I-Raw Compound 7P powder (1890208-58-8) ividiyo
I-Raw Compound 7P powder (1890208-58-8) Incazelo
I-Raw Compound i-7P powder ekhuthaza ukuphuma kwe-neurite kwe-neurons eyinhloko ekhushulwa evela ku-hippocampus, i-cortex ye-cerebral, ne-retina. ekwenzeni imfuyo ye-optic nerve injection, i-Raw Compound 7P powder yaboniswa ukukhuthaza ukukhula kwe-axon-gnumx axx emihle, okubonisa ukuthi umsebenzi we-in vitro neurite we-Raw Compound 43P powder uhumusha ekuvuseleleni ukuvuselelwa kwe-axon ku-vivo. I-Raw Compound 7P powder kanye nokucaciswa kwezinqubo ezenza kube khona ukuvuselelwa kwe-axon e-vivo kuzohlinzeka ngesisekelo esihle semizamo yesikhathi esizayo yokuthuthukisa amasu ekwelashwa.
Raw I-2 - [(2-methoxyphenyl) [(4-methyl phenyl) sulfonyl] amino] -N- (4-methoxy-3-pyridinyl) acetamide (i-Compound 7P) powder (1890208-58-8) Siziqu
| Igama Product | I-2 - [(2-methoxyphenyl) [(4-methyl phenyl) sulfonyl] amino] -N- (i-4-methoxy-3-pyridinyl) i-acetamide (i-Raw Compound 7P powder) |
| Igama leKhemikhali | 2 - [(2-methoxyphenyl) [(4-methyl phenyl) sulfonyl] amino] -N- (4-methoxy-3-pyridinyl) acetamide (I-Raw Compound 7P powder) |
| Brand NAme | I-Raw Compound 7P powder |
| I-Drug Class | Izidakamizwa zeNootropic |
| CAS Inombolo | 1890208-58-8 |
| InChIKey | I-NAXWKPFXCOBXLE-UHFFFAOYSA-N |
| I-molecular Fi-ormula | C22H23N3O5S |
| I-molecular Weziyisishiyagalombili | 441.508g |
| IMisa ye-Monoisotopic | 440g / mol |
| Iphuzu lokuxuba | N / A |
| Fukuvuselela kabusha Pi-oint | N / A |
| I-Half Half-Life | N / A |
| Color | powder emhlophe |
| Sukufaneleka | kancane incibilika emanzini nase-ethanol. |
| Sukuhlushwa Tukushisa | Gcina ekamelweni lokushisa, emgodini ovalwe, gwema ukushisa okuqinile nokukhanya. |
| Aukuphikisana | • Ukwandisa ukuxhumana • Ithuthukisa isimo sengqondo • Kusiza ukulwa nokukhathala • Ukuvimbela uketshezi ngaphakathi kwengqondo • Ukuphatha umonakalo ohlotshiswe ngophuzo ophuzweni |
Raw I-XLUMXP yekhamera powder (1890208-58-8) Incazelo
I-Raw Compound 7P (2 - [(2-methoxyphenyl) [(4-methyl phenyl) sulfonyl] amino] -N- (4-methoxy-3-pyridinyl) acetamide) powder ekhuthaza ukuphuma kwe-neurite kwama-neurons ayisisekelo akhule atholakala ku-hippocampus , i-cerebral cortex, ne-retina. kumodeli yezilwane yokulimala kwe-optic nerve, i-Raw Compound 7P powder ikhonjiswe ukukhulisa ukukhula kwe-gap-43 axon positive, okukhombisa ukuthi umsebenzi we-in vitro neurite outgrowth weRaw Compound 7P powder uhumusha ekuvuseleleni ukuvuselelwa kwe-axon ku vivo. I-Raw Compound 7P powder kanye nokucaciswa kwezindlela ezenza ukuthi ukuvuselelwa kwe-axon ku-vivo kuzohlinzeka ngesisekelo esinengqondo semizamo yesikhathi esizayo yokuthuthukisa amasu okwelashwa.
Ukusetshenziswa kwe-Compound 7P powder (1890208-58-8)
I-Compound 7p (2 - [(2-methoxyphenyl) [(4-methyl phenyl) sulfonyl] amino] -N- (4-methoxy-3-pyridinyl) acetamide) ibonise umsebenzi ophakeme ngokumelene namangqamuzana omdlavuza wesibeletho. Emgodini ongenasici we-xenograft model owafakelwa ngama-HeLa cells, i-7p yabonisa ukuvinjelwa kwesilinganiso somthamo wokukhula kwesisu somlomo wesibeletho. Ukuhlolwa kwakhe kwezinto eziphathekayo ezithwala izicubu kuveza ukuthi i-7p ithuthukise i-microstructure ngendlela exhomeke emthamo. I-Compound 7p iphinde yandise inani lama-HeLa amaseli ku-G0 / G1 nesigaba se-S futhi yehlise kakhulu lokho kwesigaba se-G2 / M. Imiphumela ye-7p ku-C-caspase-3, C-caspase-9, Bcl-2 ne-Bax inkulumo ku-HeLa amaseli nayo yanqunywa.
I-tubulin polymerization test, ukuhlolwa kwe-immunofluorescence, ukuhlaziywa kwesigidi se-cell kanye nesimo sokuncintisana se-tubulin-binding kwafakazela ngokuqinile ukuthi i-7p iyi-colchicine yokubopha indawo yesimiso se-tubulin.
Izinzuzo of I-XLUMXP yekhamera powder (1890208-58-8)
Ukuvuselelwa okuhlanganisiwe kwe-7p kwe-optic echotshoziwe
Lungisa ikhanda lekhanda elilimazayo
Kunconywe I-XLUMXP yekhamera powder (1890208-58-8) Isilinganiso
I-Compound 7p ibonise i-100% ukuvimbela ama-parasitemia ngosuku 4 ngamanani amaningi (i-100, i-50, ne-25 mg / kg) enikeziwe ngezinsuku ezine ezilandelanayo, kodwa ku-100 mg / kg, zonke izigundane zisinda futhi zelashwa, kuyi-50 mg / kg, amagundane amathathu amahlanu asinda futhi amakhambi amabili aphulukiswa, futhi ku-25 mg / kg, akekho namagundane asinda
