INicotinamide Mononucleotide (NMN) (1094-61-7)

October 30, 2018
SKU: 1094-61-7

I-Raw Nicotinamide Mononucleotide (NMN) powder icindezele ukukhuluphala komzimba okuhambisana nobudala ……


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum
Umthamo: 1370kg / inyanga

Ividiyo yeNicotinamide Mononucleotide (NMN) (1094-61-7)

I-Raw Nicotinamide Mononucleotide (NMN) powder (1094-61-7) Incazelo

I-Nicotinamide Mononucleotide powder ephezulu ("NMN" ne "β-NMN") iyinucleuclede etholakala ku-ribose ne-nicotinamide. Njenga-nicotinamide riboside, i-NMN yikhiqiza ye-niacin, futhi abantu bane-enzymes engasebenzisa i-NMN ukukhiqiza i-nicotinamide adenine dinucleotide (i-NADH).

Ngenxa yokuthi i-NADH iyinkampani ye-cofactor yezinqubo ngaphakathi kwe-mitochondria, ye-sirtuin, ne-PARP, i-NMN iye yafundwa ngezibonelo zezilwane njenge-agent engahlinzeki nge-neuroprotective ne-anti-aging agent. Izinkampani zokondla ezokudla ziye zathengisa ngenkani imikhiqizo ye-NMN efuna lezo zinzuzo, nakuba kungekho isifundo somtholampilo kubantu abashicilelwe okwamanje.

 

I-Raw Nicotinamide Mononucleotide (NMN) powder (1094-61-7) Imininingwane

Igama Product Iphunga elimnyama likaNicotinamide Mononucleotide (NMN)
Igama leKhemikhali I-Beta-nicotinamide ribose monophosphate; I-Nicotinamide Mononucleotide powder emanzini; I-AC1Q6RVF; I-AC1L23AN; I-NMN (+); SCHEMBL6858129
Brand NAme Mirailabo
I-Drug Class Ukwengeza kokudla
CAS Inombolo 1094-61-7
InChIKey DAYLJWODMCOQEW-TURQNECASA-N
I-molecular Fi-ormula C11H15N2O8P
I-molecular Weziyisishiyagalombili 334.22
IMisa ye-Monoisotopic I-335.229 g / mol
Ukuxuba Pi-oint  > 96 ° C
Fukuvuselela kabusha Pi-oint Ayikho idethi etholakalayo
I-Half Half-Life Ngakho-ke, njengoba kuboniswe kuFi. 3, i-nicotinamide yanyamalala egazini nge-half-life yamahora we-5.3, kanti ingxenye yokuphila ye-nicotinic acid yayingu-1.1 ihora.
Color Mhlophe uphawuda omhlophe
Sukufaneleka  I-Methanol (Kancane), Amanzi (Kancane)
Sukuhlushwa Tukushisa  I-Hygroscopic, -20˚C Freezer, ngaphansi kwe-Inert Atmosphere
Aukuphikisana Ukuze udlale indima yokukhulisa impilo nokuphatha isifo sikashukela

 

I-Nicotinamide Mononucleotide ebomvu (I-NMN) powder (1094-61-7) Incazelo

I-Nicotinamide Mononucleotide powder ephezulu ("NMN" ne "β-NMN") iyinucleuclede etholakala ku-ribose ne-nicotinamide. Njenga-nicotinamide riboside, i-NMN yikhiqiza ye-niacin, futhi abantu bane-enzymes engasebenzisa i-NMN ukukhiqiza i-nicotinamide adenine dinucleotide (i-NADH).

Ucwaningo olusha luphakamisa ukuthi i-NMN ingabuyisa imetabolism yamaselula, futhi ibe nomthelela omkhulu wokuguga. Njengoba kwenzeka ngokwemvelo emzimbeni, i-NMN (β-Nicotinamide mononucleotide) ibalulekile ekuguqulweni kwezakhi zibe namandla. Ukwengeza i-NMN njengengxenye yohulumeni wakho wansuku zonke kunganikeza amandla okuvuselela amandla, ukuvikelwa ekugugeni, nokunciphisa ingozi yezinkinga zenhliziyo. I-NMN i-cofactor ekusebenzeni kabusha kwe-redox, inqubo ebalulekile ekusebenzeni komzimba ekubunjweni kwe-ATP i-molecule enikezela amandla ephezulu. I-NMN iqukethe i-Sirtuin ekhiqiza inhlanganisela ekhuthaza ukucacisa nokuphila isikhathi eside.

Ukusetshenziswa kweNicotinamide Mononucleotide (NMN) powder (1094-61-7)

  1. I-Nicotinamide mononucleotide emangqamuzaneni omuntu ibamba indima ebalulekile ekuzalweni kwamandla, ihilelekile ku-NAD ye-intracellular (i-nicotinamide adenine dinucleotide, i-cell energy conversion conversion coenzyme ebalulekile), isetshenziselwa ukuguga, ukuwa ushukela wegazi kanye neminye imikhiqizo yokunakekelwa kwempilo.
  2. I-Nicotinamide Mononucleotide iyinvithamini engenawo amanzi, Umkhiqizo uwu-powder omhlophe omswakama, onamafutha noma ongenamakha, onomuncu, enomuncu, ekhululekile emanzini noma ethanol, engancibilika ku-glycerin.
  3. I-Nicotinamide Mononucleotidepowderis kulula ukuyitholela ngomlomo, futhi ingasakazwa kabanzi emzimbeni, imetabolites engaphezu kwesibalo noma i-prototype ngokushesha ixoshe umchamo. I-Nicotinamide iyingxenye ye-coenzyme I ne-coenzyme II edlala indima ye-hydrogen ekulethwa kwe-oxidation engxenyeni yokuphefumula, ingakhuthaza izinqubo zokufakelwa kwe-biological and tissu metabolism, igcine izicubu ezivamile (ikakhulukazi isikhumba, indlela yokugaya umzimba kanye nesistimu yezinzwa) ubuqotho bunendima ebalulekile.

Ngaphezu kwalokho, i-nicotinamide inokuvimbela nokwelapha kwe-block block, umsebenzi we-node node kanye nama-arrhythmias wokuhlola okusheshayo, i-nicotinamide ingathuthukisa kakhulu izinga lokushaya kwenhliziyo ne-atrioventricular block ebangelwa i-verapamil.

Izinzuzo of Nicotinamide Mononucleotide (I-NMN) powder (1094-61-7)

  • I-NMN Ithuthukisa I-Energy Metabolism - I-NAD + isiza ekuhlukaniseni ukudla njengoshukela emandleni.
  • Ikhuthaza Ubunono Bempilo Kanye Nomsebenzi Wezinhliziyo.
  • Ukulungiswa kwe-DNA Yokuguga - I-NAD + isetshenziselwa ukulungisa imicu ye-DNA ephukile.
  • ISIRTUIN Activator - I-NAD + iyadingeka ukuze izakhi zethu zofuzo ezinde ziphile.
  • I-NMN yi-COMPound esetshenziswa yi-Harvard Sosayensi ukuguqula ezinye izibonakaliso zezicubu eziguga emagundeni owaqala ukugijima ku-NAD.
  • Ukwelashwa kwe-NMN kuvimbela ukulimala kakhudlwana kobuchopho obushukumisayo
  • Ukwelashwa kwe-NMN kukhulula ukukhubazeka kwengqondo
  • I-Nicotinamide mononucleotide inqanda ukuvuselelwa kwe-JNK ukuguqula isifo se-Alzheimer
  • I-NMN ingabuyisa ukuqondiswa kwamakhompi ku-r model

I-Nicotinamide Mononucleotide enconyiwe (I-NMN) powder (1094-61-7) Isilinganiso

Isilinganiso esivunyelwe ngokujwayelekile se-Nicotinamide Mononucleotide powder noma ikuphi phakathi kwe-250 - 1500 mg ngosuku.

I-NMN ixhunyiwe ngokushesha kakhulu futhi ine-half-life-life, ngakho-ke ukugcina ama-NAD + aphakeme kakhulu usuku ngangokunokwenzeka kunconywa ukuthi uthathe i-capsule eyodwa ye-125 mg lapho evuka futhi enye ntambama uma uthatha i-250 mg ngosuku.

Okuqhamuka uma udla imishanguzo of Nicotinamide Mononucleotide (I-NMN) powder (1094-61-7)

Ngenkathi i-Nicotinamide mononucleotide (NMN) powder iyisengezo esisha futhi ucwaningo lusaqhubeka, ucwaningo olwenziwe kuze kube manje lukhombise ukuthi luphephe kakhulu futhi alunabo ubuthi.

Imiphumela emibi ayidlame, kodwa ukuzwakalisa, ukuzondwa, ukujuluka, nokucabangela kubike kwezinye izimo.

 

Okubhekwayo
  1. UNina Klimova, uTibor Kristian. Imiphumela Eqondiswe Kakhulu yeNicotinamide Mononucleotide ku-Brain Bioenergetic Metabolism. I-Neurochem Res. 2019 Okthoba; 44 (10): 2280-2287. i-doi: 10.1007 / s11064-019-02729-0. PMID: 30661231.
  2. U-Aaron N Long, uKatrina Owens, u-Anna E Schlappal, uTibor Kristian, uPaul S Fishman, uRosemary A Schuh. Umphumela we-nicotinamide mononucleotide ekushodweni kokuphefumula kwe-mitochondrial ku-Alzheimer's model of murine model. BMC Neurol. 2015 Mar 1; 15: 19. i-doi: 10.1186 / s12883-015-0272-x. PMID: 25884176.
  3. UJi H Park, u-Aaron Long, uKatrina Owens, uTibor Kristian. INicotinamide mononucleotide ivimbela ukwehliswa kwesithunzi kwe-post-ischemic NAD (+) futhi ithuthukisa kakhulu ukulimala kobuchopho kulandela i-global cerebral ischemia. INeurobiol Dis. 2016 Nov; 95: 102-10. i-doi: 10.1016 / j.nbd.2016.07.018. I-Epub 2016 Jul 15. PMID: 27425894, PMCID: PMC558024.
  4. UJunichiro Irie, uHiroshi Itoh. Ukuguga ne-homeostasis. Izifo ezihambisana nobudala nokusetshenziswa kwemitholampilo kwe-NMN (Nicotinamide Mononucleotide). Umtholampilo weCalcium. 2017; 27 (7): 983-990. I-PMID: 28649105.
  5. UGolam Mezbah Uddin, uNeil A Youngson, uBronte M Doyle, uDavid A Sinclair, uMargaret J Morris. Ukwengeza kweNicotinamide mononucleotide (NMN) kuthuthukisa umthelela wokukhuluphala komama kumagundane: ukuqhathanisa nokuvivinya umzimba. ISci Rep. 2017 Nov 8; 7 (1): 15063. i-doi: 10.1038 / s41598-017-14866-z. I-PMID: 29118320, PMCID: PMC5678092.
  6. Izidakamizwa Zakamuva Zokulwa Nokuguga: I-Nicotinamide Mononucleotide (NMN)