I-Raw Tadalafil enamandla (171596-29-5)

October 20, 2018
SKU: 171596-29-5

I-Raw Tadalafil powder ngaphansi kwegama le-Cialis isetshenziselwa ukwelapha ukungasebenzi (ukungabi namandla) kanye nezimpawu ze-benign prostatic ………


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum
Umthamo: 1190kg / inyanga

Ividiyo ye-Tadalafil

 

Ulwazi oluyisisekelo

Igama Product Tadalafil powder
Igama leKhemikhali (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
Brand NAme I-Cialis, i-Adcirca
I-Drug Class I-PAH, i-PDE-5 Inhibitors; I-Phosphodiesterase-5 Enzyme Inhibitors
CAS Inombolo 171596-29-5
InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N
I-molecular Fi-ormula C22H19N3O4
I-molecular Weziyisishiyagalombili 389.4
IMisa ye-Monoisotopic I-389.138 g / mol
Ukuxuba Pi-oint  I-298-300 ° C
Fukuvuselela kabusha Pi-oint 2 ℃
I-Half Half-Life 17.5 amahora
Color I-White kuya ku-Cyrstalline e-Off-White Eqinile
Sukufaneleka  I-Soluble ku-DMSO (78 mg / ml ku-25 ° C), i-methanol, amanzi (<1 mg / ml ku-25 ° C), i-dichloromethane, ne-ethanol (<1 mg / ml ku-25 ° C)
Sukuhlushwa Tukushisa  Gcina ekamelweni lokushisa eliphakathi kuka-59 ° F no-86 ° F (15 ° C no-30 ° C). Ungayigcini le mithi ezindaweni ezimanzi noma ezimanzi.
Ti-adalafil Aukuphikisana Amaphilisi amancane ama-tadalafil amancane, i-candy yobulili, ikhofi yocansi, njll.

 

Incazelo

I-Tadalafil, (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6, I-3,4] i-pyrido [1,4-b] i-indole-5-dione (i-Cialis), uhlobo lwe-PDE5 inhibitor kanye nesidakamizwa esilawulwa ngomlomo. It is a b-carboline derivative and is a structably structured from vardenafil (Levitraw) and sildenafil (Viagraw), womabili angama-PDE171596 inhibitors asuselwa kusakhiwo se-pyrimidine esihlanganisiwe. I-Tadalafil powder (i-CAS 29-5-2003) inyusa ukugeleza kwegazi kungene ku-corpus cavernosum ngokuphumuza imisipha yemithambo yegazi, futhi lokhu kwenza indoda ikwazi ukufeza ukwakhiwa. I-Tadalafil powder yamukelwa yi-United States (US) i-Food and Drug Administration (i-FDA) e-XNUMX ekwelapheni ukungasebenzi kahle (i-ED), futhi yathengiswa emhlabeni wonke ngaphansi kwegama lomkhiqizo i-Cialis. Ibuye isetshenziselwe ukwelapha umfutho wegazi ophakeme wamaphaphu kanye ne-benign prostatic hyperplasia, okuyisimo lapho indlala ye-prostate ikhuliswa khona, idale izinkinga ngokuchama.

Isici esihlukanisayo se-Tadalafil se-pharmacologic yimpilo yaso ende (amahora ayi-17.5) uma kuqhathaniswa neViagra neLevitra (amahora angu-4-5). Lesi sigamu sempilo eside senza isikhathi eside sokwenza futhi, ngokwengxenye, sibhekene nesidlaliso seCialis "sephilisi lempelasonto." Lesi sigamu sempilo ende futhi siyisisekelo sophenyo lwamanje lokusetshenziswa kwe-tadalafil ku-pulmonary arterial hypertension njengokwelashwa okukodwa nsuku zonke.

Indlela Yokusebenza

Ukwakhiwa kwe-Penile ngesikhathi sokugqugquzela ngokocansi kutholakala ngokuphumula kwemithambo ye-penile ne-corpus cavernosal muscle smooth, okuholela ekwandiseni ukugeleza kwegazi ku-organ. Lokhu kuphumula kuvumela ukugeleza kwegazi okwandayo ngokusebenzisa imishanguzo ye-penile, kanti leli gciwane ligcwalisa amakamelo amabili ngaphakathi kwepenisi okuthiwa i-corpora cavernosa. Njengoba amakamelo agcwalisa igazi, ipeni likhula liqinile. Ukulungiswa kuqeda lapho inkontileka yemisipha kanye negazi eliqoqiwe lingadlulela emithanjeni ye-penile.

Le mpendulo iqondiswa ukukhishwa kwe-nitric oxide (NO) kuma-nerve terminals kanye nama-endothelial cell, avuselela ukuhlanganiswa kwe-cGMP kumaseli wemisipha abushelelezi bese ilawula ukunwebeka nokuncipha kwemithambo yegazi ethwala igazi liye nasesipondweni. I-cyclic GMP ibangela ukuphumula kwemisipha ebushelelezi nokwenyuka kokugeleza kwegazi kungene ku-corpus cavernosum, futhi kwehliswa uhlobo lwe-cGMP oluthile lwe-phosphodiesterase 5 (PDE5) ku-corpus cavernosum etholakala eduze kwepipi. I-Tadalafil ivimbela i-PDE5 futhi ngaleyo ndlela ithuthukise ngokwandisa inani le-cGMP etholakalayo. I-Tadalafil imisa i-PDE5 ekubhubhiseni i-cGMP bese inyusa i-cGMP etholakalayo yokufeza umsebenzi futhi ibangele ukwakhiwa ukuthi kuhlale isikhathi eside.

Kodwa-ke, njengoba isigamu sempilo yeTadalafil sifushane, umphumela wayo uyaphela phakathi nezinsuku ezimbili okwenza i-PDE2 ibuye futhi impilo yakho yezocansi - iye iba yimbi. Ungadinga ukuthatha isikhathi eside ukufeza umphumela owufunayo, njengamandla aphansi we-Cialis 5-4 izinsuku zezinsuku ze-5-4.

Isicelo

  • Ukungasebenzi kwe-Erectile (ED)
  • I-pulmonary arterial hypertension
  • Benign prostatic hyperplasia
  • I-Analgesic
  • I-blocker yokuthola i-Norepinephrine
  • I-Mu-opiod receptor agonist

Kunconywe i-Tadalafil powder Isilinganiso

I-Cialis iza ngamathebulethi aphuzi, ambozwe ifilimu nama-alimondi kuma-5, 10 no-20 milligram (mg) amanani. Isilinganiso sokuqala esinconywayo se-Cialis powder ukuze sisetshenziswe njengoba kudingeka ezigulini eziningi yi-10 mg, ethathwe ngaphambi kokwenza umsebenzi wezocansi obulindelekile.

Umthamo wokuqala yi-10 milligrams (mg) okungenani imizuzu engu-30 ngaphambi kocansi. Umthamo ungangena ku-20 mg noma wehla ku-5 mg, ngokusekelwe ekusebenzeni komuntu ngamunye nokubekezela. Kodwa, ukuphakama okungu-20 mg njengesilinganiso esisodwa. Ukuphakama okuphakanyisiwe okuphakanyisiwe kunesidingo ngosuku ngalunye ezigulini eziningi. akufanele kuthathe okungenani isilinganiso esisodwa kumahora we-24. Iziguli ezilindele ukuthi zisebenze ngokocansi okungenani kabili ngesonto zingathatha umthamo wansuku zonke we-5 mg, futhi lokhu kungancishiswa ku-2.5 mg kanye nsuku zonke, kuye ngokuphendula komuntu ngamunye.

I-Cialis powder yokusebenzisa njengoba kudingeka iboniswe ukuthuthukisa umsebenzi ngokuqhathaniswa ne-placebo kuze kube ngamahora we-36 kulandela i-dosing. Ngakho-ke, lapho ululeka iziguli ngokusetshenziswa kahle kwe-Cialis powder, lokhu kufanele kubhekwe.

Kuyaqapheleka ukuthi ukwakheka ngeke kwenzeke ngokuthatha iphilisi. Futhi ungathathi i-Cialis uma ungasebenzi kahle uma uthatha i-Adcirca ye-pulmonary arterial hypertension. Ngaphandle, iTadalafil yokungasebenzi kahle isetshenziswa kuphela ngabantu abadala abaneminyaka engu-18 nangaphezulu.

Izinzuzo

Powder I-Tadalafil powder ingasiza ukukhulula imisipha ku-prostate nasesinyeni sakho. Lokhu kungasiza ekuthuthukiseni izimpawu zakho ze-BPH.

Improve Ukwenza ngcono izimpawu ze-ED, i-tadalafil powder isiza ukukhuphula ukugeleza kwegazi kuye endondeni. Lokhu kungakusiza uthole futhi ugcine ukwakhiwa. Ukuze i-tadalafil powder ikusize ube nokwakhiwa, udinga ukuvuswa ngocansi.

♦ Ye-PAH, i-tadalafil powder isebenza ukuthuthukisa ikhono lakho lokuzivocavoca ngokuphumula imithambo yegazi emaphashini akho. Lokhu kwandisa ukugeleza kwegazi.

Okuqhamuka uma udla imishanguzo

Kanye nemiphumela yayo edingekayo, umuthi ungabangela ezinye izinto ezingafuneki. Nakuba kungeke kwenzeke zonke lezi zemihelo, uma kwenzeka kungenzeka badinga ukunakekelwa kwezokwelapha. Sicela uhlole imiphumela emibi elandelayo ye-tadalafil powder:

Imiphumela emibi evamile

▪ ikhanda

▪ uphazamise isisu

▪ ubuhlungu emuva

▪ ama-muscle aches

▪ ukuqhuma (isikhumba obomvu)

▪ impumu egcwele noma egijima

▪ isifo sohudo

Imiphumela emibi kakhulu kodwa embi kakhulu 

Ukwakhiwa okwesikhashana okungaholela ekulimazeni ipeni, izinkinga zombono, nokulahleka kokuzwa.

Uma lemiphumela iba mncane, ingahamba phakathi kwezinsuku ezimbalwa noma amasonto ambalwa. Uma behlukumezekile kakhulu noma bengayi kude, khuluma nodokotela wakho noma umuthi wemithi.

Abantu abanezimo ezilandelayo akufanele bathathe i-Cialis powder ngaphandle uma udokotela evuma:

Izinkinga zenhliziyo, i-angina, nanoma yiluphi uhlobo lwesifo senhliziyo

Umfutho wegazi ophakeme noma ophansi

Ukuhluleka kwenhliziyo ukuhlushwa noma ukushaywa phakathi kwezinyanga zokugcina ze-6, noma ukuhlukunyezwa kwe-myocardial phakathi nezinyanga zokugcina ze-3

I-sickle cell anemia, i-myeloma eminingi, i-hemophilia, i-leukemia, noma enye i-disorder blood

Isifo noma isifo sezinso

Isisu sesisu

Retinitis pigmentosa

Ukukhubazeka kwesakhiwo sowesilisa, njengesifo sikaPeyronie

Noma yisiphi isimo sempilo eseluleka ngaso ukuba angabi nobulili

Ukuxhumana kweTadalafil

Uma usebenzisa i-tadalafil, kungase kube nezinye izidakamizwa ezingathinta izidakamizwa, ezingabangela imiphumela emibi. Ukusebenzisana kwezidakamizwa kungashintsha ukuthi imithi yakho isebenza kanjani noma ukwandisa ingozi yemiphumela emibi kakhulu.

I-Talalafil inomphumela omuhle wokusebenzisana ekunciphiseni kwe-nitrate ekunciphiseni kwegazi. I-talalafil ingabangela ukwehla okukhulu kwegazi lakho uma kusetshenziselwa i-nitrate, okungaholela ekutheni isisu, ukuphelelwa amandla, nokungahle kwenzeke ukuhlasela kwenhliziyo noma isifo sohlangothi. Ungasebenzisi i-tadalafil nganoma yikuphi okulandelayo: izidakamizwa ezithile ezisetshenziselwa ukuphatha ubuhlungu besifuba / i-angina (i-nitrate njenge-nitroglycerin, i-isosorbide), izidakamizwa zokuzilibazisa ezibizwa ngokuthi "ama-poppers" aqukethe i-amyl noma i-nitrite ye-butyl.

Uma uthatha imithi ye-alpha blocker (njenge doxazosin, i-tamsulosin) yokwelapha i-prostate eyandisiwe / i-BPH noma i-high blood pressure, ingcindezi yakho yegazi ingase ibe phansi kakhulu okungase iholele ekuziphatheni komzimba noma ukuphelelwa amandla. Udokotela wakho angase aqale ukwelashwa nge-dose ephansi ye-tadalafil noma ulungise imithi yakho ye-alpha blocker ukuze unciphise ingozi yokucindezela kwegazi ephansi.

Ezifundweni zemitholampilo, amanani abalulekile okuphendula abikwa afinyelela ku-36 h kulandela ukumuncwa kwezidakamizwa. I-Tadalafil yenziwe kakhulu kusibindi esikhaleni yi-CYP3A4 ezintweni ezingasebenzi ngokumelene ne-PDE5 futhi yekwa ikakhulu njengama-metabolites emgodini nomchamo. I-pharmacokinetics ye-tadalafil ayithinteki yizici ezinjengokudla ukudla notshwala, ubudala, ukuba khona kwesifo sikashukela, kanye nokuntula okungatheni kwe-hepatic noma ngokulinganisela. Imicimbi ejwayelekile ehlobene nokusebenzisa izidakamizwa yikhanda, ubuhlungu emuva, i-dyspepsia, ne-myalgia. Kwi-10 ne-20 mg imithamo, i-Tadalafil ayinawo umthelela omkhulu ekucindezelweni kwegazi kanye nokushaya kwenhliziyo futhi ayiholeli ekwandeni kwezifo ze-myocardial infarction. Imibiko engafani yokuqalwa kwesikhathi eside kakhulu kune-4 h nokuqagela kuye kwaphawulwa ngokusetshenziswa kwe-tadalafil. I-Priapism, uma ingaphathwa kahle, ingahle ibangele ukulimala okungaphendukeki kwezicubu. Iziguli ezinomugqa ohlala mkhulu kune-4 h ziyelulekwa ukuba zifune usizo oluphuthumayo lwezokwelapha. Ezigulini ezinesifo sikashukela, ukuthuthukiswa kokusebenza kwe-tadalafil akunandaba uhlobo lwesifo sikashukela kanye nohlobo lokwelashwa kwesifo sikashukela.

Eminye imithi ingathinta ukususwa kwe-tadalafil emzimbeni wakho, okungase kuthinte indlela i-tadalafil esebenza ngayo. Izibonelo zifaka i-azole antifungals (njenge-itraconazole, i-ketoconazole), ama-antibiotic ama-macrolide (njenge-clarithromycin, i-erythromycin), i-HIV protease inhibitors (njenge-fosamprenavir, i-ritonavir), i-virus ye-hepatitis C inhibitors (i-boceprevir, telaprevir), i-rifampin, phakathi kwabanye .

Ungathathi lo muthi nanoma yimuphi omunye umkhiqizo oqukethe i-tadalafil noma eminye imishanguzo efanayo esetshenziselwa ukwelapha ukungasebenzi kahle kwe-hyp noma i-pulmonary hypertension (njenge-sildenafil, vardenafil).

Ngokuphathelene nokusebenzisana kwe-tadalafil nezinye izidakamizwa kusenokuningi, uma ufuna ukusebenzisa izidakamizwa nge-tadalafil powder (CAS 171596-29-5), khumbula ukubonana nodokotela wakho futhi uzokunika iseluleko esisebenzayo nesokwethenjelwa.

Ulwazi olunzulu

I-Tadalafil powder, i-sildenafil powder, ne-vardenafil powder konke kusebenza ngokuvimbela i-enzyme ye-PDE5, kepha lezi zidakamizwa zivimbela ama-enzyme we-PDE 6, 1, no-11 ngamazinga ahlukahlukene. Isibonelo, iSildenafil ne-vardenafil inhibit PDE6, i-enzyme etholakala esweni, ngaphezu kwe-tadalafil. Abanye abasebenzisi be-sildenafil babona i-bluish tinge futhi banokuzwela okuphezulu ekukhanyeni ngenxa yokuvinjelwa kwe-PDE6. Ngaphandle kwalokho, iSildenafil ne-vardenafil nazo zivimbela i-PDE1 ngaphezu kwe-tadalafil. I-PDE1 itholakala ebuchosheni, enhliziyweni, nasemisipha ebushelelezi yemisipha. Kucatshangwa ukuthi ukuvinjelwa kwe-PDE1 yi-sildenafil ne-vardenafil kuholela ekuvuselweni kwe-vasodilation, flushing, ne-tachycardia.

Uma kuqhathaniswa nokusebenza ku-PDE6 ne-PDE1, i-tadalafil yenza okuvelele ku-PDE11. I-PDE11 iboniswa emisipha yamathambo, i-prostate, isibindi, izinso, i-pituitary gland kanye nama-testes. Noma kunjalo, imiphumela emzimbeni wokuvimbela i-PDE11 aziwa.