Ividiyo ye-NADP disodium salt (24292-60-2)
I-β-Nicotinamide adenine dinucleotide phosphate disodium salt (usawoti we-NADP disodium) Siziqu
| Igama Product | I-β-Nicotinamide adenine dinucleotide phosphate disodium salt (usawoti we-NADP disodium) |
| Igama leKhemikhali | I-NADP Disodium; Nadide phosphate disodium; I-NADP; β-NADP; I-Triphosphopyridine nucleotide disodium usawoti; |
| CAS Inombolo | 24292-60-2 |
| InChIKey | I-UNRRSQIQTVFDLS-WUEGHLCSSA-L |
| SMILE | C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+] |
| Formula Yamamolekhula | C21H26N7Na2O17P3 |
| isisindo Yamamolekhula | 787.37 |
| IMisa ye-Monoisotopic | I-787.039342 g / mol |
| I-Melting Point | I-175-178 ° C |
| Color | Yellow |
| Sithempeli le-torage | -20 ° C |
| Water solubility | > 50 g / L |
| Isicelo | I-Coenzyme ku-aerobic ne-anaerobic oxidations |
Uyini usawoti we-β-Nicotinamide adenine dinucleotide phosphate disodium (NADP disodium salt)?
INicotinamide adenine dinucleotide phosphate (NADP +) iyi-cofactor esetshenziswa ekuphenduleni kwe-anabolic. I-β-Nicotinamide adenine dinucleotide phosphate disodium usawoti ungusawoti we-disodium we-NADP +, yi-coenzyme edingekayo ekuvutsheni kotshwala kwe-glucose kanye ne-oxidative dehydrogenation yezinye izinto. Futhi kwenzeka kabanzi kwizicubu eziphilayo, ikakhulukazi esibindini.
I-Nicotinamide adenine dinucleotide phosphate (NADP) ne-NADPH bakha i-redox pair. Isilinganiso se-NADPH / NADP silawula amandla we-redox we-intracellular, ikakhulukazi impendulo ye-anaerobic, ngaleyo ndlela ithinte impendulo ye-metabolic emzimbeni. Izibonelo zingumbala we-lipid ne-nucleic acid. I-NADP futhi iyimbhangqwana ye-coenzyme ezinhlelweni ezahlukahlukene ze-cytochrome P450 kanye ne-oxidase / reductase reaction system efana ne-thioredoxin reductase / thioredoxin system.
I-NADPH ihlinzeka ngokunciphisa okufana nokuphendula kokuphilayo futhi inikeze imiphumela ye-redox ukuvikela ubuthi bezinhlobo ze-oksijini ezisebenzayo (i-ROS), ngaleyo ndlela iphinde ivuselele i-glutathione (GSH). Ibuye isetshenziswe ezindleleni ze-anabolic ezinjenge-cholesterol synthesis kanye nokunwebeka kwamafutha acid Chain.
Ngaphezu kwalokho, uhlelo lwe-NADPH lubhekele ukukhiqiza ama-radicals mahhala kumaseli omzimba nge-NADPH oxidase. Le radicals yamahhala isetshenziselwa ukucekela phansi ama-pathogen enqubo ebizwa ngokuthi ukuqhuma kokuphefumula. Kuyinto ecishe inciphise yomthombo we-cytochrome P450 hydroxylated aromatics, steroid, alcohols, nezidakamizwa.
Isicelo ka-β-Nicotinamide adenine dinucleotide phosphate disodium usawoti
I-Nicotinamide adenine dinucleotide phosphate (NADP) ne-NADPH bakha i-redox pair. I-NADP / NADPH iyi-coenzyme esekela ukusabela kwe-redox ngokuhanjiswa kwama-elekthronikhi ezinhlotsheni eziningi zezicelo, ikakhulukazi ukusabela kwe-anaerobic njenge-lipid ne-nucleic acid synthesis. I-NADP / NADPH ingumbhangqwana we-coenzyme ezinhlelweni ezahlukahlukene ze-cytochrome P450 kanye ne-oxidase / reductase reaction system, efana ne-thioredoxin reductase / thioredoxin system.
Amanye ama-enzyme asebenzisa i-NADP njenge-coenzyme yile: I-Alcohol dehydrogenase: I-NADP encike kuyo; I-Aromatic ADH: Ukuncika kwe-NADP; Ukudilizwa kabusha kweFendeoxin-NADP; I-L-Fucose dehydrogenase; Gabase; I-Galactose-1-phosphate uridyl yokudlulisa; I-glucose dehydrogenase; I-L-Glutamic dehydrogenase; I-Glycerol dehydrogenase: I-NADP ethile; Isocitric dehydrogenase; Ama-enzymes we-Malic; 5,10-Methylenetetrahydrofolate dehydrogenase; I-6-Phosphogluconate dehydrogenase ne-Succinic semialdehyde dehydrogenase.
Izikhombo:
- IHashida SN, Kawai-Yamada M. Inter-Organelle NAD Metabolism Ngaphansi Kokukhanya Kokuphendula Okuphendulayo Kwe-NADP kuZitshalo. I-Front Plant Sci. 2019 Jul 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
- UTak U, Vlach J, uGarza-Garcia A, uWilliam D, uDanilchanka O, de Carvalho LPS, uSaad JS, uNiederweis M. Isifo sofuba i-necrotizing toxin iyi-NAD + ne-NADP + glycohydrolase enezici ezihlukile ze-enzymatic.J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Dec 28. PMID: 30593509. PMCID: PMC6398120.
- I-Liang J, Huang H, i-Wang S. Distribution, i-Evolution, i-Catalytic Mechanism, kanye ne-Physiological Imisebenzi ye-Flavin-based Electron-Bifurcating NADH-Dependent Reedued Fosedoxin: NADP + Oxidoreductase. I-Front Microbiol. 2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
- UKawai S, uMurata K. "Ukwakheka nokusebenza kwe-NAD kinase ne-NADP phosphatase: ama-enzyme abalulekile alawula ibhalansi ye-intracellular ye-NAD (H) ne-NADP (H)". I-Bioscience, i-Biotechnology, ne-Biochemistry. 72 (4): 919-30. i-doi: 10.1271 / bbb.70738. I-PMID 18391451.
- UHanukoglu I. "Ukongiwa kwe-Enzyme-Coenzyme Interfaces ku-FAD naku-NADP Binding Adrenodoxin Reductase-A Enzyme Yonke indawo". Ijenali ye-Molecular Evolution. 85 (5-6): 205–218. I-Bibcode: 2017JMolE..85..205H. i-doi: 10.1007 / s00239-017-9821-9. PMID 29177972.
