J-147 Ukubuka konke

J-147 impushana yaba khona ngonyaka we-2011 eCellular Neurobiology Laboratory yeSalk Institute. Kusukela yasungulwa, kube nezifundo eziningi eziqinisekisa ukusebenza kwayo kahle ekwelapheni isifo i-Alzheimer's kanye nokubuyisela emuva inqubo yokuguga.

UDkt Dave Schubert nabanye abacwaningi abasebenza naye eSalk Institute badlale indima ebalulekile esifundweni se-curcumin kaJ-147. Ku-2018, izazi ze-neurobiologists zembula indlela yokusebenza kwe-J-147 ye-nootropic neqhaza layo ekuphatheni izifo ze-neurodegenerative.

Ukutadisha nokucwaninga kwalesi sidakamizwa kugxile ekubalulekeni kwayo ekuphathweni kwe- I-Alzheimer's isimo. Kodwa-ke, abasebenzisi abanempilo babe nentshisekelo kuzinzuzo ze-J-147 njengokuthuthukisa inkumbulo, ukukhulisa amandla okufunda, nokuvuselelwa kwama-neurons.

Ku-2019, osokhemisi baqala ukuzama i-J-147 Alzheimer's antidote kubantu.

Yini i-Nootropic J-147 Powder?

I-J-147 powder kuvela ku-curcumin naku-Cyclohexyl-Bisphenol A. Isidakamizwa esihlakaniphile sinezici zombili ze-neuroprotective ne-neurogenic. Ngokungafani nama-nootropics amaningi, ukulwa nokuguga kwe-J-147 ukwengeza ithuthukisa ukuqonda ngaphandle kokuthinta ama-enzyme e-acetylcholine noma i-phosphodiesterase.

ICurcumin iyinhlangano esebenzayo ye-turmeric futhi inenzuzo ekuphatheni izifo ze-neurodegenerative. Kodwa-ke, le polyphenol ayiweli kahle umgoqo wegazi nobuchopho. Ngenxa yalokhu, i-J-147 nootropic yaba yi-sub yokugcina njengoba yeqa umgoqo wegazi nobuchopho kalula.

Isebenza kanjani i-J-147?

Kuze kube ngu-2018, umphumela we-J-147 esitokisini uhlala ungaziwa kuze kube yilapho iSalk Institute Neurobiologists isichaze le phazili. Isidakamizwa sisebenza ngokubopha i-ATP synthase. Le protein ye-mitochondrial modulates ukukhiqizwa kwamandla eselula, yingakho, ilawula inqubo yokuguga.

Ukuba khona kwesengezo se-J-147 ohlelweni lomuntu kuvimbela ubuthi obuhlobene nobudala obudalwa yimitochondria engasebenzi kahle kanye nokukhiqizwa ngokweqile kwe-ATP.

Indlela yokusebenza ye-J-147 futhi kuzokwengeza amazinga ama-neurotransmitter ahlukahlukene afaka i-NGF ne-BDNF. Ngaphandle kwalokho, isebenza kumazinga we-beta-amyloid, ahlala ephakeme kakhulu phakathi kweziguli ezine I-Alzheimer's nokuwohloka komqondo.

Imiphumela ye-J-147 ifaka phakathi ukunciphisa ukuqhubeka kwe I-Alzheimer's, ukuvimbela ukusilela kwememori, nokwengeza ukukhiqizwa kwamaseli we-neuronal.

Izinzuzo Ezingaba khona ze-J-147

Khuthaza Ukuqashelwa

Isengezo se-J-147 sithuthukisa inkumbulo yendawo neyesikhathi eside. Isidakamizwa siguqula ukukhubazeka kwengqondo phakathi kwabantu asebekhulile abanenkinga yokukhubazeka kwengqondo. I-J-147 iyathengiswa itholakala njengomthamo wokuthenga futhi isizukulwane esisha siyayithatha ukukhulisa amandla okufunda.

Ukuthatha J-147 ukulwa nokuguga izidakamizwa zizophinde zithuthukise inkumbulo, umbono, nokucaca kwengqondo.

Ukuphathwa Kwezifo Ze-Alzheimer's

j-147

I-J-147 isiza iziguli ezine-Alzheimer's ngokwehlisa ukuqhubeka kwesimo. Isibonelo, ukuthatha ukwengeza inciphisa amazinga we-beta-amyloid encibilikayo (i-Aβ), okuholela ekungasebenzi kahle kwengqondo. Ngaphandle kwalokho, i-J-147 curcumin modulates signaling neurotrophin ukuqinisekisa ukusinda kwe-neuronal, ngakho-ke, ukwakheka kwememori nokuqonda.

Iziguli ezine-AD zinezici ezimbalwa ze-neurotrophic. Kodwa-ke, ukuthatha isengezo se-J-147 Alzheimer's kukhulisa i-NGF ne-BDNF. Lawa ma-neurotransmitters asiza ukwakheka kwememori, ukufunda, nokusebenza kwengqondo.

neuroprotection

I-J-147 nootropic kuvimbela ukufa kwe-neuronal ngenxa yokuxineka kwe-oxidative.

Lesi sithasiselo sibuye sivimbele ukusebenza ngokweqile kwama-receptors e-NMDA (N-Methyl-D-aspartate), abhekele ukusebenza kwe-neurodegeneration.

Ukuthatha isidakamizwa i-J-147 kuzokwengeza izici ezithathwe ebuchosheni (BDNF) nezici zokukhula kwemizwa (NGF). La ma-neurotransmitters amabili ahambisa phansi izifo ze-neurodegenerative ezinjenge-Alzheimer's kanye ne-dementia. Ngaphezu kwalokho, i-BDNF ibalulekile ku-neurogeneis.

Ithuthukisa umsebenzi we-Mitochondrial

j-147

Ukuthatha isidakamizwa i-J-147 kuzothuthukisa ngokungaqondile amazinga e-ATP ngokukhulisa imisebenzi ye-mitochondrial.

Ukuguga kunesibopho sokwehla kwe-mitochondria ngenxa yokungasebenzi kahle nokwanda kwezinhlobo zomoya-mpilo ezisebenzayo. Noma kunjalo, Isengezo se-J-147 ilwa nale ndlela ngokuvimbela i-ATP5A synthase. Izifundo eziningi zibala kumuthi wokwandisa impilo yomuntu.

I-J-147 ne-Anti-ukuguga

Ngokusho kwabacwaningi beSalk, i-J-147 yokwengeza ukulwa nokuguga yenza amangqamuzana asebekhulile abonakale esemusha.

I-mitochondria engasebenzi iyasheshisa inqubo yokuguga. I-homeostasis yeselula izonciphisa, ngakho-ke, ukwehla kokusebenza komzimba. Ngaphandle kwalokho, ukulimala kwamaseli kanye nokuwohloka kwe-mitochondrial kuzokwenzeka ngenxa yokukhiqizwa kweROS (izinhlobo zomoya-mpilo ezisebenzayo). Ukuthatha i-J-147 powder kuzomelana nalomphumela, ngakho-ke, kunciphisa i-senescence.

Ukuguga kuhlotshaniswa nokwehla kokuqonda kanye nokuphazamiseka kwe-neurodegenerative. Noma kunjalo, eziningana Okuhlangenwe nakho kuka-J-147 qinisekisa ukusebenza kwezidakamizwa ekubuyiseleni emuva inkumbulo, ukwenza ngcono amakhono okuqonda, nokwelapha ukuwohloka komqondo, I-Alzheimer's, nezinye izifo ezihlobene nobudala.

Umthamo Ojwayelekile we-J-147

(1) Umthamo ojwayelekile

Umthamo ojwayelekile wansuku zonke we-J-147 uphakathi kuka-5mg no-30mg. Ungahlukanisa ifayili le- Isilinganiso se-J-147 zibe zibili. Ngokuncanyelwayo, umthamo wakho kufanele ube sezingeni eliphansi futhi uwukhulise ngokususelwa ekubekezeleleni komzimba wakho.

Lesi sithasiselo sisebenza ngomlomo. Kufanele uyeke ukuyithatha ngokuhlwa noma ebusuku ngoba ezinye izibuyekezo ze-J-147 zithi zingaphazamisa iphethini yakho yokulala.

(2) Umthamo wesineke

Abaphenyi basebenzise i-10mg / kg yomthamo we-J-147 ukwelapha I-Alzheimer's isifo kumamodeli wegundane.

Noma kunjalo, umthamo wakho kufanele uxhomeke esimweni sakho. Thatha, isibonelo, uma ngemuva kokuthuthukisa ukuqonda kwakho, kufanele uqinisekise ukuthatha i-5mg iye ku-15mg. Ngokuphambene nalokho, ngokuvikelwa kwemizwa nokuphathwa kwezifo ze-neurodegenerative, ungakhuphula umthamo ube ngu-20mg no-30mg.

In Izilingo zomtholampilo ze-J-147, izihloko zazizothatha umthamo ngokushesha ngemuva kokuzila ubusuku bonke kwehora eli-8.

Umehluko phakathi kuka-J-147 no-T-006

I-T-006 isuselwe ku-J-147 nootropic. Isakhi sakhiwe ngokufaka esikhundleni seqembu le-methoxyphenyl le-J-147 curcumin powder ne-tetramethylpyrazine.

Ukwengeza nge T-006 cishe izinyanga ezintathu kuzonciphisa inkungu yobuchopho futhi kukhuphule amandla wonke. Ngaphezu kwalokho, impuphu inyusa amandla okukhuluma futhi yenze umsebenzisi abe nozolile. Ngokuphambene nalokho, okuhlangenwe nakho kwe-J-147 kufaka phakathi inkumbulo ethuthukisiwe, umbono, nephunga.

Ngaphandle komehluko ongasho lutho, lezi zithasiselo ezimbili zinemiphumela efanayo.

Ngabe i-J-147 iphephile uma usebenzisa?

Isidakamizwa se-J-147 siphephile. Kuphumelele ngempumelelo ukuhlolwa kobuthi ekuhlolweni kwezilwane njengoba kudingwa yi-Food and Drug Administration (FDA). Ngaphandle kwalokho, izivivinyo zokwelashwa ze-J-147 seziqhubeke isikhathi esithile.

Awekho amarekhodi okuphikisana Imiphumela ye-J-147 kuzo zombili izivivinyo zangaphambi kokuqonda nezabantu.

Isivivinyo somtholampilo se-J-147

Isigaba sokuqala sesivivinyo somtholampilo i-J-147 siqale ekuqaleni kuka-2019 njengoba sixhaswe ngabakwa-Abrexa Pharmaceuticals, Inc. Inhloso yocwaningo bekuwukukala ukuphepha nokubekezelela ukuthatha i-nootropic, kanye nezakhiwo zayo ze-pharmacokinetic ezifundweni ezinempilo.

Ucwaningo lomtholampilo lwalubandakanya bobabili abasha nabadala. Iqembu locwaningo lalilawulwa ngokungahleliwe, lingaboni kabili, futhi lilawulwa nge-placebo ngamanani akhuphukayo awodwa.

Ekupheleni kokuvivinywa komuntu, ososayensi kufanele basungule umphumela ngokuya ngemiphumela emibi, ukushaya kwenhliziyo nesigqi, izinguquko zomzimba, kanye Izinzuzo ze-J-147 ohlelweni lwezinzwa.

j-147

Ukubuyekezwa komsebenzisi / okuhlangenwe nakho ngemuva kokusebenzisa i-J-147

Nazi ezinye zezibuyekezo ze-J-147;

ICapybara ithi;

“… Kungabuye kube nomuzwa wamandla amaningi kakhulu ekuqaleni. Hhayi uhlobo lwe-caffeine noma i-amphetamine yamandla, kepha amandla angaphezulu emvelo. Ngisijabulele lesi sigaba kwazise ngikwazile ukucabanga ngokwenza okuthile njengokugibela ibhayisikili, bese ngikwenza ngaphandle kokungabaza noma ukuzikholisa ukuthi ngizoqala. Ukuzikhuthaza kwakungelula. Lokhu kwahlakazeka kakhulu ngemuva kwamasonto ambalwa, futhi ngenkathi ngijabulela lo muzwa, omunye kungenzeka, ngakho-ke ngibhala lokhu njengomthelela ongase ube khona. ”

Imisebenzi kaF5 ithi;

“Kubukeka njenge-nootropic ethokozisayo nethembisayo. Kubikwa ukuthi bekunocwaningo lomtholampilo e-US ngonyaka odlule. ”

Omunye umsebenzisi uthi;

“Kulungile, ngiyitholile izolo futhi sengiphuze i-10mg ngemithamo emi-3. Ngiyithathile kancane futhi yancibilika kahle. Ayinambitheki kabi. Umphumela osheshayo waqala ngokushesha kakhulu kimi. Umbono wami nengqondo yami kwakubonakala kucijile ngandlela thile, kepha kungaba yi-placebo nje. Akubonakali kunomphumela omubi nhlobo, kodwa kusesekuseni kakhulu ukusho… Ngizwe konke kuhamba kahle futhi nginikwe amandla usuku lonke ngomunye u-10 mg ekuseni ngabo-6 ekuseni. ”

UFafner55 uthi;

"Ngiyaqhubeka nokuthatha i-J147 ngaphandle kwenzuzo ebonakalayo ngaphandle kokunciphisa ukuvuvukala nokuvuvukala okuphawulwe ngaphambili."

Singayitholaphi i-J-147 powder?

Ukuba semthethweni kwale nootropic kuseyithambo lombango kepha ngeke kukuvimbe ekutholeni imikhiqizo esemthethweni. Ngemva kwakho konke, I-J-147 Alzheimer's ukuhlolwa kwemitholampilo kuyaqhubeka. Ungathenga i-powder ezitolo eziku-inthanethi njengoba uthola ilungelo lokuqhathanisa amanani we-J-147 kubathengisi abahlukahlukene. Kodwa-ke, kufanele uqiniseke ukuthi uthenga kusuka kubahlinzeki abavumelekile ngokuhlolwa okuzimele kwelabhoratri.

Uma ufuna ezinye J-147 iyathengiswa, ngena esitolo sethu. Sinikezela ngama-nootropics amaningi ngaphansi kokulawulwa kwekhwalithi. Ungathenga ngobuningi noma wenze ukuthenga okukodwa ngokuya ngomgomo wakho we-psychonautic. Qaphela ukuthi, intengo ye-J-147 inobungane kuphela uma uthenga ngobuningi.

Okubhekwayo
  1. ILapchak, AP, iBombien, R., neRajput, SP (2013). I-J-147 i-Novel Hydrazide Lead Compound Yokwelapha I-Neurodegeneration: I-CeetoxTM Ukuhlaziywa Kokuphepha kanye neGenotoxicity. Ijenali yeNeurology neNeurophysiology.
  2. Ngaphambi kwalokho, M., et al. (2013). I-Neurotrophic Compound J147 Ibuyisa Ukuwohloka Kokuqonda Kamagundane Esifo Esikhulile se-Alzheimer's. Ucwaningo Nokwelashwa Kwe-Alzheimer's.
  3. Izidakamizwa ze-Alzheimer Zijikisa i-Clock Emuva ku-Powerhouse of Cell. ISalk Institute.Januwari 8, 2018.
  4. Qi, Chen., Et al. (2011). Isidakamizwa se-Novel Neurotrophic for Enhancement Cognitive and Alzheimer's Disease. Umtapo Wezincwadi Womphakathi weSayensi.
  5. UDaugherty, DJ, et al. (2017). I-Novel Curcumin Derivative for the Treatment of Diabetic Neuropathy.
  6. ULejing, uLian., Et al. (2018). Imiphumela efana ne-anti-depressant ye-Novel Curcumin Derivative J147: Ukubandakanywa kwe-5-HT1A I-Neuropharmacology.
  7. I-RAW J-147 POWDER (1146963-51-0)

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