I-N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

Mashi 11, 2020
SKU: 146-48-5

I-NACET (N-Acetylcysteine ​​ethyl ester) iyinhlangano ye-cysteine ​​evumelekile yeseli epophicic evunyelwe ngesici esingajwayelekile se-pharmacokinetic futhi ngokumangalisayo… ..


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum

Ividiyo ye-N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) ividiyo

Ukucaciswa kwe-NACET (59587-09-6)

Igama Product I-NACET (59587-09-6)
Igama leKhemikhali R) -ethyl 2-acetamido-3-mercaptopropanoate;
I-L-Cysteine, i-N-acetyl-, i-ethyl ester;
I-N-ACETYL-L-CYSTEINE ETHYL ESTER;
ethyl (2R) -2-acetamido-3-sulfanylpropanoate;
I-L-Cysteine, i-N-acetyl-, i-ethyl ester;
I-N-Acetylcysteine ​​ethylester;
CAS Inombolo 59587-09-6
InChIKey I-MSMRAGNKRYVTCX-LURJTMIESA-N
SMILE CCOC (= O) C (CS) NC (= O) C
Formula Yamamolekhula C7H13NO3S
isisindo Yamamolekhula 191.25
IMisa ye-Monoisotopic I-191.061614 g / mol
I-Melting Point I-44.1-44.5 ° C
ukubila Point 337.6 ± 32.0 ° C (Kubikezelwe)
Ubuningi 1.138 0.06 3 g / cmXNUMX (Kubikezelwe)
Color Ayisekho mhlophe
Isicelo Ama-Nootropics nezidakamizwa ezi-smart, zingasetshenziselwa ukukhulisa inkumbulo, ukugxila, ubuqambi, ubuhlakani nokukhuthaza. Ingasetshenziswa futhi njengesengezo sokudla.

Kuyini I-NACET(N-Acetylcysteine ​​ethyl ester)?

I-NACET (N-Acetylcysteine ​​ethyl ester) i-cyophine ye-cysteine ​​yesinodi evumelekayo yesitho esingenasici ngesici esingajwayelekile se-pharmacokinetic kanye ne-antioxidant emangalisayo. I-NACET ine-bioavailability ephezulu yomlomo. Ungumbhali oqinile we-antioxidant futhi ocebile we-GSH, okuhlobene ne-acid yayo yamahhala i-N-acetyl -L ehlukile kune--cysteine ​​(NAC). I-NACET yimpuphu emhlophe ekushiseni kwegumbi futhi inyibilika ngokukhululekile emanzini nasezinyibiliki zomzimba.

I-NAC isuselwa ku-cysteine. Kusukela ngawo-1970s, ibisetshenziselwa ukwelapha iziguli ezine-acetaminophen overdose kanye nokuphazamiseka kwemizwa, futhi ithengiswa njengomuthi kanye nokungezelela kokudla. Uma kuqhathaniswa ne-NAC, i-NACET ine-lipophilicity ephezulu kanye nezakhiwo zamakhemikhali ezenziwe ngcono kakhulu. Inamandla okufaka esikhundleni se-NAC ye-pharmacological, njenge-ejenti ye-mucolytic, antioxidant, umphakeli we-GSH, i-paracetamol antidote, futhi okungenani neDonor ye-gaseous transmitter H 2 S kanye ne-ejenti yokuvikela ye-UV.

Ngaphezu kwalokho, i-nucleophilicity enamandla nokunciphisa amandla we-NACET kuye kwafakazelwa nangamaseli abomvu egazi lomuntu. Kutholakale ukuthi kuqongelela amangqamuzana abomvu egazi lomuntu, ukumelana ngempumelelo nomonakalo we-oxidative obangelwe yi-hydroperoxides. Ngakho-ke, amandla we-NACET njenge-anti-nitrite-indased antioxidant akhulu kakhulu kunele-NAC methemoglobinemia namanye ama-oxidants aqinile. Ucwaningo kumagundwane lithole ukuthi i-NACET igxilwa ngokushesha kakhulu kune-NAC lapho i-NACET iphathwa ngomlomo. Iyakwazi ukungena kumaseli ikhiqize i-NAC ne-cysteine, ekhulisa i-hydrogen sulfide (H (2) S) ekujikelezeni kwegazi. Kuyinto enhle yokusebenzisa ukusetshenziswa komlomo njengomkhiqizi we-H (2) S,

Izinzuzo ze-NACET (I-N-Acetylcysteine ​​ethyl ester)

Njenge-antioxidant enamandla, i-NACET inezinzuzo ezinhle empilweni yabantu.

- Thuthukisa izimo eziningi zezempilo futhi unciphise izimpawu zokugula kwengqondo;

- Ukwelashwa kwe-acetaminophen overdoses, ukuvikela izinso nesibindi;

- Kuthuthukisa ukusebenza kwamaphaphu ngokunciphisa ukuvuvukala kanye nokwephuka kwe-mucus, ngaleyo ndlela kunciphise izifo ezingapheli zokuphefumula.

- Ukuthuthukisa impilo yobuchopho ngokulawula i-glutamate kanye nokungezelela i-glutathione, ingasetshenziswa ekwelapheni izifo ezifana nesifo i-Alzheimer's kanye nesifo sikaParkinson;

- Thuthukisa ukuzala kwabesilisa nabesifazane

- Kwangathi kungathuthukiswa umsebenzi wokuzivikela ezifweni eziningi, kuvikele ukulimala kwe-oxidative enhliziyweni, futhi kunciphise nengozi yesifo senhliziyo.

- Kwangathi Ungamisa Ushukela Wegazi Ngokunciphisa Ukuvuvukala Kumaseli E-Fat

Ukusebenza kwe-NAECT (I-N-Acetylcysteine ​​ethyl ester)

Ngoba i-NACET ikhombisile imiphumela emihle yokugula kwengqondo, izifo zokuphefumula ezingamahlalakhona kanye nokugula kwengqondo, kuvame ukusetshenziswa njengomuthi kanye nesengezo sokudla ukuvikela ubuchopho, ukuthuthukisa ukusebenza kwengqondo nomzimba, ukuze kuthuthukiswe inkumbulo, ukuqonda kanye nokusebenza kwezemidlalo.

Izikhombo:

  • I-Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): i-cysteine ​​esuselwa ku-lipstein yeseli evumelekile yeselula kanye nesici esingajwayelekile se-pharmacokinetic kanye ne-antioxidant emangalisayo. I-Biochem Pharmacol. 2012 Dec 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
  • I-S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) ne-N-acetyl-L-cysteine ​​ethyl ester (NACET) -I-Cysteine-based drug-based drug printer with a kipekee profiles of pharmacological for use oral as NO, H2S and GSH abahlinzeki kanye njengama-antioxidants: Imiphumela nokubuka konke. 2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Ukubuyekezwa. PMID: 29568662
  • I-N-acetylcysteine ​​ethyl ester njenge-GSH yokuthuthukisa kumaseli we-endothelial eyinhloko yabantu: Ucwaningo lokuqhathanisa nezinye izidakamizwa. I-2018 Oct; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
  • DimitriosTsikasa, uKathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. I-S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) ne-N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cysteine ​​esekwe izidakamizwa esekwe emaphrofayilini enamaphrofayili ehlukile ekhemisi asetshenziswa ngomlomo njengo-NO, H2S kanye nabahlinzeki be-GSH kanye njengama-antioxidants: Imiphumela nokubuka konke. Ijenali yokuhlaziywa kwemithi. UmQulu 8, Isikhalazo 1, Febhruwari 2018, amakhasi 1-9.