I-Nicotinamide riboside (NR) ne-nicotinamide riboside (i-Chloride)

I-Nicotinamide riboside (NR) i-chloride iyindlela eneklorini ye-nicotinamide riboside (NR).

1.Yini i-Nicotinamide Riboside (NR)?

I-NR uhlobo lwevithamini B3 noma i-niacin. Le ngxube yatholwa ngawo-1940 njengesimo sokukhula se- H. umkhuhlane. Ekuqaleni kwama-21st Ikhulu leminyaka, izifundo eziningi zingafakazela ukuthi i-NR iyisandulela se-NAD +. Emzimbeni womuntu, lesi sakhi somzimba sehlisa amazinga e-cholesterol, sinciphisa ubungozi bezifo zenhliziyo, sikhulise ukusebenza kobuchopho, futhi sinciphise isifo samathambo.

INicotinamide riboside (NR) iyi-pyridine-nucleoside, esebenza njengesandulela se-NAD + (Nicotinamide adenine dinucleotide). I-NAD + ibhebhethekisa imisebenzi eminingi yemvelo kubandakanya ukulungisa i-DNA, ukukhiqizwa kwamandla eselula, ukusetha isigqi somzimba sokujikeleza, nokuningi. Ngeshwa, lawa ma-molecule ngokwemvelo ancipha nge-senescence.

2.Yini i-Nicotinamide Riboside (NR) Chloride?

INicotinamide Riboside (NR) chloride (NIAGEN) isuselwe ku-NR kanye ne-chlorine. I-compound inyusa amazinga we-NAD + futhi isebenze i-SIRT1 ne-SIRT3. Ibuyisela emuva ukuguga ngokwandisa imetabolism ye-oxidative nokuphikisana nokuhlangana komzimba okuhlobene nokudla.

E-US, i-nicotinamide riboside chloride ngokuvamile kuthathwa njengokuphephile. Ngakho-ke, kuyisithako sokudla esivunyiwe sokusetshenziswa ekunyakazisweni kwamaprotheni, amanzi e-vitamin, izinsini, nokunye okuhlobene nakho Izithako.

3.Isiphetho

Ubuntu bebulokhu buphikisana nokuguga ngokukhomba esikhunjeni. Ngesinye isikhathi, kufanele ukuthi uhlangabezane nokunye anti-ukuguga okhilimu bokusula imibimbi ebusweni ejulile, isikhumba esixegayo, kanye nebala elimnyama. Kodwa-ke, lezi zindlela zokwelapha aziguquki futhi zesikhashana. Indlela eqinisekisiwe yokuguga ngomusa kungukusungula izinguquko zebhayoloji ngemuva kwe-senescence nokubhekana nomsuka wembangela.

Abaphenyi selokhu basungula ukuxhumana phakathi kwamazinga aphansi e-NAD + nezifo ezihlobene nobudala. Lokhu kutholakala okukhulu kube ngukuqhekeka kwekhekhe emkhakheni wezokwelapha ngokwengeza amathuba okuguqula inqubo yokuguga. Ngokwalesi sizathu, i-nicotinamide riboside chloride powder uye kaningi emaphaseji wezindawo zokucwaninga ngomtholampilo ngenxa yokusebenza kwawo kahle ekubhukuqeni iwashi lezinto eziphilayo.

Ukucaciswa Kwamakhemikhali we-Nicotinamide Riboside (Chloride) Powder

Igama Product I-Nicotinamide riboside chloride (NR-CL) (23111-00-4)
Igama leKhemikhali I-NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; I-Nicotinamide ribose chloride; I-3-Carbamoyl-1- (β-D-ribofuranosyl) i-pyridinium chloride; I-3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) i-pyridin-1-ium chloride; INicotinamide BD Riboside Chloride (WX900111); I-NR-CL;
CAS Inombolo 23111-00-4
InChIKey I-YABIFCKURFRPPO-IVOJBTPCSA-N
SMILE C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-]
Formula Yamamolekhula C11H15ClN2O5
isisindo Yamamolekhula 290.7002
IMisa ye-Monoisotopic I-290.066949 g / mol
I-Melting Point N / A
Color white
Isigcini sesitoreji -20 ° C I-Freezer
Isicelo izithasiselo zokudla, insimu yezemithi

I-Nicotinamide riboside chloride

Ukwazi Izinzuzo zeNicotinamide riboside (NR), yiziphi izinzuzo zeNicotinamide Riboside Chloride?

Izinzuzo ze-nicotinamide riboside chloride vs nicotinamide riboside ziyefana ngoba zombili zisebenza ukwenza amaprotheni we-NAD ne-sirtuin 1.

I-Healthy Metabolism Yokuphatha Ukukhuluphala

Izilinganiso zocwaningo zifakazele ukusebenza kwe-nicotinamide riboside chloride ekwehliseni isisindo. Abasebenzisi bangalahlekelwa kufika ku-10% wamafutha abo omzimba ngaphandle kokucindezelwa kwesifiso noma ukuqeqeshwa ngokomzimba.

Ukuthatha lesi sidakamizwa kusiza ukwehlisa i-cholesterol ye-LDL ngenkathi kukhulisa amazinga we-cholesterol enhle. Lokhu kwenzeka lapho kugodla ukusebenza kwama-enzyme abhekele ukuhlanganiswa kwama-triglycerides. Ngenxa yalokho, ukukhiqizwa kwama-lipoprotein amancane kakhulu kuyehla.

INicotinamide riboside chloride izuzisa iziguli ezikhuluphele ezinesifo sikashukela. Isengezo sandisa umzimba ngokuthuthukisa ukungabekezelelani kweglucose

neuroprotection

Lapho amazinga e-NAD ewela ngaphansi kokulunga, uhlelo lwakho lwezinzwa nempilo yokuqonda lungaba sengozini. Thatha, isibonelo, iziguli ezinesifo i-Alzheimer's zibonisa ukuhlushwa okuphansi kwe-NAD + nokungasebenzi kahle kwe-mitochondria.

Phakathi kokusetshenziswa komtholampilo we-nicotinamide riboside chloride, ukuphathwa kwe-neurodegeneration ekugugeni kuphakamisa uhlu. Isidakamizwa sisebenza ngokumelene nokulimala kwe-intracerebral, isifo se-ischemic, ukuvuvukala kwemizwa nokufa kwe-neuronal.

Isengezo Sokulwa Nokuguga

Enye yezinto ezisemqoka ezisetshenziswa yiNicotinamide riboside chloride ifaka phakathi ukuphromotha Enempilo ukuguga. Le nhlanganisela iholela ekwandeni komkhiqizo we-NAD, odlala indima enkulu esitokisini. Isibonelo, iphakamisa amazinga wamandla eselula ngaphakathi kwemisipha, isibindi nezinso. Ngaphandle kwalokho, i-Nicotinamide riboside chloride ivimbela i-senescence ngokwandisa ukujikeleza kwegazi kulezi zitho ezibalulekile.

Ukulungiswa kwe-DNA

INicotinamide riboside chloride izuzisa ukwakheka kofuzo ngokulungisa i-DNA endala neyonakele. Uma ukuwa kwe-NAD kuwela, i-deoxyribonucleic acid elimele ingadala izinhlobo ze-oksijeni ezisebenzayo, okuholele ekucindezelekeni kwe-oxidative, nasekungenweni ngumdlavuza.

I-Nicotinamide riboside chloride

Ngabe i-Nicotinamide Riboside Chloride Reverse Aging?

Ngesikhathi sokuguga, umzimba uhlangabezana nezinguquko ezithile zomzimba njengoba imisebenzi yeselula ibuyela emuva. Isibonelo, umzimba uqeda amaprotheni we-NAD + ne-SIRT1 kunalokho ongakwenza. Amazinga aphansi ala ma-coenzymes asheshisa i-senescence ngenkathi evusa ama-comorbidities ahlobene nobudala afaka phakathi isifo sikashukela, izifo zenhliziyo, nokukhuluphala.

Ukuphatha i-nicotinamide riboside chloride kuzuzisa amasosha omzimba ngokukhulisa imithambo yegazi, njengama-lymphocyte nama-leucocyte. Le nhlanganisela ihlanganisa ukuhlanganiswa kwe-NAD +, ngakho-ke, inyusa amazinga wamaprotheni we-SIRT1. Ngenxa yalokho, i-SIRT1 ibambezela ukuguga kwemithambo yegazi ngokwandisa ukugeleza kwegazi kuye emisipheni yamathambo, uhlelo lwezinhliziyo nemithambo yegazi.

Ngaphandle kwalokho, i-nicotinamide riboside chloride supplement kubuyisa ukuguga ngokukhiqiza i-NAD + ngaphezulu ukusiza ekulungisweni kwe-DNA ngaphakathi kwesakhiwo seselula. Lo mphumela uvimbela ukucindezeleka okwenziwe nge-oxidative

Ucwaningo olutholakalayo luqinisekisa nokuthi i-nicotinamide riboside chloride iyabala ukuqina kwamathambo, ukwehla kokukhiqizwa kwezinyembezi, kanye ne-fundus hypopigmentation. Zonke lezi zimo zisabalele kubantu abadala.

Abethuli be-NAD⁺: Nicotinamide Riboside Chloride vs Nicotinamide Mononucleotide

Kukhona okungaphezulu kwesihlanu okwandulelayo kwe-NAD + kepha okwamanje, singadlulisela ukugxila kwethu kunicotinamide riboside chloride vs i-nicotinamide mononucleotide (i-NMN).

Lezi zinhlanganisela ezimbili zandisa amazinga e-NAD + emzimbeni ukuthuthukisa ukusebenza kwamaselula nokunciphisa ukuswenka.

Okuhlukanisa laba bobabili ukuthi i-NMN akuyona ifomu le-vitamin B3. Ikhemikhali alingene ngeseli lize liguqulele ku-nicotinamide riboside. Isizathu ukuthi ubukhulu bayo bamangqamuzana bukhulu kakhulu ngokuqhathaniswa nobuka-nicotinamide riboside chloride powder. Ngenxa yalesi sakhiwo, ukutholakala kwe-NMN namathemba ayo wokusebenzisa amazinga we-NAD + kube yithambo lombango endaweni yocwaningo.

Ngokusho kukaDkt.Sinclair, isazi sezofuzo eHarvard University, ukusebenza kahle kwe-NMN akunakuqhathaniswa. Uyavuma ukuthi usebenzise lokhu ukwengeza, okumenza azizwe esemncane futhi evuselelekile. I-Sinclair ilingana nokusebenza kwe-NMN ekusebenzeni endaweni yokunyathela. Usosayensi uqaphele ukuthi ithuthukisa ukujikeleza kwegazi, ikhuthaza ukukhuthazela kwemisipha, kanye nokusebenza kahle komzimba.

Ngakolunye uhlangothi, iNicotinamide riboside chloride ithathwa ngqo yiseli. I-molecule enye i-vitamin B3 ehlukile. Izokwengeza amazinga we-NAD + ngaphezulu kwe-60% emzimbeni womuntu. Ngokungafani nabaningi Abanduleli be-NAD, okusohlwini lwamawashi e-FDA, i-nicotinamide riboside (NR) chloride ikuhlu olumhlophe lwemikhiqizo yokudla ye-GRAS (Ngokuvamile Eyaziwa Njengokuphephile).

Kungani ungathathi i-NAD powder ngqo? INicotinamide Riboside Chloride vs Nicotinamide Adenine Dinucleotide (NAD)

Njengoba ukugxila kwethu kumayelana nokuphakamisa i-NAD emzimbeni, mhlawumbe ubuza ukuthi kungani impikiswano nge-nicotinamide riboside chloride. Akufanele yini uphathe NAD ngqo kusistimu yakho kunokuba udlule enkingeni yokusebenzisa abalamaphakathi njenge-NIAGEN, NR, noma i-NMN? Hhayi-ke, ngivumele ngikufushane nge-nicotinamide riboside chloride vs nicotinamide adenine dinucleotide.

Isizathu esiyinhloko sokuthi kungani ungafanele uthathe i-NAD ngqo ukuthi i-biomarker ayinakulinganiswa neseli.

Ukuhlanganiswa kokusebenzisa i-nicotinamide riboside chloride vs nicotinamide adenine dinucleotide ukuthi eyokuqala ingavunyelwa ulwelwesi lwe-plasmic. Izinga lokumunca kwalo liphakeme kakhulu ngohlelo lokugaya ukudla, ekungeneni kwegazi, futhi ekugcineni liye ebuchosheni.

I-Nicotinamide riboside chloride

Isikali seNicotinamide riboside (NR) Chloride: Ungasisebenzisa Kanjani?

Ngo-2016, isengezo se-nicotinamide riboside chloride sathola isimo se-GRAS. Ngonyaka owedlule, i-FDA yayikwamukele njengomthombo we-niacin nesithako sokudla esilinganisweni sansuku zonke sika-180mg.

Njengamanje, isilinganiso esiphezulu selayisensi ye-nicotinamide riboside chloride iye ku-300mg ngosuku. Kodwa-ke, kwezinye izilingo zabantu, lezi zihloko zazizofaka ku-2000mg wesidakamizwa. Kufanele wazi ukuthi ukweqa umthamo ka-500mg kungahle kuholele emiphumeleni emibi ye-nicotinamide riboside.

Umthamo we-niacin usebenza kuphela ku- Enempilo abantu abadala, okubandakanya abesifazane abalindele nomama abancelisayo.

Imiphumela emibi ye-Nicotinamide Riboside Chloride: Ingabe Kuphephile ukusebenzisa i-Nicotinamide Riboside Chloride Supplement?

I-Nicotinamide riboside chloride powder iphephile futhi ibamba isimo esifiswa kakhulu sezinto ze-GRAS. Leli qiniso alisho ukuthi i-compound ayinazo izimpawu ezimbi. Ngemuva kwakho konke, amanzi ayimpilo kepha futhi ahudula ezinye izichasiso ezingezinhle lapho uwasebenzisa kabi. Ukumelana nemiphumela emibi, qiniseka ukuthi isilinganiso sakho seNicotinamide riboside chloride siphansi ngangokunokwenzeka.

Okunye ukusabela okungathandeki kufaka phakathi;

  • Isisu sithukuthele
  • I-nausea
  • Ukuvota
  • Uhudo
  • Ukusabela kwesikhumba njengokuqubuka nokulimala okwandayo

Ngaphandle kwemiphumela emibi ye-nicotinamide riboside chloride, kungenzeka ukuthi uhlangabezane nayo kwesisindo. Kodwa-ke, lo mphumela uyisibusiso esifihliwe ikakhulukazi uma ukhuluphele ngokweqile, ukukhuluphala ngokweqile, noma uzama ukugcina isisindo sakho sihlolwa.

Ungayithenga kuphi (i-NR) iNicotinamide Riboside Chloride ngobuningi?

Ungenza ukuthenga kwe-nicotinamide riboside chloride esitolo esiku-inthanethi. Kungakhathaliseki ukuthi ufuna i-powder-grade grade ngobuningi noma okunye okungeziwe kokudla, qiniseka ukuthi ubheka umhlinzeki wangempela. Ukuhlanganiswa kokuthenga okubonakalayo ukuthi ungaqhathanisa amanani futhi uhlole impendulo yamakhasimende wesikhathi sangempela. Kodwa-ke, futhi kungenzeka ukuthi uwele kumgunyathi.

Singumkhiqizo othembekile futhi yonke imikhiqizo yethu ihambisana nezinyathelo zokulawula ikhwalithi. Sibhekana namakhemikhali ahlukene futhi Izithako zokudla. Xhumana nathi nge-oda lakho kanye nekhotheshini enobungane.

Okubhekwayo
    1. IConze, D., Brenner, C., neKruger, CL (2019). Ukuphepha kanye neMetabolism Yokuphathwa Kwesikhathi Eside kwe-NIAGEN (Nicotinamide Riboside Chloride) ku-Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Healthy Overweight Adult. Imibiko yeSayensi.
    2. IBogan, KL & Brenner, C. (2008). I-Nicotinic Acid, i-Nicotinamide, ne-Nicotinamide Riboside: Ukuhlolwa Kwezakhi Zamavithamini Wangaphambi Kwama-NAD + ku-Human Nutrition. Ukubuyekezwa Kwaminyaka Yonke Kwezomsoco.
    3. UMehmel, M., Jovanovic, N., noSpitz, U. (2020). INicotinamide Riboside - Isimo Samanje Sokucwaninga Nokusetshenziswa Kwezokwelapha.
    4. UTurck, D., uCastenimiller, uJ., Et al. (2019). Ukuphepha kweNicotinamide Riboside Chloride njengeNewvel Food Pursuant to Regulation (EU) 2015/2283 kanye nokutholakala kweNicotinamide okuvela kulo Mthombo, ku-Context of Directive 2002/46 / EC. Ijenali ye-EFSA.
    5. U-Elhassan, YS et al. (2019). INicotinamide Riboside Yengeze Imisipha Yomuntu Ekhulile NAD + Metabolome futhi Ikhuthaze Amasiginesha weTranscriptomic ne-Anti-Inflammatory. Imibiko Yeseli.
    6. Aman, Y., Qiu, Y., Tao, J., & Fang, EF (2018). Amandla Okwelapha Okukhuthaza i-NAD + ekuguleni nasezifo ezihlobene nobudala. Imithi Yokuhumusha Yokuguga.
    7. I-RAW NICOTINAMIDE MONONUCLEOTIDE (NMN) IPODA (1094-61-7)
    8. I-RAW LORCASERIN HCL POWDER (846589-98-8)

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