropoflavin iyi-flavone yokwenziwa. Kuyi-molecule encane ekhethiwe esebenza kuma-TrkB receptors, isamukeli esiyinhloko sezici ze-neurotrophic ezithathwe ebuchosheni. I-Eutropoflavin ithathwe ekuguqulweni kwesakhiwo namakhemikhali e-tropoflavin.
Uma kuqhathaniswa ne-tropoflavin, i-eutropoflavin iboniswe inomsebenzi ongcono kakhulu ku-TrkB receptor. I-Eutropoflavin yatholwa inamandla kakhulu kune-tropoflavin futhi yabonisa isikhathi eside sokusebenza ezifundweni zezilwane. I-4′-Dimethylamino-7,8-dihydroxyflavone itholakale inezindawo ze-neuroprotective, neurogenic, kanye ne-antidepressant-like ezilwaneni.
7,8-Dihydroxyflavone vs 4′-dma-7 8-dihydroxyflavone
Kokubili i-7,8-Dihydroxyflavone kanye ne-4'-DMA-7 8-dihydroxyflavone kuboniswe ukukhiqiza imiphumela efanayo ezifundweni zezilwane. Umphumela usazocwaningwa ezivivinyweni zabantu.
Nakuba kokubili kuyizinhlanganisela ezifanayo, umehluko omkhulu watholakala phakathi komsebenzi wabo bobabili. Izivivinyo zemitholampilo kanye nocwaningo lwabonisa ukuthi i-eutropoflavin yayinamandla kakhulu kune-tropoflavin futhi yabonisa ngisho nobude besikhathi sokusebenza.
Kanjalo, nakuba i-7,8-dhf kanye ne-4′-DMA-7 8-dihydroxyflavone afana ngamakhemikhali futhi anemiphumela efanayo, i-4′-DMA-7 8-dihydroxyflavonne itholwe inesenzo esinamandla futhi yasebenza isikhathi eside, ucwaningo olwenziwe kumamodeli ezilwane.
Kungani Ukuthatha I-Tropoflavin powder Ithola Ukuthandwa?
I-Tropoflavin powder noma i-7,8-Dihydroxyflavone powder ithola ukuthandwa. Ngocwaningo olusha kanye nezilingo zomtholampilo ezivela ngemiphumela emihle, i-7,8-Dihydroxyflavone powder iphuma njengesihloko esishisayo ngisho nasembuthanweni wesayensi.
Azikho izivivinyo zomtholampilo noma ucwaningo olwenziwe kubantu kusukela manje. Kodwa-ke, labo abasebenzise i-7,8-Dihydroxyflavone powder baye bathi i-powder ibe nokuthuthuka okuphawulekayo kubo:
- Memory
- Energy
- Learning
- Mood
- Inkumbulo Nokusekelwa Kwengqondo
I-Tropflavin powder nayo ifakazelwa ukuthi iyasebenza ukuze kuzuzwe isimo sengqondo esilinganiselayo, ukuba nokukhiqizwa kwamandla okuhle, ukuba nezindawo zokuvikela ubuchopho, ukuba nezindawo zokulwa ne-oxidant kanye nokusekela amagciwane amathumbu.
Izinzuzo nemiphumela ye-7,8-Dihydroxyflavone - Yenzani i-7,8-Dihydroxyflavone?
I-7,8-Dihydroxyflavone powder (7,8-dhf) iboniswe ukuthi inezinzuzo ezihlukahlukene. Kodwa-ke, kuze kube manje, izivivinyo zomtholampilo ezinomkhawulo kanye nocwaningo lwenziwe kubantu. I-7,8-Dihydroxyflavone powder ibonakale iphumelela ocwaningweni nasekuhlolweni okwenziwa kumamodeli ezilwane kanye nocwaningo olusekelwe kumaseli. Ucwaningo olwengeziwe mayelana nokusebenza kahle kwabantu lusadingeka. Eminye yemiphumela emihle evela ocwaningweni nasezivivinyweni ku-7,8-dhf powder evela ezifundweni zezilwane ibhalwe ngezansi:
- Imemori nokuFunda
- Ukulungisa Ubuchopho
- neuroprotection
- I-Anti-Inflammatory
- Indima ku-Neurodegenerative Disease
- Ukucindezeleka
- Addiction
- Ukukhuluphala
- Ukushaya kwegazi
- Ukuguga Kwesikhumba
- Cancer
Imemori nokuFunda
I-7,8-Dihydroxyflavone powder ibonakale iwusizo ekuthuthukiseni inkumbulo nokuqashelwa kwezinto, nokunciphisa ukucindezeleka kumagundane. Kuphinde kwabonwa ukuthi kuyasebenza ekuthuthukiseni inkumbulo kumagundane aguga.
Ukulungisa Ubuchopho
I-7,8-Dihydroxyflavone powder (7,8-dhf) ibonakale iphumelela ekukhuthazeni ukulungiswa kwamangqamuzana ezinzwa ezilimele, okwandisa ukukhiqizwa kwama-neurons amasha ebuchosheni bamagundane amadala ngemva kokulimala kobuchopho nasekukhuthazeni ukukhula kwamangqamuzana ezinzwa ezintsha. amagundane asebekhulile
Ngokufanayo, i-7,8-Dihydroxyflavone powder, nayo ibonakala iphumelela ekuthuthukiseni imisebenzi yobuchopho kumagundane abe nokulimala kobuchopho okubuhlungu.
neuroprotection
I-7,8-Dihydroxyflavone powder ibonakale iphumelela ekuvikeleni ukulimala kobuchopho obuhlobene nesifo sohlangothi, ikakhulukazi kumagundane wesifazane. Iphinde yavimbela ukulimala kwamaseli ezinzwa kumagundane ngemva kokulimala kobuchopho okubuhlungu.
Anti-Inflammatory
I-7,8-Dihydroxyflavone powder ibonakale inemiphumela elwa nokuvuvukala. Kuye kwabonakala ukuthi ikwazi ukwehlisa ukuvuvukala ebuchosheni namangqamuzana egazi amhlophe.
Indima ku-Neurodegenerative Disease
I-7,8-dhf powder ibonakale idlala indima ehlukene ezifweni ezihlukahlukene ze-neurodeergenerative, okuxoxwa ngazo ngezansi.
Izifo ze-Alzheimer
Izinhlobo zezilwane zibonise imiphumela exubile yesifo i-Alzheimer's. Ezinye izifundo zibonise ukuthi i-7,8-Dihydroxyflavone powder yayinendima ebalulekile ekuyivimbeleni, kuyilapho abanye bengabonisi izinzuzo. Ucwaningo olwengeziwe luyadingeka kule ndawo.
Isifo sikaParkinson
I-7,8-Dihydroxyflavone powder ibonwe ukuthuthukisa imisebenzi yezimoto kumamodeli wezilwane. Kuphinde kwabonakala kunezenzo zokuzivikela ekufeni kwama-neurons. Kuphinde kuvimbele ukufa kwama-neurons azwela i-dopamine kumamodeli wezinkawu zesifo sika-Parkinson.
Isifo SikaHuntington
I-7,8-Dihydroxyflavone powder ibonwe ukwandisa isikhathi sokuphila sezilwane ezinezifo zikaHuntington.
Yesifo sokuwohloka kwezinzwa nemisipha (ALS)
I-7,8-Dihydroxyflavone powder ithuthukise ukusilela kwezimoto kanye nokwanda kokusinda ezifundweni ezenziwe kumodeli yegundane nge-ALS.
Sclerosis multiple
I-7,8-Dihydroxyflavone powder yehlise ubukhulu besifo.
schizophrenia
I-7,8-Dihydroxyflavone powder ithuthukise imisebenzi yokufunda kumamodeli wamagundane.
Down Syndrome
Ukungenelela kwangaphambi kwesikhathi nge-7,8-Dihydroxyflavone powder (7,8-dhf) kuye kwabonakala ukwandisa ukukhiqizwa kwama-neurons amasha kanye nokufunda okungcono kanye nenkumbulo.
I-Fragile X Syndrome
I-Fragile X syndrome yisimo sofuzo. Kudala izinkinga eziningi zokuthuthuka ezihlanganisa ukukhubazeka kwengqondo kanye nokukhubazeka kokufunda.
Kumodeli yegundane ye-X syndrome ebuthakathaka, i-7,8-Dihydroxyflavone powder ibonakale ithuthukisa umsebenzi wokuqonda futhi inciphise ukungahambi kahle komgogodla kumamodeli wegundane we-Fragile X Syndrome.
I-Right Syndrome
I-7,8-Dihydroxyflavone powder ibonakale ithuthukisa izimpawu kumodeli yegundane ye-Rett syndrome-njengokukhula kancane kancane, ukulawulwa kokuxhumana okunzima, nezindaba zolimi.
Ukucindezeleka
I-7,8-Dihydroxyflavone powder ibonwe ukunciphisa ukuziphatha okucindezelayo kumagundane.
Addiction
I-7,8-Dihydroxyflavone powder iboniswe ukuthi iyasebenza ekwehliseni injabulo nemiphumela ezuzisayo ye-cocaine kumagundane.
Ukukhuluphala
I-7,8-Dihydroxyflavone powder ibonakale ikwazi ukunciphisa ukukhiqizwa kwamafutha kanye nokwakhiwa kwamafutha ezifundweni zezilwane.
Ukushaya kwegazi
I-7,8-Dihydroxyflavone powder ibonakale ibonisa ukunciphisa ukucindezeleka kwegazi lapho ijojowe. Amanani omlomo akwazi ukunciphisa ukucindezeleka kwegazi, kodwa kwakungeyona into ebaluleke kakhulu uma kuqhathaniswa nalapho i-7,8-Dihydroxyflavone powder inikezwa ngamafomu ajojowe.
Ukuguga Kwesikhumba
I-7,8-Dihydroxyflavone powder ibonwe ukunciphisa ukuvuvukala, ukwandisa ukukhiqizwa kwe-collagen, nokwandisa amazinga e-enzyme e-antioxidant kumaseli esikhumba somuntu asebekhulile.
Cancer
I-7,8-Dihydroxyflavone powder ibonakale iphumelela ekubulaleni amangqamuzana omdlavuza womlomo we-squamous kanye nomdlavuza wesikhumba owaziwa ngokuthi i-Melanoma ezifundweni zesitsha. Nokho, kusadingeka ucwaningo olwengeziwe ukuze kufinyelelwe esiphethweni, ikakhulukazi kubantu.
Indlela yokuthatha 7,8-Dihydroxyflavone supplement?| Ingakanani i-tropoflavin powder okufanele ngiyithathe?
7,8-Dihydroxyflavone Isikali
Azikho izifundo zomtholampilo nezivivinyo ezenziwa kubantu kusukela manje. Ngakho-ke, umthamo ophephile we-7,8-Dihydroxyflavone powder awukaziwa kubantu.
Umthamo ovame kakhulu ezithanjeni ezitholakalayo ezithengiswayo ngu-10 - 30 mg ngosuku. Nokho, kufanele uhlole nodokotela wakho ngaphambi kokuba uqale ukuthatha ibhekwa.
7,8-Dihydroxyflavone side effects
Njengoba kungekho zilingo zomtholampilo ezenziwe ngabantu, izici zobungozi kanye nemiphumela emibi ye-7, 8-Dihydroxyflavone akwaziwa. Noma yiluphi ulwazi ngokuphepha noma imiphumela engemihle luvela ocwaningweni olwenziwe ngezinhlobo zezilwane. Nokho, kubasebenzisi abathathe i-7, 8-Dihydroxyflavone, imiphumela elandelayo yaphawulwa:
- Ukweqisa ngokweqile
- Ukuphumula
- isiyezi
- I-nausea
- Ukuthukuthela
- Inkinga yokulala
Kuyafaneleka futhi ukuqaphela ukuthi i-7,8-Dihydroxyflavone powder ingase ihlanganyele nezinye izidakamizwa zemithi. 7, 8-Dihydroxyflavone iyasebenza kakhulu namanye ama-molecule nezinhlanganisela. Ubufakazi buye babonakala buphakamisa indima ye-7,8-Dihydroxyflavone ekuguquleni isenzo se-CYP450 ye-enzyme yesibindi. Lokhu kungashintsha indlela ezinye izidakamizwa ezisebenza ngayo. Ngakho-ke, kuphephile ngaso sonke isikhathi ukubonana nodokotela, ikakhulukazi uma usebenzisa izidakamizwa.
7,8-Imithombo yokudla ye-Dihydroxyflavone - Ungengeza kanjani 7,8-Dihydroxyflavone ngokwemvelo?
I-7,8-Dihydroxyflavone iwela ngaphansi komndeni we-flavonoid, okuyiqembu lezinto zamakhemikhali ezivele ngokwemvelo ezinezakhiwo eziguquguqukayo ze-phenolic. Imithombo yokudla ecebile ku-7, 8-Dihydroxyflavone ihlanganisa itiye eliluhlaza, uviniga, isoya, i-turmeric, amaqanda, ikhofi, ama-blueberries, amagilebhisi kanye noshokoledi omnyama. Kodwa-ke, ukuthola umphumela omuhle kakhulu ku-7,8-dihydroxyflavone, ukumunca kulokhu kudla ngeke kube indlela ekahle kakhulu, indlela eqondile kakhulu ukuthatha izithasiselo ze-7,8-dihydroxyflavone. Thola umphakeli ongcono kakhulu we-7,8-dihydroxyflavone powder, ungaba lapha. Futhi uthenge i-7,8-dihydroxyflavone powder wholesale izothola intengo engcono.
Izibuyekezo ze-7,8-Dihydroxyflavone
Azikho izifundo zomtholampilo kubantu mayelana ne-7,8-dhf. Kodwa-ke, izifundo zezilwane zibonise ukuthi ziyasebenza futhi zilungile. Ukuhlolwa kwemitholampilo kumamodeli ezilwane kubonise ukuthi i-7,8-Dihydroxyflavone powder inezinzuzo ezihlukahlukene ekuthuthukiseni inkumbulo, ukuvikela amangqamuzana obuchopho nokugcina umsebenzi wobuchopho.
Abantu abawudlayo banemiphumela engemihle ebikiwe emincane kakhulu njengokushukumisa ngokweqile, ukungahlaliseki, isiyezi, isicanucanu, ukuphatheka kabi kanye nenkinga yokulala.
Ucwaningo oluningi lusadingeka ukuphetha izinzuzo eziqondile kanye nezingozi ze-7,8-Dihydroxyflavone powder kubantu.
Khipha ku-internet I-7,8-Dihydroxyflavone powder Umkhiqizi/ Lapho ongathenga khona I-7,8-Dihydroxyflavone powder inqwaba?
Kunama-7 8-dihydroxyflavone amaningi athengiswayo kulayini. I-7,8-Dihydroxyflavone powder ingathengwa ku-intanethi ngokusebenzisa izitolo ezihlukahlukene kanye nezingosi. Ungayithenga ngamanani avumelana nawe. Ukuthenga i-7,8-Dihydroxyflavone powder ngamanani amaningi kungakusiza ngezindleko eziphelele.
Uma ubheka ukuthenga i-7,8-Dihydroxyflavone powder supplement, kubalulekile ukubheka kahle ngabakhiqizi be-powder 7,8-Dihydroxyflavone kanye neziqinisekiso zabo. Ukuvakashela endaweni ukuze ubone inqubo yokukhiqiza kungaqinisekisa ukuthi imihlahlandlela efanele yokuphepha kanye nezinqubo zokukhiqiza ziyalandelwa ngesikhathi sokukhiqiza.
Ngakho-ke, ikhwalithi yomkhiqizo kufanele iqinisekiswe ngaphambi kokuthi uqede ukuthenga i-7,8-Dihydroxyflavone powder.
Imibuzo Evame Ukubuzwa (FAQs) Mayelana ne-7, 8-Dihydroxyflavone (7, 8-DHF), noma i-Tropoflavin
Ingabe i-Tropoflavin i-Nootropic?
Ama-Nootropics ayaziwa nangokuthi izidakamizwa ezihlakaniphile. Isidakamizwa/inhlanganisela ye-nootropic sithuthukisa ukusebenza kwengqondo noma ukusebenza kobuchopho. Ukuhlolwa komtholampilo ezilwaneni kuphakamise ukuthi i-Tropoflavin ingaba i-nootropic agent. Kodwa-ke, abukho ubufakazi obuphelele futhi ucwaningo olwengeziwe lusadingeka.
Kubantu, asikho isilingo somtholampilo esenziwe kuze kube manje nge-7,8-Dihydroxyflavone powder. Ngakho-ke akunakwenzeka ukusho ukuthi i-7,8-Dihydroxyflavone powder inomsebenzi we-nootropic kubantu.
Kungani uthenge I-7,8-Dihydroxyflavone powder ukuze uthole impilo engcono yobuchopho?
I-7,8-Dihydroxyflavone powder ibonise ukuthi inezinzuzo ezihlukahlukene. Ngokucwaninga okubanzi kanye nokuhlolwa komtholampilo okwenziwa ezilwaneni, i-7,8-Dihydroxyflavone powder itholakale inomphumela omuhle enkumbulo nokufunda, ukulungiswa kobuchopho, i-neuroprotection, anti-inflammation, ukucindezeleka, umlutha, ukukhuluphala, ukucindezelwa kwegazi nokuguga kwesikhumba.
I-7,8-Dihydroxyflavone powder nayo inamandla kakhulu kune-BDNF eyenzeka ngokwemvelo emzimbeni wethu. Lapho,
Uyini Umehluko Phakathi kwe-7, 8-Dihydroxyflavone ne-BDNF?
I-BDNF ikhiqizwa ngokwemvelo emzimbeni wakho kuyilapho i-7,8-Dihydroxyflavone powder itholakala ezinhlobonhlobo zezitshalo ezimbalwa. I-7,8-Dihydroxyflavone powder ngaleyo ndlela ikhiqizwa ngokwenziwa futhi idliwe ngenxa yemiphumela yayo emihle ehlukahlukene ebuchosheni.
I-7,8-Dihydroxyflavone powder ibonwe ukuthi ine-half-life ende kanye namandla kunalokho uma kuqhathaniswa ne-BDNF. I-7,8-Dihydroxyflavone powder nayo ingangena ebuchosheni ngenxa yobukhulu bayo obuncane kakhulu.
Ungasithatha kanjani isithasiselo esingu-7, 8-Dihydroxyflavone ukuze uthole umphumela omuhle kakhulu?
Okwamanje azikho izifundo zomuntu ku-7,8-Dihydroxyflavone powder ukuze kubhekiselwe ku-dosing yezidakamizwa. Iningi lezilinganiso lilinganiselwa ngokwezibalo kusukela ocwaningweni lwamagundane. Iningi locwaningo lwezilwane olwenziwe lubonise imiphumela emihle emafomu okujovwa. Nge-dosing yomlomo nge-7,8-Dihydroxyflavone powder, imiphumela yabonakala, noma kunjalo, yayingabaluleki kangako ngokuqhathaniswa.
Njengoba uvivinyo lwabantu lungenziwanga, kunzima ukuphawula ngomthamo kubantu. Ukubonisana nodokotela kungasiza ekucaciseni lokhu.
Ingabe i-Tropoflavin Isekela Ukulahlekelwa Kwesisindo?
Izilingo zomtholampilo kanye nocwaningo luye lwakwazi ukukhombisa ukuthi i-7,8-Dihydroxyflavone powder ibangela ukulahlekelwa isisindo, ikakhulukazi kumagundane wesifazane. Lokhu okutholakele akukabonakali kubantu njengoba lungekho ucwaningo olwenziwe kuze kube manje.
Kukhona futhi evi
i-dence ephakamisa ukuthi i-7,8-Dihydroxyflavone powder ingabangela ukulahlekelwa isisindo ngokuthuthukisa ukusekelwa okuphelele kwamabhaktheriya amathumbu.
Ingabe i-Tropoflavin Idala Ukuqothuka Kwezinwele (noma Ukusekela Ukukhula Kwezinwele)?
Kuze kube manje, abukho ubufakazi bokuthi i-7,8-Dihydroxyflavone powder ibangela ukulahlekelwa izinwele nganoma yiluphi uhlobo. Ezinye izifundo zezilwane zibonise ukuthi i-BDNF nezinye izinhlanganisela zingabamba iqhaza ekulawuleni ukukhula kwezinwele. Ucwaningo olunzulu nokuhlolwa komtholampilo kusadingeka kubantu ukuze baphawule ngalolu daba.
Ungagcina kanjani i-Dihydroxyflavone (Tropoflavin)?
Njenganoma yimuphi omunye umuthi, kuhlale kuphephile ukugcina i-7,8-Dihydroxyflavone powder kude nalapho izingane zingafinyeleleki khona. Kuhle ukuyibeka kude nelanga eliqondile futhi kufanele igcinwe endaweni epholile, eyomile.
Ingabe i-7-8 Dihydroxyflavone ikhulisa ukucindezeleka?
I-7,8-Dihydroxyflavone powder ibonakale iphumelela ekunciphiseni ukuziphatha okucindezelayo kumagundane. Ayikho idatha yomtholampilo etholakalayo kusukela manje ngendima ye-7,8-Dihydroxyflavone powder ekucindezelekeni kubantu.
Okubhekwayo
[1] I-7,8-dihydroxyflavone, i-agonist ye-molecular TrkB encane, iwusizo ekwelapheni ukuphazamiseka okuhlukahlukene kwabantu okuhlobene ne-BDNF. Chaoyang Liu, Chi Bun Chan, Keqiang Ye Transl Neurodegener. 2016; 5: 2. Kushicilelwe ku-inthanethi 2016 Jan 6. doi: 10.1186/s40035-015-0048-7PMCID: PMC4702337
[2]I-Flavonoids: uhlolojikelele. AN Panche, AD Diwan, SR Chandra J Nutr Sci. 2016; 5: e47. Ishicilelwe ku-inthanethi 2016 Dec 29. doi: 10.1017/jns.2016.41 PMCID: PMC5465813
[3]I-Neurotrophic Factor Esuselwa ebuchosheni: I-Molecule Ebalulekile Yenkumbulo ebuchosheni obunempilo kanye ne-Pathological. Buyekeza i-athikili. Miranda M. Front Cell Neurosci. 2019 PMID: 31440144PMCID: PMC6692714
[4]Isici se-neurotrophic esisuselwa ebuchosheni kanye nemithelela yayo yomtholampilo. Bathina S. Arch Med Sci. 2015 PMID: 26788077PMCID: PMC4697050
[5]Izenzo Ze-Neurotrophic Factor Esuselwa ebuchosheni kanye Nokucindezeleka Kwe-Glucocorticoid ku-athikili Yokubuyekeza Ye-Neurogenesis. Numakawa T. Int J Mol Sci. 2017 PMID: 29099059PMCID: PMC5713281
[6]I-Neurotrophic Factor Esuselwa ebuchosheni: I-Molecule Ebalulekile Yenkumbulo ebuchosheni obunempilo kanye ne-Pathological. Magdalena Miranda, Juan Facundo Morici, María Belén Zanoni kanye noPedro Bekinschtein. Ngaphambili. Iseli. I-Neurosci., 07 Agasti 2019 | https://doi.org/10.3389/fncel.2019.00363
[7]I-prodrug ye-7,8-dihydroxyflavone development kanye nempumelelo yokwelapha yokwelapha isifo i-Alzheimer's. I-Chen C. Proc Natl Acad Sci US A. 2018 PMID: 29295929PMCID: PMC5777001
[8] I-TrkB i-agonist ekhethiwe enemisebenzi enamandla ye-neurotrophic nge-7,8-dihydroxyflavone
Sung-Wuk Jang 1, Xia Liu, Manuel Yepes, Kennie R Shepherd, Gary W Miller, Yang Liu, W David Wilson, Ge Xiao, Bruno Blanchi, Yi E Sun, Keqiang Ye
PMID: 20133810 PMCID: PMC2823863 DOI: 10.1073/pnas.0913572107
[9] I-molecule encane ye-BDNF mimetics yenza kusebenze ukusayinda kwe-TrkB futhi ivimbele ukonakala kwe-neuronal kumagundane. UStephen M Massa , Tao Yang, Youmei Xie, Jian Shi, Mehmet Bilgen, Jeffrey N Joyce, Dean Nehama, Jayakumar Rajadas, Frank M Longo.
PMID: 20407211 PMCID: PMC2860903 DOI: 10.1172/JCI41356
[10] Isenzo se-Antioxidant se-7,8-dihydroxyflavone sivikela amaseli e-PC12 ngokumelene ne-6-hydroxydopamine-induced cytotoxicity. Xiaohua Han, Shaolei Zhu, Bingxiang Wang, Lei Chen, Ran Li, Weicheng Yao, Zhiqiang Qu. 2014 Jan; 64:18-23. doi: 10.1016/j.neuint.2013.10.018. I-Epub 2013 Nov 9.
PMID: 24220540 DOI: 10.1016/j.neuint.2013.10.018
[11] I-7,8-dihydroxyflavone, i-TrkB receptor agonist, ivimba ukukhubazeka kwenkumbulo yesikhathi eside okubangelwa ukucindezeleka kokungakwazi ukuhamba kwamagundane. Raül Andero, Núria Daviu, Rosa Maria Escorihuela, Roser Nadal, Antonio Armario
PMID: 21136519 DOI: 10.1002/hippo.20906
[12]Ama-agonists e-molecule encane ye-trkB akhuthaza ukukhiqizwa kabusha kwe-axon kuzinzwa ezisikiwe zaseceleni. Arthur W English , Kevin Liu, Jennifer M Nicolini, Amanda M Mulligan, Keqiang Ye.
2013 Okthoba 1;110(40):16217-22. doi: 10.1073/pnas.1303646110. Epub 2013 Sep 16.
PMID: 24043773 PMCID: PMC3791704 DOI: 10.1073/pnas.1303646110
[13]Indima ye-7,8-Dihydroxyflavone Ekuvimbeleni Ukuwohloka kwe-Dendrite ku-Cortex Ngemva Kokulimala Okumaphakathi Kobuchopho Okuhlukumezekile. Shu Zhao, Xiang Gao, Weiren Dong, Jinhui Chen. I-Mol Neurobiol. 2016 Apr;53(3):1884-1895. doi: 10.1007/s12035-015-9128-z. Epub 2015 Mar 24.
I-PMID: 25801526 PMCID: PMC5441052
[14] I-7,8-Dihydroxyflavone inciphisa ukukhululwa kwabaxhumanisi be-pro-inflammatory kanye nama-cytokines kumaseli e-BV2 microglial avuselelwe i-lipopolysaccharide ngokucindezelwa kwe-NF-κB kanye ne-MAPK izindlela zokubonisa. Hye Young Park, Cheol Park, Hye Jin Hwan, Byung Woo Kim, Gi-Young Kim, Cheol Min Kim, Nam Deuk Kim, Yung Hyun Choi.
I-J Mol Med. 2014 Apr;33(4):1027-34. doi: 10.3892/ijmm.2014.1652. I-Epub 2014 Feb 10.
PMID: 24535427 DOI: 10.3892/ijmm.2014.1652
[15] I-7,8-dihydroxyflavone ivimbela ukulahlekelwa kwe-synaptic kanye nokulahlekelwa kwenkumbulo kumodeli yegundane yesifo se-Alzheimer's. Zhentao Zhang, Xia Liu, Jason P Schroeder , Chi-Bun Chan, Mingke Song, Shan Ping Yu, David Weinshenker, Keqiang Ye.
I-Neuropsychopharmacology. 2014 Feb;39(3):638-50. doi: 10.1038/npp.2013.243. Epub 2013 Sep 11.
I-PMID: 24022672 PMCID: PMC3895241
[16]7,8-dihydroxyflavone Ithuthukisa Ukushoda Kwezimoto Ngokucindezela I-α-synuclein Expression kanye Nokucindezeleka Kwe-Oxidative Kumodeli Yegundane elenziwe yi-MPTP le-Parkinson's Disease. Xiao-Huan Li, Chun-Fang Dai, Long Chen, Wei-Tao Zhou, Hui-Li Han, Zhi-Fang Dong.
I-CNS Neurosci Ther. 2016 Jul;22(7):617-24. doi: 10.1111/cns.12555. I-Epub 2016 Ephreli 15.
I-PMID: 27079181 PMCID: PMC6492848
[17]7,8-Dihydroxyflavone ithuthukisa ukusebenza kwemoto futhi ithuthukise ukusinda kwe-motor neuronal ephansi kumodeli yegundane ye-amyotrophic lateral sclerosis.
Orhan Tansel Korkmaz, Nurgul Aytan, Isabel Carreras, Ji-Kyung Choi, Neil W Kowall, Bruce G Jenkins, Alpaslan Dedeoglu,
I-Neurosci Lett. 2014 Apr 30;566:286-91. doi: 10.1016/j.neulet.2014.02.058. Epub 2014 Mar 15.
I-PMID: 24637017 PMCID: PMC5906793
[18]Ama-agonists ama-molecule amancane e-TrkB receptor athuthukisa ukusebenza kwemoto futhi andise ukuphila kumodeli yegundane lesifo sika-Huntington.
Mali Jiang, Qi Peng, Xia Liu, Jing Jin, Zhipeng Hou, Jiangyang Zhang, Susumu Mori, Christopher A Ross, Keqiang Ye, Wenzhen Duan
Hum Mol Genet. 2013 Jun 15;22(12):2462-70. doi: 10.1093/hmg/ddt098. I-Epub 2013 Feb 27.
I-PMID: 23446639 PMCID: PMC3658168
[19]I-agonist ye-TrkB, i-7,8-dihydroxyflavone, inciphisa ukuqina komtholampilo kanye ne-pathological yemodeli ye-murine ye-multiple sclerosis. Tapas K Makar, Vamshi KC Nimmagadda, Ishwar S Singh, Kristal Lam, Fahad Mubariz, Susan IV Judge, David Trisler, Christopher T Bever Jr.
J Neuroimmunol. 2016 Mar 15;292:9-20. doi: 10.1016/j.jneuroim.2016.01.002. I-Epub 2016 Jan 6.
I-PMID: 26943953
[20]I-molecule encane ye-TrkB agonist 7,8-dihydroxyflavone ihlehlisa ukushoda kwepulasitiki yengqondo ne-synaptic kumodeli yegundane le-schizophrenia.
Yuan-Jian Yang, Yan-Kun Li, Wei Wang, Jian-Guo Wan, Bin Yu, Mei-Zhen Wang, Bin Hu.
I-Pharmacol Biochem Behav. 2014 Jul;122:30-6. doi: 10.1016/j.pbb.2014.03.013. Epub 2014 Mar 21.
I-PMID: 24662915
[21]I-agonist ye-flavonoid ye-TrkB receptor ye-BDNF ithuthukisa i-hippocampal neurogenesis kanye nenkumbulo encike ku-hippocampus kumodeli yegundane ye-TS65Dn ye-DS.
Fiorenza Stagni , Andrea Giacomini, Sandra Guidi, Marco Emili, Beatrice Uguagliati, Maria Elisa Salvala, Valeria Bortolotto, Mariagrazia Grilli, Roberto Rimondini, Renata Bartesaghi
Exp Neurol. 2017 Dec;298(Pt A):79-96. doi: 10.1016/j.expneurol.2017.08.018. Epub 2017 Sep 4.
I-PMID: 28882412
[22]7, 8-Dihydroxyflavone induced expression of synapse of AMPA GluA1 futhi ithuthukise ukukhubazeka kwengqondo nomgogodla kumodeli yegundane le-X syndrome ebuthakathaka.
Mi Tian, Yan Zeng, Yilan Hu, Xiuxue Yuan, Shumin Liu, Jie Li, Pan Lu, Yao Sun, Lei Gao, Daan Fu, Yi Li, Shasha Wang, Shawn M McClintock.
I-Neuropharmacology. 2015 Feb;89:43-53. doi: 10.1016/j.neuropharm.2014.09.006. Epub 2014 Sep 16.
I-PMID: 25229717
[23] I-7,8-dihydroxyflavone ibonisa ukusebenza kahle kokwelapha kumodeli yegundane ye-Rett syndrome. Rebecca A Johnson, Maxine Lam, Antonio M Punzo, Hongda Li, Benjamin R Lin, Keqiang Ye, Gordon S Mitchell, Qiang Chang.
J Appl Physiol (1985). 2012 Mar;112(5):704-10. doi: 10.1152/japplphysiol.01361.2011. I-Epub 2011 Disemba 22.
I-PMID: 22194327 PMCID: PMC3643819
[24]7,8-Dihydroxyflavone, i-agonist ye-TrkB, inciphisa ukuziphatha okungavamile kanye neurotoxicity kumagundane ngemva kokuphathwa kwe-methamphetamine.
Qian Ren, Ji-Chun Zhang, Min Ma, Yuko Fujita, Jin Wu, Kenji Hashimoto.
I-Psychopharmacology (Berl). 2014 Jan;231(1):159-66. doi: 10.1007/s00213-013-3221-7. Epub 2013 Aug 10.
I-PMID: 23934209
[25]https://www.sciencedirect.com/topics/medicine-and-dentistry/7-8-dihydroxyflavone
