I-Ursodeoxycholic acid (UDCA) powder

I-Ursodeoxycholic Acid Powder (128-13-2) Imininingwane

Igama Product	I-Ursodeoxycholic acid
Igama leKhemikhali	(R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
I-synonym	I-UDCA; Ursodiol; i-Tauroursodiol, i-Urosodeoxycholic Acid; Ursodeoxycholic acid (micronized); I-URSODEOXYCHOLIC ACID; I-URSODESOXYCHOLIC ACID; I-URSODEOXYCHOLOC ACID;
CAS Inombolo	128-13-2
InChIKey	RUDATBOHQWOJDD-UZVSRGJWSA-N
I-molecular Fi-ormula	C24H40O4
I-molecular Weziyisishiyagalombili	392.57
IMisa ye-Monoisotopic	392.29265975
I-Melting Point	203-204 °C (okhanyisiwe)
Ukubilisa Pi-oint	I-437.26 ° C (ukulinganisa okulinganiselwe)
Ubuningi	0.9985 (isilinganiso esinzima)
Color	Okumhlophe - cishe kumhlophe
solubility	i-ethanol: 50 mg/mL, ecacile
Storage Tukushisa	I-2-8 ° C
Isicelo	I-Ursodeoxycholic acid (UDCS) iyisivikeli seseli esetshenziswa kakhulu ekwelapheni izifo zesibindi kanye ne-biliary. I-Ursodeoxycholic acid ingase isetshenziselwe ukutadisha imisebenzi yayo ethile esukela ekwehliseni ukumuncwa kwe-cholesterol, ukuchithwa kwe-cholesterol enyongweni kuye ekucindezelweni kokusabela komzimba.
Umbiko Wokuhlola	Iyatholakala

 

I-Ursodeoxycholic acid (UDCA), eyaziwa nangokuthi i-Ursodiol, iyi-asidi ye-bile ekhishelwa kujusi ye-bile. Yaqala ukutholwa enyongweni yamabhere. Nakuba ingeyona i-bile acid enkulu kubantu, kutholakale ukuthi inezinto ezibalulekile zokwelapha. Umlando wokusetshenziswa kwe-UDCA kubantu ungalandelelwa kusukela ezikhathini zasendulo eShayina.

 

Njengamanje, i-UDCA yangaphandle isetshenziswa emhlabeni wonke ukwelapha nokuphatha izimo ezahlukahlukene ze-hepatobiliary, njengezifo ze-gallstone (cholelithiasis), i-primary biliary cholangitis, kanye ne-primary sclerosing cholangitis.

Kungani udinga ukuthatha i-ursodeoxycholic acid (urodiol)?

I-Ursodeoxycholic acid (ursodiol) isiza ukuvikela ama-hepatocyte nama-cholangiocyte futhi ivimbele noma yimuphi omunye umonakalo kuwo. I-UDCA powder nayo iboniswe ukuthuthukisa ukusinda okuphelele kweziguli ezimweni ezihlukahlukene ze-hepatobiliary.

 

Iyini i-Ursodeoxycholic Acid(UDCA) Powder?

Njengoba kushiwo ngenhla, i-Ursodeoxycholic acid powder iyindlela yokwenziwa ye-UDCA esetshenziselwa ukwelapha iziguli ezibhekene nezimo ezihlukahlukene ze-hepatobiliary. I-Ursodeoxycholic acid powder itholakale iphumelela ku-Primary Biliary Cirrhosis futhi iboniswe ukuthuthukisa ukusinda kweziguli. Ukuze uthole i-Ursodeoxycholic acid powder engcono kakhulu futhi uthole intengo enhle, mhlawumbe udinga ukuthenga i-Ursodeoxycholic acid powder wholesale.

 

Izakhiwo ze-Physicochemical of Ursodeoxycholic Acid

I-UDCA (3α, 7β-dihydroxy5β-cholanoic acid) iyi-bile acid yesibili. Yakheka ngemuva kwesenzo se-enzymatic sama-microorganisms amathumbu kuma-acid ayisisekelo e-bile. Ama-acid e-bile ayisisekelo nawo akhiwa ngenxa yokusabela kwe-enzymatic hydroxylation ye-cholesterol.

I-UDCA powder iboniswe ukuthi inezici ze-hepato-protective. Imvamisa, iningi lama-acid ayisisekelo nesesibili akhiqizwa yi-hydrophobic. Ngakolunye uhlangothi, i-Ursodeoxycholic acid powderis hydrophilic futhi yehlisa umonakalo we-oxidative obangelwa ama-hydrophobic acid. Impahla ye-hydrophilic ye-Ursodeoxycholic acid powder iyisisekelo sokwelashwa kwe-UDCA ngomlomo, okulula futhi okulula.

Ngemva kokuthatha i-UDCA yangaphandle ngomlomo, ukumuncwa kwenzeka ngokuyinhloko emathunjini amancane ngokusakazwa okungeyona i-ionic okungenzi lutho. I-UDCA ibe isihlukaniswa ku-proximal jejunum ngenkathi ihlangana nama-micelles e-endogenous bile acids. Ngemuva kokungena kwayo esibindini, ukuhlanganiswa kwe-UDCA kwenzeka. I-UDCA ibe isihlanganiswa ne-glycine futhi ibe sezingeni elincane nge-taurine. Ngemuva kwalokho ikhiqizwa ku-bile nge-enterohepatic circulation.

Ama-conjugates e-Ursodeoxycholic acid akhiwe kanjalo amuncwa ikakhulukazi e-distal ileum. I-Nonabsorbed UDCA idlulela kukholoni futhi iguqulwa ngamabhaktheriya amathumbu abe yi-lithocholic acid. I-Lithopolis acid ayincibiliki futhi ikhishwa endle. Ingxenye encane ye-lithocholic acid iyamuncwa. Khona-ke i-sulfate esibindini, ikhishelwa enyongweni, futhi ekugcineni ikhishwe endle.

 

I-Ursodeoxycholic Acid/Ursodiol Powder Mechanism of Action

I-Ursodeoxycholic acid powder ibonise ukuthi inezindlela eziningi zokwenza, futhi kusekhona izindlela ezisacwaningwayo.

I-Ursodeoxycholic acid powder ibonise ukuthi iwusizo kakhulu ekuvikeleni ukulimala kwe-cholangiocyte emiphumeleni enobuthi ye-bile acids, ukugqugquzela ukukhishwa kwe-biliary okuphazamisekile ngaphambili, ukugqugquzela inqubo yokukhishwa kwe-detoxification ngokumelene ne-hydrophobic bile acids, noma ukuvinjelwa kwe-apoptosis, okungukuthi, i-self-medicated cell cell. ukufa kwama-hepatocytes.

Namanje akukaqondwa kahle ukuthi iyiphi kulezi zindlela ezibhekele ikakhulukazi imiphumela enenzuzo ye-UDCA. Ngaphandle kwalokho, izinga lenzuzo evela ku-UDCA nalo lincike esimweni esithile somuntu kanye nesigaba sesifo.

 

Yimiphi Imithombo Eyinhloko ye-Ursodeoxycholic acid powder Emakethe?

Nakuba abantu bekhiqiza i-UDCA, iphansi kakhulu kunamanye ama-bile acid akhiqizwayo. Ngakho-ke, okunye ukusesha kusaqhubeka. Kuze kube manje, ukukhiqizwa kwe-ursodeoxycholic acid powder kumabhere kube ngamanani abalulekile.

Njengoba kunemithelela yamalungelo ezilwane kanye nengozi yokuzingela ngokungemthetho, eminye imithombo iyabhekwa. Phakathi kwabo, i-bovine UDCA powder ibonise imiphumela emihle. Eminye imithombo efana nemvubelo ne-algae nayo iyabhekwa. Ukukhiqizwa kokwenziwa kwe-UDCA kusuka kuma-molecule andulelayo nakho kunentshisekelo enkulu. Nokho, kucatshangelwa nemiphumela yezindleko. Intuthuko yakamuva endaweni ibheka imithombo yezitshalo njengenye indlela. Kunezinto eziningi zokwenziwa ze-ursodeoxycholic acid powder ezithengiswayo, thola umthombo wangempela we-ursodeoxycholic acid powder supplier, udinga ukunaka kakhulu. Futhi izithako ze-ursodeoxycholic acid ziyatholakala kulayini.

 

Izinzuzo kanye Nemiphumela Ye-Ursodeoxycholic Acid Powder

Yiziphi izinzuzo ze-ursodeoxycholic acid? I-UDCA powder ibonise ukuthuthukiswa okuphawulekayo futhi inqunyelwe ezimweni ezihlukahlukene ze-hepatobiliary. Isetshenziselwa ukwelapha nokuphatha izimo ezihlukahlukene ze-hepatobiliary, njengezifo ze-gallstone (cholelithiasis), i-primary biliary cholangitis, kanye ne-primary sclerosing cholangitis.

Kuye kwaboniswa ukuthi kunomthelela omuhle ekulawuleni amasosha omzimba, ukwehlisa i-cholesterol, ukuqothula amatshe e-gallbladder, ukuvikela isibindi, nokwehlisa amazinga e-lipids egazi ukubiza ezimbalwa. Nakuba indlela okuyiyona yona i-UDCA eyenza ngayo lokho kuseyindawo yocwaningo, izindlela ezaziwayo sezixoxiwe ngazo ngenhla.

 

Iyini i-Ursodeoxycholic acid powder Isetshenziselwa?

I-Ursodeoxycholic acid (i-ursodiol) isetshenziswa kakhulu futhi kakhulu ekwelashweni okuhlukahlukene kwesibindi kanye ne-bile ducts. Kodwa-ke, ukusetshenziswa kwayo akugcini nje ezimweni ze-hepatobiliary per se. Phakathi neminyaka yocwaningo olunamandla, umthelela omuhle we-UDCA ekwelapheni izimo ezihlukahlukene ufakazelwe. Lokhu kuhlanganisa ukuncibilikisa amatshe enyongo kanye nokuvimbela nokwelapha i-cholesterol enyongweni. I-UDCA powder iphinde isetshenziswe njenge-anionic detergent yocwaningo lwamakhemikhali, i-anti-cholelithiasis ejenti, i-anticonvulsant, ne-cytoprotective agent. Okunye ukusetshenziswa kwe-ursodeoxycholic acid powder kuseyindawo enentshisekelo ocwaningweni oluhlukahlukene oluqhubekayo nokuhlolwa kwemitholampilo.

 

Ungayithatha kanjani i-Ursodeoxycholic Acid Powder?

Isengezo se-Ursodeoxycholic acid ngokuvamile asithengiswa phezu kwekhawunta futhi, isikhathi esiningi sidinga incwadi kadokotela. Ngaphambi kokusebenzisa i-UDCA, kubalulekile ukuxoxa nodokotela wakho ngengozi engaba khona ngokumelene nenzuzo. Udokotela uzovame ukuxoxa ngemigqa yomlando wezokwelapha, ikakhulukazi izifo ze-hepatobiliary kanye nomlando wokungezwani komzimba. Noma i-UDCA isetshenziselwa izifo ze-hepatobiliary, kunezinye izifo ze-hepatobiliary lapho kufanele kuqashelwe khona.

Ngakho-ke, ingxoxo ebanzi nodokotela ibaluleke kakhulu futhi ikakhulukazi uma unomlando wezokwelapha owedlule eduze komugqa we-ascites (ukunqwabelana koketshezi emgodini we-peritoneal), i-varice yokopha (imithambo ekhulisa futhi yopha), i-hepatic encephalopathy (ubuchopho). i-pathology ngenxa yokwehluleka kwesibindi), ukulimala kwesibindi esikhathini esidlule, ukufakelwa kwesibindi, ukuvinjelwa kokuphuma kwe-biliary tract, izinkinga ze-biliary tract, kanye ne-pancreatitis.

Lapho zonke izingxoxo zingabonisi ubungozi obubalulekile, i-UDCA ivamise ukubekwa ngale ndlela elandelayo:

 

Ngesifo se-gallstone:

Abantu abadala kanye nezingane ezineminyaka engu-12 nangaphezulu—Umthamo we-ursodeoxycholic acid uvame ukuba amamiligremu angu-8 kuya kwangu-10 (mg) ngekhilogremu (kg) yesisindo somzimba ngosuku, ihlukaniswe imithamo emibili noma emithathu.

Izingane ezingaphansi kweminyaka engu-12 ubudala-Lokhu ngokuvamile kunqunywa udokotela.

 

Okwe-primary biliary cirrhosis:

Abantu Abadala—Umthamo uvame ukuba yi-13 kuya ku-15 milligrams (mg) ngekhilogremu (kg) yesisindo somzimba ngosuku, ihlukaniswe ngemithamo emibili kuya kwemine. Udokotela wakho angase alungise umthamo wakho njengoba kudingeka.

Izingane— Lokhu ngokuvamile kunqunywa udokotela

 

Ukuvimbela ama-gallstones ngesikhathi sokulahlekelwa isisindo ngokushesha:

Abantu Abadala—Isilinganiso se-ursodeoxycholic acid ngokuvamile singama-milligrams (mg) angu-300 izikhathi ezimbili ngosuku.

Izingane ezingaphansi kweminyaka engu-12 ubudala- Lokhu ngokuvamile kunqunywa udokotela.

Esikhathini esiningi, uma umthamo owodwa weqiwe, kunconywa ukuthatha umthamo ophuthelwe ngokushesha ngangokunokwenzeka uma isikhathi esisuka kumthamo wokugcina besingekho amahora ama-4. Ngemithamo eminingi egejiwe, ukubonisana nodokotela kuyadingeka.

I-UDCA kufanele ithathwe ngokuhambisana nencwadi kadokotela. Esimeni se-overdose, mancane amathuba okuthi umthamo owodwa owengeziwe udale umonakalo. Kodwa-ke, uma kwenzeka kune-overdose ephawulekayo, kungcono ukuthintana nodokotela wakho noma uvakashele isibhedlela esiseduze.

Njengayo yonke imithi, kuhlale kunomphumela ongemuhle ngezinga elithile. Kungcono ukuthintana nodokotela wakho noma isibhedlela esiseduze uma kukhona noma yimiphi imiphumela emibi elandelayo ye-ursodeoxycholic acid ibonakala:

 

Izimpawu ezijwayelekile

Ubuhlungu besinye, umchamo onegazi noma oguqubele, ukuchama okushisayo noma okubuhlungu, isiyezi, ukushaya kwenhliziyo okusheshayo, ukulangazelela ukuchama njalo, ukungagayeki kahle, ubuhlungu eqolo noma ohlangothini, isicanucanu esinamandla, ukuqubuka kwesikhumba noma ukulunywa wonke umzimba, ubuhlungu besisu, ukuhlanza, ukuphelelwa amandla.

 

Izimpawu ezivamile

Indle emnyama nephuzile, ubuhlungu besifuba, amakhaza noma imfiva, ukukhwehlela, ukukhomba amabala abomvu esikhumbeni, ubuhlungu obukhulu noma obuqhubekayo besisu, umphimbo obuhlungu noma izindlala ezivuvukele, izilonda noma izilonda noma amabala amhlophe ezindebeni noma emlonyeni, ukopha okungajwayelekile noma imihuzuko, ukukhathala okungajwayelekile noma ubuthakathaka.

Ukukhululwa okuvamile kwezimpawu kuye kwaboniswa ukuthi kubonakale phakathi kwamasonto angu-3-6 okuqala ukwelashwa nge-UDCA powder. Ubude besikhathi sokwelashwa buhluka kumuntu ngamunye. Udokotela ochazayo uhlola isimo ngezikhathi ezithile. Ngakho-ke, ukulandelela ngesikhathi kubalulekile. I-Ursodeoxycholic acid powder itholakale iphephile kubantu abaye bayithatha ngokuqhubekayo kuze kufike ezinyangeni ze-6 ngisho nakubantu abayithathile izinyanga ze-48. Ngakho-ke, kuphephile ukusho ukuthi i-UDCA powder iphephile ukusetshenziswa isikhathi eside, inqobo nje uma kukhona ukulandelwa okufika ngesikhathi kanye nokuhlolwa kokusebenza kwesibindi okuvamile kwenziwa ngesikhathi.

 

Imuphi Umuthi Ongcono Kakhulu Wezifo Zesibindi?

Alikho ikhambi elingcono kakhulu eliphelele noma umbuso wokudubula owodwa wazo zonke izifo zesibindi. I-Ursodeoxycholic acid powder, nokho, iyasiza futhi ayikhawulelwe ezimeni ezahlukahlukene ze-hepatobiliary, njengezifo ze-gallstone (cholelithiasis), i-primary biliary cholangitis, kanye ne-primary sclerosing cholangitis.

 

Ngingathatha I-Ursodiol/Ursodeoxycholic Acid Neminye Imithi?

I-UDCA iyisidakamizwa esiphephile uma kuqhathaniswa. Kodwa-ke, ukuqapha kufanele kusetshenziswe uma noma yimiphi eminye imithi equkethe i-cholestyramine, i-colestimide, i-colestipol, i-aluminium hydroxide, ne-smectite ithathwa kanye ne-UDCA ngoba i-UDCA yokumuncwa iphazamiseka kuzo. Ukusebenzisana kwezidakamizwa ze-metabolic nezinhlanganisela ezenziwe nge-cytochrome P4503A kubonakala kanye nezinye izidakamizwa ezifana ne-cyclosporin, i-nitrendipine, ne-dapsone.

 

Ingabe i-Ursodeoxycholic Acid Powder Ilungele Isibindi?

I-Ursodeoxycholic Acid Powder iyinhle kakhulu esibindini ngenxa yezenzo zayo zokuvikela kuma-cholangiocytes nama-hepatocyte, isivikelo ekulimaleni emiphumeleni enobuthi ye-bile acid, ukugqugquzelwa kwe-biliary secretion, nokugqugquzelwa kwenqubo yokukhipha ubuthi ngokumelene ne-hydrophobic bile acid kanye nokuvinjwa kwe-apoptosis, okungukuthi. , ukufa kwamangqamuzana egazi lama-hepatocyte.

I-UDCA noma i-Udiliv(igama lezentengiso) nayo isetshenziselwe ukuphatha isifo sesibindi esinamafutha, ikakhulukazi i-non-alcoholic steatohepatitis(NASH), ngemiphumela emihle kakhulu. Kodwa-ke, ucwaningo olwengeziwe nokuhlaziywa kwe-meta kuyadingeka ukuze kuqinisekiswe ngokuphelele.

 

Uyini Umehluko Phakathi Kwe-Ursodeoxycholic Acid(UDCA) Ne-Chenodeoxycholic Acid(CDCA)?

I-UDCA ne-CDCA zombili zingama-bile acid. Kubantu, kokubili i-UDCA ne-Chenodeoxycholic Acid (CDCA) ikhiqizwa. Kodwa-ke, i-CDCA ikhiqizwa ngamanani amakhulu kakhulu. Kokubili i-UDCA ne-CDCA ziyimikhiqizo ehlukanisa i-cholesterol, okokuqala. I-CDCA iyi-asidi eyinhloko ye-bile, okungukuthi, ikhiqizwa isibindi isuka ku-cholesterol, kanti i-UDCA ikhiqizwa ngenxa yokuwohloka kwe-enzymatic ngamabhaktheriya emathunjini.

Ngakho-ke, esimweni sesifo se-gallstone, i-Ursodeoxycholic Acid (UDCA) yayisebenza ngokuphawulekayo kune-CDCA kuzo zombili izilinganiso eziphansi neziphakeme.

 

Thenga I-Ursodeoxycholic Acid impushana enkulu? | kuphi ukuthola okungcono kakhulu I-Ursodeoxycholic Acid umenzi wempuphu?

I-Ursodeoxycholic acid powder bulk ingathengwa ku-inthanethi ngokusebenzisa amawebhusayithi ahlukahlukene. Nokho, udinga ukuqaphela mayelana nobuqiniso kanye nekhwalithi yomkhiqizo. Ukuhlolwa okuningiliziwe kwezithako ezisebenzayo kanye nokugxila kufanele kwenziwe kuqala. I-Phcoker ingumkhiqizi ongcono kakhulu we-ursodeoxycholic acid powder.

 

I-Ursodeoxycholic Acid: I-Ultimate FAQ Guide

Ingabe i-ursodiol isebenza ngempela?

Yebo. I-Ursodiol ibonise ukuthi iyasebenza ekwelapheni izimo ezihlukahlukene ze-hepatobiliary, inqobo nje uma kutholakala ukuxilongwa kusenesikhathi, futhi ukwelashwa kuqalwa kusenesikhathi.

 

Yimuphi umuthi oncibilikisa udaka lwe-gallbladder?

I-UDCA powder iye yafakazelwa ukuthi iyasebenza ekuqedeni udaka lwe-gallbladder.

 

Ingabe i-ursodiol ingabangela ukuzuza kwesisindo?

I-UDCA powder ingabangela ukuzuza kwesisindo, ikakhulukazi ezinyangeni zokuqala ze-12 zokwelashwa.

 

Ingabe i-ursodiol ne-steroid?

I-steroids iyingxenye yezinhlobo ezahlukene. Kokubili ama-steroid nama-bile acid ahlanganiswa noma ayimikhiqizo ye-metabolic ye-cholesterol. Ezinye izifundo zibonise imvelo efana ne-steroid ye-bile acid ekulawuleni imisebenzi yansuku zonke yomzimba. Nokho, ucwaningo olwengeziwe kulo mkhakha luyadingeka ukuze kube nobufakazi obuqand' ikhanda.

 

Ingabe i-ursodiol iyi-immunosuppressant?

I-UDCA itholwe inezindawo ezithile zokuzivikela komzimba.

 

Ingabe i-ursodiol iyehlisa i-bile acid?

I-UDCA ibonise ukuthi iyasebenza ekukhuthazeni ukuxoshwa komzimba ngokumelene nama-hydrophobic acid. I-Ursodeoxycholic acid powder nayo iboniswe ukunciphisa i-hydrophobic acid. Nokho, ucwaningo olwengeziwe lusadingeka.

 

Ingabe i-ursodiol ithuthukisa ama-enzyme esibindi?

I-UDCA ifakazelwe ukuthi iyasebenza ekuthuthukiseni ama-enzyme esibindi kuma-pathologies ahlukahlukene wesibindi.

 

I-ursodeoxycholic acid powder kuhle izinso?

Ucwaningo olwenziwe ngamagundane aluzange lubonise ukulimala nge-UDCA powder. Nokho, ucwaningo olunzulu ngabantu lusaqhubeka.

 

Ingabe i-ursodiol ingasiza isibindi esinamafutha?

I-UDCA inenzuzo esibindini esinamafutha. Nokho, izivivinyo eziklanywe ngokucophelela zisaqhubeka ngesihloko esifanayo.

 

Ingabe i-ursodiol yehlisa i-triglycerides?

I-UDCA itholwe ukuthi yehlisa i-Low-density lipoproteins (LDL) kanye ne-Voly Low-Density Lipoproteins (VLDL). Kodwa-ke, izinga le-triglyceride eliphelele alikho izinguquko ezibalulekile ezilandela ukwelashwa nge-UDCA powder.

 

Ingabe ikhona enye indlela ye-ursodiol?

Kukhona enye indlela yokwelapha ku-UDCA. Kodwa-ke, ukusebenza ngempumelelo kanye nempumelelo yalawo ma-ejenti kube yinkulumo-mpikiswano. Ukubonisana nodokotela mayelana nendlela kanye nokuthi yini ekulungele kakhulu kungaba usizo.

 

Ingabe i-ursocol iyi-antibiotic?

Cha, i-ursocol ayiwona ama-antibiotic. Kuyisidakamizwa esinemisebenzi ehlukahlukene kodwa ngokuyinhloko sivikela ama-hepatocyte futhi sisiza ekuqhekekeni kwamatshe enyongo.

 

Ingabe i-cholestasis yisifo sesibindi?

I-Cholestasis isho nje ukuthi i-bile iyeka ukugeleza eduze kwesihlahla se-biliary noma ukugeleza kuhamba kancane. Lokhu kuvinjelwa kokugeleza kwe-bile kungabangela ukulimala kwesibindi nesifo.

 

Isebenza kanjani i-ursodeoxycholic acid?

I-UDCA iyasebenza ekwelapheni izifo ezahlukahlukene ze-hepatobiliary kanye nezinye izimo.

 

Hlobo luni lomuthi i-ursodiol?

I-UDCA iyi-asidi yesibili ye-bile. Kuwusizo kakhulu ekuvikeleni ukulimala kwe-cholangiocyte emiphumeleni enobuthi ye-bile acids, ukugqugquzela ukukhishwa kwe-biliary okungasebenzi kahle ngaphambili, ukugqugquzela enqubweni yokukhishwa kwe-detoxification ngokumelene ne-hydrophobic bile acids, noma ukuvinjelwa kwe-apoptosis okungukuthi, ukufa kwe-cell self-medicated of hepatocytes.

 

Ingabe i-ursodiol yehlisa i-cholesterol?

Ucwaningo lubonisa ukuthi i-Ursodeoxycholic acid powder inganciphisa amazinga e-cholesterol.

 

Ingabe i-ursodiol ingadala i-pancreatitis?

I-pancreatitis esebenzisa i-UDCA ayijwayelekile. I-UDCA isetshenziselwe ukwelapha i-pancreatitis.

 

Ingabe i-ursodiol ikwenza ulale?

Ukukhathala nokuba buthaka kuphakathi kwemiphumela engemihle emincane engajwayelekile ye-UDCA.

 

Okubhekwayo

1. Ukusetshenziswa kwe-ursodeoxycholic acid ezifweni zesibindi. D Kumar, RK Tandon.J Gastroenterol Hepatol. 2001 Jan;16(1):3-14. doi: 10.1046/j.1440-1746.2001.02376.x.PMID: 11206313

2. I-Ursodeoxycholic acid kusifo sesibindi se-cholestatic: izindlela zesenzo kanye nokusetshenziswa kokwelapha kubuyekeziwe.Gustav Paumgartner , Ulrich Beuers.PMID: 12198643 DOI: 10.1053/jhep.2002.36088 Hepatology. 2002 Sep;36(3):525-31.

3. Izindlela zokwenza kanye nempumelelo yokwelapha ye-ursodeoxycholic acid ku-cholestatic isifo sesibindi.Gustav Paumgartner, Ulrich Beuers.PMID: 15062194 DOI: 10.1016/S1089-3261 (03) Clinlin Disc. 00135 Feb;1(2004):8-1, vi.

4. Uhlolojikelele lwe-Bile Acids Signaling kanye Nombono Kusiginali ye-Ursodeoxycholic Acid, the Most Hydrophilic Bile Acid, in the Heart.Noorul Izzati Hanafi, Anis Syamimi Mohamed, Siti Hamimah Sheikh Abdul Kadir, Mohd Hafiz Dzarfan Othman.PMID: 30486474 PMCID : 6316857/biom10.3390 Biomolecules. 8040159 Nov 2018;27(8):4.

5. Impendulo ye-Ursodeoxycholic Acid Ihlotshaniswa Nokwehliswa Kokufa Ku-Primary Biliary Cholangitis With Compensated Cirrhosis.Binu V John, Nidah S Khakoo, Kaley B Schwartz, Gabriella Aitchenson, Cynthia Levy, Bassam Dahman, Yangyang Deng, David S Goldberg, Paul Eplan Martin, David S Goldberg, Paul Martin , Tamar H Taddei.PMID: 33989225 PMCID: PMC8410631 (itholakala ku-2022-09-01) DOI: 10.14309/ajg.0000000000001280 Am J Gastroenterol. 2021 Sep 1;116(9):1913-1923.

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10. I-Gallstone dissolution therapy nge-ursodiol. Ukusebenza kahle nokuphepha. G Salen.PMID: 2689115 DOI: 10.1007/BF01536661 Dig Dis Sci. 1989 Dec;34(12 Suppl):39S-43S.

11. I-Ursodeoxycholic acid - imiphumela emibi nokusebenzisana kwezidakamizwa. Hempfling, K. Dilger, U. Beuers
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13. Ukwelashwa kwe-ursodeoxycholic acid enedosi ephezulu ye-steatohepatitis engeyona eyotshwala: ukuhlolwa okungaboni kahle okuphindwe kabili, okungahleliwe, okulawulwa yi-placebo†.Ulrich FH Leuschner,Birgit Lindenthal,Günter Herrmann,Joachim C. Arnold,Martin Rössle,Hans-Jörg Cordes,uStefan Zem U-Hein, uThomas Berg, iQembu Lokufunda le-NASH

14. I-Ursodeoxycholic acid yokwelapha i-non-alcoholic steatohepatitis: Imiphumela yokuhlolwa okungahleliwe.Keith D. Lindor,Kris V. Kowdley,E. UJenny Heathcote, M. Edwyn Harrison,Roberta Jorgensen,Paul Angulo,James F. Lymp,Lawrence Burgart,Patrick Colin

15. Indima ye-ursodeoxycholic acid ku-steatohepatitis engeyona utshwala: ukubuyekezwa okuhlelekile.Zun Xiang, Yi-peng Chen, Kui-fen Ma, Yue-fang Ye, Lin Zheng, Yi-da Yang, You-ming Li, Xi Jin.PMID : 24053454 PMCID: PMC3848865 DOI: 10.1186/1471-230X-13-140 BMC Gastroenterol. 2013 Sep 23;13:140.

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