Yini i-Oxiracetam?

I-Oxiracetam ingenye ye-nootropic endala Izithako emndenini we-racetam. Kwakuyinhlanganisela yesithathu ye-racetam ngemuva kwe-piracetam ne-aniracetam futhi yaqala ukwenziwa ngawo-1970. I-Oxiracetam isuselwa kumakhemikhali we-racetam yoqobo, i-piracetam.

Njengamanye ama-racetams, i-oxiracetam iqukethe i-pyrrolidone engxenyeni yayo. Kodwa-ke, i-oxiracetam ineqembu le-hydroxyl, yingakho inamandla kakhulu kunokwakhiwa komzali, i-piracetam.

Kuyaziwa kakhulu ngekhono layo lokuthuthukisa ukusebenza kwengqondo njengokukhumbula, ukugxila kanye nokufunda kanye nemiphumela evuselelayo eyinikezayo. I-oxiracetam nootropics ngokuvamile ithuthukisa impilo yakho yobuchopho iyonke.

I-Oxiracetam powder: Isetshenziselwani i-Oxiracetam?

Kunokusetshenziswa okuhlukahlukene kwe-oxiracetam okubikwe ngabaphenyi kanye nokuhlangenwe nakho kwe-oxiracetam okwabiwe kuzingxenyekazi ezahlukahlukene.

I-Oxiracetam, njenganoma iyiphi enye i-racetam, isetshenziselwa ukuthuthukisa ukuqonda ngokuthuthukisa ikhono lokwenza inkumbulo yesikhashana neyesikhathi eside. Ngakho-ke isetshenziswa yinoma ngubani odinga ukufunda nokukhumbula imininingwane. Kuhle kakhulu kubafundi abadinga ukuvelela ezivivinyweni zabo, ngoba kuzosiza kakhulu ekubasizeni bafunde futhi bakhumbule izinto kalula. Kuyabasiza nokuthi bagxile futhi baqhubeke nokugxila isikhathi eside.

I-Oxiracetam isebenzisa ihlukile ngoba inikeza ukuthuthukiswa kokuqonda ngenkathi ivuselela ingqondo yakho ukuthi igxile futhi iqaphe. Into enhle ngemiphumela yayo evuselelayo ngukuthi ngokungafani nokunye okuvuselelayo okushiya umuzwa owodwa unxanxathela futhi ungenakuhlaliseka, i-oxiracetam izoshukumisa ingqondo futhi ikushiye uzolile futhi ukhululekile. Kubasebenzi abadinga ukugxila nokugxila ngempela, ulwazi lwe-oxiracetam alungabazeki.

Ucwaningo lukhombisa nokusetshenziswa kwe-oxiracetam ekwelapheni ukwehla kwengqondo okubandakanya ukwehla kwenkumbulo ezigulini ezinesifo i-Alzheimer ngokunikeza ukuvikelwa kwe-neuronal.

Lapho ngokwesibonelo umuntu elungiselela inhlolokhono, kuzobaluleka ukuvela uhlakaniphile. I-Oxiracetam ithuthukisa ukukhuluma ngokusobala okusiza abantu ukuthi basebenzise isilulumagama esiphelele esithuthukisa amathuba abo okuthola imisebenzi yabo yamaphupho.

I-Oxiracetam powder futhi kuyinketho ye- ngcono inkumbulo kubantu asebekhulile abavame ukuhlushwa inkumbulo noma ukwehla.

Njengoba imizimba yethu ingazivezi i-oxiracetam iyodwa, ukuvuna izinzuzo ze-oxiracetam ezishiwoyo uzocabanga ukuthi i-oxiracetam iyathenga kubathengisi abathembekile. ?????

Ucwaningo oluningi lwabantu lususelwe kubantu asebekhulile futhi kubantu abangenampilo, yingakho ukucwaninga okwengeziwe ngabantu abaphilile kungadingeka ukuqinisekisa ukusetshenziswa kwe-oxiracetam. Kodwa-ke, ukubuyekezwa komuntu siqu kwe-oxiracetam kukhombisa amandla we-oxiracetam kubantu abaphilile nabancane.

I-Oxiracetam

I-Oxiracetam: Isebenza Kanjani?

Ngenkathi, izinzuzo ze-oxiracetam zaziwa kahle ukuthi izindlela zokusebenza ezisebenzayo zisazocaciswa kahle. Kodwa-ke, izindlela eziningi zesenzo se-oxiracetam zibikiwe.

Ngezansi kunezinye zezindlela zokusebenza kwe-oxiracetam;

i. Ilawula i-neurotransmitter, i-acetylcholine

La ma-neurotransmitters amabili adlala indima ebalulekile emandleni ethu ekwakheni inkumbulo yesikhashana neyesikhathi eside, ukufunda nokusebenza kwengqondo okuphelele.

I-Oxiracetam inethonya ezinhlelweni ze-cholinergic ne-glutamate ngaleyo ndlela iguqula ukukhishwa kwalezi zinzwa ezibalulekile ze-neurotransmitters, i-acetylcholine ACh ne-glutamate.

Ngokuqondile, i-oxiracetam inyusa ukuzwela kwama-acetylcholine receptors. Ikwenza lokhu ngokuthuthukisa i-enzyme ye-protein kinase C (PKC) ethonya ama-M1 acetylcholine receptors.

I-oxiracetam nootropic nayo ikhonjisiwe ukuthi iyakwazi ukulungisa ama-receptors alimele ngaleyo ndlela iqinisekisa amazinga aphezulu we-ACh ahambisana nokusebenza kwengqondo.

ii. Izakhiwo ezikhuthaza ingqondo

I-Oxiracetam nootropics inikela ngemiphumela evuselelayo emnene kuhlelo oluphakathi lwezinzwa.

I-Oxiracetam iwela emndenini wama-ampakine wama-compounds. I-Ampakine yaziwa ngokukhombisa izakhiwo ezivuselelayo. I-ampakine yizidakamizwa ezinomthelela kuma-glutamatergic AMPA receptors. Ngenhlanhla, ngokungafani nezinye izikhuthazi ezifana ne-caffeine ekushiya ungalali futhi uvalo, i-ampakine ayikushiyi ngemiphumela emibi.

I-Oxiracetam ngakho-ke inikeza imiphumela evuselelayo ekugcina uqaphile futhi ugxile ngenkathi ikushiya ingqondo nomzimba uzolile futhi ukhululekile.

Ngaphezu kwalokho, i-oxiracetam ingakhuphula amazinga ama-phosphates anamandla amakhulu adlala indima ekufukuleni amandla futhi ukuqinisa ukugxila.

Iii. Linganisa uhlelo lwe-glutamate

I-Oxiracetam ithinta uhlelo lwe-glutamate bese iba nomthelela ekukhishweni kwe-neurotransmitter, glutamate. Inikeza imiphumela enamandla kakhulu futhi isikhathi eside.

I-Glutamate ingenye ye-neurotransmitter egcwele kakhulu ohlelweni lwe-neural evame ukuthumela amasiginali ebuchosheni nasemzimbeni wonke.

I-Glutamate idlala indima ebalulekile ekusebenzeni kwengqondo futhi ikakhulukazi ngememori nokufunda.

iv. Ithuthukisa ukuxhumana phakathi kwama-neurons

Olunye ucwaningo lukhombisa ukuthi i-oxiracetam ithuthukisa ukuxhumana phakathi kwe-neurons ku-hippocampus. IHippocampus yingxenye yobuchopho ethonya inkumbulo, imizwa, kanye nohlelo lwemizwa oluphakathi.

I-Oxiracetam ifinyelela lokhu ngezindlela ezimbili. Okunye kungukuqala kokukhishwa kwe-D-aspartic acid futhi okwesibili, ngokuthinta i-lipid metabolism. I-lipid metabolism iqinisekisa ukuthi kunamandla anele engqondo adingekayo ekusebenzeni kwe-neurons.

Imiphumela nezinzuzo ze-Oxiracetam

Kunezinhlobonhlobo zezinzuzo ze-oxiracetam ezibikiwe yize isengezo singavunyelwe yi-Food and Drug Administration (FDA).

Ngezansi kukhona izinzuzo ze-oxiracetam;

i. Kuthuthukisa inkumbulo nokufunda

I-Oxiracetam ithandwa kakhulu ngenxa yokukwazi kwayo ukukhulisa inkumbulo. Ithuthukisa ukwakheka kwenkumbulo entsha futhi inyuse ijubane lapho ingqondo icubungula khona futhi ikhumbule imininingwane.

I-Oxiracetam ibuye ithuthukise inkumbulo ngokususa ukulimala kwe-neuron, ukubuyisela emuva i-lipid metabolism ebuchosheni, ukukhuphula ukugeleza kwegazi kanye nokuvimbela ukwenziwa kwe-astrocyte.

Ukuhamba kwegazi endaweni yobuchopho kubaluleke kakhulu ukuqinisekisa ukuthi umoya-mpilo owanele ufika ebuchosheni ukuze kusebenze kahle ubuchopho kubandakanya inkumbulo.

Ngaphezu kwalokho, ukucindezeleka okwenziwe nge-oxidative kungenzeka ngenxa yezizathu eziningana futhi uma kungalawulwa kungaholela ekulimaleni kwe-neuronal. Isengezo se-Oxiracetam ngisize ngokulungisa umonakalo wezinzwa.

Ngaphezu kwalokho, i-oxiracetam iphakanyiswa ukuthi ithuthukise amandla wesikhathi eside mhlawumbe ngenxa yokwanda kokukhishwa kwe-glutamate ne-aspartic acid ku-hippocampus.

Ekucwaningweni kwabantu asebekhulile abangama-60 abanokwehla kwengqondo, umthamo we-oxiracetam ka-400 mg kathathu nsuku zonke watholakala ukhulisa kakhulu inkumbulo ngenkathi kunciphisa izimpawu zokwehla kwengqondo.

Kwesinye isifundo sabantu asebekhulile abangama-40 abane-dementia, i-oxiracetam ku-2,400 mg nsuku zonke itholakale ithuthukisa isikhathi esifushane inkumbulo kanye nokukhuluma ngokushelelayo.

ii. Ithuthukisa ukugxila nokugxila

Lapho ubhekene nomsebenzi odinga ukunakekelwa okugcwele isikhathi eside, i-oxiracetam kungaba ukukhetha okuhle kakhulu. Impilo yengxenye ye-Oxiracetam imayelana namahora we-8-10 ngakho-ke ingahlinzeka ngezinzuzo ezinde.

I-Oxiracetam ingakusiza ukugxila emsebenzini isikhathi eside ngaphandle kokulahlekelwa ukugxila nokunaka. I-Oxiracetam ihlobene nokukhiqizwa kwamandla ebuchosheni yingakho inikezela amandla adingekayo ukuze agxile emsebenzini isikhathi eside futhi afunde izinto ezintsha kalula.

I-Oxiracetam inikela ngemiphumela evuselelayo emincane ekusiza ukuthi ugxile ngaphandle kokulahlekelwa inzalo nokunakwa.

Ezilingweni ezimbili zabantu ezibandakanya abantu asebekhulile abangama-96 abanokuwohloka komqondo kanti okunye okubandakanya abantu abangama-43 abanomsebenzi owehlisiwe wobungcweti, ukutholakala kwe-oxiracetam kwatholakala ukuthi kuthuthukisa isikhathi sokuphendula kanye nokunakwa.

I-Oxiracetam

Iii. Imiphumela engasebenzi kahle

Isengezo se-Oxiracetam sinezinzuzo ze-neuroprotective njengoba sikwazi ukuvikela ukulimala kohlobo lobuchopho kanye nokwehla kwengqondo ngenxa yeminyaka yobudala noma ukulimala kobuchopho.

Ngakho-ke i-Oxiracetam ingahlinzeka ngokuvikela ebuchosheni ekulimaleni okudalwe yisifo i-Alzheimer's kanye nokunye ukuphazamiseka komqondo.

Izifundo eziningana zezilwane ziphakamisa ukuthi i-oxiracetam ingahle ivikele ubuchopho ekulimaleni. Isibonelo, ocwaningweni lapho kwethulwa khona ama-neurotoxin ukukhubaza ukwakheka kwememori njengokulimala okujwayelekile kobuchopho, ukutholwa kwangaphambi kokwelapha nge-oxiracetam kwatholakala ukuvimbela i-neurotoxicity.

Izifundo ezengeziwe ziveze ukuthi, ukwelashwa ngemuva kwe-oxiracetam kungavikela amagundane ekushayweni yischemic ngokunciphisa ukungasebenzi komgoqo wegazi.

Ocwaningweni lomuntu lweziguli eziyi-140 eziphethwe imivimbo ngenxa yengcindezi yegazi (nomfutho wegazi ophezulu), i-oxiracetam yayiphathwa kanye ne- isici sokukhula kwesisindo (NGF). Lokhu kwelashwa kutholakale kusiza ubuchopho ukuthi kutholakale futhi kwandise ukusinda. Ucwaningo luqhubeke lwabika ukunciphisa ukuvuvukala namandla e-muscle akhulisiwe ayizimpawu zokululama ngemuva kokulimala kobuchopho.

iv. Ithuthukisa ukuqonda kwezinzwa

I-Oxiracetam ithinta indlela esibona ngayo izinto ngezinzwa ezinhlanu zokubona, ukunuka, ukuthinta, ukuzwa ngisho nokunambitha.

Uma uthatha i-oxiracetam yandisa ukugeleza kwegazi lobuchopho okwenza ingqondo ikwazi ukubona kangcono nokuhlela futhi ihumushe esikubonayo.

Ukuqonda kwezinzwa okuthuthukisiwe kusho ukwenza izinqumo ezingcono ngendlela ezolile.

v. Kuthuthukisa ukukhuluma ngokushelelayo

I-Oxiracetam ikhonjiswa ukukhulisa ukusebenza kobuchopho futhi ingathuthukisa ukukhuluma ngokushelelayo. Ukuqephuza ngomlomo kungenye yomsebenzi wokuqonda osisiza ukuthola ulwazi kwimemori yakho.

Esicwaningweni sabantu abangama-73 abaphethwe ukuwohloka komqondo okuyi-multi-infarct dementia (MID) noma okuyisifo sokuwohloka komqondo okuyisisekelo okukhubazayo (PDD), i-oxiracetam yatholwa ivimbela ukwehla kokuqonda futhi yathuthukisa kakhulu amagama abo ngokushelelayo.

vi. Kwandisa ukuqapha

Ukuhlala uphapheme futhi ugxile kubalulekile ekusebenzeni kahle. I-Oxiracetam inikeza imiphumela emincane evuselelayo ekusiza ukuthi uhlale uphapheme ngokwandisa ukugeleza kwegazi ebuchosheni.

Ocwaningweni lwabantu abangama-289 abaphethwe ukuwohloka komqondo, i-oxiracetam itholakale ithuthukisa imisebenzi yokuqonda. Kubikwe nokuthi kuthuthukisa ukuqapha ngenkathi kunciphisa ukukhathazeka nokwesaba.

I-Oxiracetam Powder: Indlela Yokulinganisa?

Ngokuya ngokuhlolwa komtholampilo umthamo we-oxiracetam onconyiwe ungu-750-1,500 mg ngosuku. Umthamo we-oxiracetam uhlukaniswe ngemithamo emibili ethathwe ekuseni kakhulu nantambama.

Kufanele ugweme ukuthatha isengezo se-oxiracetam kusihlwa njengoba inemiphumela evuselelayo emincane engaphazamisa ukulala kwakho.

Njengoba i-oxiracetam incibilika emanzini ingathathwa ngendlela yethebhulethi, i-capsule noma ifomu lempuphu, ngokudla noma ngaphandle kokudla.

Ucwaningo lukhombisa ukuthi i-oxiracetam ithatha cishe amahora we-1-3 ukufinyelela amazinga ayo aphezulu ku-serum ngakho-ke kufanele ithathwe ihora elilodwa ngaphambi komsebenzi ohlosiwe ofana nomsebenzi wokufunda. Impilo yengxenye ye-oxiracetam imayelana namahora we-8-10 futhi kufanele ulindele ukufinyelela ekusebenzeni okuphezulu esikhathini seviki.

Noma kunjalo, ezinye izifundo zisebenzise imithamo ephezulu ye-oxiracetam efinyelela ku-2,400 mg nsuku zonke, njalo qala kusuka kumthamo osebenza ophansi ukhuphukela phezulu njengoba kudingeka.

Ngaphezu kwalokho, njengoba i-oxiracetam ithuthukisa ukusebenza kahle kwe-acetylcholine ebuchosheni, qiniseka ukuyifaka ngomthombo omuhle we-choline njenge I-Alpha GPC noma i-CDP choline. Lokhu kuzokusiza uvikele imiphumela emibi ejwayelekile ye-oxiracetam ikakhulukazi ikhanda ngenxa ye-choline enganele ebuchosheni.

Imiphumela emibi ye-Oxiracetam

I-oxracetam nootropic ngokuvamile ibhekwa njengephephile futhi ibekezelelwa kahle ngumzimba.

Kodwa-ke, eminye imiphumela emibi ye-oxiracetam ebikiwe ifaka phakathi;

Ukuphathwa yikhanda- lokhu kwenzeka lapho umuntu ekhohlwa ukufaka i-oxiracetam enomthombo omuhle we-choline. Ubuhlungu bekhanda buvela ngenxa yokunganele kwe-choline ebuchosheni. Lokhu kungagwenywa ngokuthatha isitaki se-oxiracetam ngomthombo we-choline njenge-Alpha GPC.

Ukuqwasha nokungahlaliseki kuyimiphumela emibi kakhulu ye-oxiracetam. Zibikwa lapho umuntu ethatha imithamo ephezulu ngokweqile ye-oxiracetam noma ethatha isengezo kusihlwa. Ukulwa nale miphumela emibi ye-oxiracetam, njalo thatha isilinganiso esinconyiwe futhi ukwenze umkhuba ukuthatha i-oxiracetam ngaphambi kwemini ukuze ugweme ukuphazamiseka kokulala.

Eminye imiphumela emibi ye-oxiracetam ifaka phakathi;

  • isicashunwe,
  • Umfutho wegazi ophezulu,
  • Uhudo noma ukuqunjelwa, futhi

I-Oxiracetam

Iseluleko se-Oxiracetam Stacks

I-Oxiracetam powder isebenza ngokugqamile ukuthuthukisa ukuqonda futhi ivuselele isistimu yezinzwa ephakathi iyodwa noma ihlanganiswe nezinye izengezo.

-oxiracetam Alpha GPC isitaki

Njengamanye ama-racetams, isitaki se-Oxiracetam esinomthombo we-choline sibaluleke kakhulu. Ukuyifaka nge-Alpha GPC akugcini nje ngokukhulisa imiphumela yayo kepha futhi kusiza ukuvimbela ukuvela kwamakhanda ikakhulukazi okuhlobene nokusilela kwe-choline ebuchosheni.

Umthamo wesitaki se-oxiracetam alpha GPC ungaba yi-750 mg ye-oxiracetam ne-150-300 mg ye-Alpha GPC ethathwe ngemithamo emibili, ekuseni nantambama.

-oxiracetam noopept isitaki

I-Noopept ingenye yama-nootropics amahle kakhulu aziwa ukuthuthukisa ukusebenza kwengqondo konke futhi isebenza ngokufana kakhulu nama-racetams.

Lapho ufaka i-oxiracetam nge noopept, ulindele ukuzwa ukusebenza kwengqondo okubandakanya, inkumbulo, ukufunda, ukuqapha, ukugqugquzela nokugxila.

Umthamo ojwayelekile walesi sitaki uzoba yi-750 mg ye-oxiracetam ne-10-30 mg ye-noopept, ethathwa nsuku zonke.

-unifiram oxiracetam isitaki

I-Unifiram iyinhlanganisela ye-nootropic ethathwe ukuthuthukisa ukuqonda futhi isakhiwo sayo samakhemikhali esifana naleso sezinhlanga. Kodwa-ke, izivivinyo zomtholampilo ziyashoda futhi lokhu kwenza kube nzima ukusho ukuthi yini engabamba kahle ngayo.

Kepha futhi, ngoba isebenza ngokufana nama-racetams, isitaki se-unifiram esinezinhlanga ezibandakanya i-oxiracetam kungahle kuholele ekusebenzeni okuthuthukile kokuqonda. Kuboniswa ukuthi kunamandla kakhulu kunama-racetams ngakho-ke amanani aphansi kakhulu azodingeka ukufeza imiphumela.

Ngokusekelwe kokuhlangenwe nakho komuntu siqu kwe-unifiram kanye ne-oxiracetam umthamo kufanele ube ngu-5-10 mg we-unifiram no-750 mg we-oxiracetam othathwa nsuku zonke.

-Oxiracetam nePramiracetam Stack

I-Oxiracetam izitaki kahle kakhulu ezinye izinhlanga.

Lapho usebenzisa isitaki se-oxiracetam nge pramiracetam, ukusebenza kwengqondo kwengqondo, ukugxila kanye nogqozi kuthuthukiswa kakhulu futhi umkhiqizo wakho unganda.

Umphumela omnene wokuvuselela i-oxiracetam nawo uyathuthukiswa ngaleyo ndlela ukhulisa ukuqapha nokugxila ngenxa yamandla engqondo athuthukisiwe.

Umthamo onconywayo walesi sitaki ngu-750 mg we-oxiracetam kanye no-300 mg we-pramiracetam othathwa kanye ngosuku. I-Oxiracetam ingathathwa esiswini esingenalutho selokhu incibilikiswe ngamanzi ngenkathi i-pramiracetam ingafakwa esidlweni sokuqala ngoba iyisengezo esincibilika ngamafutha.

Ungathenga kuphi i-oxiracetam

I-oxiracetam nootropic itholakala kalula ku-inthanethi. Uma ucabanga ukuthatha i-oxiracetam yithenge kubathengisi abadume kakhulu be-nootropic online. Cabanga ukutadisha ngokucophelela mayelana ne-oxiracetam powder ethile, amaphilisi noma ifomu lethebulethi elinikezwayo.

Ukuhlolela okuhlangenwe nakho kwe-oxiracetam okwabiwe kumawebhusayithi enkampani kungenye yezindlela zokuqinisekisa ukuthi uyakuthola okudingayo.

Ukubuyekezwa kwe-Oxiracetam kusayithi labathengisi kuvula iso le-oxiracetam nootropics ehamba phambili ngoba akuyona yonke ezonikela ngemikhiqizo esezingeni eliphakeme.

Okubhekwayo
  1. UDysken, MW, Katz, R., Stallone, F., & Kuskowski, M. (1989). I-Oxiracetam ekwelapheni ukuwohloka komqondo okunama-infarct amaningi kanye nokuwohloka komqondo okuyisisekelo okuwohlokayo. Ijenali ye-neuropsychiatry kanye ne-neuroscience yomtholampilo, 1(3), i-249-252.
  2. UHlinák Z, uKrejcí I. (2005). I-Oxiracetam ngaphambi nangemuva kokwelashwa ivimbele ukusilela kokuqashelwa komphakathi okukhiqizwa nge-trimethyltin kumagundane.
  3. UHuang L, uShang E, uFan W, uLi X, uLi B, yena uS, uFu Y, uZhang Y, uLi Y, uFang W. (2017). I-S-oxiracetam ivikela ukushaywa yischemic ngokunciphisa ukungasebenzi kwesithiyo segazi kumagundane I-Eur J Pharm Sci.
  4. UMaina, G., Fiori, L., Torta, R., Fagiani, MB, Ravizza, L., Bonavita, E., Ghiazza, B., Teruzzi, F., Zagnoni, PG, & Ferrario, E. (1989 ). I-Oxiracetam ekwelapheni ukuwohloka komqondo okuyisifo esikhubazayo kanye nokukhubazeka okuningana okungaqondakali: isifundo esilawulwa izimpumputhe kabili, esilawulwa yi-placebo. I-Neuropsychobiology, 21(3), i-141-145.
  5. URozzini R, uZanetti O, uBianchetti A. (1992). Ukusebenza kahle kokwelapha i-oxiracetam ekwelapheni ukusilela kokuqonda okuya phambili kokuwohloka komqondo okuyisisekelo okwehlayo. I-Acta Neurol (Napoli).
  6. ILanga, Y., Xu, B., & Zhang, Q. (2018). Isici sokukhula kwemithambo sihlangene ne-Oxiracetam ekwelapheni Ukopha Okukhuphuka Komfutho Wegazi. Iphephabhuku lasePakistan lesayensi yezokwelapha, 34(1), i-73-77.

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