I-Urolithin powder

I-Phcoker inamandla okukhiqiza ngobuningi nokuhlinzeka nge-urolithin a, urolithin b ne-Urolithin A 8-Methyl Ether ngaphansi kwesimo se-cGMP.

Kuyini i-Urolithin A?

I-Urolithin A iyinhlanganisela ye-metabolite evela ekuguqulweni kwama-ellagitannins ngamagciwane esiswini. Kungokwesigaba sezinhlanganisela eziphilayo ezaziwa ngokuthi ama-benzo-coumarins noma ama-dibenzo-α-pyrones. I-Urolithin A ikhonjisiwe ukukhuthaza i-mitophagy nokwenza ngcono impilo yemisipha ezilwaneni ezindala nakumamodeli wangaphambi kokuguga. Okwamanje, futhi kukhonjisiwe ukuthi kweqa isithiyo sobuchopho begazi, futhi kungahle kube nemiphumela yokuvikela isifo ekulweni nesifo i-Alzheimer's.

I-Urolithin A powder ingumkhiqizo wemvelo onomsebenzi wokulwa ne-antiproliferative kanye ne-antioxidant. I-Urolithin A yakhiwa yi-metabolism evela kuma-polyphenols atholakala kwamanye amantongomane nezithelo, ikakhulukazi amapomegranati. Izandulela zayo - ama-ellagic acid nama-ellagitannins - atholakala yonke indawo emvelweni, kufaka phakathi izitshalo ezidliwayo, njengamapomegranati, ama-strawberry, ama-raspberries, ama-walnuts, itiye nama-grape e-muscat, kanye nezithelo eziningi zase-tropical.

Kusukela ngama-2000s, i-urolithin A ibilokhu ingaphansi kwezifundo zokuqala maqondana nemiphumela yayo yebhayoloji.

Urolithin A usebenza kanjani?

I-Urolithin A iyi-urolithin, i-microbial metabolite yabantu yokudla okuvela ku-ellagic acid (okufana ne-ellagic acid). Ku-metabolism wamathumbu wamabhaktheriya, i-ellagitannin ne-ellagic acid iholela ekwakheni ama-urolithins asebenzayo A, B, C no-D. Phakathi kwawo, i-urolithin A (UA) yi-metabolite yamathumbu esebenzayo kakhulu futhi esebenzayo, engasetshenziswa njenge-anti esebenzayo -yokuvuvukala ne-antioxidant.

Ezifundweni zaselebhu, kukhonjisiwe ukuthi i-urolithin A induces mitochondria, okungukululama okukhethiwe kwemitochondria ngokusebenzisa i-autophagy. I-Autophagy inqubo yokususa i-mitochondria enamaphutha ngemuva kokulimala noma ukucindezeleka, futhi isebenza kahle ngesikhathi sokuguga. phansi nangaphansi. Lo mphumela ubonwe ezinhlotsheni ezahlukahlukene zezilwane (amaseli wezilwane ezincelisayo, amagundane nama-elegans eCaenorhabditis).

Kodwa-ke, ngoba umthombo we-ellagitannin wehlukile, ukwakheka kweqembu ngalinye lamagciwane nakho kuzohluka, ngakho-ke ukusebenza kahle kokuguqulwa kwe-urolithin A kwehluke kakhulu kubantu, futhi abanye abantu kungenzeka bangabi nokuguqulwa.

Izinzuzo ze-Urolithin A

I-Urolithin A (UA) ingukudla kwemvelo, i-metabolite etholakala emphakathini wamagciwane. Inezinzuzo ezahlukahlukene zezempilo, kufaka phakathi ukunciphisa ukusayina okuvuvukalayo, imiphumela elwa nomdlavuza nokuvimbela ukuqongelela kwe-lipid.

Njenge-metabolite yamathumbu esebenzayo kakhulu futhi esebenzayo, i-urolithin A (UA) ingasebenza njenge-anti-inflammatory ne-antioxidant esebenzayo. Ingakhuthaza futhi i-phagocytosis ye-mitochondrial ezilwaneni ezindala nakumamodeli wangaphambi kokuguga futhi ithuthukise impilo yemisipha.

Ngabe i-Urolithin A ingasetshenziswa njengezithasiselo?

Ngo-2018, i-US Food and Drug Administration yahlukanisa i-urolithin A njengesithako esiphephile ekudleni noma emikhiqizweni yokunezela ekudleni, ngamanani asukela kuma-milligram angama-250 kuya ku-1 gramu ngokusebenza ngakunye.

Ingabe kukhona imiphumela emibi ye-Urolithin A?

Izifundo zokuphepha kubantu abadala asebekhulile zikhombisile ukuthi i-urolithin A ibekezeleleke kahle. Ezifundweni ze-vivo azikanqumi ukuthi bukhona yini ubuthi noma imiphumela emibi ethile yokudla kwe-urolitin A.

Futhi, ukuphepha kwesikhathi eside kokungezelela kwe-Urolithin A nepomegranate akwaziwa, yize ukwelashwa kwesikhashana okukhishwa ngehalananda kuphephile.

Kuyini i-Urolithin B? I-Urolithin B powder?

I-Urolithin B powder (i-CAS NO: 1139-83-9) iyi-urolithin, uhlobo lwama-phenolic compounds akhiqizwa emathunjini omuntu ngemuva kokumunca ukudla okuqukethe ama-ellagitannins njengepomegranate, ama-strawberry, ama-raspberries abomvu, ama-walnuts noma iwayini elibomvu elidala le-oak . I-Urolithin B itholakala emchameni ngendlela ye-urolithin B glucuronide.

I-Urolithin B inciphisa ukonakala kwamaprotheni futhi inciphisa imisipha hypertrophy. I-Urolithin B ivimbela ukusebenza kwe-aromatase, i-enzyme eguqula i-estrogen ne-testosterone.

I-Urolithin B ingumkhiqizo wemvelo onomsebenzi wokulwa ne-antiproliferative kanye ne-antioxidant. I-Urolithin B ikhonjisiwe ukuthi yeqa isithiyo sobuchopho begazi, futhi ingaba nemiphumela yokuvikela isifo ekulweni nesifo i-Alzheimer's.

I-Urolithin B iyi-metabolite yama-bacterial sebacterial ye-ellagitannis futhi ikhombisa ukusebenza okunamandla okulwa ne-oxidant kanye ne-pro-oxidant ngokuya ngohlelo nemibandela yokulinganisa. I-Urolithin B nayo ingabonisa umsebenzi we-estrogenic kanye / noma wokulwa ne-estrogenic.

Usetshenziselwa ini u-Urolithin B? Izinzuzo ze-Urolithin B (UB)

Izinzuzo zika-Urolithin B:

Kushukumisa Imisipha Amaprotheni Synthesis

Yehlisa Ukuwohloka Kwamaprotheni Emisipha

Kungaba Nemiphumela Yokuvikela Imisipha

Kungaba Nezindawo Zokulwa Ne-Aromatase

I-Urolithin B yesisindo semisipha

I-Urolithin B inganciphisa ukulimala kwemisipha etholakala ngesikhathi sokuzivocavoca kakhulu futhi ivikele nemisipha ekucindezelekeni okubangelwa wukudla okunamafutha amaningi. Ukucwaninga kwemitholampilo nge-Urolithin B kumagundane kuthola ukuthi kuthuthukisa ukukhula kwe-myotubes kanye nomehluko ngokwandisa ukwakheka kwamaprotheni. Kubonise ikhono lokuvimbela i-ubiquitin-proteinasome pathway (UPP), indlela eyinhloko yeprotheas catabolism. Iphinde yenyusa i-hypertrophy yemisipha futhi yanciphisa nokuqina kwemisipha.

Uma kuqhathaniswa ne-testosterone, i-Urolithin B lapho ithathwa ku-15 M yandisa umsebenzi we-androgen receptor ngo-90% ngenkathi i-testosterone ikwazile ukufeza umsebenzi owengeziwe we-receptor ka-50% ku-100uM. Lokhu kusho ukuthi kuthatha i-Urolithin B encane kakhulu ukukhulisa umsebenzi we-androgen ngokuphumelelayo kakhulu-ke inani eliphakeme le-testosteronewhich inyusa umsebenzi we-androgen ngokungaphumeleli.

Ngaphezu kwalokho, i-15uM esebenza ngempumelelo kakhulu ye-Urolithin B emikhulu yemisipha yamaprotheni nge-96% uma uyiqhathanisa ne-100uM ye-insulin, equkethe izicubu zamaprotheni emisipha emikhulu ngokusebenzisa ama-61% asebenza kakhulu. Inkolelo yokuthi kuthatha indlela ende kakhulu i-Urolithin B yokwelula ukwakheka kwamaprotheni emisipha ngezinga eliphezulu kakhulu lokusebenza.

Lolu cwaningo lukhombisa ukuthi i-Urolithin B ingavimbela ukubonakala kwamaprotheni ngenkathi ngesikhathi esifanayo inyusa ukwakheka kwamaprotheni, kuyisithako semvelo esisiza ekwakheni izicubu zomzimba ngenkathi kuvimbela ukuwohloka kwemisipha.

I-Urolithin B ingelinye lama-metabolites we-gut microbial we-ellagitannins, futhi inemiphumela yokulwa nokuvuvukala kanye ne-antioxidant. I-Urolithin B ivimbela umsebenzi we-NF-κB ngokunciphisa i-phosphorylation nokucekelwa phansi kwe-I VerBcy, futhi icindezela i-phosphorylation ye-JNK, i-ERK, ne-Akt, futhi ithuthukise i-phosphorylation ye-AMPK. I-Urolithin B nayo iyisilawuli semisipha yamathambo.

Yini i-Urolithin A 8-Methyl Ether?

Ama-urolithin angama-metabolites asekondari we-ellagic acid asuselwa kuma-ellagitannins. Kubantu i-ellagitannins iguqulwa yi-gut microflora ibe yi-ellagic acid ebuye iguqulwe i-urolithins A, urolithin B, urolithin C kanye ne-urolithin D emathunjini amakhulu.

I-Urolithin A 8-Methyl Ether ingumkhiqizo ophakathi nesikhathi sokuhlanganiswa kwe-Urolithin A. Kuyinto ebalulekile yesibili ye-ellagitannin futhi ine-antioxidant kanye nezinto ezilwa nokuvuvukala.

Isebenza kanjani i-Urolithin A 8-Methyl Ether?

(1) Izakhiwo ze-Antioxidant

I-Urolithin A 8-Methyl Ether inomphumela we-antioxidant ngokunciphisa ama-radicals wamahhala, ikakhulukazi ukunciphisa izinga lezinhlobo zomoya-mpilo ezisebenzayo (ROS) kumaseli, nokuvimbela i-lipid peroxidation ezinhlotsheni ezithile zamaseli.

(2) Izakhiwo ezilwa nokuvuvukala

I-Urolithin A 8-Methyl Ether inezinto ezilwa nokuvuvukala ngokuvimbela ukukhiqizwa kwe-nitric oxide. Zivimbela ngokukhethekile ukubonakaliswa kweprotheni ye-nitric oxide synthase (iNOS) engafakwanga kanye ne-mRNA ebangela ukuvuvukala.

Izinzuzo ze-Urolithin A 8-Methyl Ether

I-Urolithin A 8-Methyl Ether ingumkhiqizo ophakathi nenqubo yokuhlanganisa i-Urolithin A, kanye ne-metabolite yesibili ebalulekile ye-ellagitannin, enezakhiwo zokulwa ne-antioxidant kanye ne-anti-inflammatory. Njenge-metabolite ye-Urolithin A, ingahle ibe nezinzuzo ezithile ze-Urolithin A:

(1) Ingangezela isikhathi sokuphila;
(2) Siza ukuvimbela umdlavuza wendlala yesinye;
(3) Ukuthuthukiswa kwengqondo;
(4) Okungenzeka ukunciphisa umzimba

Ukusetshenziswa kwe-Urolithin A 8-Methyl Ether supplements?

Izithako ze-Urolithin A zitholakala kalula emakethe njengezithako zokudla ezinothe nge-ellagitannin. Njengomkhiqizo we-Urolithin A, i-Urolithin A 8-Methyl Ether nayo ingasetshenziswa kuma-supplements.

Kodwa-ke, awekho ama-datas amaningi ngemininingwane yawo yokwengeza, futhi kudingeka olunye ucwaningo.

Izikhombo:

  1. UGarcia-Munoz, uCristina; UVaillant, uFabrice (2014-12-02). "I-Metabolic Fate ye-Ellagitannins: Imiphumela Yezempilo, Nemibono Yocwaningo Yezinto Ezintsha Zokudla Okusebenzayo". Ukubuyekezwa Okubalulekile kuSayensi Yezokudla Nondlekile. 54 (12): 1584-1598. i-doi: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. I-PMID 24580560. S2CID 5387712.
  2. URyu, D. et al. I-Urolithin A induces mitophagy futhi yelula isikhathi sempilo ku-C. elegans futhi inyuse ukusebenza kwemisipha kumagundane. Nat. IMed. 22, 879-888 (2016).
  3. "Isaziso se-FDA GRAS GRN No. 791: urolithin A". Ukuphathwa Kwezokudla Nezidakamizwa zase-US. 20 Disemba 2018. Ibuyiswe ngomhlaka 25 Agasti 2020.
  4. USingh, A .; Andreux, P.; UBlanco-Bose, W .; URyu, D.; I-Aebischer, P .; I-Auwerx, J .; URinsch, C. (2017-07-01). "I-urolithin A elawulwa ngomlomo iphephile futhi iguqula ama-biomarker emisipha kanye ne-mitochondrial kubantu abadala" Ukuqamba ekugugeni. 1 (suppl_1): 1223-1224.
  5. UHeilman, uJacqueline; U-Andreux, uPénélope; ITran, Nga; URinsch, uChris; UBlanco-Bose, uWilliam (2017). "Ukuhlolwa kokuphepha kwe-urolithin A, i-metabolite ekhiqizwa yi-gut gut microbiota ekudleni kokudla kwezitshalo ezitholakala kuma-ellagitannins ne-ellagic acid". Ukudla kanye neKhemikhali Toxicology. 108 (Pt A): 289–297. i-doi: 10.1016 / j.fct.2017.07.050. I-PMID 28757461.