I-Nicotinamide riboside chloride (NR-CL) (23111-00-4) ividiyo
I-Nicotinamide riboside chloride (NR-CL) (23111-00-4) Siziqu
| Igama Product | I-Nicotinamide riboside chloride (NR-CL) (23111-00-4) |
| Igama leKhemikhali | I-NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; I-nicotinamide ribose chloride; 3-Carbamoyl-1- (β-D-ribofuranosyl) pyridinium chloride; 3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) i-pyridin-1-ium chloride; I-Nicotinamide BD Riboside Chloride (WX900111); I-NR-CL; |
| CAS Inombolo | 23111-00-4 |
| InChIKey | I-YABIFCKURFRPPO-IVOJBTPCSA-N |
| SMILE | C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-] |
| Formula Yamamolekhula | C11H15ClN2O5 |
| isisindo Yamamolekhula | 290.7002 |
| IMisa ye-Monoisotopic | I-290.066949 g / mol |
| I-Melting Point | N / A |
| Color | white |
| Sithempeli le-torage | -20 ° C I-Freezer |
| Isicelo | izithasiselo zokudla, insimu yezemithi |
Kuyini I-Nicotinamide riboside chloride(NR-CL)?
I-Nicotinamide riboside (NR) iyi-nicotinamide adenine dinucleotide (NAD +) yevithamini eyandulelayo yamuva nje. Uhlobo lwe-crystalline lwe-NR chloride lubizwa ngokuthi i-NIAGEN, okuyindlela yokwenza okwenziwe nge-nicotinamide riboside nomthombo lapho i-nicotinamide ngohlobo lwe-nicotinic acid ingatholakala khona nge-bioavaav futhi ibhekwa njengephephile (GRAS) ngokujwayelekile. I-NR chloride iyisihloko sezaziso ezimbili zokudla zokuthambisa, ezisetshenziswa ikakhulu kwizithasiselo zokudla.
INicotinamide Riboside Chloride iyisithako semvelo esitholakala obisini. Empeleni ihlobene ne-niacin nezinye izinhlobo zikavithamini B3. Olunye ucwaningo luthole ukuthi iNicotinamide Riboside Chloride inezici ezithile ezihlukile ezingakhulisa imetabolism yomuntu ukusiza ukushisa ama-calories amaningi nokuvikela ukuzuza kwesisindo. Ngaphezu kokwehla kwesisindo, kusiza futhi ukukhulisa ukusebenza kwemisipha, kwandise ukusetshenziswa kwamandla, futhi kunciphise izinto ezinobungozi zesifo sikashukela.
Futhi, ucwaningo kubantu luye lwabonisa ukuthi bobabili i-Nicotinamide Riboside Chloride iphakamisa amazinga e-NAD +, asiza ukujabulisa izimo ezithile ezihlobene nobudala, noma ngabe maduze nje ukwazi ukuthi kuzophumelela kangakanani.
Izinzuzo I-Nicotinamide riboside chloride(NR-CL)
I-Nicotinamide riboside chloride iyindlela yokwenziwa ye-nicotinamide riboside, izinzuzo zayo / umsebenzi wayo ufana ne-nicotinamide riboside. Ibamba iqhaza ekuguqulweni komzimba emzimbeni, ingasetshenziselwa ukuvimbela i-pellagra noma esinye isifo se-niacin defence kanye nokwehlisa i-cholesterol ne-triglycerides egazini. Ibuye isetshenziselwe ukwehlisa ingozi yokuhlaselwa yisifo senhliziyo kubantu abane-cholesterol ephezulu asebevele benesifo senhliziyo. Kwesinye isikhathi isetshenziselwa ukwelapha isifo semithambo yegazi (i-atherosclerosis), ukuvikela ubuchopho nesibindi (senhliziyo, isifo sikashukela, isifo i-Alzheimer's).
Ngaphandle kwalokho, i-Nicotinamide riboside chloride nayo inezinye izinzuzo kubantu:
- Ukugaya kahle nokufakwa kwamaprotheni namafutha;
- Siza ukuguqula i-troptophan ebalulekile ye-amino acid ibe yiacin;
- Yehlisa ukugabha, futhi unciphise imiphumela yokuthatha imishanguzo ngenxa yomlomo owomile nobunzima bokuchama;
- Khuthaza ukuhlangana kwe-nucleic acid futhi uvikele ukuguga kwezicubu nezitho zomzimba, ngaleyo ndlela kufezeke inhloso yokulibazisa ukuguga;
- I-Slow nocturnal muscle spasm, ukukhubazeka kwe-spastic kanye ne-neuritis yezandla neyezinyawo;
- Ukwelashwa kwe-hypometabolism ye -gengenic kanye nokuthuthukisa imetabolism;
- Ukuvimbela kanye nokwelashwa kokuntuleka kwe-Vitamin B6;
- Ukwelashwa kwe-carpal tun tun syndrome;
- Isiza ukunciphisa umzimba futhi iqinise ukusebenza kwemisipha.
- Thuthukisa ukumelana komzimba namaseli womdlavuza
- Vimbela ukulahleka kwezindlebe
- Ingabe i-diuretic yemvelo.
- Ukuthatha imithamo emikhulu kungakhulula umlutha wezidakamizwa futhi kube nomphumela omuhle wokudedelwa.
- Ukwenza ngcono ukusebenza kwamaseli we-epidermal, kanye nemisebenzi yamanye amaseli emzimbeni womuntu, ukugcina isikhumba siqhakaza.
I-Nicotinamide riboside chloride(NR-CL) ukusetshenziswa
Ngoba iNicotinamide riboside chloride inezakhi zemithi ezinenzuzo, ijwayele ukusetshenziselwa izithako zokudla, umuthi kanye nensimu yokudla.
Izikhombo:
- UConze D, uBrenner C, uKruger CL. Ezokuphepha kanye ne-Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in Clomical Clinical Agency Of Healthy Overweight Adult, Blindinamide Riboside Chloride). I-Sci Rep. 2019 Jul 5; 9 (1): 9772. doi: 10.1038 / s41598-019-46120-z. PMID: 31278280 PMCID: PMC6611812.
- UBogan, KL, uBrenner, C. (2008). "I-Nicotinic acid, i-nicotinamide, ne-nicotinamide riboside: ukuhlolwa kwamangqamuzana ama-NAD + amavithamini angaphambi kokudla komuntu". U-Annu. UMfu Nutr. 28: 115-130. i-doi: 10.1146 / annurev.nutr.28.061807.155443. I-PMID 18429699.
- UChi Y, uSauve AA (Novemba 2013). "I-Nicotinamide riboside, isakhi somsoco ekudleni, i-vitamin B3 enemiphumela kumandla we-metabolism kanye ne-neuroprotection". ICurr Opin Clin Nutr Metab Ukunakekelwa. 16 (6): 657-61. i-doi: 10.1097 / MCO.0b013e32836510c0. I-PMID 24071780.
