I-Pyrroloquinoline quinone (PQQ) (72909-34-3)

Mashi 11, 2019
SKU: 108-09-8
5.00 koku 5 ngokusekelwe ku 1 isilinganiso ikhasimende

I-Pyrroloquinoline quinone (PQQ), ebizwa nangokuthi i-methoxatin, iyi-redox cofactor. Kutholakala emhlabathini nasekudleni okufana ne-kiwifruit, njengoba …… ..


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum

I-Pyrroloquinoline quinone (PQQ) (72909-34-3) ividiyo

Imininingwane yePyrroloquinoline quinone (PQQ) (72909-34-3)

Igama Product I-Pyrroloquinoline quinone (PQQ)
Igama leKhemikhali I-Coenzyme PQQ; Methoxatine; Pyrrolo-quinoline quinone;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

CAS Inombolo 72909-34-3
InChIKey MMXZSJMASHPLLR-UHFFFAOYSA-N
SMILE C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
Formula Yamamolekhula C14H6N2O8
isisindo Yamamolekhula 330.21
IMisa ye-Monoisotopic I-330.012415 g / mol
Iphoyinti leBoliing 1018.6 ± 65.0 ° C (Kubikezelwe)
I-Flashing Point 569.8 ° C (1,057.6 ° F; 842.9 K)
Ubuningi 1.963 0.06 3 g / cmXNUMX (Kubikezelwe)
Color I-Orange-Red Solid
Isigcini sesitoreji I-2-8 ° C
solubility I-soluble emanzini
Isicelo I-PQQ kuye kwabikwa ukuthi isebenza njengevithamini / i-cofactor encibilikayo futhi njenge-antioxidant. Yenzelwe futhi ukusetshenziswa kwezithasiselo zokudla, njengamandla, ukufakwa esikhundleni sokudla, nemigoqo evikelekile njll.

Kuyini I-Pyrroloquinoline quinone(PQQ)?

I-Pyrroloquinoline quinone (PQQ), ebizwa nangokuthi i-methoxatin, iyi-redox cofactor. Kutholakala emhlabathini nasekudleni okufana ne-kiwifruit, kanye nobisi lwebele lomuntu. I-Pyrroloquinoline quinone iyi-pyrroloquinoline enamaqembu e-oxo ezikhungweni ezi-4 ne-5 nezama-carboxy ezikhundleni ezi-2-, 7- no-9. Inendima njengevithamini enganyibiliki emanzini ne-cofactor. Futhi, kungumenzeli wesiginali wamaprotheni kinases abathintekayo ekwahlukanisweni kwamangqamuzana ezincelisayo. Amandla aphezulu okusebenzisa kabusha i-redox kabusha kwe-PQQ angawanikeza indima ye-pharmacological ekuvikeleni i-neurodegeneration kanye nomdlavuza. (Njengomenzeli we-redox, iPyrroloquinoline quinone izinzile kakhulu futhi ingabamba iqhaza ekuphendukeni okungaphezulu kakhulu kwamanye ama-antioxidants, njenge-ascorbic acid, quercetin, ne-epicatechin)

I-Pyrroloquinoline quinone iyi-biofactor yenoveli, futhi yaqashelwa njenge-cofactor enzyme kumagciwane. Ucwaningo lukhombisa ukuthi kungenzeka ukuthi iPinroloquinoline quinone ibikhona kuwo wonke lo mbono wokuqala wokuzalwa kanye nokuvela kwemvelo. Njengesici esinamandla sokukhula kwezitshalo, sikhona ekukhuleni kwezilwane nabantu. I-Pyrroloquinoline quinone kubikwa ukuthi ibamba iqhaza emisebenzini ehlukahlukene yemvelo enenzuzo ebonakalayo yokusinda (isib. Ukukhula okuthuthukile kwe-neonatal kanye nokusebenza kokuzala) ezilwaneni.

Ngaphezu kwalokho, i-Pyrroloquinoline quinone ine-antioxidant kanye ne-B-vitamini-efana nezinzuzo eziningi zobuchopho nomzimba. Ikhuthaza impilo nenkumbulo engqondweni ngokulwa nokungasebenzi kahle kwe-mitochondrial futhi ivikele ama-neurons ekulimaleni kwe-oxidative. Izifundo zemitholampilo kubantu zikhombisile ukuthi iPyrroloquinoline quinone ithuthukisa inkumbulo yesikhathi esifushane nokunakwa, ithuthukisa amandla we-metabolism kanye nokuguga okunempilo, futhi inciphise izimpawu zokuvuvukala, kanye nokwenza ngcono imizwa ejwayelekile yenempilo.

Kwenzeka kanjani iPyrroloquinoline quinone(I-PQQ) ukusebenza?

Izifundo zamagagasi zibonisa ukusebenza okuhlaba umxhwele kwePinroloquinoline quinone ekukhuthazeni i-mitochondrial biogeneis. Ama-hepatocytes amagundane afakwe nge-PQQ ngo-10- 30 μM kuboniswe u-24- 48 h kubonisiwe Ukuqalwa kwale nqubo kwenzeke ngokusebenzisa ukusebenza kwe-cAMP reaction protein binding protein (CREB) ne-peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), indlela eyaziwa ngokulawula i-mitochondrial biogenesis. ” Ezifundweni ze-vivo kumagundane nawo akhombisa imiphumela enenzuzo evela kokungezelelwa kokudla nge-PQQ (2mg PQQ / kg yokudla). Lokhu kufaka phakathi ukuncipha kwe-pligma triglycerides, ukukhuphuka kwezindleko zamandla (kuhlanganiswe nokuqukethwe kwe-hepatic mitochondrial), kanye nokubekezelelana okungcono kokuthathwa kwenhliziyo ne-ischemia / reperfusion. Izinhlobo zokuhlola zokulimala kokulimala nokulimala komgogodla zibonisa ukuthi i-Pyrroloquinoline quinone ithola ukufa kweseli ye-neuronal, ngokwengxenye ngokusebenzisa iPyrroloquinoline quinone evikela ama-receptors eN-methyl-d-aspartic acid (NMDA). Izinhlobo zamagciwane zesifo sikaParkinson zibonisa ukuthi i-Pyrroloquinoline quinone supplementation inciphisa ukulahleka kwe-neuronal, ikhuphula amandla e-oxygen asebenzayo okuqeda amandla, futhi ihlinzeka ngezinqubo ezingezekile.

Izinzuzo ze I-Pyrroloquinoline quinone(PQQ) izinzuzo

Engqondweni nasemzimbeni, i-PQQ inezinzuzo eziningi.

- I-PI-QQ isekela umsebenzi we-mitochondrial ofanele

IMitochondria ingabakhiqizi bamandla kumaseli ethu futhi badlala indima ebalulekile kwimpilo yethu iyonke. I-PQQ ngokuvikela i-mitochondria ekhona futhi ikhuthaza isizukulwane se-mitochondrial, ngakho-ke khiqiza i-ATP (Amandla). Ukusebenza okwengeziwe mitochondria, amandla amaningi.

- I-PQQ isekela izinto ezikhulisa izinzwa

I-PQQ ivuselela ukukhiqizwa kweNerve Growth Factor (NGF.), Ivikela futhi ibuyisele amangqamuzana obuchopho nezinzwa, ngakho-ke ivimbela ukwehla kwengqondo (ukulahlekelwa inkumbulo, ubunzima bokufunda, njll.) Ngenxa yobudala, ukuhlaselwa yisifo noma ukuphazamiseka kwe-neurodegenerative., Futhi kuthuthukisa ukuzivikela komzimba kanye ne-antioxidant imisebenzi, nokuvikelwa ezenzakalweni zenhliziyo nezinhliziyo ze-ischemic.

- I-PQQ ivimbela ukucindezelwa kwe-oxidative

I-PQQ ihlinzeka ngokuvikelwa okunamandla kwe-antioxidant, ivikela amaseli emzimbeni kusuka kumonakaliso we-oxidative kanye ne-demage radicals yamahhala. Ixhasa i-metabolism yamandla nokuguga okunempilo, futhi icabangele i-cofactor yenoveli enomsebenzi we-antioxidant ne-B efana ne-vitamini.

Ngaphandle kwalokho, i-PQQ nayo ingavimbela futhi iphathe ukulimala kwesibindi kanye nomsebenzi oqinile we-anticancer.

Ukusetshenziswa / ukusetshenziswa kwe I-Pyrroloquinoline quinone(PQQ)

Ocwaningweni olwenziwe ngo-2009 olushicilelwe ephephabhukwini lezokwelapha i-Food Style, i-Pyrroloquinoline Quinone ikhonjisiwe ukuthi inekhono lokusiza ukuvikela. Isetshenziselwa ukwelapha ukwehla kwengqondo (ukulahlekelwa inkumbulo, ubunzima bokufunda, njll.) Ngenxa yobudala, ukuhlaselwa yisifo sohlangothi noma ukuphazamiseka kwe-neurodegenerative, nokuvikelwa emicimbini wenhliziyo ne-ischemic ye-neurological. Imiphumela efanayo yabikwa ocwaningweni lokulandela luka-2011 lapho iPyrroloquinoline Quinone nayo yanikezwa ngokuqondile njengesengezo sokudla, njengotshwala obudakiswe obisini.

Ungathola kanjani okwenele I-Pyrroloquinoline quinone(PQQ)?

Empilweni, ungathola i-PQQ kokudla okuthile okumuncu, kuba khona ngokwemvelo ekudleni naseziphuzweni ezahlukahlukene, kufaka phakathi upelepele oluhlaza, iparsley, itiye noma i-kiwifruit njll. Nokho, uma ubala inani lokudla umuntu alidla nsuku zonke, iningi kithi asikwazi ukuthola i-PQQ eyanele ekudleni kwethu kwansuku zonke. Ngakho-ke, uma ufuna izinzuzo ezinkulu ngokwengeziwe, ungathola i-PQQ eningi ngezinye izindlela, njengesengezo sokudla sePQQ.

Izikhombo:

  • Drain, uKelsey (12 February 2017). "I-Antioxidant yemvelo Ingavikela Ukugula Kwesibindi". msn.com. Kubuyiselwe 14 kuFebhuwari 2017.
  • Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). "I-Pyrroloquinoline quinone: ukumbiwa kwe-methylotrophs nokukhuthaza ukukhula kwama-microorganisms". Ama-BioFactors. 1 (1): 51–3. PMID 2855583.
  • UFelton LM, Anthony C (2005). "I-Biochemistry: indima ye-PQQ njenge-cofactor yezilwane ezincelisayo?". Imvelo. 433 (7025): E10, ingxoxo E11-2. doi: 10.1038 / nature03322. PMID 15689995.
  • U-Westerling J, uFrank J, uDuine JA (1979). "Iqembu elenziwe nge-methanol dehydrogenase elivela kuHyphomicrobium X: ubufakazi be-electron spin resonance besakhiwo se-quinone". I-Biochem Biophys Res Commun. 87 (3): 719–24. doi: 10.1016 / 0006-291X (79) 92018-7. PMID 222269.
  • I-Matsutani M, i-Yakushi T. Pyrroloquinoline dehydrogenases-encicone de-estrogen ye-bacterium ye-acetic.Appl Microbiol Biotechnol. 2018 Nov; 102 (22): 9531-9540. doi: 10.1007 / s00253-018-9360-3. Epub 2018 Sep 15. PMID: 30218379.

UKUHLELWA KANYE Nesitatimende:

Le Material ithengiswa Ukusetshenziswa Kocwaningo Kuphela. Imibandela Yokuthengisa Faka isicelo. Hhayi Ukusetshenziswa Komuntu, noma Ezokwelapha, Izilwane, noma Ukusetshenziswa Kwasekhaya.