I-Ganglioside GT1b (59247-13-1)

Mashi 15, 2020
SKU: 167933-07-5

Igama elithi Ganglioside laqala ukusetshenziswa ngusosayensi waseJalimane u-Ernst Klenk ngo-1942 kuma-lipids asanda kwehlukaniswa avela kumaseli e-ganglion yobuchopho… ..

 


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum

 

IGanglioside GT1b (59247-13-1) ividiyo

IGanglioside GT1b Siziqu

Igama Product IGanglioside GT1b
Igama leKhemikhali I-GANGLIOSIDE GT1B TRISODIUM SALT; I-GT1B 3NA; I-GT1B-GANGLIOSIDE; I-GT1B (NH4 + SALT); i-ganglioside, gt1; (ganglioside gt1B) kusuka ebuchosheni bezinkomo; i-trisialoganglioside-gt1b evela ebuchosheni bezinkomo; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; I-Trisialoganglioside GT1b (i-NH4 + usawoti)
CAS Inombolo 59247-13-1
InChIKey I-SDFCIPGOAFIMPG-VLTFPFDUSA-N
Formula Yamamolekhula C95H162N5Na3O47
isisindo Yamamolekhula I-2158.4 g / mol
IMisa ye-Monoisotopic I-2157.119189 g / mol
I-Melting Point N / A
Sithempeli le-torage -20 ° C
solubility I-DMSO: inyibilika
Isicelo Umuthi; chromatography;

 

Kuyini I-Ganglioside GT1b?

Igama elithi Ganglioside laqala ukusetshenziswa ngusosayensi waseJalimane u-Ernst Klenk ngo-1942 kuma-lipids asanda kwehlukaniswa avela kumaseli e-ganglion yobuchopho. Iyimolekyuli eyakhiwe ngama-glycosphingolipids (ama-ceramide nama-oligosaccharides) kanye ne-sialic acid eyodwa noma ngaphezulu exhunywe ochungechungeni lukashukela. Kuyingxenye yolwelwesi lwe-cytoplasmic olulawula imicimbi yokudluliswa kwesiginali yeselula. Izinhlobo ezingaphezu kwama-60 zama-gangliosides ziyaziwa, futhi umehluko omkhulu phakathi kwazo isikhundla nenombolo yezinsalela ze-NANA.

IGanglioside GT1b ingelinye lama-ganglioside amaningi futhi iyi-trisialic ganglioside enezinsalela ezimbili ze-sialic acid exhunywe kwiyunithi yangaphakathi ye-galactose. Kunomphumela ovimbelayo ekuphenduleni kokuzivikela komzimba okuhlekisayo. Ku-0.1-10 μM, ingavimbela ukukhiqizwa okuzenzakalelayo kwe-IgG, i-IgM ne-IgA ngamangqamuzana egazi e-peripheral egazi le-mononuclear. IGanglioside GT1b nayo iphakanyisiwe njenge-host cell receptor ye-Merkel cell polyoma virus futhi njengendlela ekwazi ukubangela izifo ezibanga iMerkel cell carcinoma.

IGanglioside GT1b nayo ibilokhu ifakwe emikhakheni eminingi yomdlavuza we-neuronal futhi kubhekwa njengeqembu lezigelekeqe elihlotshaniswa nama-metastases obuchopho. Ucwaningo luthole ukuthi i-GM1, GD1a, ne-GT1b inemiphumela emvimbelayo yokuqhamuka kwe-epermermal factor factor receptor signation and adhesion kanye nokufuduka kwe-keratinocyte, futhi ukuba khona kwayo kungenzeka kube i-biomarker ewusizo yokuhlola amandla we-brain metastatic.

IGanglioside GT1b nayo ithinta amasosha omzimba. IGanglioside GT1b inemiphumela evimbelayo ekuphenduleni kwamagciwane omzimba womuntu futhi ivimbela ama-immunoglobulin akhiqizwa ngamangqamuzana egazi e-mononuclear egazi lomuntu. Kunobufakazi bokuthi i-GD1b, i-GT1b, ne-GQ1b ingathuthukisa ukukhiqizwa kwama-cytokines we-Th1 ngokuvimbela ukusebenza kwe-adenylate cyclase, ngenkathi ivimbela ukukhiqizwa kwe-Th2.

Njenge-receptor ebona ubuthi obunhlobonhlobo besakhiwo sayo i-oligosaccharide, i-ganglioside GT1b iyi-receptor lapho uClostridium botulinum bacterium botulinum neurotoxin engena kumaseli wezinzwa. Ucwaningo luye lwabonisa ukuthi i-tetanus toxin ingena kumaseli wezinzwa ngokuxutshwa ne-GT1b namanye ama-gangliosides, ivimbela ukukhishwa kwama-neurotransmitters ohlelweni lwezinzwa oluphakathi, futhi ibangele ukukhubazeka kwe-spastic. Uhlobo lwe-botulinum C i-neurotoxin engena ku-nerve luphenye umphumela ongaba khona we-apoptotic wamaseli akhiqizwa yi-ganglioside GT1b ebopha i-neuroblastoma.

Ngaphezu kwalokho, i-ganglioside GT1b ilawula ukungahambi kahle kwamaseli, ukufakwa emzimbeni, nokubambelela ku-fibronectin (FN) ngokusebenzisana ngqo kwamangqamuzana ne-α5 subunit ye-α5β1 inclin, ukutholwa okungasetshenziswa ukuthuthukisa ukwelashwa komdlavuza. Ukuhlanganiswa kwe-GT1b ne-MAG ngaphezulu kwama-neurons kungalawula ukusebenzisana kwe-GT1b engxenyeni ye-plasma yama-neurons, okuholele ekuvimbeleni ukukhula kwe-neurite.

 

Izinzuzo ze-Ganglioside GT1b

IGanglioside GT1b iyi-acid glycosphingolipid eyakha ama-lipid rafts kumaseli we-neuronal wesistimu yezinzwa ephakathi futhi ibandakanyeka ekwandisweni kweseli, umehluko, ukunamathela, ukuguqulwa kwesiginali, ukuhlangana kwamaseli, iseli ne-metastasis.

Izimpendulo ze-autoimmune kuma-gangliosides zingaholela ku-Guillain-Barre syndrome. IGanglioside GT1b ikhuthaza ukonakala kwe-dopaminergic neuron, okungaba nomthelela ekuqaleni noma ekuthuthukiseni isifo sikaParkinson.

IGanglioside GT1b iyi-scavenger ye • radical yamahhala ye-OH, evikela ubuchopho ekulimaleni kwe-mtDNA, ekuthatheni kanye ne-lipid peroxidation ebangelwa ngabakhiqizi be-oksijini abasebenzayo.

Ama-Ehrlich tumors aveza i-ganglioside GT1b, futhi i-anti-GT1b inamandla amakhulu okwelapha kulo mdlavuza. Le ganglioside nayo ihlotshaniswa ne-Miller Fisher syndrome.

 

Imiphumela emibi ye I-Ganglioside GT1b

Ama-gangliosides angabopha kuma-lectins, asebenze njengama-immune and cell adhesion receptors, abambe iqhaza ekusayinisweni kwamaseli, i-carcinogeneis kanye nokwehluka kweseli, athinte ukwakheka kwe-placenta nokukhula kwezinzwa, abambe iqhaza ekuqineni kwe-myelin nasekuvuseleleni izinzwa, futhi enze njengamagciwane kanye nokungena kokufaka ubuthi kumaseli .

Ukuqongelelwa kwe-ganglioside GT1b kuxhunyaniswe nezifo eziningana kufaka phakathi isifo saseThailand-Sachs nesifo seSandhof

IGanglioside GT1b inqanda impendulo yokwanda kwe-antigen noma i-mitogen eyenziwe nge-T futhi ikhonjwe njenge-receptor ye-botulinum toxin, ubuthi obungajwayelekile obunemiphumela emibi yomzimba.

IGanglioside GT1b itholakala cishe kuphela kumaseli ezinzwa futhi ivezwa kwi-adventitia. I-GT1b ikhuthaza ukuhlukaniswa kwe-neuronal nokwakheka kwe-dendritic, okuveza isimilo esiyingozi futhi kuthuthukise i-hyperalgesia ne-allodynia.

IGanglioside GT1b ingathinta amasosha omzimba. Inomphumela ovimbelayo ekuphenduleni kwamagciwane omzimba womuntu futhi ivimbela i-immunoglobulin ekhiqizwa ngamangqamuzana egazi e-mononuclear egazi lomuntu.

Ngaphezu kwalokho, iGanglioside GT1b ihlobene nalezi zifo ezilandelayo: umkhuhlane, i-guillain – garré syndrome, ikholera, isifo sokuqina kwemisipha, i-botulism, uchoko nokukhuluphala ngokweqile.

 

Izikhombo:

  • U-Erickson, KD, uGarcea, RL, no-Tsai, uB. Ganglioside GT1b yisithasiselo esingesihle sokwamukela iseli seMerkel cell polyomavirus. Ijenali ye-Virology 83 (19), 10275-10279 (2009).
  • I-Kanda, N., neTamaki, K. Ganglioside GT1b icindezela ukukhiqizwa kwe-immunoglobulin ngamangqamuzana egazi omuntu wegazi eliphakeme. I-Immunology 96 (4), 628-633 (1999).
  • I-Schengrund, C.-L., DasGupta, BR, neRandler, NJ Ukubopha kwe-botulinum ne-tetanus neurotoxins kumagenge e-ganglioside GT1b nokuphuma kuyo. J. Neurochem. 57 (3), 1024-1032 (1991).
  • Ama-Gangliosides, ukwakheka, okwenzekayo, ibhayoloji kanye nokuhlaziywa ”. ILibid Library. I-American Oil Chemists 'Society. Kufakwe kungobo yomlando kusuka kokwangempela ngo-2009-12-17.
  • UNicole Gaude, Ijenali yeBiological Chemistry, Vol. 279: 33 maq. 34624-34630, 2004.
  • U-Elizabeth R Sturgill, uKazuhiro Aoki, uPablo HH Lopez, njll. I-Biosynthesis yama-gangliosides amakhulu obuchopho i-GD1a ne-GT1b. IGlycobiology, Umqulu 22, Issue 10, Okthoba 2012, Amakhasi 1289–