I-Raw Caffeic acid enamandla kakhulu i-phenethyl ester powder (104594-70-9)

December 28, 2018
SKU: 104594-70-9

I-Caffeic acid ekhulu kakhulu i-phenethyl ester powder yi-phenethyl ester ester of acffe caffeic kanye ne-bioactive ......


Isimo: Ekukhiqizeni kweMisa
Iyunithi: 25kg / Drum
Umthamo: 1180kg / inyanga

I-Raw Caffeic acid ekhululekile i-phenethyl ester powder (i-104594-70-9) ividiyo

I-Raw Caffeic acid enamandla kakhulu i-phenethyl ester powder (104594-70-9) Siziqu

Igama Product I-Raw Caffeic acid e-phenethyl ester powder
Igama leKhemikhali I-Raw Caffeic acid ekhululekile phéethyl ester powder;

I-caffeate ye-Phenylethyl; I-caffeate ye-phhenethyl; I-Caffeic acid 2-phenylethyl ester; I-β-Phenylethyl caffeate;

2-Phenylethyl (2E) -3- (3,4-dihydroxyphenyl) acrylate

Brand NAme Ayikho idatha etholakalayo
I-Drug Class I-Tyrosine Kinase Inhibitors, ama-Inhibitors
CAS Inombolo 104594-70-9
InChIKey I-SWUARLUWKZWEBQ-VQHVLOKHSA-N
I-molecular Fi-ormula C17H16O4
I-molecular Weziyisishiyagalombili I-284.311 g / mol
IMisa ye-Monoisotopic I-284.31 g · mol-1
Ukuxuba Pi-oint I-125-126ºC (umq.)
Iphuzu lokubilisa I-498.6 ± 45.0 ° C ku-760 mmHg
I-Half Half-Life Ayikho idatha etholakalayo
Color ayisekho mhlophe
Sukufaneleka I-soluble e-ethyl acetate ku-50mg / ml. I-Soluble ku-DMSO ne-ethanol.
Sukuhlushwa Tukushisa Gcina ku-0 ° C
I-Raw Caffeic acid ekhululekile phéethyl ester powder Aukuphikisana I-agent ye-cytotoxic ngokumelene nomdlavuza wesigcawu. Inhibitor ye-ornithine decarboxylase kanye namaphrotheni tyrosine kinase. Kutholakale ukuthi kuyisimo esithile se-inhibitor ye-nuclear transcription factor, i-NF-kB. Kubuye kuboniswe ngokucindezela kakhulu indlela ye-lipoxygenase ye-arachidonic acid metabolism ngesikhathi sokuvuvukala.

I-Raw Caffeic acid ephezulu i-phenethyl ester powder (104594-70-9) Incazelo

I-Raw Caffeic acid e-phenethyl ester powder yi-phenethyl ister ester of acffe caffeic kanye nesakhi se-bioactive se-honeybee isidleke propolis, nge-antineoplastic, imisebenzi ye-cytoprotective kanye ne-immunomodulating. Phezu kokuphatha, iRaw Caffeic acid i-phenethyl ester powder (i-CAPE) inqabela ukusebenza kwe-nuclear-factor NF-kappa B futhi ingase ikhusele i-p70S6K kanye ne-Akt-driven path signaling pathways. Ukwengeza, i-CAPE inqanda ukusabalalisa kwe-PDGF yamaseli esisindo e-vascular smooth muscle ngokusebenzisa i-p38-activated kinase (MAPK) ne-hypoxia-inducible factor (HIF) -1alpha nokufakelwa kwe-heme oxygenase-1 (HO-1) .

I-caffeic acid i-phenethyl ester ibikwa ukuthi inezindawo zokulwa ne-carcinogenic, anti-inflammatory, kanye ne-immunomodulatory. I-CAPE ibuye ivimbele i-HIV-1 integrase. Izici eziphikisana nokuvuvukala ziye zacatshangwa ukuthi zibangelwa ukususwa kwe-lipoxygenase endleleni ye-arachidonic acid metabolism yi-CAPE. Ucwaningo luye lwabonisa ukuthi i-CAPE ibe inhibitor ethize futhi enamandla yokusebenza kwe-NF kappa B, eyinkimbinkimbi yamaprotheni elawula ukubhalwa kwe-DNA. I-Caffeic Acid I-Phenethylester iyisimiso se-ODC noTyrosine Kinase

I-Caffeic acid i-phenethyl ester powder (i-104594-70-9) Inqubo yesenzo

I-Caffeic acid i-phenethyl ester iyingxenye ye-propolis yama-honeybee, okuvimbela ukusebenza kuka-NF-κB okubangelwa i-phorbol ester, i-ceramide, i-okadaic acid, ne-hydrogen peroxide ngokuvimbela ukudluliselwa kwe-p65 subunit ye-NF-κB kwinucleus. Kulolu chungechunge lwezinhlayiya ze-tumor cell, i-Caffeic acid i-phenethyl ester ibonisa umsebenzi othembisayo wokulwa nomzimba we-EC50 we-1.76, i-3.16, i-13.7, ne-44.0 μM ngokumelene ne-murine colon 26-L5, i-murine B16-BL6 melanoma, i-HT-1080 fibrosarcoma namaphaphu abantu A549 i-adenocarcinoma cell lines, ngokulandelana. I-Caffeic acid i-phenethyl ester, njenge-antioxidant enamandla kakhulu, isebenzisa umphumela wayo wokulwa ne-apoptotic kuma-granule amangqamuzana we-cerebellar ngokuvimbela ukubunjwa kwe-ROS nokuvimbela umsebenzi we-caspase. Ngaphezu kwalokho, i-Caffeic acid i-phéethyl ester igxilisa iphrofotype evuvukalayo ye-HPS-evuselelwe i-HSC, nokukhushulwa kwe-LPS kwe-HSC kuma-cytokines e-fibrogenic ngokuvimbela ukuphawula kwe-NF-κB.

Ku-vivo, i-Caffeic acid i-phenethyl ester (i-10 mg / kg, i-ip) ivimbela ukukhula kanye ne-angiogenesis yamathumba ayisisekelo ku-C57BL / 6 nama-BALB / c amagundane anqunywe ne-Lewis lung carcinoma, i-colon carcinoma, namaseli e-melanoma. I-Caffeic acid i-phenethyl ester (i-5, i-10, i-20 mg / kg) ibonisa nemiphumela yokuzivikela e-vivo ngokunciphisa isisindo sakho se-thymus kanye / noma iselula ye-thymus ne-spleen.

Ukusetshenziswa kwe-Caffeic acid phenethyl ester powder (104594-70-9)

▪ I-Antineoplastic

▪ Okungajwayelekile

▪ Iimmunomodulator

▪ Ukuvimba kwe-NFkB

Izinzuzo I-Caffeic acid i-phenethyl ester powder (104594-70-9)

I-phenethyl caffeate iyinhlanganisela etholakala ku-propolis, ingxube ekhishwa izinyosi. I-Caffeic acid i-phenethyl ester (i-CAPE) ingaba nekhono ekuvimbeleni nasekwelapha izifo ezivuthayo ezihlanganisa isifo samathambo, i-systemic lupus erythematosus ne-psoriasis, amakhemikhali nezifo ezihlukahlukene ezihlanganisa ukukhipha isisu, i-cataracts, nezinye izifo ezibangelwa ukucindezeleka kwe-oxidative. Ngaphezu kwalokho, i-CAPE ingasetshenziselwa ukwelapha ukutheleleka nge-HIV uma ihlangene nokwakheka kwemithi ngezinto ezivimbela ukuphindaphinda kwe-HIV. Futhi ingasetshenziswa ukulwa ne-atherosclerotic, antioxidative, i-cardioprotective, anti-fatness and antimitogenic.