α-ketoglutaric

I-Phcoker inamandla okukhiqiza ngobuningi kanye nokuhlinzekwa ngeCalcium 2-oxoglutarate ne-Alpha-Ketoglutaric Acid ngaphansi kwesimo se-cGMP.

Yimaphi amanye amagama i-alpha-ketgoglutaric acide eyaziwa ngawo?

A-cétoglutarate, A-Ketoglutaric Acid, Acide 2-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, Alfa-Cetoglutarato, Alpha-Cétoglutarate, Alpha-Cétoglutarate d'Arginine de Alphagin, Alpha-Cétoglutarate d'Arginine, Isitolo esidayisa yonke impahla , I-Alpha-Cétoglutarate de Glutamine, i-Alpha-Cétoglutarate de L-Arginine, i-Alpha-Cétoglutarate de L-Leucine, i-Alpha-Cétoglutarate de Taurine, i-Alpha Keto Glutaric Acid, i-Alpha Ketoglutarate, i-Alpha Ketoglutaric Acid, i-Alpha KG, i-Alpha KG, i-Alpha KG, -Ketoglutarate, Calcium Alpha-Ketoglutarate, Creatine Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Arginine AKG, L-Arginine Alpha Keto Glutarate, L-Leucine Alpha-Ketoglutarate, Taurine Alpha-Ketoglutarate, 2-Oxoganotic I-asidi.

Kuyini i-Alpha-Ketoglutaric acid?

I-Alpha-ketoglutaric (AKG) iyi-organic acid ebaluleke kakhulu ekuguqulweni komzimba okufanele kwawo wonke ama-amino acid abalulekile kanye nokudluliswa kwamandla eselula kumjikelezo we-citric acid. Kuyisandulela se-glutamic acid, i-amino acid engabalulekile ebandakanyeka ekuhlanganisweni kwamaprotheni nasekulawuleni amazinga eglucose egazini. Ngokuhlanganiswa ne-L-glutamate, i-AKG inganciphisa amazinga e-ammonia akhiwe ebuchosheni, emisipheni nasezinso, futhi isize ukulinganisa i-nitrogen chemistry yomzimba futhi ivimbele i-nitrogen ngokweqile ezicutshini zomzimba nakuketshezi. Abantu abanamaprotheni amaningi, ukutheleleka ngamagciwane, noma i-dysbiosis yamathumbu bangazuza ku-AKG yokwengeza ukusiza ukulinganisela amazinga e-ammonia nokuvikela izicubu.

Abanye abantu bathatha i-alpha-ketoglutarate ukuthuthukisa ukusebenza kwezemidlalo okuphezulu. Abahlinzeki bezithasiselo zokudla okunomsoco kwezemidlalo bathi i-alpha-ketoglutaric acid ingaba ukungezwa okubalulekile ekudleni okufanele nasekuqeqesheni umgijimi ofuna ukusebenza okuphezulu. Basekela lesi simangalo ezifundweni ezibonisa i-ammonia eyengeziwe emzimbeni ingahlangana ne-alpha-ketoglutarate ukunciphisa izinkinga ezihambisana ne-ammonia eningi kakhulu (i-ammonia toxicity). Kepha, kuze kube manje, izifundo kuphela ezibonisa i-alpha-ketoglutarate ezinganciphisa ubuthi be-ammonia zenziwe ezigulini ze-hemodialysis.

Abahlinzeki bezempilo kwesinye isikhathi banikeza i-alpha-ketoglutarate ngemithambo yegazi (nge-IV) ukuvikela ukulimala enhliziyweni okubangelwa izinkinga zokugeleza kwegazi ngesikhathi sokuhlinzwa kwenhliziyo kanye nokuvimbela ukuwohloka kwemisipha ngemuva kokuhlinzwa noma ukuhlukumezeka.

Izindlela zokusebenza kwe-Alpha-Ketoglutaric acid

Izindlela eziqondile zesenzo se-α-Ketoglutarate azikacaci. Ezinye zezenzo ze-α-Ketoglutarate zifaka phakathi ukusebenza kumjikelezo weKrebs njengokuphakathi, ukuphendulwa kokuguquguquka ngesikhathi semetabolism yama-amino acid, kwakheka i-glutamic acid ngokuhlanganisa ne-ammonia, nokunciphisa i-nitrogen ngokuhlanganisa nayo futhi. Ngokuphathelene nezenzo ze-α-Ketoglutarate nge-ammonia, kuphakanyiswa ukuthi i-α-Ketoglutarate ingasiza iziguli ezine-propionic academia ezinamazinga aphezulu e-ammonia namazinga aphansi e-glutamine / glutamate egazini lazo. Ngoba i-endo native glutamate / glutamine ikhiqizwa kusuka ku-α-Ketoglutarate, iziguli ze-propionic acidemia zikhiqize kahle i-α-Ketoglutarate kanye nokwengezwa kwe-α-Ketoglutarate kufanele ithuthukise isimo salezi ziguli. Olunye ucwaningo lokuhlola luye lwabonisa nokuthi ukuphathwa kwe-α-Ketoglutarate kokudla okunomzali okunikezwe iziguli zangemva kokuhlinzwa kusize ekunciphiseni ukuncipha kokuhlanganiswa kwamaprotheni emisipha avame ukubonwa ngemuva kokuhlinzwa. Lokhu kuncipha kwemisipha kucatshangelwa ukuthi kungenxa yamazinga aphansi kakhulu we-α-Ketoglutarate.

I-Alpha ketoglutaric acid (AKG) engeza - Ziyini izinzuzo ze-Alpha ketoglutaric acid?

I-Alpha-Ketoglutarate (AKG) njenge-Athletic Performance Supplement
I-Alpha ketoglutaric acid, noma i-Alpha-ketoglutarate ingumkhiqizo we-mitochondria futhi idlala indima ebalulekile ekuguqulweni kokudla kube ngamandla. Futhi kungumthombo we-glutamine ne-glutamate. Emisipheni, i-glutamine ne-glutamate kuvimbela ukuwohloka kwamaprotheni futhi kwandise amaprotheni synthesis.

I-Alpha-ketoglutarate ithuthukisa ukwakheka kwamathambo. Ilawula ukuhlanganiswa kwe-collagen ngokunokwenzeka ngokwandisa inani lama-molecule atholakalayo ukuze kuhlanganiswe. I-Collagen yingxenye ebalulekile yezicubu zethambo.

I-Alpha-ketoglutarate ivuselela ukukhiqizwa kwe-insulin-efana ne-factor factor-1 ne-hormone yokukhula. Lawa womabili ama-hormone alawula ukuvuselelwa kwamathambo nokwakheka kwezicubu ezintsha zethambo.

i-alpha ketoglutaric acid izuzisa ngokuguga
Ucwaningo lukhombisile ukuthi i-AKG ingaphatha izimo eziningi lapho ithathwa njengokuyalelwa.

Kodwa-ke, kunezinye izinkomba zokuthi i-Alpha-Ketoglutarate (AKG) ingakwazi ukusiza ngezindawo ezilwa nokuguga.

Ucwaningo olulodwa olukhulu olwenziwe eBuck Institute for Research on Aging kanye noPonce de Leon Health luthole impilo ephucukile ngamaphesenti angama-60 esifundweni sabo semammalia.

α-ketoglutaric
I-AKG inweba isikhathi sokuphila sabantu abadala se-C. elegans. (A) I-AKG yandisa isikhathi sempilo yabantu abadala. (B) Ijika lempendulo yedosi lomphumela we-AKG empilweni ende.
Ngaphezu kwalokho, uPonce De Lon Health (PDL) ukhiphe umbiko wokuhlola, umbiko okhombisa ukuthi ngemuva kwengxenye yonyaka, iminyaka yomzimba yezifundo yehle ngokwesilinganiso seminyaka eyi-8.5 ngemuva kokuthatha i-alpha-ketoglutarate (AKG) equkethwe yile nkampani.

Amanye amakhompiyutha, njenge-rapamycin yezidakamizwa yokuguga kanye ne-metformin yokwelashwa kwesifo sikashukela, akhombise imiphumela efanayo ekuhlolweni kwegundane. Kepha i-AKG ngokwemvelo yenziwe ngamagundane nangemizimba yethu, futhi sekuvele kuthathwa njengokuphephile ukudliwa ngabalawuli.

Izinto okudingeka sizinake ukuthi i-alpha ketoglutaric acid emsulwa ine-asidi kakhulu futhi akulula ukuyidla. Izithako zokuqina emakethe zengezwa nge-arginine-α-ketoglutarate (AAKG), ingxenye eyinhloko eyi-arginine, kuyilapho yona esetshenziswa yiPonce De Lon Health i-α-ketoglutarate calcium.

I-Alpha-ketoglutarate nayo inezakhiwo ezithuthukisa izivikeli mzimba
I-AKG ibizwa nangokuthi isakhi somzimba sokuzivikela ezifweni futhi ibamba iqhaza elibalulekile ekwehleni komzimba jikelele. Kuyaziwa vele ukuthi i-AKG ingumthombo obalulekile we-glutamine ne-glutamate, ichazwa njenge-glutamine homologue ne-derivative. Emzimbeni, iguqulwa ibe yi-glutamine. I-Glutamine ingakhuphula amazinga amangqamuzana amhlophe egazi (ama-macrophage nama-neutrophils). I-AKG njenge-glutamine homologue inezakhiwo ezikhuthaza ama-immuno, ingagcina umgoqo wamathumbu, ikhulise amaseli omzimba kanye nokusebenza kwama-neutrophils ne-phagocytosis, kunciphise ukuhanjiswa kwamagciwane ku-vivo.

Izikhombo:

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  2. UWernerman J, uHammarqvist F, uVinnars E. Alpha-ketoglutarate kanye ne-postoperative muscle catabolism. ILancet1990; 335: 701-3.
  3. I-Blomqvist BI, iHammarqvist F, i-von der Decken A, i-Wernerman J. Glutamine ne-alpha-ketoglutarate ivimbela ukwehla kokuhlushwa kwe-glutamine yemisipha futhi kuthinte amaprotheni synthesis ngemuva kokushintshwa okuphelele kwe-hip. I-Metabolism 1995; 44: 1215-22.
  4. UHammarqvist F, Wernerman J, von der Decken A, Vinnars E. Alpha-ketoglutarate igcina amaprotheni synthesis kanye ne-glutamine yamahhala emisipha yamathambo ngemuva kokuhlinzwa. Ukuhlinzwa 1991; 109: 28-36.
  5. UZhang W, Qu J, Liu GH, et al. I-epigenome egugile nokuvuselelwa kwayo [J]. Ukubuyekezwa Kwemvelo I-Molecular Cell Biology, 2020, 21 (3).
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  7. I-Alpha-Ketoglutarate, iMetabolite Endogenous, Yandisa Isikhathi Sokuphila futhi Icindezela Isimo Sokuhlukumezeka Emagundeni Asegugile. Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ.