I-Pyrroloquinoline quinone disodium usawoti (122628-50-6)

Mashi 16, 2020
SKU: 65-19-0-2

I-PQQ uhlobo olusha lwamavithamini ancibilikiswa amanzi, yaqala ukutholwa njenge-cofactor ye …….


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum

I-Pyrroloquinoline quinone disodium salt (122628-50-6) ividiyo

Imininingwane yePyrroloquinoline quinone disodium usawoti (122628-50-6) Imininingwane

Igama Product I-Pyrroloquinoline quinone disodium usawoti (122628-50-6)
Igama leKhemikhali I-Pyrroloquinoline quinone sodium usawoti; disodium4,5-dihydro-4,5-dioxo-1h-pyrrolo (2,3-f) quinoline-2,7,9-tricarboxylat; PQQ, Pyrrolo-quinoline-quinone disodium usawoti; sodiuM 9-carboxy-4,5 -dioxo-4,5-dihydro-1H-pyrrolo [2,3-f] quinoline-2,7-dicarboxylate; PQQ disodium
CAS Inombolo 122628-50-6
InChIKey UFVBOGYDCJNLPM-UHFFFAOYSA-L
SMILE C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)[O-])C(=O)[O-].[Na+].[Na+]
Formula Yamamolekhula C14H4N2Na2O8
isisindo Yamamolekhula 374.17
IMisa ye-Monoisotopic I-373.976304 g / mol
I-Melting Point > 300 ℃ (kubolile ngesikhathi sokuthenwa)
Color Ubomvu we-orange ku-Reddish brown Fine Powder
Isigcini sesitoreji I-2-8 ° C
solubility I-soluble emanzini
Isicelo I-podium ye-pyrroloquinoline quinone (PQQ) isetshenziswa ngosawoti ngenxa yenani layo elinomsoco e-United States (US) ekudleni, njengamandla, ezemidlalo, neziphuzo ze-isotonic; iziphuzo ezingekho ebisini ezisuselwa ebisini; amanzi (asemabhodleleni, athuthukisiwe, aqinisiwe); iziphuzo ezithathelwa esikhundleni sobisi; imigoqo yokusanhlamvu ne-granola; namandla, ukushintshwa kokudla, namabha avikelekile.

Yini iPyrroloquinoline quinone disodium usawoti (PQQ disodium salt)?

I-PQQ uhlobo olusha lwamavithamini ancibilikiswa amanzi, yaqala ukutholwa njenge-cofactor yokuphendula kwe-enzyme kumabhaktheriya, lapho isebenza khona into efanayo namavithamini we-B kubantu. Kuyinto oxidoreductase-based, ikhona kwezinye izidalwa eziphilayo, izitshalo kanye nezicubu zezilwane, engabandakanywa kuphela ku-oxidation ye-catalytic yokusabela komzimba, kodwa futhi inomsebenzi othile okhethekile wokusebenza kanye nokusebenza komzimba. Ukulandelela kwe-PQQ kungathuthukisa i-metabolism yezicubu zezinto eziphilayo nokukhula komsebenzi, kubaluleke kakhulu.

Wenza kanjani uPyrUmsebenzi we-roloquinoline quinone disodium kasawoti?

I-Pyrroloquinoline quinone disodium usawoti ingafaka isenzo esiqondile kuma-enzyme asemqoka abandakanyeka ekwenziweni kwamandla ekhiqiza amaseli ethu - i-mitochondria, theapy ithuthukisa ukukhiqizwa kwamandla. I-Pyrroloquinoline quinone disodium usawoti Ngaphezu kokuba nomphumela onamandla we-antioxidant, nayo ingavikela ekulimaleni kwe-mitochondrial. Ayivikeleli kuphela i-mitochondria ekucindezelweni kwe-oxidative, iphinde futhi ikhuthaze isizukulwane esizenzakalelayo se-mitochondria entsha ngaphakathi kwamaseli wokuguga.

Izinzuzo zePyrroloquinoline quinone disodium usawoti

I-Pyrroloquinoline quinone disodium usawoti iyinhlangano esetshenziswayo esevele ikhona kumaseli ethu, inezinzuzo ezinhle kubantu:

- Siza ukuthuthukisa ukusebenza komzimba nokusebenza kwengqondo okuphezulu;

- Vimbela futhi welapha ukulimala kwesibindi;

- Yehlisa ukulimala kwamahhala emzimbeni womuntu;

- Lawula izifo ezahlukahlukene zemizwa;

- Sula ukumuncwa kwama-amino acid;

- Vimbela futhi welapha isifo se-alzheimer's;

- Amaseli e-NK asebenzayo, athuthukisa umsebenzi we-antitumor;

- Ikhwalithi yokulala eyenziwe ngcono nobude kanye namanye amamethrikhi wesibili ukwenza ngcono ukulala;

- Ukwanda kokubhaliwe kwezinto ezisebenza kusebenze izindlela ze-antioxidant;

- Kuthuthukisa ukwakheka kwe-mitochondria entsha futhi kwandisa ukukhiqizwa kwamandla kwamaselula.

Ukusetshenziswa kwe I-Pyrroloquinoline quinone disodium usawoti

I-Pyrroloquinoline quinone disodium usawoti yi-disodium usawoti we-Pyrroloquinoline quinone, ukusebenza kwawo kuyefana nePyrroloquinoline quinone.

Ocwaningweni olwenziwe ngo-2009 olushicilelwe ephephabhukwini lezokwelapha iFood Isitayela, i-Pyrroloquinoline Quinone ikhonjisiwe ukuthi inekhono lokusiza ekuvikeleni. Isetshenziselwa ukuvikela ukwehla kwengqondo (ukulahlekelwa inkumbulo, ubunzima bokufunda, njll.) Ngenxa yobudala, ukuhlaselwa yisifo sohlangothi noma ukuphazamiseka kwe-neurodegenerative, nokuvikelwa emicimbini wenhliziyo ne-neurological ischemic. Imiphumela efanayo yabikwa ocwaningweni lokulandela luka-2011 lapho iPyrroloquinoline Quinone nayo yanikezwa ngokuqondile njengesengezo sokudla, njengotshwala obudakiswe obisini.

Izikhombo:

[1] Nakano M, Takahashi H, Koura S, Chung C, Tafazoli S, Roberts A. Acute kanye ne-subchronic toxicity izifundo ze-pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ ™) ngamagundane. Lawula i-Toxicol Pharmacol. Ngo-2014 Oct; 70 (1): 107-21. doi: 10.1016 / j.yrtph.2014.06.024. Epub 2014 Jul 1. PMID: 24995591.

[2] Itoh Y, Hine K, Miura H, Uetake T, Nakano M, Takemura N, Sakatani K. Umphumela we-Antioxidant Supplement Pyrroloquinoline Quinone Disodium Usawoti (BioPQQ ™) Kwemisebenzi yokuqonda. I-Adv Exp Med Biol. 2016; 876: 319-325. doi: 10.1007 / 978-1-4939-3023-4_40. PMID: 26782228.

[3] Nakano M, Kawasaki Y, Suzuki N, Takara T. Imiphumela ye-Pyrroloquinoline Quinone Disodium salt Intake kumaSerum Cholesterol Levels of Healthy Japan Adults. J Nutr Sci Vitaminol (Tokyo). Ngo-2015; 61 (3): 233-40. doi: 10.3177 / jnsv.61.233. I-PMID: 26226960.

[4] Rucker R, Chowanadisai W, Nakano M. Ukubaluleka ngokomzimba okungenzeka kwe-pyrroloquinoline quinone. I-Altern Med Rev. (2009)

[5] Noji N, et al. Indlela elula futhi ebucayi yokuhlaziywa kwe-pyrroloquinoline quinone (PQQ) ekudleni okuhlukahlukene kusetshenziswa i-liquid chromatography / electrospray-ionization tandem mass spectrometry. J Agric Chem Chem. (2007)